Clinical trials: Ventricular
Brain Damage, External Ventricular Drain
Pupillometry : Predictive Indicator in External Ventricular Drain Clamping ?
Pupillar diameter variation to predict success or failure of external ventricular derivation clamping. Pupillometry utilisation as a diagnostic tool in external ventricular clamping test in neurological ICU should improve…
- Conditions
- Brain Damage, External Ventricular Drain, Hydrocephalus
- Trial name
- CLAMP (NCT03823430)
- Testing
- Pupillometry
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- Association Pro-arte
Hypertension and Left Ventricular Hypertrophy (Thickening of the Main Pumping Chamber of the Heart)
Losartan Intervention For Endpoint Reduction in Hypertension (LIFE) Study (0954-133)
The LIFE study was conducted from 1995-2001. This study was conducted in 9193 patients with high blood pressure and thickening of the main pumping chamber of the heart.
- Trial name
- NCT00338260
- Testing
- MK0954, /Duration of Treatment : 5 Years, Comparator : atenolol /Duration of Treatment : 5 Years
- Volunteers
- 496 people
- Sponsor
- Organon and Co
Aortic Stenosis, Left Ventricle Hypertrophied
Effect of Dapagliflozin on Myocardial and Renal Function Following Aortic Valve Stenosis Intervention
Randomized, double-blinded, placebo-controlled study in AS patients with subclinical or clinical heart failure undergoing treatment with TAVR.
- Trial name
- DAPAS (NCT05241431)
- Testing
- SGLT2 inhibitor
- Where
- Denmark
- Volunteers
- 106 people
- Sponsor
- University of Aarhus
Cardiac Arrhythmia
Novel Cardiac Signal Processing System
This study is designed to collect parallel intracardiac signal data during pre-defined periods of clinical interest from the PURE EP system and the existing signal recording and mapping systems.
- Trial name
- NCT04112433
- Testing
- PURE EP 2
- Where
- 3 sites in United States
- Volunteers
- 104 people
- Sponsor
- BioSig Technologies, Inc.
Hypertension
Predictive Factors of Systolic Dysfunction in Non-complicated Hypertensive Patients
Hypertension is a major cardiovascular risk factor. Heart failure is one of its main complications but the factors that influence its development are still insufficiently known.
- Trial name
- GLOBAL-HTN (NCT02841696)
- Testing
- Cardiac echography
- Where
- France
- Volunteers
- 183 people
- Sponsor
- University Hospital, Bordeaux
Premature Ventricular Contractions
Use of MIBG Scan Images in PVC Ablations
The purpose of this study is to assess if Single Photon Emission Computed Tomography (SPECT) demonstrating cardiac innervation can be integrated into current electrophysiology voltage mapping system and provide improved guidance…
- Trial name
- PVC-MIBG (NCT02279030)
- Testing
- MIBG nuclear scan
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Left Ventricular Function, Arrhythmia
Impact of Radiofrequency Ablation on Left Ventricular Function in Supraventricular Tachyarrhythmias Patient Using Speckle Tracking Echocardiography
In this study, we aimed to evaluate atrial and ventricular function in supraventricular tachyarrhythmia patients before and 3 months after RFA using 2DSTE.
- Trial name
- NCT05225662
- Testing
- radiofrequency ablation
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Mitral Valve Prolapse
Myocardial Characterization of Arrhythmogenic Mitral Valve Prolapse (STAMP: STretch and Myocardial Characterization in Arrhythmogenic Mitral Valve Prolapse)
Mitral valve prolapse (MVP) is a frequent affection of the mitral valve or its sub-valvular apparatus with a prevalence of 2-3% in the general population.
- Trial name
- STAMP (NCT02879825)
- Testing
- Cardiac MRI
- Where
- France
- Volunteers
- 239 people
- Sponsor
- Central Hospital, Nancy, France
Ventricular Failure
Inter-observer Reproductibility of Visual Estimation of Left Ventricular Ejection Fraction in Critical Care
Inter-observer reproductibility of visual estimation of left ventricular ejection fraction is known to be good in cardiology but has not been studied in ICU.
- Trial name
- NCT04978389
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Montpellier
Ventricular Tachycardia, Arrhythmia
Imaging With a Radio Tracer to Guide VT Ablations
Some patients are at risk for life-threatening fast heart rates. These can frequently be treated by using a catheter inside the heart to burn away the cells that create the fast heart rates.
- Trial name
- NCT01250912
- Testing
- 123I-metaiodobenzylguanidine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Maryland, Baltimore
Left Ventricular Thrombus
Apixaban in Patients With Left Ventricular Thrombus
Open label randomized controlled clinical trial to evaluate the efficacy and safety of apixaban versus warfarin in treating left ventricular thrombus in patients with acute or recent myocardial infarction (MI).
- Trial name
- NCT05208398
- Testing
- Apixaban, Warfarin
- Where
- Saudi Arabia
- Volunteers
- 50 people
- Sponsor
- Saud Al Babtain Cardiac Center
Premature Ventricular Complex
Electrocardiographic and Cardiac Magnetic Resonance Predictors of Ventricular Arrhythmias in Cardiomyopathic Patients
This study aims to assess ECG changes for predicting ventricular arrhythmia in cardiomyopathic patients
- Trial name
- NCT05078125
- Testing
- Holter monitoring
- Volunteers
- 79 people
- Sponsor
- Assiut University
Ventricular Septal Defect, Appetite Loss
The Effect of Transcatheter VSD Closure on Children's Appetite, Hormones and Growth
In this study; Changes in appetite, hormones and growth of ventricular septal defect patients treated with non-surgical method were evaluated.
- Conditions
- Ventricular Septal Defect, Appetite Loss, Growth Delay
- Trial name
- NCT05200910
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Kayseri City Hospital
Hypertrophic Cardiomyopathy, Hypertrophic Obstructive Cardiomyopathy
Comparison of Squat-to-Stand Maneuver With Amyl Nitrite, Valsalva, and Exercise Stress Echocardiography in Inducing Latent Left Ventricular Outflow Obstruction in Hypertrophic Cardiomyopathy
The purpose of this study is to assess the effectiveness of squat-to-stand maneuver in eliciting left ventricular outflow gradients in patients with Hypertrophic Cardiomyopathy (HCM) compared to Valsalva, amyl nitrite inhalation…
- Conditions
- Hypertrophic Cardiomyopathy, Hypertrophic Obstructive Cardiomyopathy, Cardiomyopathy, Hypertrophic
- Trial name
- NCT04905173
- Testing
- Squat-to-stand maneuver, Amyl nitrite inhalation, Valsalva
- Sponsor
- Mayo Clinic
Left Ventricular Dysfunction
Strategic Management to Improve CRT Using Multi-Site Pacing Post Approval Study (Reference # C1918)
Prospective, multi-center, single arm, post approval study to be conducted in the United States.
- Trial name
- SMARTMSP (NCT03257436)
- Testing
- CRT-D
- Where
- 54 sites in United States
- Volunteers
- 586 people, healthy volunteers welcome
- Sponsor
- Boston Scientific Corporation
Pulmonary Embolism, Pulmonary Thromboembolisms
Catheter-Directed Thrombolysis Versus Anticoagulation Monotherapy in Intermediate-High Risk PE
In an open-label parallel groups blinded-endpoint randomized clinical trial, the investigators aim to assess the safety and efficacy of conventional catheter-directed thrombolysis (CDT) vs anticoagulation monotherapy on outcomes…
- Conditions
- Pulmonary Embolism, Pulmonary Thromboembolisms, Embolism, Pulmonary, Right Ventricular Dysfunction
- Trial name
- CANARY (NCT05172115)
- Testing
- Conventional catheter-directed thrombolysis (CDT) with recombinant tissue plasminogen activator (rtPA), Enoxaparin
- Where
- Iran
- Volunteers
- 94 people
- Sponsor
- Rajaie Cardiovascular Medical and Research Center
Post-myocardial Infarction Ventricular Tachycardia
Facilitating Catheter Guidance to Optimal Site for VT Ablation
Each year in the UK, approximately 150,000 people have a heart attack when the blood supply to their heart is compromised. As a result, affected regions of the heart can become diseased and scarred.
- Trial name
- CPS (NCT03862989)
- Testing
- Radiofrequency catheter ablation
- Where
- United Kingdom
- Sponsor
- University of Exeter
Cardiac Ultrasound Phenotypes, Septic Myocardial Suppression
A Multicenter Cross-sectional Study of Cardiac Ultrasound Phenotypes in Patients With Sepsis
The heart, one of the most important organs for oxygen supply and consumption, is frequently involved in sepsis, i.e. septic cardiomyopathy, also known as septic myocardial suppression.
- Conditions
- Cardiac Ultrasound Phenotypes, Septic Myocardial Suppression, Hyperdynamic State Left Ventricular Function in Sepsis Patients, Outcome
- Trial name
- NCT05161104
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Fujian Provincial Hospital
Brugada Syndrome, Channelopathies
Defining the Electrocardiographic Effect of Propofol on the Ajmaline Provocation Drug Challenge: A Prospective Trial
Background: Brugada Syndrome is an inherited channelopathy associated with risk of ventricular fibrillation and sudden cardiac death in a structurally normal heart.
- Conditions
- Brugada Syndrome, Channelopathies, Ventricular Fibrillation, Cardiac Death
- Trial name
- NCT04580992
- Testing
- Ajmaline
- Where
- Belgium
- Volunteers
- 25 people
- Sponsor
- Universitair Ziekenhuis Brussel
Left Ventricular Assist Device
Blood-pressure Measuring in Patients Carrying a Left Ventricular Assist Device
To prove the novel device is able to reliably detect pulsatility in patients with CF-VADs and to analyze whether pre-programmed intrinsic pulsatility of the 3rd generation CF-VADs can also be picked up.
- Trial name
- LVAD (NCT03458988)
- Testing
- Blood-pressure measuring (Nellcor™ Adult SpO2 Sensor)
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern