Clinical trials: Ventricular Arrhythmias, active
Ventricular Tachycardia (VT), Atrial Tachycardia
Clinical Study on the Efficiency of Rapid Arrhythmia Mapping Using EasyStars™ High Density Mapping Catheter Applications
The primary objective of this study was to evaluate the clinical feasibility, safety, and surgical characteristics of the EasyStars™ High Density Mapping Catheterin in patients with complex arrhythmias.
- Conditions
- Ventricular Tachycardia (VT), Atrial Tachycardia, Typical Atrial Flutter, Paroxysmal Atrial Fibrillation (PAF)
- Trial name
- Rapid Arrhythm (NCT07079813)
- Testing
- EasyStars™ High Density Mapping Catheter
- Volunteers
- 300 people
- Sponsor
- Shanghai MicroPort EP MedTech Co., Ltd.
Cardiac Arrest, Out-Of-Hospital Cardiac Arrest
Initial Double Sequential External Defibrillation in Out of Hospital Cardiac Arrest
Double Sequential External Defibrillation (DSED) represents an alternative treatment of refractory ventricular fibrillation (rVF) in out-of-hospital cardiac arrest (OHCA).
- Conditions
- Cardiac Arrest, Out-Of-Hospital Cardiac Arrest, Ventricular Fibrillation
- Trial name
- DUALDEFIB (NCT06672159)
- Testing
- Two defibrillators, One defibrillator
- Where
- Norway
- Volunteers
- 356 people
- Sponsor
- St. Olavs Hospital
Ventricular Tachycardia (VT)
Sympathetic Ablation for Ventricular Arrhythmias
Enrolled patients will undergo an acute procedure in which a catheter is inserted near the heart to ablate a sympathetic nerve, reducing signals that trigger ventricular arrhythmias.
- Trial name
- NCT07501819
- Testing
- Central sympathetic nerve ablation
- Volunteers
- 10 people
- Sponsor
- SymKardia
Bradycardia, Atrioventricular Block
Procedural Endpoint in Left Bundle Branch Area Pacing: Conduction System Capture Versus LV Septal Capture
This is a prospective, multicenter, randomized controlled trial designed to determine whether direct capture of the left ventricular conduction system must be achieved as the procedural endpoint of left bundle branch area pacing…
- Conditions
- Bradycardia, Atrioventricular Block, Sick Sinus Syndrome, Cardiac Pacing
- Trial name
- COMPARE-SYNC (NCT07804394)
- Testing
- LBBAP with mandatory left ventricular conduction system capture (LBBP or LFP), LBBAP with left ventricular septal capture as the accepted procedural endpoint (LVSP)
- Volunteers
- 300 people
- Sponsor
- Yonsei University
Atrial Fibrillation, Ventricular Tachycardia
Defining the Risk of Ventricular Tachycardia in Genetic Cardiomyopathies
The goal of this observational study is to determine if electrophysiologic mapping and cardiac MRI can help identify patients that have genetic forms of cardiomyopathy that are at high risk for development of dangerous…
- Conditions
- Atrial Fibrillation, Ventricular Tachycardia, Premature Ventricular Contraction
- Trial name
- NCT06575881
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Vanderbilt University Medical Center
Ventricular Arrhythmia, Cardiomyopathies
ElectroPhySiological Characterization Of the Arrhythmia Substrate for Sudden Cardiac Death PrEdiction
EP-SCOPE is a prospective, multicentric, non-randomized pilot study that aims to estimate the risk of life-threatening ventricular arrhythmia through use of advanced electrophysiological studies in patients with ischemic or…
- Conditions
- Ventricular Arrhythmia, Cardiomyopathies, Left Ventricular Ejection Fraction Less Then or Equal to 50percent
- Trial name
- EP-SCOPE (NCT07020702)
- Testing
- Implantation of an ICD
- Where
- 3 sites in France
- Volunteers
- 210 people
- Sponsor
- University Hospital, Bordeaux
Left Bundle-Branch Block, Aortic Valve Stenosis
Clinical Monitoring Strategy Versus Electrophysiology-guided Algorithmic Approach With a New LBBB After TAVI
The primary hypothesis of the proposed study is that an electrophysiology-based algorithmic approach is superior to standard clinical follow-up with 30-day monitoring in reducing the combined endpoint of syncope, hospitalization…
- Trial name
- COME-TAVI (NCT03303612)
- Testing
- Pacemaker implant, Transcutaneous cardiac monitor
- Where
- 10 sites in Canada, France
- Volunteers
- 250 people
- Sponsor
- Montreal Heart Institute
Acute Myocardial Infarction, Non-ST Elevation Myocardial Infarction
BEtablocker Treatment After Acute Myocardial Infarction in Patients Without Reduced Left Ventricular Systolic Function
The study aims to investigate whether oral betablocker (BB) therapy is superior to no such treatment following an acute myocardial infarction (AMI).
- Conditions
- Acute Myocardial Infarction, Non-ST Elevation Myocardial Infarction, ST Elevation Myocardial Infarction
- Trial name
- BETAMI (NCT03646357)
- Testing
- Non-betablocker, Betablocker
- Where
- 20 sites in Norway
- Volunteers
- 2,895 people
- Sponsor
- Oslo University Hospital
Ventricular Tachycardia
Catheter Ablation of Haemodynamically Not-tolerated Electrical Storm in Structural Heart Disease
This is a multi-center, parallel-group, randomized, open-label trial evaluating the clinical outcome and efficacy of emergency catheter ablation versus conventional stepped-care strategies in patients with haemodynamically…
- Trial name
- NCT06455020
- Testing
- Catheter ablation, Stepped-care strategies
- Where
- 4 sites in China
- Volunteers
- 96 people
- Sponsor
- Beijing Anzhen Hospital
Atrial Fibrillation, Coronary Artery Disease
Prospective Project to Identify Biomarkers of Morbidity and Mortality in Cardiovascular Interventional Patients
The objective of CAREBANK study is to establish definitive relationships with human cardiac samples and clinical phenotypes in patients undergoing cardiac procedures.
- Conditions
- Atrial Fibrillation, Coronary Artery Disease, Aortic Valve Stenosis, Aortic Valve Disease
- Trial name
- CAREBANK (NCT03444259)
- Testing
- Cardiac surgery
- Where
- Finland
- Volunteers
- 1,001 people
- Sponsor
- University of Turku
Aortic Stenosis, Right Bundle-Branch Block
Prophylactic Permanent Pacemaker in Patients With Right Bundle Branch Block Undergoing Transcatheter Aortic Valve Implantation
The goal of this clinical trial is to learn about the safety and outcome of prophylactic pacemaker implantation in patients with right bundle-branch block undergoing trans-catheter aortic valve (TAVI) implantation in patients…
- Trial name
- TAVI-PACE (NCT05889208)
- Testing
- Prophylactic pacemaker implantation
- Volunteers
- 320 people
- Sponsor
- Aalborg University Hospital
Out-Of-Hospital Cardiac Arrest, Hypothermia
Prehospital Resuscitation Intranasal Cooling Effectiveness Survival Study 2
The aim of this clinical trial is to study the impact of ultra-early transnasal evaporative cooling after cardiac arrest and subsequent hypothermia at hospital, on survival with complete neurologic recovery, compared to currently…
- Conditions
- Out-Of-Hospital Cardiac Arrest, Hypothermia, Ventricular Fibrillation
- Trial name
- PRINCESS2 (NCT06025123)
- Testing
- Early transnasal evaporative cooling with the RhinoChill device
- Where
- 17 sites in Austria, Belgium and 6 more
- Volunteers
- 1,022 people
- Sponsor
- Karolinska Institutet
Ventricular Tachycardia (VT), Catheter Ablation
Using Non-Invasive Mapping To Eliminate Structural Heart Disease Ventricular Tachycardia
Ventricular tachycardia (VT) is an abnormal and dangerous heart rhythm affecting the lower chambers of the heart (the ventricles).
- Trial name
- UNITE-VT (NCT07759427)
- Testing
- VIVO-assisted mapping
- Where
- 3 sites in United Kingdom
- Volunteers
- 110 people
- Sponsor
- University of Warwick
Ventricular Arrhythmia, Ventricular Tachycardia (V-Tach)
Proton Radiosurgery for the Treatment of Malignant Ventricular Tachyarrhythmias
Ventricular arrhythmias (VAs) are the leading cause of sudden cardiac death (SCD) worldwide. The implantable defibrillator (ICD) increases survival in patients at risk of VA, with data of superiority to antiarrhythmic drugs.
- Trial name
- TOVEL (NCT06769451)
- Testing
- Stereotactic Arrhythmia Radioablation (STAR) with Proton Therapy
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- Azienda Sanitaria Universitaria Integrata del Trentino
Bradycardia, Pacing
"Physiological vs Right Ventricular Pacing Outcome Trial Evaluated for bradyCardia Treatment" (PROTECT-HF)
The PROTECT-HF multi-centre randomised controlled trial will compare two different pacing approaches for treating patients with slow heart rates.
- Conditions
- Bradycardia, Pacing, Right Ventricular Pacing, His Bundle Pacing
- Trial name
- PROTECT-HF (NCT05815745)
- Testing
- Pacemaker - Physiological pacing, Pacemaker - Right Ventricular pacing
- Where
- 45 sites in Ireland, Slovenia and 1 more
- Volunteers
- 2,600 people
- Sponsor
- Imperial College London
Mitral Valve Prolapse
STretch and Myocardial Characterization in Arrythmogenic Mitral Valve Prolapse-2
Mitral valve prolapse (MVP) is a frequent affection of the mitral valve with a prevalence of 2-3% in the general population. This valvular disease is generally considered as benign, but may at term evolve toward mitral valve…
- Trial name
- STAMP-2 (NCT04852731)
- Testing
- Cardiac MRI, Blood collection, Prolongation of the MRI examination
- Where
- France
- Volunteers
- 280 people
- Sponsor
- Central Hospital, Nancy, France
Severe Symptomatic Aortic Stenosis (Defined as New York Heart Association (NYHA) Class ≥ II)
PERFECT - Portuguese Evolut Registry Studying the Outcomes of Medtronic Evolut™ FX+ TAVI System by Evaluating an Optimal Care Pathway for TAVI
The goal of this registry is to learn how the Medtronic Evolut™ FX+ transcatheter aortic valve implantation (TAVI) System performs in adults with severe, symptomatic aortic stenosis who need valve replacement.
- Trial name
- PERFECT (NCT07343674)
- Where
- 12 sites in Portugal
- Volunteers
- 500 people
- Sponsor
- Portuguese Association of Interventional Cardiology
Implantable Cardioverter Defibrillator(ICD)
To Evaluate the Delivery Timing Safety and Efficacy of AntiTachycardia Pacing (BIO|ATP)
To compare Treatment Group (settings of Early Multiple ATP) and Control Group (settings of extended detection time for the conventional ATP) in Japanese patients, and confirm their safety and efficacy
- Trial name
- BIO|ATP (NCT05426785)
- Testing
- 1:1 ratio for Treatment Group and Control Group
- Where
- Japan
- Volunteers
- 398 people
- Sponsor
- Biotronik SE & Co. KG
Ventricular Tachycardia
Characterization of Cardiac Electrophysiological Effects of Autonomic Neuromodulation
Prospective cohort study evaluating the electrophysiologic and biochemical effects of stellate ganglion block in patients with ventricular tachycardia.
- Trial name
- NCT05377216
- Testing
- Stellate Ganglion Block
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Permanent Atrial Fibrillation, Preserved Ejection Fraction
Bundle Branch Pacing to Preserve Ejection Fraction in Atrial Fibrillation Trial
The goal of this clinical trial is to learn whether left bundle branch area pacing, a technique designed to activate the heart's natural electrical conduction system, is better than conventional right ventricular pacing in adults…
- Trial name
- BEAT (NCT07759700)
- Testing
- LBBA pacing, Conventional pacing
- Where
- France
- Volunteers
- 642 people
- Sponsor
- Poitiers University Hospital