Clinical trials: Ventricular Failure
Dilated Cardiomyopathy, Ventricular Remodeling
The Impact of Ivabradine on Left Ventricular Reverse Remodeling in Nonischemic Dilated Cardiomyopathy (NIDCM) on Current Medical Therapy Era
In non-ischemic dilated cardiomyopathy (NIDCM), left ventricular reverse remodeling (LVRR) can be achieved through guideline-directed medical therapy (GDMT).
- Conditions
- Dilated Cardiomyopathy, Ventricular Remodeling, Heart Failure, Reduced Ejection Fraction
- Trial name
- NCT05973591
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Yonsei University
Right Heart Failure
Serial Multiparametric Evaluation of Right Ventricular Function After Left Ventricular Assist Device Implantation
The primary purpose of this study is to investigate the evolution of Right Ventricular (RV) function before and after left ventricular assist device (LVAD) implantation, using novel echocardiographic quantification of RV size and…
- Trial name
- EuroEchoVAD (NCT03552679)
- Testing
- Echocardiography
- Where
- 9 sites in Germany, Hungary and 5 more
- Volunteers
- 600 people
- Sponsor
- Erasmus Medical Center
Heart-Assist Devices, Heart Failure NYHA Class IV
Exergaming in Advanced HF With Multiple Chronic Conditions Prior to LVAD Implantation or Heart Transplant
The purpose of this study is to test a home-based exergaming intervention designed to decrease frailty and fatigue and improve affective well-being, functional capacity, and immune function in individuals with advanced heart…
- Conditions
- Heart-Assist Devices, Heart Failure NYHA Class IV, Exercise Training
- Trial name
- PREHAB-HF (NCT03580759)
- Testing
- PREHAB
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Nebraska
Heart Failure, LVAD
The Left Ventricular Assist Device (LVAD) Off or On Pump Implantation Study
The purpose of this study is to compare adverse events after off-pump LVAD surgery or on-pump LVAD surgery.
- Trial name
- LVAD-ON-OFF (NCT04219618)
- Testing
- Off-Pump, On-Pump
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cardiogenic Shock, Heart Failure
Left Ventricular Volume Index in the Adjustment of Initial Dose of Dobutamine in Heart Failure and Cardiogenic Shock
Recent studies have suggested that the use of left ventricular ejection volume index calculation may aid in the hemodynamic management of critically ill patients.
- Trial name
- NCT03727282
- Testing
- adjust dobutamine according to the ejection volume index, adjust dobutamine according to the attending physician
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo General Hospital
End-stage Heart Failure, Cardiomyopathies
VentrAssistTM LVAD as a Bridge to Cardiac Transplantation - Pivotal Trial
The purpose of this study is to evaluate the safety and effectiveness of VentrAssistTM LVAD in individuals who are awaiting heart transplants.
- Trial name
- NCT00483197
- Testing
- VentrAssistTM Left Ventricular Assist Device
- Where
- 29 sites in United States
- Volunteers
- 140 people
- Sponsor
- Ventracor
Advanced Refractory Left Ventricular Heart Failure
MOMENTUM 3 Pivotal Cohort Extended Follow-up PAS
The study will be a prospective, multi-center, non-blinded, controlled study, intended to evaluate the extended use of the HM3 LVAS compared to the HMII LVAS in those patients that are ongoing at the 2-year follow-up in the…
- Trial name
- NCT03982979
- Testing
- HM3 LVAS
- Where
- United States
- Volunteers
- 295 people
- Sponsor
- Abbott Medical Devices
Left Ventricular Assist Device, Prognosis
PROgnostic Value of Exercise Capacity Measured as Peak Oxygen Uptake (pVO2) in Recipients of Left Ventricular Assist Devices
Pooling of earlier VO2-studies conducted at the dept. of cardiology, Rigshospitalet, Denmark, and all LVAD centres of the World that wish to participate.
- Conditions
- Left Ventricular Assist Device, Prognosis, Advanced Heart Failure
- Trial name
- PRO-VAD (NCT04423562)
- Testing
- No intervention
- Where
- Denmark
- Volunteers
- 500 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Advanced Heart Failure
Post Market Surveillance of the HeartMate 3 Left Ventricular Assist System in Korea
The Korea HM3 PMS is a prospective, single arm, open-label, multi-center, post market surveillance is designed to evaluate clinical and functional outcomes with the HM3 LVAS as a treatment for advanced heart failure.
- Trial name
- NCT04915924
- Testing
- HeartMate 3™ left ventricular assist system (HM3 LVAS)
- Where
- 22 sites in South Korea
- Volunteers
- 358 people
- Sponsor
- Abbott Medical Devices
Pacing-Induced Cardiomyopathy, Heart Failure
Physiological Versus Right Ventricular Outcome Trial Evaluated for Bradycardia Treatment Upgrades
Guidelines for patients having first-time implants advocate that even when heart function is only mildly impaired, modern pacing approaches should be utilised to avoid the potentially damaging effects of RV pacing to preventing…
- Trial name
- PROTECT-UP (NCT06052475)
- Testing
- Physiological Pacing Upgrade (Conduction System Pacing or Biventricular Pacing), Continued RV Pacing (Right Ventricular Pacing)
- Where
- 12 sites in United Kingdom
- Volunteers
- 155 people
- Sponsor
- Imperial College London
Sinus Bradycardia, Sinus Node Disease
Real Life Automatic Atrial Capture Device Control
The main objective of this study is to verify the effectiveness of the new ACAP ® Confirm algorithm in the automatic management of atrial capture.
- Conditions
- Sinus Bradycardia, Sinus Node Disease, Atrio-ventricular Block, Heart Failure
- Trial name
- NCT02400983
- Testing
- Pacemaker, ICD
- Volunteers
- 318 people
- Sponsor
- Maria Vittoria Hospital
Hypotension, Heart Failure
Dapagliflozin on Hypotensive Heart Failure Patients After Sacubitril/Valsartan Therapy
The DAPA-HF trial demonstrated that dapagliflozin was able to reduce the risk of worsening heart failure events and cardiovascular death comparing to placebo in patients with reduced ejection fraction further to standard of care.
- Trial name
- NCT04575675
- Testing
- Dapagliflozin, Sacubitril-Valsartan, Beta blocker
- Where
- Taiwan
- Volunteers
- 78 people
- Sponsor
- Cheng-Hsin General Hospital
Heart Failure
Acute Oral Ketones or Carbohydrate Supplement Modify Heart Function in Heart Failure?
Does oral intake of exogenous ketone salt improve heart function measured by cardiac MRI in heart failure compared to oral intake of a carbohydrate placebo?
- Trial name
- NCT05651529
- Testing
- exogenous ketone salt supplement, exogenous carbohydrate supplement
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- Université de Sherbrooke
Heart Failure，Congestive
Serum Catestatin Expression and Cardiometabolic Parameters in Patients With Congestive Heart Failure
The congestive heart failure (HF) is a condition associated with substantial morbidity, mortality, and high healthcare expenditures.
- Trial name
- CATSTAT-HF (NCT03389386)
- Testing
- Blood withdrawal for laboratory analysis, Standard-of-care treatment, Transthoracic echocardiography (TTE)
- Where
- Croatia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Josko Bozic
Heart Failure
The Prognostic Role of the Right Ventricle in Patients With Heart Failure or Congenital Heart Disease
The objectives are 1. to validate quantification of 2D and 3D right ventricular strian measurements of right ventricular performance in cross comparison to cardiac MRI and to evaluate its relation to right ventricular fibrosis.
- Trial name
- RV-STRAIN (NCT03969394)
- Testing
- Medical imaging
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Chronic Heart Failure
Drug Compliance and Quality of Life in Patients With Heart Failure Dosed With Either Once-daily or Twice-daily Coreg
The purpose of this study is to compare dosing compliance between study patients taking controlled release carvedilol once a day, and study patients taking immediate release carvedilol (Coreg) twice a day.
- Trial name
- NCT00272805
- Testing
- carvedilol
- Where
- 54 sites in United States
- Volunteers
- 400 people
- Sponsor
- Cardiovascular Clinical Sciences Inc
Heart Failure, Left Ventricular Dysfunction
Effects of Home-based Exercise Rehabilitation on Healthcare Utilization in HeartMate 3 Patients
To demonstrate that home-based exercise rehabilitation (HER) compared to usual care (UC) results in a significant reduction in healthcare utilization in HeartMate 3 (HM3) left ventricular assist device (LVAD) patients.(defined as…
- Trial name
- MOVE-LVAD (NCT04942353)
- Testing
- Home-based Exercise Rehabilitation., Usual Care
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Rochester
Heart Failure, Healthcare Associated Infection
Ventricular Assist Device (VAD) Infection Prevention Survey
Annually, more than 250,000 patients in the U.S. with end-stage heart failure stand to benefit from ventricular assist device (VAD) therapy.
- Conditions
- Heart Failure, Healthcare Associated Infection, Ventricular Assist Device
- Trial name
- NCT03843021
- Testing
- VAD Infection Prevention Survey
- Where
- United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Acute Heart Failure With Reduced Ejection Fraction, Decompensation; Heart, Congestive
The FOCUS-ADHF Registry
Acute heart failure (AHF) represents a significant clinical and economic burden due to its impact on patients' quality of life, poor prognosis, and high healthcare costs.
- Conditions
- Acute Heart Failure With Reduced Ejection Fraction, Decompensation; Heart, Congestive, Regurgitation, Mitral
- Trial name
- FOCUS-ADHF (NCT06726109)
- Where
- 4 sites in Belgium, Italy
- Volunteers
- 600 people
- Sponsor
- ASL Città di Torino
Heart Failure, Heart Failure With Reduced Ejection Fraction
Effects of Dapagliflozin on Cardiorespiratory Parameters in Heart Failure
Dapagliflozin is a molecule belonging to the class of sodium-glucose transporter type 2 (SGLT2-i) inhibitors. This type of drug, initially used in the treatment of diabetes mellitus, has in recent years demonstrated significant…
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction, Left Ventricle Remodeling, Sleep Apnea
- Trial name
- NCT05770167
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Centro Cardiologico Monzino