Clinical trials: Ventricular Function
LVM, Type 2 Diabetic Patients With IHD
Pioglitazone Regress Left Ventricular Mass in Type 2 Diabetes With Ischeamia Heart Disease
Cardiovascular complications account for the highest mortality in type 2 diabetic patients, mainly due to ischeamia heart disease (IHD).
- Conditions
- LVM, Type 2 Diabetic Patients With IHD, Endothelial Function
- Trial name
- NCT01947790
- Testing
- pioglitazone group, Metformin group
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- Xiang Guang-da
Valve Heart Diseases
Impact of Diffuse Myocardial Fibrosis on the Ventricular Function in Regurgitant Left-Sided Valve Heart Diseases ( The DIFFUsE Study)
New strategies are needed to early detect myocardial involvement in these diseases. Histological studies showed that diffuse fibrosis and cardiomyocyte hypertrophy precede the LV remodelling (dilatation) observed by cardiac…
- Trial name
- DIFFUsE (NCT02747485)
- Testing
- Cardiac MRI, blood samples, myocardial biopsy
- Where
- France
- Volunteers
- 316 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Left Ventricular Function Good
Left Atrial Volume and Function in Children Assessed by Echo 3DRT: Reference Values for Normal Children
The investigators study is trying to find the normal value to left atrial volume and left atrial function in healthy children by tridimensional real time echocardiography avaluation.
- Trial name
- NCT01481415
- Where
- 2 sites in Brazil
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Hospital Israelita Albert Einstein
Anemia
Anemia in Heart Failure With a Preserved Ejection Fraction (HFPEF)
The purpose of this study is to determine if treating anemia with subcutaneous erythropoetin in patients with heart failure and a preserved ejection fraction (HFPEF) will be associated with reverse ventricular remodeling…
- Trial name
- NCT00286182
- Testing
- Erythropoietin alpha
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Mathew S. Maurer
Heart Failure
Effects of Increased CF-LVAD Pump Speed During Sustained Submaximal Exercise
This randomized trial has been designed to study if it is possible to enhance work capacity during submaximal efforts in heart failure patients supported with continuous-flow left ventricular assist devices (CF-LVAD).
- Trial name
- NCT02335684
- Testing
- CF-LVAD pump speed baseline., CF-LVAD pump speed increased.
- Where
- Denmark
- Volunteers
- 31 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Heart Failure, Heart Failure With Reduced Ejection Fraction
Effects of Dapagliflozin on Cardiorespiratory Parameters in Heart Failure
Dapagliflozin is a molecule belonging to the class of sodium-glucose transporter type 2 (SGLT2-i) inhibitors. This type of drug, initially used in the treatment of diabetes mellitus, has in recent years demonstrated significant…
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction, Left Ventricle Remodeling, Sleep Apnea
- Trial name
- NCT05770167
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Centro Cardiologico Monzino
Congestive Heart Failure
Candesartan Cilexetil in Heart Failure Assessment of Reduction in Mortality and Morbidity (CHARM Added)
A study to evaluate the effect of Atacand on patients with heart failure with depressed left ventricular function
- Trial name
- NCT00634309
- Testing
- Candesartan
- Volunteers
- 597 people
- Sponsor
- AstraZeneca
Reference Values of BNP in Healthy Newborn
Normal Values of Brain Natriuretic Peptide in Healthy Newborn
Brain natriuretic peptide (BNP) is an important tool for diagnosis, risk stratification and prognosis in pediatric patients with heart failure1.
- Trial name
- NCT02574806
- Testing
- Blood sample and BNP measurement
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Instituto de Cardiología y Medicina Vascular Hospital Zambrano-Hellion Tec Salud
Ventricular Septal Defect
Cardiopulmonary Function in Adults Born With a Ventricular Septal Defect
The overall objective for this study is to evaluate the cardiopulmonary function of VSD-patients compared with healthy age- and gender-matched controls.
- Trial name
- NCT03684161
- Testing
- Cardiopulmonary function
- Where
- Denmark
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Heart Failure, Low T3 Syndrome
Liothyronine and Heart Failure. The Long Term Effect of Liothyronine on Left Ventricular Ejection Fraction (LVEF)
Purpose: The purpose of the study is to examine if treatment with liothyronine increases left ventricular ejection fraction (LVEF) in patients with stable, chronic heart failure.
- Trial name
- LIHFA (NCT01481402)
- Testing
- Liothyronine
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Jens Faber
Hypertension, Blood Pressure Monitoring, Ambulatory
Nocturnal Blood Pressure Dipping and Ventricular Repolarization in Hypertension
The primary aim is to determine whether non-dipping status is associated with adverse repolarization markers and impaired myocardial mechanics compared to dipper hypertensive patients.
- Conditions
- Hypertension, Blood Pressure Monitoring, Ambulatory, Circadian Rhythm, Electrocardiography
- Trial name
- NBP-DIP (NCT07200856)
- Testing
- Nocturnal Blood Pressure Dipping
- Volunteers
- 140 people
- Sponsor
- Assiut University
Single Ventricle Heart Disease After Fontan Surgery
Study of Effects of Sildenafil on Patients With Fontan Heart Circulation
The study will investigate the cardiovascular effects of sildenafil on patients with Fontan circulation. Recent studies suggest that sildenafil may improve exercise in patients with Fontan circulation.
- Trial name
- NCT01815502
- Testing
- Cardiac catheterization
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical University of South Carolina
Amyloidosis
Multiple Treatment Session Study to Assess GSK2398852 Administered Following and Along With GSK2315698
The study is intended to evaluate whether monthly repeated courses of administration of GSK2315698 followed by GSK2398852 is associated with a reduction in cardiac amyloid load in patients with cardiac amyloidosis, monitored by…
- Trial name
- NCT03044353
- Testing
- GSK2315698 (CPHPC), GSK2398852 (anti-SAP mAb)
- Where
- 3 sites in United States, United Kingdom
- Volunteers
- 7 people
- Sponsor
- GlaxoSmithKline
Heart Failure, Type 2 Diabetes
The Effect of Hyperglycemia on LV Function and Exercise Capacity in Diabetics With and Without Heart Failure.
Diabetes and Heart Failure are diseases with high morbidity and increased risk of death. Former investigations has shown that diabetes worsens the prognosis of heart failure.
- Trial name
- METAMOD (NCT01071772)
- Testing
- insulin
- Where
- Denmark
- Volunteers
- 18 people
- Sponsor
- University of Aarhus
Tricuspid (Valve) Insufficiency (Rheumatic)
PROphylactic triCuspID Annuloplasty in Patients With Dilated Tricuspid Annulus
Patients elected to undergo mitral valve surgery (either repair or replacement) with less equal than moderate (≤+2) tricuspid regurgitation and dilated tricuspid annulus (>21mm/m2) at preoperative echocardiography will be…
- Trial name
- PROCIDA (NCT03129737)
- Testing
- Mitral valve surgery, Tricuspid valve annuloplasty
- Where
- 8 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Ettore Sansavini Health Science Foundation
Hypoplastic Left Heart, Congenital Heart Disease
Cardiac Biomarkers in Patients With Single Ventricle Physiology
All neonates with congenital heart disease undergoing stage one palliation (Norwood procedure, Damus-Kaye-Stansel procedure) at Texas Children's Hospital will be regularly monitored for B-type natriuretic peptide (BNP) and…
- Conditions
- Hypoplastic Left Heart, Congenital Heart Disease, Cyanotic Congenital Heart Disease, Cardiac Disease
- Trial name
- NCT03678909
- Testing
- Norwood Palliation / DKS / Damus-Kaye-Stansel procedure
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Baylor College of Medicine
Coronary Artery Bypass Surgery, Right-Sided Heart Failure
The SWEDEGRAFT Right-Heart-Substudy
BACKGROUND Right ventricular dysfunction is a common echocardiographic finding after cardiac surgery. Pericardial disruption has been suggested as the most probable cause as the phenomenon occurs within minutes after pericardial…
- Trial name
- NCT05049421
- Testing
- Echocardiography
- Where
- Denmark
- Volunteers
- 207 people
- Sponsor
- Aarhus University Hospital Skejby
Heart Failure
Comparative Effects of Nebivolol and Carvedilol on Diastolic Function in the Elderly Heart Failure Patients
Heart failure (HF) is a common and disabling condition in the elderly. Randomized clinical trials and meta-analyses have clearly demonstrated that long-term use of β blockers improves the outcomes of patients with HF.
- Trial name
- NCT02619526
- Testing
- Nebivolol, Carvedilol
- Where
- South Korea
- Volunteers
- 62 people
- Sponsor
- Dong-A University
Cognitive Impairment, Older People--Abuse of
Pre- and Post TAVI Cognitive Functioning and Intraoperative Carotid Flow Measurements
Purpose: 1. Measuring and optimize the usability of the BAMCOG (games to measure cognitive functioning) 2. Concurrent validation of BAMCOG with MoCA to see if BAMCOG can serve as a monitoring instrument/screener 3.
- Conditions
- Cognitive Impairment, Older People--Abuse of, Aortic Stenosis, Severe
- Trial name
- NCT05813353
- Where
- Netherlands
- Volunteers
- 54 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Aortic Stenosis, Hypertension
Transcatheter Aortic Valve Implantation in Western NORway
A prospective study of 600 patients with severe aortic stenosis (AS) and symptoms who underwent TAVI at the Haukeland university hospital, Bergen, Norway.
- Trial name
- TAVI-NOR (NCT04417829)
- Testing
- Biological prosthesis in the aortic valve
- Volunteers
- 600 people
- Sponsor
- Haukeland University Hospital