Clinical trials: Ventricular Function
Aortic Stenosis
Pilot Study of Cognitive and Functional Outcomes Following TAVI
Narrowing of the aortic valve in the heart, known as severe aortic stenosis, can impede blood delivery and is associated with poor quality of life and death.
- Trial name
- NCT02089945
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- Sunnybrook Health Sciences Centre
Myocardial Infarction, Heart Failure
Effect of Exercise Training on Left Ventricular Function in Patients Post Myocardial Infarction
Patients who have suffered a heart attack are at risk of developing worsening heart function and heart failure. Exercise training has a beneficial effect on heart function and prevents heart failure.
- Conditions
- Myocardial Infarction, Heart Failure, Coronary Artery Disease
- Trial name
- EXIT-V (NCT02048696)
- Testing
- Secondary prevention and cardiac rehabilitation clinic
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- Montreal Heart Institute
Hypertension, Hypertrophy, Left Ventricular
Does Allopurinol Reduce Thickening of the Left Ventricle of the Heart in Patient With Treated Hypertension?
The presence of Left ventricular hypertrophy (LVH) confers high cardiovascular risk in hypertensive patients. LVH remains highly prevalent even when blood pressure (BP) is controlled.
- Trial name
- ALLAY (NCT02237339)
- Testing
- Allopurinol
- Where
- United Kingdom
- Volunteers
- 72 people
- Sponsor
- University of Dundee
Right Ventricular Dysfunction
Right Heart International NETwork During Exercise in Different Clinical Conditions
The aim of this registry will be to compare the pathophysiological response of the morphology and function of the right heart and pulmonary circulation assessed with resting and stress-echocardiography in patients with various…
- Trial name
- RIGHT-Net (NCT03041337)
- Testing
- stress echocardiography
- Where
- Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera OO.RR. S. Giovanni di Dio e Ruggi D'Aragona
Pulmonary Hypertension, Infant, Premature
Novel Echocardiographic Methods for Early Identification of Neonates at Risk for Chronic Pulmonary Hypertension
Chronic pulmonary hypertension (cPHT) is a serious cardiopulmonary disorder that causes low oxygen levels in the blood, difficulty in breathing and ultimately heart failure.
- Trial name
- NCT04402645
- Where
- 6 sites in United States, Canada and 2 more
- Volunteers
- 350 people
- Sponsor
- Mount Sinai Hospital, Canada
Mitral Valve Insufficiency, Left Ventricular Systolic Dysfunction
Ertugliflozin for Functional Mitral Regurgitation
In patients with heart failure (HF) and left ventricular (LV) dilation, adverse LV remodeling causes tethering of mitral valve (MV) preventing sufficient coaptation of normal leaflets and resulting in functional MR.
- Trial name
- EFFORT (NCT04231331)
- Testing
- Ertugliflozin
- Where
- 3 sites in South Korea
- Volunteers
- 128 people
- Sponsor
- Asan Medical Center
Heart Failure, Aortic Stenosis, Severe
Effects of Levosimendan on Cardiac Function After TAVR in Patients With Heart Failure
Patients with severe aortic stenosis combined with severe heart failure often miss the opportunity for surgery, and the prognosis is poor with drug therapy alone.In recent years, the emergence of transcatheter aortic valve…
- Trial name
- NCT06196177
- Testing
- Levosimontane injection
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Qilu Hospital of Shandong University
ST Elevation (STEMI) Myocardial Infarction of Anterior Wall
CD-NP (Cenderitide) Therapy for the Preservation of Left Ventricular Function
The primary endpoint is to assess the safety and tolerability of Cenderitide (CD-NP) with the incidence of symptomatic hypotension being one of the key safety variables.
- Trial name
- BELIEVE III (NCT02071602)
- Testing
- CD-NP
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Fontan Physiology, Frailty
WE BEAT - HEART Club Fontan Wellness Project: A Virtual Resilience Promotion and Frailty Prevention Program
This trial is being conducted to evaluate the effect of a small-group wellness education program combined with a longitudinal, individualized prescription exercise program on the wellness, resiliency, and daily activity levels of…
- Conditions
- Fontan Physiology, Frailty, Single Ventricle Heart Disease
- Trial name
- NCT05199857
- Testing
- WE BEAT Group Wellness Education program - phase 1, HEART Club Home Exercise program - phase 2
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Michigan
Chronic Thromboembolic Pulmonary Hypertension
The Right Ventricle in Chronic Pressure Overload: Identifying Novel Molecular Targets for Functional Imaging
Chronically elevated pulmonary pressures do not immediately result in right ventricular failure. During the initial period of exposure, the RV adapts to the increased afterload by altering its metabolism and morphology so as to…
- Trial name
- MVD (NCT03199131)
- Testing
- Right ventricular biopsies
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Type 2 Diabetes Mellitus, Chronic Kidney Disease
Extended Release Exenatide Versus Placebo In Diabetic Patients With Type 4 Cardiorenal Syndrome
Among adult individuals with type 2 diabetes mellitus and at risk for heart failure with impaired relaxation of the heart mildly reduced kidney filtration function (Type 4 cardiorenal syndrome) this trial will evaluate the…
- Conditions
- Type 2 Diabetes Mellitus, Chronic Kidney Disease, Left Ventricular Diastolic Dysfunction
- Trial name
- NCT02251431
- Testing
- BYDUREON
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Baylor Research Institute
Hypovitaminosis D, Cardiovascular Diseases
Vitamin D Supplementation on in Major Orthopedic Surgery
Prospective, monocentric study in open, aimed at evaluating the effects of supplementation with calcifediol on left ventricular function parameters in cardiopathic subjects undergoing major orthopedic surgery.
- Trial name
- NCT03403933
- Testing
- Didrogyl
- Where
- Italy
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Endothelial Dysfunction, Vascular Stiffness
Sodium Lowering Vascular Effects Trial
The proposed mechanistic trial will test the effect of dietary sodium reduction on cardiac and vascular structure and function in those with elevated blood pressure or hypertension.
- Conditions
- Endothelial Dysfunction, Vascular Stiffness, Left Ventricular Hypertrophy, Left Ventricular Dysfunction
- Trial name
- SOLVE (NCT05388032)
- Testing
- Sodium Reduction Intervention
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- Tulane University
Congestive Heart Failure
Study to Evaluate the Safety of Twice Daily Oral Carvedilol
The objective of this study is to evaluate the long-term safety of carvedilol in pediatric patients with chronic heart failure, who completed the Pediatric Carvedilol Study 321.
- Trial name
- NCT00129363
- Testing
- Carvedilol
- Where
- 17 sites in United States
- Volunteers
- 75 people
- Sponsor
- Shaddy, Robert, M.D.
Hydrocephalus, Cerebral Ventricle
Impact of Cerebral Ventricular Dilatations and Cerebrospinal Fluid Pulsations on Periventricular White Matter in Hydrocephalic Patients
Hydrocephalus is characterized by excessive accumulation of cerebrospinal fluid (CSF) in the ventricles of the brain. One of the forms of hydrocephalus is called "normal pressure", although one of the main signs is precisely an…
- Conditions
- Hydrocephalus, Cerebral Ventricle, Cerebrospinal Fluid, White Matter Fiber
- Trial name
- HYDRODIFF (NCT05825521)
- Testing
- MRI
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Right Ventricular Dysfunction
Right Ventricular Echocardiography in caRdiac SurgEry
Postoperative right ventricular (RV) dysfunction increases mortality and risk of cardiac failure after cardiac surgery substantially.
- Trial name
- ReVERSE (NCT03301571)
- Testing
- Change in preload and afterload, Inspired oxygen, Pacemaker mode
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Heart Failure
The Effects of Sacubitril/Valsartan on Cardiac Oxygen Consumption and Efficiency of Cardiac Work in Heart Failure Patients
This is a phase IV, prospective, randomized, double-blind, double-dummy, parallel-group study. The study assessed the effects of 6 weeks of stable sacubitril/valsartan therapy, as compared with valsartan therapy, on the…
- Trial name
- TurkuPET (NCT03300427)
- Testing
- sacubitril/valsatran, valsartan
- Where
- Finland
- Volunteers
- 55 people
- Sponsor
- Novartis Pharmaceuticals
Heart Failure, Diastolic, Aortic Valve Stenosis
Changes in Cardiac Deformation Following Physiologic Alterations and Inotropic Support.
The investigators want to compare the effects of two drugs, levosimendan and milrinone, on cardiac muscle, both in terms of contractility and relaxation. Half of the participants will be randomized to each drug.
- Conditions
- Heart Failure, Diastolic, Aortic Valve Stenosis, Monitoring, Physiologic, Physiology
- Trial name
- NCT02408003
- Testing
- Levosimendan, Milrinone
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Sahlgrenska University Hospital
Pulmonary Arterial Hypertension
Assessment of Right Ventricular Function by Cardiac MRI in Patients With Pulmonary Arterial Hypertension (IRMA)
Pulmonary hypertension (PH) is a pathophysiological condition defined by an increase in pulmonary arterial pressure above 20mmHg, which encompasses many very dissimilar conditions.
- Trial name
- IRMA (NCT05624242)
- Testing
- cardiac magnetic resonance imaging
- Where
- France
- Volunteers
- 112 people
- Sponsor
- Central Hospital, Nancy, France
Disorder; Heart, Functional, Postoperative, Cardiac Surgery
Effects a Rehabilitation Program in Patients With Left Ventricular Dysfunction After Coronary Artery Bypass Grafting
This study aims to analyze effects of three types of cardiac rehabilitation protocol on fuctional capacity, inflammatory markers, pulmonary function and clinical outcomes after coronary artery bypass grafting (CABG) in patients…
- Trial name
- NCT02763774
- Testing
- Walking exercise, Stationary cycling exercise, Neuromuscular electrical stimulation
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- Federal University of São Paulo