Clinical trials: Ventricular Function
Obesity, Diabetes
Metabolic Parameters 3 Months, 9 Months, and 2 Years After Bariatric Surgery
An original cohort of 43 patients were recruited for analysis of anthropometrics, metabolic profile, skeletal muscle biopsy, echocardiogram at baseline, 3 months and 9 months post bariatric surgery.
- Conditions
- Obesity, Diabetes, Heart Failure, Insulin Resistance
- Trial name
- NCT00178633
- Testing
- Bariatric surgery
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- The University of Texas Health Science Center, Houston
Valvular Aortic Stenosis
Physical Activity in Patients After Aortic Valve Replacement (Valve-ex)
A structured and supervised, 3-month physical activity intervention in patients after aortic valve replacement due to severe stenosis, accompanied by examination of cardiac size and function, exercise capacity and endothelial…
- Trial name
- NCT00860678
- Testing
- Physical activity, no Intervention
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Technical University of Munich
Cardiogenic Shock
Physiology of Unloading VA ECMO Trial
The goal of this clinical trial is to compare the use of veno-arterial extracorporeal membrane oxygenation (VA ECMO) with and without left ventricular (LV) unloading in patients being treated for cardiogenic shock (CS).
- Trial name
- NCT06336655
- Testing
- IABP
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of Utah
Chronic Ischaemic Heart Failure
Bone Marrow Derived Adult Stem Cells for Chronic Heart Failure
The purpose of this study is to determine whether adult bone marrow derived stem/progenitor cells improve cardiac function and symptoms in patients with heart failure and to establish the optimal method of delivery of these…
- Trial name
- REGEN-IHD (NCT00747708)
- Testing
- Granulocyte-colony stimulating factor, Percutaneous intracoronary injection, Percutaneous intramyocardial injection
- Where
- United Kingdom
- Volunteers
- 148 people
- Sponsor
- Barts & The London NHS Trust
Myocardial Infarction
The Pressure-controlled Intermittent Coronary Sinus Occlusion on VentrIcular PERformance Study
The PICSO ViPER study is a prospective single centre cohort study of the use of PICSO in patients presenting acute myocardial infarction and impaired function of the left ventricle and candidate to angioplasty the left anterior…
- Trial name
- PICSO-ViPER (NCT04032925)
- Testing
- PICSO
- Where
- United Kingdom
- Volunteers
- 2 people
- Sponsor
- Oxford University Hospitals NHS Trust
Autosomal Dominant Polycystic Kidney Disease, Glomerular Filtration Rate > 40 ml/Min
Effects of Somatostatin on ADPKD Heart
Autosomal dominant polycystic kidney disease (ADPKD) is associated with early onset hypertension and left ventricular (LV) hypertrophy.
- Trial name
- NCT02119013
- Testing
- Octeotride
- Volunteers
- 35 people
- Sponsor
- Federico II University
Heart Failure
ARNI Combined With SGLT2 Inhibitors on Functional Mitral Regurgitation Remodeling
This study aimed to compare the effects of ARNI monotherapy versus combined ARNI and SGLT2 inhibitor therapy on Mitral Remodeling Index (MRIx) and Functional mitral regurgitation (FMR) remodeling in patients with heart failure…
- Trial name
- NCT07379788
- Testing
- Sacubitril/Valsartan 49 MG-51 MG Oral Tablet [ENTRESTO], Empagliflozin10Mg Tab
- Where
- Saudi Arabia
- Volunteers
- 180 people
- Sponsor
- Rehab Werida
Pulmonary Arterial Hypertension
Empagliflozin to Improve Right Ventricular Function in Pulmonary Arterial Hypertension
Randomized, triple-masked, parallel arm clinical trial of empagliflozin versus placebo in pulmonary arterial hypertension (PAH) participants on stable approved PAH-targeted medical therapy.
- Trial name
- EmPATH (NCT06992440)
- Testing
- Empagliflozin 10 MG
- Where
- 3 sites in United States
- Volunteers
- 78 people
- Sponsor
- Gustavo A Heresi, MD, MS
Heart Diseases
Evaluation of Left Ventricular Volumes by Real-Time 3-Dimensional Echocardiography
Quantitative measurements of left ventricular volume and ejection fraction are useful in the management of patients with heart disease.
- Trial name
- NCT00001740
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Pulmonary Arterial Hypertension
A Study of a Mean Pulmonary Artery Pressure-Targeted Approach With Early and Rapid Treprostinil Therapy to Reverse Right Ventricular Remodeling in Participants With Pulmonary Arterial Hypertension
The primary objective of this study is to assess the effect of early and rapid treprostinil therapy for mean pulmonary artery pressure (mPAP) reduction to improve right ventricular (RV) function and reverse RV remodeling in…
- Trial name
- ARTISAN (NCT05203510)
- Testing
- Parenteral Treprostinil, Oral Treprostinil
- Where
- 28 sites in United States
- Volunteers
- 52 people
- Sponsor
- United Therapeutics
Heart Disease, Congenital, Single Ventricle
Single Ventricle Outcome
The objective of this research proposal is to perform an ongoing single institution prospective clinical trial examining the overall clinical outcome of children with single ventricle physiology.
- Conditions
- Heart Disease, Congenital, Single Ventricle, Hypoplastic Left Heart Syndrome
- Trial name
- NCT00308217
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Emory University
Single Ventricle Heart Disease
Fontan Udenafil Exercise Longitudinal Assessment Trial
This study will evaluate the clinical efficacy and safety of udenafil, an orally administered, potent and selective inhibitor of PDE5, versus placebo for the treatment of adolescent subjects who have undergone the Fontan…
- Trial name
- FUEL (NCT02741115)
- Testing
- Udenafil
- Where
- 30 sites in United States, Canada and 1 more
- Volunteers
- 400 people
- Sponsor
- Mezzion Pharma Co. Ltd
Septic Shock
Right Ventricular Dysfunction in Septic Shock Patients in ICU
Assesment of right ventricular dysfunction in septic shock patients in intensive care unit.
- Trial name
- Septicshock (NCT05193682)
- Volunteers
- 25 people
- Sponsor
- Shimaa Hammad Ahmed
Chronic Myocardial Ischemia
Intracoronary Infusion of Bone Marrow Mononuclear Cells in Patients With Previous Myocardial Infarction.
Phase II clinical trial which will include all patients diagnosed with chronic anterior myocardial infarction (more than 6 months from the acute phase and the complete revascularization in which it is assessed the evolution of…
- Trial name
- NCT01454323
- Testing
- Bone marrow mononuclear cells
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Andalusian Initiative for Advanced Therapies - Fundación Pública Andaluza Progreso y Salud
Heart Failure
Phase I Interaction Study of Istaroxime and Digoxin in Subjects With Stable Heart Failure
This study explores a potential drug-drug interaction between istaroxime and digoxin in patients with stable CHF on chronic oral digoxin treatment.
- Trial name
- NCT00869115
- Testing
- Istaroxime
- Sponsor
- Debiopharm International SA
Ventricular Tachycardia, Sudden Cardiac Death
Functional Substrate-Only Guided VT Ablation
Ventricular tachycardia (VT) is a leading cause of death and suffering in the Veteran population. Currently, ablation procedures are performed to destroy the diseased tissue that causes this problem.
- Trial name
- SLO-VT (NCT06464315)
- Testing
- Functional Substrate-Only Mapping without VT Induction, Standard-of-Care Mapping/Imaging
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development
Fontan Procedure, Hypoplastic Left Heart Syndrome
Impact of Vitamin C on Endothelial Function and Exercise Capacity in Fontan-Palliated Patients
In this study, investigators will evaluate the effect of vitamin C on endothelial function, exercise tolerance and quality of life in patients with a single ventricle who have been palliated to Fontan physiology.
- Conditions
- Fontan Procedure, Hypoplastic Left Heart Syndrome, Tricuspid Atresia
- Trial name
- NCT00974025
- Testing
- Vitamin C
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Myocardial Infarct, Remodeling, Left Ventricle
Heart Attack Blood Oxygen Therapy Trial
'Heart attack', known as acute ST-segment elevation myocardial infarction, is a leading cause of heart failure and death. A lack of blood and oxygen damages the heart muscle potentially causing heart failure and premature death.
- Trial name
- SSO2 Radial MI (NCT06662890)
- Testing
- Supersaturated oxygen
- Where
- United Kingdom
- Volunteers
- 56 people
- Sponsor
- NHS National Waiting Times Centre Board
Hypertrophy, Left Ventricular
Assessment of Efficacy of Mirabegron, a New beta3-adrenergic Receptor in the Prevention of Heart Failure
This study will assess the efficacy of mirabegron, a new beta3-adrenergic receptor in the prevention of heart failure. This is a two armed, prospective, randomized, placebo-controlled, multi-centric european phase IIb trial with…
- Trial name
- Beta3_LVH (NCT02599480)
- Testing
- mirabegron, Echocardiography, Cardiac MRI
- Where
- 10 sites in Belgium, France and 6 more
- Volunteers
- 296 people
- Sponsor
- Jean-Luc Balligand
Sodium-glucose Cotransporter 2, Inhibitors
Impact of Sodium Glucose Co-transporter 2-Inhibitors on Clinical Outcome and Left Ventricular Function in Patients Presented by Acute Myocardial Infarction
This study aimed to assess the effect of adding sodium glucose co-transporter two inhibitors on clinical outcome and left ventricular function in patients with acute myocardial Infarction.
- Conditions
- Sodium-glucose Cotransporter 2, Inhibitors, Clinical Outcome, Left Ventricule
- Trial name
- NCT06964607
- Testing
- Sodium-glucose cotransporter-2 Inhibitors, Conventional treatment
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Tanta University