Clinical trials: Ventricular Function
Heart Failure and Reduced Ejection Fraction, Heart Failure
PRIMA-HF: Predicting Myocardial Recovery in Heart Failure Using Cardiac Imaging HAI-HF: High Dosing vs. Standard Dosing Adenosine During Myocardial Perfusion in Heart Failure
Background: Heart failure with reduced ejection fraction (HFrEF) is a heterogeneous condition with variable potential for left ventricular ejection fraction (LVEF) recovery.
- Trial name
- PRIMA-HF (NCT07243119)
- Testing
- HAI-HF: Adenosine Stress [¹⁵O]H₂O PET Imaging, Two different doses of adenosine
- Where
- Denmark
- Volunteers
- 180 people
- Sponsor
- Gødstrup Hospital
Ebstein Anomaly
Assessment of Left and Right Ventricular Function in Patients With Ebstein Anomaly With Different Echocardiographic Methods
Ebstein anomaly is a rare congenital heart disease. It encompasses abnormalities of the tricuspid valve, the right atrium and the right ventricle (RV).
- Trial name
- NCT01907971
- Where
- Switzerland
- Volunteers
- 18 people
- Sponsor
- Angela Oxenius
Laryngeal Disease
Hemodynamic Effects of Apnoeic Oxygenation With High-flow Nasal Oxygen in Adults Undergoing Laryngeal Surgery
During apnoeic oxygenation there is a continuous raise in carbon dioxide with subsequent respiratory acidosis. The hypercapnia and respiratory acidosis have several dose-related effects on both the systemic and the pulmonary…
- Trial name
- CAPOX (NCT06316063)
- Testing
- Apnoeic oxygenation with high-flow nasal oxygen, Mechanical ventilation
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Region Stockholm
Congenital Disorders
Effects of Beta-adrenergic in Adults w/Transposition of Great Arteries on Systemic Ventricular Function
The purpose of this chart review study is to examine the effects of beta -adrenergic blocking agents on systemic ventricular dimensions, systemic atrioventricular valve function and exercise tolerance in patients with…
- Trial name
- NCT00313352
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Emory University
Mitral Valve Regurgitation, Left Ventricular Dysfunction
VIVID - Valvular and Ventricular Improvement Via iCoapsys Delivery - Feasibility Study
The purpose of this prospective, non-randomized, single-arm feasibility study is to evaluate safety and feasibility of the iCoapsys System in patients with functional mitral valve insufficiency caused by annular dilation and/or…
- Conditions
- Mitral Valve Regurgitation, Left Ventricular Dysfunction, Heart Failure, Mitral Insufficiency
- Trial name
- VIVID (NCT00512005)
- Testing
- Percutaneous mitral valve repair
- Where
- 4 sites in United States
- Volunteers
- 30 people
- Sponsor
- Myocor
High Altitude Pulmonary Hypertension
Right Ventricular Function at Rest in Highlanders/Lowlanders
The purpose of the current study is to evaluate the progression of right ventricular function and dimension in Kyrgyz highlanders with high altitude pulmonary hypertension (HAPH) by performing a cross sectional case-control study.
- Trial name
- NCT03165656
- Where
- Kyrgyzstan
- Volunteers
- 173 people
- Sponsor
- University of Zurich
Hypoplastic Left Heart Syndrome, Single Ventricle
Cardiac Stem/Progenitor Cell Infusion in Univentricular Physiology (APOLLON Trial)
The purpose of this study is to evaluate the efficacy and safety of intracoronary injection of JRM-001 after reconstructive surgery in pediatric patients with functional single ventricle
- Trial name
- APOLLON (NCT02781922)
- Testing
- Autologous cardiac stem cells (JRM-001)
- Where
- 4 sites in Japan
- Volunteers
- 40 people
- Sponsor
- Metcela Inc.
Heart Failure, Left Ventricular (LV) Systolic Dysfunction
AI-based Prediction of Cardiac Function Using Echocardiography and Body Composition Data (ECHO-FIT Study)
This prospective observational study (ECHO-FIT Study) aims to develop and validate a predictive model for cardiac function, particularly left ventricular ejection fraction (LVEF), by integrating echocardiographic measurements…
- Conditions
- Heart Failure, Left Ventricular (LV) Systolic Dysfunction, Body Composition Measurement, Artificial Intelligence (AI)
- Trial name
- ECHO-FIT (NCT06811519)
- Testing
- Body Composition Analyzer (ACCUNIQ BC720)
- Where
- South Korea
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Right Ventricular Ejection Fraction
Effect of Atrial Pacing on Right Ventricular Function After Cardiac Surgery
Temporary pacing with an external pacemaker after open heart surgery - besides preventing arrhythmias and AV-conduction disorders - is used to improve cardiac output.
- Trial name
- Outpace (NCT04151745)
- Testing
- external pacemaker switched off
- Sponsor
- Frisius Medisch Centrum
Right Ventricular Dysfunction, Hypoxia
Impact of Iron Supplementation on Right Ventricular Function and Exercise Performance in Hypoxia
The purpose of this study is to determine if taking iron supplement pills improves exercise performance in low-oxygen conditions.
- Trial name
- NCT05349630
- Testing
- Ferrous sulfate 325mg
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Right Ventricular Dysfunction
Evaluation of Right Ventricular Function Post Mitral Valve Operations
We aim to determine the function of Right ventricle post mitral valve surgeries in patients with pulmonary hypertension using transthoracic echocardiography3- and 6-months post-operatively to detect the effect of mitral valve…
- Trial name
- NCT05620992
- Testing
- Echocardiography
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Congenital Disorders
Predictors for Pulmonary Valve Replacement - Anatomic and Hemodynamic Using MRI
Magnetic Resonance Imaging (MRI) is a non-invasive test that can look at the heart without using radiation. An MRI will allow the doctors to look at the heart in order to assess how well the ventricle is pumping, the amount of…
- Trial name
- NCT00489788
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Emory University
Heart Disease, Ischemic Heart Disease
Stem Cell Injection to Treat Heart Damage During Open Heart Surgery
Background: Bone marrow stromal stem cells (also known as mesenchymal stem cells) have been isolated and are found to make large amounts of growth factors.
- Conditions
- Heart Disease, Ischemic Heart Disease, Coronary Artery Disease, Coronary Artery Disease (CAD)
- Trial name
- NCT01557543
- Testing
- Cell Therapy
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Takotsubo Cardiomyopathy, Beta-blockers
Beta-Blockers in Takotsubo Syndrome Study
The Beta-blockers in Takotsubo syndrome (TTS) (β-Tako) trial, is an academic, pragmatic, prospective, multicenter randomized clinical trial, aiming to assess the efficacy of beta-blockers (BB) in TTS patients.
- Conditions
- Takotsubo Cardiomyopathy, Beta-blockers, Echocardiography, Left Ventricular Function
- Trial name
- β-Tako (NCT06509074)
- Testing
- Beta blocker
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Spanish Society of Cardiology
Functional Tricuspid Regurgitation
Risk Stratification in Severe Treatment-naive, Tricuspid Regurgitation
This registry is aimed to characterize patients with severe tricuspid regurgitation for the purpose of patient selection for interventional treatment and identify factors related to adverse outcomes.
- Trial name
- TRuE (NCT04173091)
- Testing
- No Intervention
- Where
- 5 sites in Germany, Israel
- Volunteers
- 2,000 people
- Sponsor
- Charite University, Berlin, Germany
Heart Failure, Central Sleep Apnea
Central Sleep Apnea Prevalence and Impact on Cognitive Function in Patients With Heart Failure With Reduced or Mildly Reduced Left Ventricular Ejection Fraction
Study to assess the prevalence of central sleep apnea in patients with heart failure with reduced or mildly reduced left ventricular ejection fraction (LVEF <50%) followed by case-control study to assess the link between central…
- Trial name
- COG01 (NCT06313840)
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Zoll Medical Corporation
Diabetes Mellitus, Left Ventricular Dysfunction
Early Assessment of Impaired Cardiac Function in Patients With Diabetes Mellitus
This is a single-center, prospective, observational study to explore the clinical features and risk factors of impaired cardiac function detected by two-dimensional speckle tracking echocardiography in patients with diabetes…
- Trial name
- NCT05484817
- Testing
- Assessment of cardiovascular risk factor, endocrine hormones and related biomarker
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Ventricular Tachycardia
Stereotactic Non-invasive Ablation of Ventricular Tachycardia
STereotactic Ablative Radiosurgery of recurrent Ventricular Tachycardia in structural heart disease (STAR-VT).
- Trial name
- NCT03819504
- Testing
- 4-D navigated stereotactic radio surgical ablation
- Where
- 3 sites in Czechia
- Sponsor
- University Hospital Ostrava
ARDS Due to Disease Caused by SARS Co-V-2, Right Ventricular Dysfunction
Cardiopulmonary Effects of Prone Position in CARDS
In coronavirus disease-2019 (COVID-19)-related ARDS (C-ARDS), especially in the severe form, increased shunt rate, impaired ventilation/perfusion ratio (V/Q), hypoxic pulmonary vasoconstriction inhibition, and increased immune…
- Trial name
- NCT06456606
- Testing
- before prone position, the first hour of prone position, the first hour of returning to the supine position
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Heart Failure, Arrhythmias, Cardiac
Evaluation of a Proactive Clinical Management and Early Diagnosis of Arrhythmias in Patients With Heart Failure and Non Severely Reduced Left Ventricular Function Through a Telemonitoring System
Vasco trial is a no profit, multicenter, international, prospective, randomized study designed to evaluate the clinical benefits of a remote monitoring management based on ILR vs standard practice in patients with high risk of…
- Trial name
- VASCO (NCT05974306)
- Testing
- implantable loop recorder
- Volunteers
- 331 people
- Sponsor
- Leonardo Calò, MD