Clinical trials: Ventricular Function
Pulmonary Hypertension
Neuromodulation in Patients With Pulmonary Arterial Hypertension
Patients with Group 1 pulmonary hypertension will be enrolled in this study. Investigators will test the hypothesis of low-level tragal stimulation in patients with pulmonary hypertension.
- Trial name
- NIP (NCT06802380)
- Testing
- Low-level tragus stimulation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Oklahoma
Healthy
Japan Central Aortic Pressure Prospective Study
Purpose of the study 1. The predictive value of central aortic pressure and aortic pulse wave velocity (PWV) in a Japanese population is not known.
- Trial name
- J-CARP (NCT01243840)
- Where
- Japan
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Yoshio Matsui
Patients With Type 2 Diabetes
A Randomised, Double-Blind, Placebo-Controlled Study Assessing the Effect of Fenofibrate, Coenzyme Q10 and Their co-Administration on Ventricular Diastolic Function in Patients With Type 2 Diabetes
The purpose of this study was to study the effect of different combinations of fenofibrate and coenzyme Q10 on ventricular diastolic function in patients with Type II diabetes
- Trial name
- NCT00703482
- Testing
- Fenofibrate/CoQ10
- Where
- 3 sites in Australia
- Volunteers
- 278 people
- Sponsor
- Solvay Pharmaceuticals
Hypoplastic Left Heart Syndrome, Obstructive Sleep Apnea Syndrome
Sleep Disordered Breathing in Children With Single Ventricle Physiology
This is an exploratory study designed to evaluate the incidence of, and to quantify sleep disordered breathing following stage I Norwood reconstructive surgery. Sleep disordered breathing will be correlated with: 1.
- Conditions
- Hypoplastic Left Heart Syndrome, Obstructive Sleep Apnea Syndrome, Single Ventricle Physiology
- Trial name
- NCT00156455
- Where
- United States
- Sponsor
- University of Rochester
Heart Failure, Systolic Dysfunction
A Pilot Study of Spinal Cord Stimulation in Heart Failure Patients With Depressed Left Ventricular Function
A randomized pilot study of spinal cord stimulation in patients with chronic heart failure aiming to show whether this therapy impacts central haemodynamic and autonomic regulations.
- Trial name
- RAPID-HELP (NCT02450110)
- Testing
- Spinal cord stimulation
- Where
- Russia
- Volunteers
- 3 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Ischemic Cardiomyopathy, Nonischemic Cardiomyopathy
Left Ventricular Structural Predictors of Sudden Cardiac Death
Sudden cardiac death (SCD) poses a significant health care challenge with high annual incidence and low survival rates. Implantable cardioverter defibrillators (ICDs) prevent SCD in patients with poor heart function.
- Trial name
- NCT01076660
- Where
- 2 sites in United States
- Volunteers
- 400 people
- Sponsor
- Johns Hopkins University
Dilated Cardiomyopathy, Heart Failure
PUFAs and Left Ventricular Function in Heart Failure
The purpose of this study is to test the hypothesis that n-3 PUFAs improve left ventricular systolic function in patients with stable chronic HF secondary to nonischemic dilated cardiomyopathy (NICM).
- Trial name
- CS-PUFA-02 (NCT01223703)
- Testing
- n-3 PUFAs
- Where
- Italy
- Volunteers
- 133 people
- Sponsor
- Università degli Studi di Brescia
Hypoxia, Altitude, Hypoxia
Effect of Acute Hypoxia on RIght VEntRicular Function in Asthma.
More and more people are engaging in sports in the mountains, including individuals with heart or lung diseases. At the same time, such diseases are becoming more common in Switzerland.
- Conditions
- Hypoxia, Altitude, Hypoxia, Normobaric Hypoxia, Right Ventricular Function
- Trial name
- RIVER-Asthma (NCT07431580)
- Testing
- Normobaric Hypoxia
- Where
- Switzerland
- Volunteers
- 18 people
- Sponsor
- Mona Lichtblau
Left Ventricular Function, Cardiac Surgery
Artificial Intelligence Versus Anesthesiologist Visual Assessment of Ejection Fraction by Transesophageal Echocardiography During Cardiac Surgery
This prospective observational study evaluated the reliability of a general-purpose artificial intelligence application in estimating left ventricular ejection fraction from intraoperative transesophageal echocardiography images…
- Trial name
- NCT07841327
- Testing
- Artificial Intelligence Assessment of TEE Images
- Where
- Egypt
- Volunteers
- 93 people
- Sponsor
- Ain Shams University
Tricuspid Regurgitation
Prognostic Value of Early Postoperative Right Ventricular Systolic Function in Patients With Isolated Severe Tricuspid Regurgitation
Preoperative right ventricular end-systolic area (RV-ESA) and hemoglobin level were suggested as independent prognosticator for predicting long-term prognosis in patients with isolated severe TR undergoing corrective surgery We…
- Trial name
- NCT01203137
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Myocardial Infarction
Left Ventricular Function After Acute Myocardial Infarction (AMI). Treatment With Angiotensin 2-Receptor Blockade (GLOBAL-Study)
The purpose of this study is to compare changes in global left ventricular (LV) function after 3 months of treatment with irbesartan compared with usual care in patients with acute myocardial infarction, a wall motion score >1.3…
- Trial name
- NCT00125645
- Testing
- Irbesartan Oral Tablet
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- University of Southern Denmark
Myocardial Infarction, Heart Failure
Effect of Exercise Training on Left Ventricular Function in Patients Post Myocardial Infarction
Patients who have suffered a heart attack are at risk of developing worsening heart function and heart failure. Exercise training has a beneficial effect on heart function and prevents heart failure.
- Conditions
- Myocardial Infarction, Heart Failure, Coronary Artery Disease
- Trial name
- EXIT-V (NCT02048696)
- Testing
- Secondary prevention and cardiac rehabilitation clinic
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- Montreal Heart Institute
LVM, Type 2 Diabetic Patients With IHD
Pioglitazone Regress Left Ventricular Mass in Type 2 Diabetes With Ischeamia Heart Disease
Cardiovascular complications account for the highest mortality in type 2 diabetic patients, mainly due to ischeamia heart disease (IHD).
- Conditions
- LVM, Type 2 Diabetic Patients With IHD, Endothelial Function
- Trial name
- NCT01947790
- Testing
- pioglitazone group, Metformin group
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- Xiang Guang-da
Heart Failure
Acute Effect of Continuous Positive Airway Pressure in Heart Failure
Acute effects of CPAP on diastolic function in patients with compensated heart failure (CHF) are unknown. The investigators hypothesized that acutely CPAP improves diastolic function, which is associated with increases exercise…
- Trial name
- NCT01088854
- Testing
- CPAP
- Where
- Brazil
- Volunteers
- 2 people
- Sponsor
- UPECLIN HC FM Botucatu Unesp
Other Intraoperative Cardiac Functional Disturbances During Cardiac Surgery
Amiodarone for the Prevention of Reperfusion Ventricular Fibrillation
This was a prospective, randomized, double blinded study in which patients undergoing a cardiopulmonary bypass (CPB) with aortic cross clamping were randomly assigned to receive amiodarone, lidocaine, or saline placebo prior to…
- Trial name
- NCT00587483
- Testing
- Lidocaine, Amiodarone
- Where
- United States
- Volunteers
- 342 people
- Sponsor
- Mayo Clinic
Coronary Heart Disease, Diastolic Dysfunction
Cardiac Metabolic Modulator Treatment for Improvement of Diastolic Function in Patients With Coronary Heart Disease
Based on accumulating evidence showing that impaired cardiac energetic metabolism plays important role in the mechanism of cardiac diastolic dysfunction,the study is designed to evaluate whether metabolic modulator treatment with…
- Trial name
- NCT03887013
- Testing
- Trimetazidine
- Where
- China
- Volunteers
- 226 people
- Sponsor
- China National Center for Cardiovascular Diseases
Phosphodiesterase Inhibitor Adverse Reaction, Right-Sided Heart Failure
Phosphodiesterase-5-inhibitors for Right Heart Failure After Left Ventricular Assist Device Implantation
Refractory right heart failure is common during the postoperative period after left ventricular assist device implantation. Oral phosphodiesterase-5 inhibitors are oft initiated in order to facilitate weaning from the intravenous…
- Trial name
- PIVAD (NCT04117659)
- Testing
- withdrawal of oral medication (phosphodiesterase-5 inhibitor) in pretreated patients
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- University Hospital, Essen