Clinical trials: Ventricular Repolarization
Sudden Cardiac Death, Prolonged QTc Interval
Smoking and Ventricular Repolarization
Randomized controlled trial of acute use of electronic cigarette or tobacco cigarette on parameters of ventricular repolarization.
- Trial name
- NCT03916341
- Testing
- EC with nicotine, EC without nicotine, control
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Small Cell Lung Carcinoma
A Study of Rovalpituzumab Tesirine to Study Cardiac Ventricular Repolarization in Subjects With Small Cell Lung Cancer
Study to evaluate the effect of rovalpituzumab tesirine on cardiac ventricular repolarization in subjects with small cell lung cancer (SCLC).
- Trial name
- NCT02874664
- Testing
- Rovalpituzumab Tesirine
- Where
- 15 sites in United States, Canada
- Volunteers
- 46 people
- Sponsor
- Stemcentrx
Neoplasm Malignant
Effect of SAR302503 on ECG Activity in Patients With Solid Tumors
Primary Objective: To assess the effect of SAR302503 (500 mg) administered as 14-day repeated doses on the QTcF interval compared to 1-day placebo in patients with advanced solid tumors.
- Trial name
- NCT01836705
- Testing
- SAR302503 (TG101348), Panolosetron
- Where
- 10 sites in United States, Belgium
- Volunteers
- 60 people
- Sponsor
- Bristol-Myers Squibb
Disease, Hodgkin, Lymphoma, Large-Cell, Anaplastic
Cardiac Safety Study of Brentuximab Vedotin (SGN-35)
The purpose of this study is to evaluate cardiac safety of brentuximab vedotin (SGN-35) in patients with CD30-positive cancers. The study will assess electrical activity of the heart before and after brentuximab vedotin…
- Conditions
- Disease, Hodgkin, Lymphoma, Large-Cell, Anaplastic, Lymphoma, Non-Hodgkin
- Trial name
- NCT01026233
- Testing
- brentuximab vedotin
- Where
- 9 sites in United States, Germany
- Volunteers
- 52 people
- Sponsor
- Seagen Inc.
Cardiac Disease, Ventricular Arrythmia
Development of an Artificial Intelligence Algorithm to Detect Pathological Repolarization Disorders on the ECG and the Risk of Ventricular Arrhythmias
Torsades de Pointes (TdP) are potentially fatal ventricular arrhythmias that are promoted by prolonged ventricular repolarization (Long QT, LQT).
- Trial name
- DEEPECG4U (NCT05829993)
- Where
- France
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiac Arrest, Long QT Syndrome
Registry of Unexplained Cardiac Arrest
The CASPER will collect systematic clinical assessments of patients and families within the multicenter Canadian Inherited Heart Rhythm Research Network.
- Conditions
- Cardiac Arrest, Long QT Syndrome, Brugada Syndrome, Catecholaminergi Polymorphic Ventricular Tachycardia
- Trial name
- NCT00292032
- Where
- Canada
- Volunteers
- 1,529 people
- Sponsor
- University of British Columbia
Brugada Syndrome, Early Repolarization Syndrome
VF Mapping in Brugada and Early Repolarization Syndromes
To determine the values and limitations of ECGI in guiding ablation and risk stratification in patients with BrS and Early Repolarization.
- Trial name
- NCT03764592
- Testing
- radiofrequency ablation
- Where
- 2 sites in Thailand
- Volunteers
- 50 people
- Sponsor
- Pacific Rim Electrophysiology Research Institute
Transgender Individuals, QTc Interval
Protocol TRANS and QT Repolarization
The consequence of hormone-based treatment on cardiac electrophysiology in transgender individuals is poorly explored. We will investigate the effects of gender affirming hormone treatments on ventricular repolarization (ie.
- Trial name
- QTrans (NCT05865262)
- Testing
- ECG, blood test (assessing ionic and hormonal circulating levels)
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Hypertension, Blood Pressure Monitoring, Ambulatory
Nocturnal Blood Pressure Dipping and Ventricular Repolarization in Hypertension
The primary aim is to determine whether non-dipping status is associated with adverse repolarization markers and impaired myocardial mechanics compared to dipper hypertensive patients.
- Conditions
- Hypertension, Blood Pressure Monitoring, Ambulatory, Circadian Rhythm, Electrocardiography
- Trial name
- NBP-DIP (NCT07200856)
- Testing
- Nocturnal Blood Pressure Dipping
- Volunteers
- 140 people
- Sponsor
- Assiut University
Premature Ovarian Insufficiency
Ventricular Repolarization in Patients With Premature Ovarian Insufficiency (QTIOP)
Ventricular repolarization, measured by corrected QT interval (QTc), is influenced by sex hormones. A QTc above 460msec predisposes to the risk of "torsades-de-pointes"(TdP).
- Trial name
- QTIOP (NCT04167033)
- Testing
- Hormone replacement therapy:effect on ventricular repolarization, ECG
- Where
- 3 sites in France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pulmonary Arterial Hypertension
Single and Multiple Ascending Doses Clinical Pharmacology Study With KAR5585
Safety, tolerability, pharmacokinetics (PK), cardiac conduction and food effect study on single and multiple ascending doses of KAR5585 in healthy adults.
- Trial name
- NCT02746237
- Testing
- KAR5585 Capsules
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Karos Pharmaceuticals
Inherited Cardiac Arrythmias, Long QT Syndrome (LQTS)
Derivation of Human Induced Pluripotent Stem (iPS) Cells to Heritable Cardiac Arrhythmias
Human induced pluripotent stem cells (hiPSCs) have driven a paradigm shift in the modeling of human disease; the ability to reprogram patient-specific cells holds the promise of an enhanced understanding of disease mechanisms and…
- Conditions
- Inherited Cardiac Arrythmias, Long QT Syndrome (LQTS), Brugada Syndrome (BrS), Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)
- Trial name
- NCT02413450
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Torsades de Pointes
A Study to Evaluate How VI-0521 Affect Cardiac Repolarization in Healthy Male and Female Volunteers
Determine whether VI-0521 has an effect on the electrical activity of the heart in healthy subjects. Find out how much VI-0521 is in the blood and any potential side effects on ECG's of healthy subjects after taking the study…
- Trial name
- TQT (NCT00839891)
- Testing
- VI-0521
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- VIVUS LLC
Azithromycin Adverse Reaction, Covid19
The Effect of Azithromycin Use on Conduction System of Heart in COVID-19 Positive Children
Azithromycin (AZ) is used in the pediatric group in COVID-19 diseas. It has been reported to cause prolongation in the QT interval in adult age group.
- Conditions
- Azithromycin Adverse Reaction, Covid19, Long QT Syndrome
- Trial name
- NCT04699097
- Testing
- Azithromycin
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people
- Sponsor
- Kayseri City Hospital
Arrhythmias, Cardiac, Diabetes Mellitus
Effect of Dapagliflozin on Electrocardiographic Parameters in Type 2 Diabetes Patients: DAPA - ECG Study
The goal of this clinical trial is to evaluate whether dapagliflozin can reduce ventricular electrical remodeling, as measured by electrocardiographic parameters, in patients with type 2 diabetes (T2D).
- Trial name
- DAPA-ECG (NCT06721442)
- Testing
- Dapagliflozin (DAPA)
- Where
- 2 sites in Brazil
- Volunteers
- 174 people
- Sponsor
- Beneficência Portuguesa de São Paulo