Clinical trials: Ventricular Tachyarrhythmias
Ventricular Tachycardia
Dose Escalation for SBRT of Recurrent VT Ventricular Tachyarrhythmia - a Single Center, Phase II Clinical Trial
The objective of this study is to demonstrate that higher radiation doses are necessary to induce transmural scar formation which is currently assumed to be the underlying mechanism of successful long-term efficacy of VT…
- Trial name
- DEFT STAR (NCT05594368)
- Testing
- Dose escalating stereotactic arrhythmia radioablation to treat ventricular tachycardia (VT)
- Where
- 3 sites in Czechia, Switzerland
- Volunteers
- 15 people
- Sponsor
- University of Zurich
Post-extrasystolic Potentiation (PESP), Ventricular Tachycardia
Post-Extrasystolic Potentiation as a Predictor of Ventricular Arrhythmias
Background: Patients at increased risk for sudden cardiac death (SCD) may receive an implantable cardioverter defibrillator (ICD).
- Trial name
- A PRIORY (NCT03631303)
- Testing
- Cardiac stimulation through the device leads
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Amsterdam UMC, location VUmc
Ventricular Tachyarrhythmias
Ablation of Ventricular Fibrillation by Accurate Targeting of Arrhythmogenic Regions (AVATAR)
This study will test the hypothesis that many human heart rhythm disorders are caused by small localized sources, where brief ablation may successfully eliminate the heart rhythm disorder.
- Trial name
- AVATAR (NCT01492764)
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- University of California, San Diego
Ventricular Tachycardia
Catheter Ablation Versus Radio-Ablation for Ventricular Tachycardia: a Randomized Controlled Trial
This study compares two arms - the current standard of care catheter ablation for Ventricular Tachycardia compared to stereotactic radiotherapy to non-invasively ablate ventricular tachycardia using a novel non-invasive ECG based…
- Trial name
- CARA-VT RCT (NCT05047198)
- Testing
- Control - Catheter Ablation for VT, Treatment - Non-Invasive Radio Ablation for VT
- Where
- Canada
- Volunteers
- 244 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Recurrent Ventricular Tachycardia
Intramural Needle Ablation for Ventricular Tachycardia
This is a single-arm non-randomized prospective observational cohort study to assess the outcomes of patients undergoing intramural needle catheter ablation of recurrent ventricular tachycardia that has failed antiarrhythmic drug…
- Trial name
- NCT02799693
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- John Sapp
Ventricular Tachycardia, Ventricular Premature Complexes
Catheter Ablation Versus Antiarrhythmic Drugs for Outflow Tract Ventricular ARrhythmias
A randomized, parallel, open study comparing catheter ablation versus antiarrhythmic drugs for outflow tract ventricular arrhythmias
- Trial name
- AVATAR (NCT01780311)
- Testing
- antiarrhythmic drugs (Flecainide or Propafenone or Sotalol), Catheter Ablation
- Where
- Italy
- Sponsor
- Ospedale San Donato
Ventricular Tachycardia
Trial in Arrhythmia Radioablation for Ventricular Tachycardia: Single Fraction vs Three Fractions
This is a research study that aims to understand if giving a lower dose of treatment all at once is as effective and safe as dividing it into three smaller doses for patients with a heart condition called refractory ventricular…
- Trial name
- NCT06743789
- Testing
- Radiation Therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Weill Medical College of Cornell University
Ventricular Tachycardia
Optimal Pharmacological Therapy In Implantable Defibrillator Patients (OPTIC)
This is an open parallel design randomized trial of amiodarone plus a beta blocker vs a beta blocker alone vs sotalol for the prevention of ICD shocks in patients receiving an ICD for spontaneous or inducible ventricular…
- Trial name
- NCT00257959
- Testing
- amiodarone beta blocker sotalol
- Where
- Canada
- Volunteers
- 400 people
- Sponsor
- Connolly, Stuart, M.D.
Ventricular Tachycardia, Chagas Disease
SBRT in Chagas Disease Ventricular Tachycardia
This is an observational study of 10 Chagas Disease patients with Ventricular Tachycardia that have failed prior catheter ablation or have this procedure contraindicated due to clinical status.
- Conditions
- Ventricular Tachycardia, Chagas Disease, Cardiac Arrhythmia
- Trial name
- NCT04984265
- Testing
- Stereotactic Body Radiation Therapy
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- University of Sao Paulo General Hospital
Ventricular Tachycardia
Catheter Evaluation for Endocardial Ablation in Patients With Ventricular Tachycardia
The primary objective is to provide additional corroborative safety and efficacy data for the Navistar ThermoCool catheter for the treatment of subjects with ischemic Ventricular Tachycardia.
- Trial name
- VT-CoA (NCT00412607)
- Testing
- NAVISTAR® THERMOCOOL® Catheter
- Volunteers
- 249 people
- Sponsor
- Biosense Webster, Inc.
Ventricular Tachycardia, Atrial Fibrillation
Defining the Risk of Ventricular Tachycardia in Genetic Forms of Early-onset Atrial Fibrillation
To use programmed ventricular stimulation at the time of AF ablation to define the prevalence and mechanism of inducible ventricular tachycardia (VT); pace-mapping to define the site of origin of ventricular arrhythmias; and…
- Trial name
- NCT06647459
- Testing
- EP Study
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Ventricular Tachycardia, Monomorphic, Cardiomyopathies
Stereotactic Radioablation as First-Line Therapy for Scar-Related Ventricular Tachycardia
Ventricular tachycardia (VT) is a dangerous fast heart rhythm originating from scarred areas of the heart muscle, often after a heart attack or in patients with cardiomyopathy.
- Trial name
- START-VT (NCT07618780)
- Testing
- Stereotactic Arrhythmia Radioablation
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Southlake Health
Arrhythmogenic Right Ventricular Cardiomyopathy, Cardiomyopathies
Mayo AVC Registry and Biobank
Arrhythmogenic ventricular cardiomyopathy (AVC) is a genetic condition which affects the heart and can lead to heart failure and rhythm problems, of which, sudden cardiac arrest or death is the most tragic and dangerous.
- Conditions
- Arrhythmogenic Right Ventricular Cardiomyopathy, Cardiomyopathies, Heart Diseases, Cardiovascular Diseases
- Trial name
- NCT03049254
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Myotonic Dystrophy, Sudden Cardiac Death
RAMYD Study - Evaluation of Arrhythmic Risk in Myotonic Dystrophy
This is a prospective multicentric Italian study to evaluate the arrhythmic risk in myotonic dystrophy type 1.
- Trial name
- NCT00127582
- Testing
- Electrophysiological study, pacemaker , implantable cardiac defibrillator or loop-recorder implant
- Where
- Italy
- Volunteers
- 537 people
- Sponsor
- Catholic University of the Sacred Heart
Long QT Syndrome, Sudden Cardiac Death
Electromechanical Profiling of the Long-QT Syndrome (LQTS)
High-resolution, non-invasive electromechanical mapping in genotyped long-QT syndrome patients and healthy controls at baseline and during smart provocation.
- Conditions
- Long QT Syndrome, Sudden Cardiac Death, Ventricular Tachycardia
- Trial name
- EMLoQ (NCT04074122)
- Testing
- Adenosine and epinephrine, isoprenaline provocation
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Ventricular Tachycardia (VT)
Non-Invasive Programmed Stimulation (NIPS) to Guide the Subsequent VT Therapeutic Strategies
The aim of this study is to define the importance of non-invasive programmed stimulation (NIPS) in risk stratification of ventricular tachycardia (VT) recurrence after catheter ablation and to determine the optimal treatment…
- Trial name
- NCT06669299
- Testing
- Re-Do ventricular tachycardia ablation, Antiarrhythmic Drug Therapy (amiodarone, sotalol, or mexiletine)
- Where
- Italy
- Volunteers
- 51 people
- Sponsor
- IRCCS Ospedale San Raffaele
Tachycardia, Ventricular
SMS: Substrate Modification Study in Patients Getting an Implantable Cardioverter Defibrillator (ICD)
The present standard of care for the management of unstable ventricular tachycardia (VT) in the setting of chronic coronary artery disease is the placement of an implantable cardioverter defibrillator (ICD) after the initial…
- Trial name
- SMS (NCT00170287)
- Testing
- ICD Ablation plus VT-ablation, ICD Therapy
- Where
- 7 sites in Denmark, Germany
- Volunteers
- 116 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Catecholaminergic Polymorphic Ventricular Tachycardia Type 1
Treatment of an Inherited Ventricular Arrhythmia
The goal of the proposed project is to determine the safety and tolerability as well as the preliminary efficacy of a novel small molecule drug, S48168 (ARM210), for the treatment of Catecholaminergic Polymorphic Ventricular…
- Trial name
- NCT05122975
- Testing
- S48168 (ARM210)
- Where
- 2 sites in United States, Netherlands
- Volunteers
- 8 people
- Sponsor
- RyCarma Therapeutics, Inc.
Ventricular Arrhythmia, Ventricular Tachycardia (V-Tach)
Proton Radiosurgery for the Treatment of Malignant Ventricular Tachyarrhythmias
Ventricular arrhythmias (VAs) are the leading cause of sudden cardiac death (SCD) worldwide. The implantable defibrillator (ICD) increases survival in patients at risk of VA, with data of superiority to antiarrhythmic drugs.
- Trial name
- TOVEL (NCT06769451)
- Testing
- Stereotactic Arrhythmia Radioablation (STAR) with Proton Therapy
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- Azienda Sanitaria Universitaria Integrata del Trentino
Ventricular Tachycardia
Inducibility and Stability of Ventricular Tachycardia Inpatients Undergoing VT Ablation Under General Anesthesia
This research study is being done to see whether general anesthesia (GA) affects our ability to start ventricular tachycardia (VT) during an VT ablation procedure.
- Trial name
- NCT02419547
- Testing
- Versed, Fentanyl, Propofol
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Brigham and Women's Hospital