Clinical trials: Ventricular Tachyarrhythmias
Structural Heart Disease
Optimised Decrement Evoked Potential (DeEP) Mapping to Guide Ventricular Tachycardia (VT) Ablation in Patients With Structural Heart Disease VT
Ventricular tachycardia (VT) is a life-threatening heart rhythm disorder. Special pacemakers called implantable cardiac defibrillators (ICDs) help treat VT episodes, however they do not prevent the VT episodes from occurring.
- Trial name
- Opto-DeEP (NCT06937983)
- Testing
- Optimised DeEP-guided ablation
- Where
- United Kingdom
- Volunteers
- 77 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Ventricular Arrythmia, Ventricular Fibrillation
Parasternal Extravascular ICD System Pivotal Clinical Investigation (ALARION EV) Study
The ALARION EV Study is a prospective, multi-center, single-arm, non-randomized study without concurrent or historical controls.
- Conditions
- Ventricular Arrythmia, Ventricular Fibrillation, Ventricular Tachycardia
- Trial name
- ALARION EV (NCT07324031)
- Testing
- Atala™ lead and EV-ICD Pulse Generator
- Where
- 35 sites in United States, Netherlands
- Volunteers
- 280 people
- Sponsor
- AtaCor Medical, Inc.
Ventricular Tachycardia
Outcomes of Functional Substrate Mapping of Ventricular Tachycardia
The goal of this registry database is to demonstrate the safety and effectiveness of functional ventricular tachycardia (VT) ablation using SENSE protocol in patients with ischaemic VT.
- Trial name
- VTFM (NCT05708131)
- Where
- 8 sites in United States, Greece and 2 more
- Volunteers
- 70 people
- Sponsor
- Mid and South Essex NHS Foundation Trust
Ventricular Tachycardia
Initial Management of Patients Receiving a Single Shock (IMPRESS)
The goal of this study is to determine the optimal treatment for patients who receive a single shock from their implantable cardioverter defibrillator (ICD).
- Trial name
- IMPRESS (NCT03531502)
- Testing
- Ventricular Tachycardia Ablation, Standard Medical Therapy, Non-Invasive Programmed Stimulation (NIPS)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Saint Luke's Health System
Long QT Syndrome, Brugada Syndrome
Healthy-related Quality of Life and Physical Activity of Children With Cardiac Malformations
The QUALIMYORYTHM trial is a multicentre controlled study, aiming to assess health-related quality of life (HRQoL) of 107 children aged 6 to 18 years old with inherited cardiac arrhythmia (long QT syndrome, Brugada syndrome…
- Conditions
- Long QT Syndrome, Brugada Syndrome, Catecholaminergic Polymorphic Ventricular Tachycardia, Arrhythmogenic Right Ventricular Dysplasia
- Trial name
- QUALIMYORYTHM (NCT04712136)
- Testing
- MRI
- Where
- France
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Ventricular Tachycardia, Ventricular Fibrillation
Evaluation of the Efficacy and Safety of Nifekalant Hydrochloride (NIF) Injection.
Efficacy and safety evaluation of amiodarone and Nifekalant hydrochloride(NIF) for the treatment of ventricular tachycardia and ventricular fibrillation.
- Trial name
- NCT03855826
- Testing
- Nifekalant hydrochloride, Amiodarone
- Where
- China
- Volunteers
- 756 people
- Sponsor
- Sichuan Baili Pharmaceutical Co., Ltd.
Arrhythmia, Quality of Life
Psychosomatic Effects of Implantable Cardioverter Defibrillator With Home Monitoring Function (QUANTUM)
Quality of life (QOL) and psychological well-being of patients with implantable cardioverter-defibrillators (ICDs) are significantly influenced by the experience of shock therapies.
- Trial name
- NCT00325221
- Testing
- HM on, HM Off
- Where
- 7 sites in Austria, Germany and 1 more
- Volunteers
- 148 people
- Sponsor
- Biotronik SE & Co. KG
Ventricular Fibrillation, Ventricular Arrythmia
Noninvasive Electrocardiographic Imaging for Individuals at Risk for Apparently Idiopathic Ventricular Fibrillation.
This study aims to evaluate the electrophysiological properties of the heart conduction system in patients with unexplained polymorphic ventricular tachycardia (VT) and/or ventricular fibrillation (VF), in patients with specific…
- Conditions
- Ventricular Fibrillation, Ventricular Arrythmia, Polymorphic Ventricular Tachycardia, Sudden Cardiac Death
- Trial name
- VIGILANCE (NCT03963271)
- Testing
- ECG-Imaging
- Where
- 3 sites in Netherlands
- Volunteers
- 500 people
- Sponsor
- Maastricht University Medical Center
Ventricular Tachycardia, Ventricular Fibrillation
MAVRIC VR ICD Registry
The purpose of this registry is to collect information on the health status of patients receiving Marquis/Maximo VR Implantable Cardiac Defibrillators (ICDs), how the devices are being programmed and how this correlates to…
- Trial name
- NCT00270933
- Testing
- Registry
- Where
- 91 sites in United States, Canada
- Volunteers
- 742 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Sudden Cardiac Arrest
AI-guided Prediction and Treatment of Cardiac Arrest
Sudden cardiac arrest is a major health problem, and most people don't survive. One big reason is that even if resuscitation is successful, people commonly have recurrent cardiac arrests (rearrest).
- Trial name
- NCT07452016
- Testing
- Machine learning-guided cardiac arrest prediction device
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- MetroHealth Medical Center
Stereotactic Radioablation for Ventricular Tachycardia
Stereotactic Arrhythmia Radioablation for Ventricular Tachycardia Management
Stereotactic Arrhythmia Radioablation (STAR) ablation is a safe and feasible option for cardiomyopathy patients for management of refractory ventricular tachycardia.
- Trial name
- STAR VTM (NCT04065802)
- Testing
- Stereotactic Radioablation
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Ventricular Tachycardia, Myocardial Infarction
Peri-Procedural Transmural Electrophysiological (EP) Imaging of Scar-Related Ventricular Tachycardia
Ventricular tachycardia (VT) contributes to over 350,000 sudden deaths each year in the US. Malignant VTs involve an electrical "short circuit" in the heart, formed by narrow channels of surviving tissue inside myocardial scar.
- Trial name
- ECGI-VT (NCT03713866)
- Testing
- EP Imaging and Testing
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- John Sapp
Cardiopulmonary Resuscitation, Cardiac Arrest
Extracorporeal Membrane Oxygenation Effect in Prolonged Cardiopulmonary Resuscitation
Analysis of the patients' data who were rescued with extracorporeal membrane oxygenation and without ECMO. The survival rate and the weaning rate were analyzed to see the effect of ECMO on the prolonged CPR.
- Conditions
- Cardiopulmonary Resuscitation, Cardiac Arrest, Ventricular Tachycardia, Ventricular Fibrillation
- Trial name
- NCT00173615
- Testing
- Extracorporeal membrane oxygenation
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Ventricular Premature Complexes, Outflow Tract
Effects of Carvedilol on Suppressing the Premature Ventricular Complex/Ventricular Tachycardia From Outflow Tract
Carvedilol is known to be effective in reducing ventricular arrhythmias and mortality in patients with heart failure. It is suggested that one of the mechanisms is its ability to block store overload-induced Calcium release which…
- Conditions
- Ventricular Premature Complexes, Outflow Tract, Carvedilol
- Trial name
- FOREVER (NCT03587558)
- Testing
- Carvedilol, Flecainide
- Where
- 11 sites in South Korea
- Volunteers
- 104 people
- Sponsor
- Keimyung University Dongsan Medical Center
Post-myocardial Infarction Ventricular Tachycardia
Facilitating Catheter Guidance to Optimal Site for VT Ablation
Each year in the UK, approximately 150,000 people have a heart attack when the blood supply to their heart is compromised. As a result, affected regions of the heart can become diseased and scarred.
- Trial name
- CPS (NCT03862989)
- Testing
- Radiofrequency catheter ablation
- Where
- United Kingdom
- Sponsor
- University of Exeter
PVC - Premature Ventricular Complex, Cardiomyopathies
PASO Automated Template Matching for PVC Ablation
Pacemapping is an essential tool during ablation of idiopathic PVC and VT. Automated template matching has been shown to have a significant influence on PVC ablation procedures, but the PASO module of CARTO3 has not been studied…
- Conditions
- PVC - Premature Ventricular Complex, Cardiomyopathies, Heart Failure, Ventricular Tachycardia
- Trial name
- PAsT-PVC (NCT04778696)
- Testing
- PASO Pacemapping, Conventional Pacemapping
- Where
- Germany
- Volunteers
- 144 people
- Sponsor
- Universitätsklinikum Köln
Ventricular Tachycardia, Ischemic Heart Disease
Real-time Automated Program for IDentification of VT Origin
RAPID-VT Pilot is a single centre prospective cohort pilot study to assess the feasibility, safety and efficacy of catheter ablation of ventricular tachycardia (VT) guided by a novel real-time software to localize the origin of…
- Trial name
- RAPIDVTPilot (NCT03523286)
- Testing
- RAPID-VT Software guided ablation
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- Amir AbdelWahab
Ventricular Arrhythmias
Antiarrhythmic Effects of Spironolactone in Patients With ICDs
This study will test whether spironolactone, an approved drug for among other things hypertension, will reduce the risk of severe arrhythmias in patients with implanted defibrillators.
- Trial name
- SPIRIT (NCT04495712)
- Testing
- spironolactone
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- VA Office of Research and Development
Ventricular Tachycardia
Endo- and Epicardial vs. Endocardial Ablation of Ventricular Tachycardia in Patients With Cardiac Disease
A significant portion of patients with cardiac diseases like coronary artery disease (CAD), dilated cardiomyopathy (DCM) and arrhythmogenic right ventricular cardiomyopathy (ARVC) develops ventricular tachycardia (VT).
- Trial name
- VTeee (NCT01767220)
- Testing
- Strategy 1 - endocardial ablation, Strategy 2 - endocardial and epicardial ablation
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University of Rostock
Ventricular Tachycardia, Myocardial Fibrosis
Ventricular Tachycardia Ablation and Myocardial Scar Characterization With Magnetic Resonance
Previous monocentric experiences have already highlighted the role of preoperative cardiac imaging, in particular of cardiac magnetic resonance (CMR) and tomography (CT), in improving the ablation results of scar-related…
- Trial name
- VOYAGE (NCT04694079)
- Testing
- Group 1, CMR-guided/aided VT ablation, Group 2, CMR-aided VT ablation, Group 3, Electroanatomical guided ablation
- Where
- 7 sites in Italy
- Volunteers
- 104 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana