Clinical trials: Ventricular Tachycardia Ablation
Ventricular Tachycardia, Ventricular Arrythmia
Preventive VT Substrate Ablation in Ischemic Heart Disease
The investigators hypothesize that preventive VT substrate ablation in patients with chronic ICM, previously selected based on imaging criteria (BZC mass) for their likely high arrhythmic risk, is safe and effective in preventing…
- Conditions
- Ventricular Tachycardia, Ventricular Arrythmia, Sudden Cardiac Death, Sudden Cardiac Death Due to Cardiac Arrhythmia
- Trial name
- PREVENT-VT (NCT04675073)
- Testing
- Ventricular tachycardia substrate-based radiofrequency ablation
- Where
- Spain
- Volunteers
- 58 people
- Sponsor
- Centro Medico Teknon
Ventricular Tachycardia, Arrhythmia
Imaging With a Radio Tracer to Guide VT Ablations
Some patients are at risk for life-threatening fast heart rates. These can frequently be treated by using a catheter inside the heart to burn away the cells that create the fast heart rates.
- Trial name
- NCT01250912
- Testing
- 123I-metaiodobenzylguanidine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Maryland, Baltimore
Ventricular Tachycardia
Modification of the Local Abnormal Ventricular Activity Only
Local abnormal ventricular activity (LAVA) is composed of high-frequency, mainly low voltage signals that represent near-field signals from slow-conducting tissue and thus potential VT isthmuses.
- Trial name
- LAVAONLY (NCT05331716)
- Testing
- Cardiac ablation therapy
- Where
- Germany
- Volunteers
- 22 people
- Sponsor
- University of Kiel
Arrhythmia, Ventricular Tachycardia (VT)
A Study to Evaluate the Effect of Vagus Nerve Stimulation in Patients Undergoing VT Ablation
Vagus nerve stimulation (VNS) has been shown to be beneficial in multiple studies including heart failure. The goal of this clinical investigation is to gain additional information about how vagus nerve stimulation relates to…
- Trial name
- NCT04359004
- Testing
- Vagus Nerve Stimulation (VNS)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of California, Los Angeles
Sustained Monomorphic VT (MMVT), Recurrent Ventricular Tachycardia
Functional ElectroAnatomiC Isochronal Late Activation Mapping for Empiric VT Ablation Trial
This is a multicenter, prospective, parallel, randomized controlled trial to test for non-inferiority with an ILAM-guided VT ablation compared to conventional voltage- based ablation.
- Trial name
- FACILE-VT (NCT06931821)
- Testing
- Isochronal Late Activation Mapping (ILAM), High Density Voltage Mapping
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- University of Arizona
Ventricular Tachycardia
Ultra-high Density Mapping With Multielectrode Catheter vs Conventional Point by Point Mapping for Ventricular Tachycardia Substrate Ablation
Ultra-high density mapping with multielectrode catheter may improve slow conduction channels identification in ventricular tachycardia substrate ablation procedures compared to conventional point by point mapping.
- Trial name
- NCT02083016
- Testing
- Ablation guided by conventional mapping., Ablation guided by ultra-high density mapping with multielectrode catheter.
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Hospital Clinic of Barcelona
Tachycardia, Ventricular
Cardiac RADIoablation Versus Repeat Catheter Ablation: a Pivotal Randomized Clinical Trial Evaluating Safety and Efficacy for Patients With High-risk Refractory Ventricular Tachycardia (RADIATE-VT)
RADIATE-VT is a pivotal, multicenter, randomized trial comparing safety and efficacy between cardiac radioablation (CRA) using the Varian CRA System and repeat catheter ablation (CA), for patients with high-risk refractory…
- Trial name
- RADIATE-VT (NCT05765175)
- Testing
- Varian Cardiac Radioablation (CRA), Catheter Ablation (CA)
- Where
- 12 sites in United States
- Volunteers
- 380 people
- Sponsor
- Varian, a Siemens Healthineers Company
Ventricular Tachycardia
Catheter Ablation of Haemodynamically Not-tolerated Electrical Storm in Structural Heart Disease
This is a multi-center, parallel-group, randomized, open-label trial evaluating the clinical outcome and efficacy of emergency catheter ablation versus conventional stepped-care strategies in patients with haemodynamically…
- Trial name
- NCT06455020
- Testing
- Catheter ablation, Stepped-care strategies
- Where
- 4 sites in China
- Volunteers
- 96 people
- Sponsor
- Beijing Anzhen Hospital
Ventricular Tachycardia, Arrythmia
SERF VT Ablation Early Feasibility Study (EFS)
This is an early feasibility, non-randomized, open-label, single group, interventional study to be conducted in up to 20 US subjects to evaluate the technical feasibility of the Durablate Catheter and Thermedical Ablation System…
- Conditions
- Ventricular Tachycardia, Arrythmia, Heart Diseases, Cardiovascular Diseases
- Trial name
- SERF VT EFS (NCT03628534)
- Testing
- Saline Enhanced Radiofrequency (SERF) ablation
- Where
- 3 sites in United States
- Volunteers
- 16 people
- Sponsor
- Thermedical, Inc.
Ventricular Tachycardia, Ischemic Cardiomyopathy
Contrast ICE for Myocardial Scar in VT Ablations
There is a high correlation between scar areas identified by contrast-enhanced ICE and scar areas identified by conventional electroanatomic mapping.
- Trial name
- NCT03212326
- Testing
- Perflutren Lipid Microsphere Intravenous Suspension [DEFINITY]
- Volunteers
- 24 people
- Sponsor
- Weill Medical College of Cornell University
Ventricular Tachycardia, Premature Ventricular Contraction
RMN Versus Manual Epicardial Retrospective PMCF
Retrospective registry will compare subjects who've undergone a mapping and/or ablation procedure for either ischemic ventricular tachycardia or premature ventricular contraction using an epicardial approach with either manual or…
- Trial name
- EPINAV (NCT04171479)
- Testing
- Epicardial mapping and/or ablation
- Where
- 3 sites in Czechia, Netherlands
- Volunteers
- 40 people
- Sponsor
- Stereotaxis
Refractory Ventricular Tachycardia
Saline Enhanced Radiofrequency (SERF) Needle Ablation for Refractory VT
The Thermedical Ablation System and Durablate catheter is indicated for use in patients with recurrent, sustained, monomorphic ventricular tachycardia (SMVT) refractory to drug therapy and conventional (approved) catheter…
- Trial name
- NCT05337241
- Testing
- Saline Enhanced Radiofrequency (SERF) Ablation
- Where
- 7 sites in United States, Canada
- Volunteers
- 130 people
- Sponsor
- Thermedical, Inc.
Premature Ventricular Complex, Ventricular Arrythmia
Non-Invasive 3D Mapping for Identifying Origin and Preferential Propagation of Ventricular Arrhythmias
This study will measure the diagnostic sensitivity and specificity of the Medtronic CardioInsight wearable 252 electrode vest in predicting the chamber of origin of premature ventricular complexes (PVCs) and compare its…
- Trial name
- NCT03831516
- Testing
- Non Invasive Electroanatomical Mapping
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwell Health
Paroxysmal Supraventricular Tachycardia, Catheter Ablation
Outcomes of PFA Vs. RFA for Patients with PSVT: a Retrospective and Propensity Score Matching Study
The goal of this retrospective study is to compare the long-term follow-up outcomes of pulses field ablation (PFA) Vs. radiofrequency ablation (RFA) for the patients with paroxysmal supraventricular tachycardia (PSVT).
- Trial name
- PFA*RFA*PSVT (NCT06573853)
- Testing
- Focal Pulsed Field Ablation (PFA), Focal Radiofrequecy Ablation (RFA)
- Where
- China
- Volunteers
- 428 people
- Sponsor
- Caijie Shen
Ventricular Tachycardia (VT)
Pan-Asia United States PrEvention of Sudden Cardiac Death Catheter Ablation Trial
The current standard of care for ventricular tachycardia (VT) includes the use of medicine called anti-arrhythmic drugs (AADs) and Implantable Cardioverter Defibrillator (ICD) therapy.
- Trial name
- PAUSE-SCD (NCT02848781)
- Testing
- Implantable Cardioverter Defibrillator (ICD), Catheter Ablation
- Where
- 12 sites in United States, China and 3 more
- Volunteers
- 180 people
- Sponsor
- University of Arizona
Monomorphic Ventricular Tachycardia
Substrate Targeted Ablation Using the FlexAbility™ Ablation Catheter System for the Reduction of Ventricular Tachycardia
To demonstrate that scar-based ventricular tachycardia (VT) ablation using the FlexAbility™ ablation catheter system results in a superior clinical outcome compared to routine drug therapy in subjects with documented Monomorphic…
- Trial name
- STAR-VT (NCT02130765)
- Testing
- Cardiac catheter ablation with ICD/CRT-D
- Where
- 38 sites in United States, Australia and 3 more
- Volunteers
- 64 people
- Sponsor
- Abbott Medical Devices
Ventricular Tachycardia
Non-invasive Ablation of Ventricular Tachycardia
Phase I/II study of 4-D Navigated Non-invasive radiosurgical ablation of ventricular tachycardia (NIRA-VT).
- Trial name
- NCT03601832
- Testing
- 4-D navigated stereotactic radiosurgical ablation
- Where
- 3 sites in Czechia
- Volunteers
- 10 people
- Sponsor
- University Hospital Ostrava
Ventricular Tachycardia, Ischemic Heart Disease
Ripple Mapping Guided Ablation of Ischaemic Ventricular Tachycardia.
The Ripple VT-1 Study is a prospective clinical trial that aims to investigate if catheter ablation of ventricular tachycardia in patients with ischaemic heart disease can be effectively performed using Ripple Mapping.
- Trial name
- RIPPLE-VT (NCT03997201)
- Testing
- Ripple Mapping guided ischaemic VT ablation
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Imperial College Healthcare NHS Trust
Ischemic Monomorphic Ventricular Tachycardia
Physician Assessment of the Clinical Utility of a Patient-Specific 3D Electro-Anatomical Heart Model in VT Ablation
ACE-VT is a clinical pilot study designed to evaluate the ability of the CardioSolv Software System to generate an output for the physician to review in a timely fashion, consistent with the standard of care VT ablation workflow.
- Trial name
- ACE-VT (NCT04841382)
- Testing
- Supporting information.
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- CardioSolv Ablation Technologies
Ventricular Tachycardia
Study of Cardiac PET/CT Imaging to Guide Ablation Treatment of Ventricular Tachycardia
Imaging is to be performed prior to procedure using positron emission tomography/ computed tomography (PET/CT), after a special dye is injected.
- Trial name
- NCT02962076
- Testing
- [C-11] Meta-hydroxyephedrine radioactive tracer (MHED)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Khaled Awad, MD