Clinical trials: Vertebral Fracture, active
Thoracolumbar Low-energy Vertebral Compression Fractures
Large-Scale Evaluation of a Clinical Decision Tree for the Management of Low-Energy Thoracic and Lumbar Vertebral Compression Fractures.
Percutaneous vertebroplasty is widely used for low-energy vertebral compression fractures, but its clinical benefits remain debated.
- Trial name
- PALMTREE (NCT07706439)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Grenoble
Vertebral Fracture, Osteoporosis
Effectiveness of Implementation of Opportunistic AI-screening for Vertebral Fractures in Clinical Practice
The aim of this study is to evaluate clinical effectiveness and cost-effectiveness after implementing a medically approved and commercially available AI support system for opportunistic vertebral fracture screening in CT…
- Trial name
- vertAIdo (NCT07100756)
- Testing
- AI vertebral fracture diagnostics (Flamingo)
- Where
- Sweden
- Volunteers
- 10,500 people
- Sponsor
- University Hospital, Linkoeping
Thoracolumbar Burst Fractures
Vertebral Augmentation and Percutaneous Fixation for Thoracolumbar Burst Fractures Requiring Corpectomy
This study evaluates minimally invasive vertebral augmentation combined with percutaneous fixation for the treatment of severe thoracolumbar burst fractures.
- Trial name
- EXVERCOR (NCT07645092)
- Volunteers
- 30 people
- Sponsor
- University Hospital, Grenoble
Fracture Lower Leg, Fracture Dislocation of Upper Limb Joint
Relationship Between Mortality Rates of Fractures in Different Sites and Several Factors in Elderly Patients
Background and Purpose: As people age, bones become weaker and break more easily. Older adults (people 60 years and older) who break bones may face serious health problems and have a higher chance of dying compared to younger…
- Conditions
- Fracture Lower Leg, Fracture Dislocation of Upper Limb Joint, Spinal Fractures
- Trial name
- NCT07147504
- Volunteers
- 3,000 people
- Sponsor
- Shanghai 6th People's Hospital
Vertebral Compression Fracture, Vertebral Compression
RISE - Study of the AGN1 LOEP SV Kit in Patients With Vertebral Compression Fractures
This study is a prospective, single-arm, multi-center, European clinical study designed to evaluate the clinical performance and safety of the AGN1 LOEP SV Kit for the treatment of painful VCFs.
- Conditions
- Vertebral Compression Fracture, Vertebral Compression, Vertebral Fracture
- Trial name
- NCT04821739
- Testing
- AGN1 LOEP SV Kit
- Where
- 3 sites in Germany, Spain
- Volunteers
- 100 people
- Sponsor
- AgNovos Healthcare, LLC
Radius; Deformity, Hip Osteoarthritis
Clinical Evaluation and Cost-effectiveness Analysis of 3D Digital Surgery in Traumatology
Digital surgery, in combination with patient specific instrumentation (PSI) is being used more and more in traumatology due to its proven benefits and applications.
- Conditions
- Radius; Deformity, Hip Osteoarthritis, Hip Arthritis, Hip Arthropathy
- Trial name
- NCT06603831
- Testing
- patients treated using 3D technology and Patient-Specific Instrumentation, Patients treated with conventional surgery, without using 3D technology
- Where
- Spain
- Volunteers
- 180 people
- Sponsor
- Corporacion Parc Tauli
Osteoporosis, Vertebral Fracture
Chiropractor Delivered Virtual Intervention After Vertebral frActure
This study will determine feasibility of a chiropractor delivered virtual intervention for individuals following osteoporotic vertebral fracture. This pilot trial will have two parallel groups with a 1:1 ratio.
- Trial name
- VIVA (NCT07288684)
- Testing
- VIVA
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of Waterloo
Vertebral Metastases, Vertebral Fracture
A Multicenter Prospective Observational Study on Vertebral Fracture Risk Stratification in Patients With Vertebral Metastases
Vertebral fracture is a common clinically significant skeletal related event in cancer patients. Stratification of patients diagnosed with one or more vertebral metastases according to the risk of pathological fracture is an…
- Trial name
- Valid-METASTRA (NCT06910618)
- Where
- 4 sites in Germany, Hungary and 2 more
- Volunteers
- 300 people
- Sponsor
- Buda Health Center
Vertebral Fracture, Multiple Myeloma
Examination of Vertebroplasty in Addition to Regular Treatment of Patients With Multiple Myeloma.
Patients with newly diagnosed or known multiple myeloma with newly diagnosed vertebral lesion(s) will be invited to participate in a cross-sectoral randomized controlled trial.
- Trial name
- NCT04533217
- Testing
- Vertebroplasty
- Where
- Denmark
- Volunteers
- 90 people
- Sponsor
- Spine Centre of Southern Denmark
Unstable Osteoporotic Vertebral Compression Fractures
RCT on the Efficacy and Safety of Minimally Invasive SAIF Technique vs Spinal Fixation in Unstable Osteoporotic Vertebral Fractures
Osteoporotic vertebral fractures (OVF) represent a significant cause of morbidity, mortality, decreased level of function and quality of life.
- Trial name
- SAIF (NCT07071870)
- Testing
- Stent-screw Assisted Internal Fixation (SAIF), Surgical stabilization
- Where
- Switzerland
- Volunteers
- 140 people
- Sponsor
- Eva Koetsier MD PhD
Vertebral Compression Fracture
Investigating Bone Cement With or Without Inossia® Cement Softener for Vertebral Compression Fractures
The overall purpose of conducting this study is to evaluate the safety and efficacy of V-Flex and V-Steady for augmentation of osteoporotic vertebral compression fractures and to verify that adding a cement softener into a PMMA…
- Trial name
- SOFTBONE (NCT05676320)
- Testing
- V-Flex, V-Steady
- Where
- 9 sites in Canada, Germany and 2 more
- Volunteers
- 203 people
- Sponsor
- Inossia AB
Vertebral Fracture, Compression Fracture
Spine Bone Cements Outcomes - Post Market Follow-up
A Post-Market Clinical Follow-Up (PMCF) Study to collect clinical data on safety and performance of all TEKNIMED Spine range of products: SPINEFIX, HIGH V+, OPACITY+ and F20 bone cements and mixing and injection systems, and all…
- Conditions
- Vertebral Fracture, Compression Fracture, Osteoporotic Fractures
- Trial name
- NCT06367582
- Testing
- Vertebroplasty (VP), Kyphoplasty (KP), Pedicular Screw Augmentation (PSA)
- Where
- 12 sites in France, Portugal and 2 more
- Volunteers
- 500 people
- Sponsor
- Teknimed
Vertebra Compression Fracture
A Clinical Study to Collect Real-wordt Data on Safety and Clinical Performance of the VCFix Spinal System for Treatment of Vertebral Compression Fractures of (Suspected) Osteoporotic Origin.
This study is designed as a prospective, post-market, multi-center, single-arm study to collect real-world data of the VCFix Spinal System used in US clinical practice.
- Trial name
- EXPAND-US (NCT07920484)
- Testing
- VCFix Spinal System in stand-alone configuration
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Amber Implants B.V.
Osteoporotic Vertebral Compression Fractures
CT-Based Deep Learning for Differentiating Acute and Chronic Osteoporotic Vertebral Compression Fractures
Osteoporotic vertebral compression fractures are common in older adults and may present as either acute or chronic fractures. Correctly distinguishing acute from chronic fractures is clinically important because treatment…
- Trial name
- CT-DL-OVCF (NCT07306858)
- Testing
- No Intervention (Observational Study)
- Where
- China
- Volunteers
- 276 people
- Sponsor
- Xin Fan
Spine Fracture, Orthosis
ORthosis vs No Orthosis After Surgically Treated Traumatic Thoracolumbar Fractures
Rationale: There is no evidence in the current literature regarding the additional value of an orthosis after surgically treated thoracolumbar spine fractures.
- Conditions
- Spine Fracture, Orthosis, Traumatic Fracture, Posterior Fixation
- Trial name
- ORNOT (NCT03097081)
- Testing
- No orthosis, Orthosis
- Where
- Netherlands
- Volunteers
- 45 people
- Sponsor
- Amsterdam UMC, location VUmc
Spine Fracture, Osteoporosis
Controlled Reduction of AO Spine B3 Fractures in Ankylosing Spinal Disorders Using an Inflatable Positioning Device: Technical Note and Retrospective Single-centre Case Series
Retrospective observational
- Conditions
- Spine Fracture, Osteoporosis, Spondylitis, Ankylosing
- Trial name
- NCT07847320
- Volunteers
- 23 people
- Sponsor
- Diakonie-Klinikum Stuttgart
Degenerative Disc Disease (DDD), Spinal Stenosis
PMCF Study on the Effectiveness and Safety of METROSAN Spinal Systems and BONEGRAFT Filling Materials
This is a prospective, multi-center, observational Post-Market Clinical Follow-Up (PMCF) study designed to collect additional safety and clinical performance data on CE-marked Titania® spinal instrumentation and fusion systems…
- Conditions
- Degenerative Disc Disease (DDD), Spinal Stenosis, Spondylolisthesis, Spinal Deformities
- Trial name
- INFO SPINE (NCT07615491)
- Testing
- Titania® Cervical Interbody Fusion Cage (Titanium), Titania® Cervical Interbody Fusion Cage (PEEK), Titania® Posterior Cervical Stabilization System
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 561 people
- Sponsor
- Metrosan End. ve Elk. Mek. Cihazlar ve Tibbi Malz. San. Tic. Ltd. Co.
Osteoporosis, Postmenopausal, Vertebral Fracture
Comparation of Treatment Strategies for OVF: Teriparatide Injection and PVP
This study aimed to compare teriparatide treatments and PVPs, focusing on its effects on life qualities and effect/coast ratio and evaluate which method is better for patients.
- Conditions
- Osteoporosis, Postmenopausal, Vertebral Fracture, Quality of Life
- Trial name
- NCT03692143
- Testing
- Teriparatide, PVP, Alendronate
- Volunteers
- 90 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Osteoporotic Vertebral Compression Fractures
Continuous Mobility and Physical Activity in Vertebroplasty vs Sham for Osteoporotic Vertebral Fracture
The aim of this clinical trial is to determine if vertebroplasty is an effective treatment for acute, painful vertebral fractures due to osteoporosis.
- Trial name
- VOPE2 COMPAS (NCT06776003)
- Testing
- Vertebroplasty
- Where
- Denmark
- Volunteers
- 64 people
- Sponsor
- Spine Centre of Southern Denmark
Spinal Metastases
Trial of Combined Radiotherapy and Vertebroplasty for Patients With Painful Metastatic Spinal Lesions
Since patients with spinal metastases are living longer, durable palliation with long-term tumor control are becoming increasingly important. EBRT results in durable local control of bone metastasis.
- Trial name
- NCT04242589
- Testing
- Radiotherapy, Vertebropladty
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- AHS Cancer Control Alberta