Clinical trials: Vertical Transmission of Infectious Disease
HIV Infections
Antibiotics to Reduce Chorioamnionitis-Related Perinatal HIV Transmission
The purpose of this study is to see if antibiotic drugs given to treat an infection of the uterus during pregnancy can reduce the chances of HIV being passed from an HIV-positive mother to her baby.
- Trial name
- NCT00021671
- Testing
- Erythromycin, Nevirapine, Ampicillin sodium
- Where
- United States
- Volunteers
- 3,720 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections, Hepatitis C
Prevalence of Hepatitis C Virus Infection in HIV-Infected Children
The purpose of this study is to find out how many children who are infected with HIV are also infected with hepatitis C virus (HCV). HCV infection is a major health concern.
- Trial name
- NCT00037076
- Where
- 39 sites in United States, Puerto Rico
- Volunteers
- 600 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pregnancy
Assessment of Obstetric, Fetal and Neonatal Risks and Vertical SARS-CoV-2 Transmission During COVID-19 Pandemic
A new coronavirus (COVID-19) highlighted at the end of 2019 in China is spreading across all continents. Most often at the origin of a mild infectious syndrome, associating benign symptoms (such as fever, cough, and headache) to…
- Trial name
- COroFet (NCT04360811)
- Testing
- COVID 19 diagnostic test by PCR
- Where
- France
- Volunteers
- 2,494 people
- Sponsor
- University Hospital, Toulouse
Immune Globulin, Prophylaxis, Telbuvidine, Vaccine
Efficacy of Antiviral Therapy in Pregnancy in Preventing Vertical Transmission of HBV in Mothers With a High Viral Load
Mother-to-child transmission (MTCT) is the most common route of hepatitis B virus (HBV) infection. After given standard immunoprophylaxis, MTCT still occurred in some infants born to a HBsAg positive mothers with high HBV DNA…
- Trial name
- NCT02253485
- Testing
- telbivudine
- Volunteers
- 600 people
- Sponsor
- Beijing Ditan Hospital
HIV Infections
Evaluating the Safety and Pharmacokinetics of Maraviroc in HIV-1-Exposed Infants at Risk of Acquiring HIV-1 Infection
This study aimed to evaluate the safety, tolerability, and pharmacokinetics of maraviroc in infants at risk for mother-to-child HIV transmission, and to determine an appropriate dose of maraviroc during the first six weeks of…
- Trial name
- NCT02778204
- Testing
- Maraviroc
- Where
- 9 sites in United States, Kenya and 2 more
- Volunteers
- 47 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pathogen Transmission, Vertical, Nosocomial Infection
Use of Disposable Cuff Cover to Prevent Carriage of Pathogen Microorganisms Originated by Cuffs
Introduction: Pathogen Microrganisms (PM) colonized on the Blood Pressure Cuff (BPC) are transported from one patient to another by health professionals, which is leading an increase in Health Care Associated Infections (HCAI).
- Conditions
- Pathogen Transmission, Vertical, Nosocomial Infection, Cross Infection, Cuff
- Trial name
- DCC (NCT05326945)
- Testing
- Presence or Absence of a Blood Pressure Cuff Sheath
- Where
- Turkey (Türkiye)
- Volunteers
- 116 people
- Sponsor
- Hasan Kalyoncu University
Chronic Hepatitis D Infection, Fibrosis, Liver
Find HDV and Determine Its Status in Turkey
The aim of these study to determine the prevalence of hepatitis Delta virus (HDV) infections and the prognosis of HDV patients in Turkey's southeast.
- Conditions
- Chronic Hepatitis D Infection, Fibrosis, Liver, Hepatocellular Carcinoma, Cirrhosis, Liver
- Trial name
- SITUHDVATION (NCT06248580)
- Testing
- Anti Delta
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Yaşar Bayındır, MD
Hepatitis C, Hepatitis C, Chronic
Vertical Transmission of Hepatitis C in Adult Children of Female Baby Boomers
The investigators aim to determine the prevalence of hepatitis C in the adult children of female baby boomers. During the years baby boomers were becoming pregnant, hepatitis C testing was either not available or was not standard…
- Trial name
- NCT03038763
- Testing
- Eligibility Screening, HCV test
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Hepatitis C
Study of Maternal Hepatitis C Infection and Influenza Vaccination in Pregnancy
The purpose of this study is to determine if hepatitis C virus and influenza virus vaccine components can cross the placenta and stimulate an immune response in the fetus.
- Trial name
- NCT00810875
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of California, San Francisco
Covid19, Vertical Transmission of Infectious Disease
Clinical Outcomes of Newborns Born to Pregnant Women With and Without COVID-19
A case-control trial was conducted to test the early postpartum period clinical outcomes of newborns born to pregnant women with and without COVID-19.
- Conditions
- Covid19, Vertical Transmission of Infectious Disease, Neonatal Infection, Pregnancy Related
- Trial name
- NCT04883801
- Testing
- Reviewed clinical records and laboratory results
- Where
- Turkey (Türkiye)
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Acquired Immunodeficiency Syndrome, Disease Transmission, Vertical
Anti-HIV Immunoglobulin (HIVIG) in Prevention of Maternal-Fetal HIV Transmission (Pediatric ACTG Protocol 185)
To determine if HIV hyperimmune globulin (HIVIG) given to HIV-positive pregnant women during the second and third trimester of pregnancy reduced the likelihood of maternal-fetal HIV transmission.
- Conditions
- Acquired Immunodeficiency Syndrome, Disease Transmission, Vertical, HIV Infections
- Trial name
- NCT00000590
- Testing
- immunoglobulins
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
HIV Infections, Pregnancy Complications, Infectious
Prenatal and Postnatal Studies of Interventions for Prevention of Mother-To-Child Transmission
The purpose of this study is to collect and study clinical and laboratory information about a pregnant or new mother and her medical care that will increase our knowledge of the best care for HIV-infected pregnant women and their…
- Trial name
- NCT00028145
- Testing
- Adherence assessment
- Where
- 77 sites in United States, Puerto Rico
- Volunteers
- 3,090 people
- Sponsor
- International Maternal Pediatric Adolescent AIDS Clinical Trials Group
Human Immunodeficiency Virus Transmission, Human Immunodeficiency Virus
Validation of Rapid Tests for the Serological Diagnosis of HIV in 9 to 24 Months Old Children
Antiretroviral therapy of the mother and of the newborn associated with alternative schemes of breastfeeding can reduce these transmission rates to 1%.
- Conditions
- Human Immunodeficiency Virus Transmission, Human Immunodeficiency Virus, Diagnoses, Syndromes, and Conditions
- Trial name
- NCT03984552
- Testing
- This was an observational study of medical devices (rapid tests) used for the HIV diagnosis in children up to 2 years
- Where
- Brazil
- Volunteers
- 502 people
- Sponsor
- The Immunobiological Technology Institute (Bio-Manguinhos) / Oswaldo Cruz Foundation (Fiocruz)
Hepatitis B, Vertical Transmission of Infectious Disease
The COMBAT HBV Feasibility Trial
This is a double-blind, randomized placebo-controlled trial (RCT) of a prophylaxis-for-all approach to prevention of mother-to-child transmission (PMTCT) of hepatitis B virus (HBV) in the Democratic Republic of Congo (DRC).
- Trial name
- COMBAT-HBV (NCT05705427)
- Testing
- Tenofovir Disoproxil Fumarate 300 MG, Hepatitis B monovalent vaccine
- Where
- Democratic Republic of the Congo
- Volunteers
- 317 people
- Sponsor
- University of North Carolina, Chapel Hill
Screening
Universal Screening Program for Cytomegalovirus Infection in the First Trimester of Pregnancy (CITEMB Study)
The aim of this study is to evaluate a universal cCMV screening programme in the first trimester of pregnancy in primary care in Catalonia (Spain).
- Trial name
- CITEMB (NCT05699421)
- Testing
- screening programme
- Where
- Spain
- Volunteers
- 3,357 people, healthy volunteers welcome
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Corona Virus Infection, Pregnancy Related
Characteristics of COVID-19 Infection Among PREGnant Women
In December 2019, Coronavirus infection (COVID-19) was identified as causing serious respiratory infection in humans. Initially COVID-19 was propagated by infected symptomatic individuals; currently the disease is disseminated by…
- Trial name
- CCOVID-PREG (NCT04398264)
- Testing
- COVID-19 positive via testing
- Where
- United States
- Volunteers
- 650 people
- Sponsor
- Inova Health Care Services
Hepatitis B, Chronic
Study of Antiretroviral Therapy to Prevent HBV Intrauterine Infection
500 pregnant patients with HBeAg-positive and HBV-DNA≥ 106copies /ml who will do their pregnant check in the First Affiliated Hospital of Xi'an Jiaotong University will be enrolled into the study.
- Trial name
- NCT02719808
- Testing
- Tenofovir1, Tenofovir2, Tenofovir3
- Where
- China
- Volunteers
- 500 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Pregnancy, HBV
Prevention of Hepatitis B Virus Vertical Transmission by Serovaccination and Tenofovir During Pregnancy
The risk of vertical HBV transmission is related to HBV DNA level in pregnant women, around 30% in women with HBV DNA above 1, 000 000 I.U/mL despite serovaccination of newborns.
- Trial name
- NCT02039362
- Testing
- Tenofovir DF
- Where
- France
- Volunteers
- 37 people
- Sponsor
- Hopital Lariboisière
HIV Infections, Neutropenia
Study to Improve Survival Among HIV-Exposed Infants in Botswana
The purpose of this study is to find ways to improve infant health and survival among infants whose mothers are HIV-infected but who do not themselves have HIV.
- Conditions
- HIV Infections, Neutropenia, Anemia
- Trial name
- Mpepu (NCT01229761)
- Testing
- cotrimoxazole prophylaxis, exclusive breastfeeding until 6 months of age, breastfeeding for 12 months
- Where
- 3 sites in Botswana
- Volunteers
- 3,724 people
- Sponsor
- Harvard School of Public Health (HSPH)
Hepatitis B Infection, Congenital Malformation
Tenofovir Disoproxil Fumarate in Combination of Hepatitis B Vaccine for Preventing Hepatitis B Vertical Transmission
Immunoprophylaxis with two hepatitis B vaccinations following the hepatitis B immune globulin (HBIg) and hepatitis B vaccine at birth is largely effective in protecting infants from hepatitis B virus (HBV) infection.
- Conditions
- Hepatitis B Infection, Congenital Malformation, Birth Defect, Viremia
- Trial name
- NCT03476083
- Testing
- Tenofovir Disoproxil Fumarate (TDF) 300 mg oral daily.
- Where
- 7 sites in China
- Volunteers
- 280 people
- Sponsor
- New Discovery LLC