Clinical trials: Viral Respiratory Infection
Acute Respiratory Distress Syndrome, COVID-19
Prone Position in Patients on High-flow Nasal Oxygen Therapy for COVID-19 (HIGH-PRONE-COVID-19)
Acute Respiratory Distress Syndrome (ARDS) induces high mortality, particularly in the context of COVID-19 disease. Preliminary data from patients with ARDS related to COVID-19 disease appear to show significant effectiveness of…
- Trial name
- NCT04358939
- Testing
- Prone decubitus
- Where
- 24 sites in France
- Volunteers
- 405 people
- Sponsor
- University Hospital, Tours
Asthma, Asthma Attack
Optimisation of ASthma In Those With Uncontrolled Symptoms (OASIS)
A digital tool, called ReferID has been developed to facilitate the review of asthma patients. It aims to assist in the identification of patients with uncontrolled and/or severe asthma and to ensure a timely referral to…
- Conditions
- Asthma, Asthma Attack, Asthma Persistent, Covid19
- Trial name
- OASIS (NCT04941001)
- Testing
- ReferID
- Where
- United Kingdom
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
COVID-19
Homologous vs Heterologous Third Vaccination in Kidney Transplant Recipients Kidney Transplant Recipients
Randomized-controlled trial comparing homologous (mRNA vaccine) vs. heterologous (vector vaccine) for third SARS-CoV-2 vaccine dose in kidney transplant recipients not responding to initial prime-boost vaccination with an mRNA…
- Trial name
- BOOST_TX (NCT05324319)
- Testing
- Ad26COVS1, ChAdOx1 SARS2 Vaccine, BNT162B2
- Where
- Austria
- Volunteers
- 200 people
- Sponsor
- Medical University of Vienna
COVID-19
Novel Coronavirus Induced Severe Pneumonia Treated by Dental Pulp Mesenchymal Stem Cells
Evaluation of novel coronavirus induced severe pneumonia by dental pulp mesenchymal stem cells
- Trial name
- NCT04302519
- Testing
- Dental pulp mesenchymal stem cells
- Volunteers
- 24 people
- Sponsor
- CAR-T (Shanghai) Biotechnology Co., Ltd.
Covid19, Severe Acute Respiratory Syndrome
Ivermectin in Adults With Severe COVID-19.
Since the onset of the disease, more than 40.5 million people have been diagnosed with COVID-19 and nearly 1.2 million people have died (October 21, 2020).
- Trial name
- NCT04602507
- Testing
- Ivermectin
- Where
- Colombia
- Volunteers
- 75 people
- Sponsor
- CES University
COVID-19 Pneumonia, COVID-19
Cardiac Magnetic Resonance Tissue Characterization in COVID-19 Survivors
The purpose of this study is to test if visualizing the heart with cardiac MRI/echo will be important in the understanding cardiac function and prediction of cardiopulmonary symptoms, physical effort tolerance, and outcomes in…
- Conditions
- COVID-19 Pneumonia, COVID-19, COVID-19 Respiratory Infection, COVID-19 Acute Respiratory Distress Syndrome
- Trial name
- NCT05164744
- Testing
- Cardiac MRI, Echocardiogram, 6-minute walk test
- Where
- 3 sites in United States
- Volunteers
- 510 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Transplantation
Assessment of the Impact of COVID-19 on Transplant Patients and on Patients Awaiting Transplantation
To provide optimal care to patients and to maintain long-term institutional viability, Transplant Centres (TC) must have an awareness of their patients' health status, their health care needs and priorities, as well as their…
- Trial name
- COWAIT (NCT04376775)
- Testing
- Transplant patient
- Where
- France
- Volunteers
- 3,602 people
- Sponsor
- University Hospital, Bordeaux
Covid19
COVID-19 Respiratory Outcomes Registry
This is a 48-week, observational study looking to see if the inflammatory process of hypoxemic respiratory failure associated with COVID-19 leads to progressive pulmonary fibrosis.
- Trial name
- NCT05074875
- Testing
- Questionnaires and Patient Reported Outcomes (PROs), Nasal Swab COVID-19 reverse transcription polymerase chain reaction test (RT-PCR), Blood Samples for Biomarkers
- Where
- 4 sites in United States
- Volunteers
- 37 people
- Sponsor
- Weill Medical College of Cornell University
Idiopathic Pulmonary Fibrosis
A Pilot Trial of Herpesvirus Treatment in Idiopathic Pulmonary Fibrosis (IPF)
The investigators will conduct a single-center, prospective, randomized, placebo-controlled, double-blind pilot study of anti-herpesvirus therapy in patients with idiopathic pulmonary fibrosis (IPF).
- Trial name
- NCT02871401
- Testing
- Valganciclovir
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Vanderbilt University Medical Center
Anosmia, Smell Loss
Intranasal Insulin for COVID-19-related Smell Loss
The aim of this study was to quantify the improvement in olfaction of 27 post-COVID-19 patients, after three intreventions of intranasal insulin during a four week period, with the help of the Threshold, Discrimination and…
- Conditions
- Anosmia, Smell Loss, Paraosmia, Hyposmia
- Trial name
- NCT05461365
- Testing
- Insulin
- Where
- Mexico
- Volunteers
- 27 people
- Sponsor
- Universidad Panamericana
COVID-19
Effect of Daily Oral Administration of Food Supplement NLC-V in Patients Diagnosed With COVID-19
This study is designed to evaluate the safety and efficacy of NLC-V in patients diagnosed with COVID-19.
- Trial name
- NCT05226767
- Testing
- NLC-V
- Where
- Israel
- Volunteers
- 31 people
- Sponsor
- Todos Medical, Ltd.
COVID-19 Disease
Back to the Traditional: Anti-COX Drugs Can Improve the Outcome of COVID-19 Patients Admitted to ICU
Retrospective multicenter study to evaluate the data of COVID-19 patients who were admitted to university hospitals in relation to their recent administration or maintenance on non-steroidal anti-inflammatory drugs (NSAID) prior…
- Trial name
- NCT04757792
- Testing
- File inquiry
- Where
- Egypt
- Volunteers
- 475 people
- Sponsor
- Benha University
Covid19
COVID-19 and HIV Patients
As of May 26, 2020, 5,508,904 confirmed cases (145,279 in France) of COVID-19 and 346,508 deaths (28,457 in France) have been reported since December 8, 2019 worldwide.
- Trial name
- COCOVIH (NCT04523012)
- Testing
- Seroprevalence of SARS-CoV-2 infection in patients with HIV infection
- Where
- France
- Volunteers
- 2,200 people
- Sponsor
- Centre de Recherches et d'Etude sur la Pathologie Tropicale et le Sida
Communicable Disease, COVID-19
COVID-19 Diagnostic Self-testing Using Virtual Point-of-care
The goal of the research is to assess candidate COVID-19 rapid diagnostic tests (e.g. immunodiagnostic antibody tests, like Cellex qSARS-CoV-2 IgG/IgM Rapid Test, or antigen tests, like Turklab Test-It COVID-19 Home Test, AllBio…
- Conditions
- Communicable Disease, COVID-19, Sars-CoV2, Infectious Disease
- Trial name
- NCT04348864
- Testing
- COVID-19 Antigen/Antibody Rapid Testing, mobile device image capture and telemedicine support, Telemedicine
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Neuroganics LLC
Post-COVID-19 Syndrome, Fatigue Syndrome, Chronic
REGAIN: RCT of Oxaloacetate for Fatigue in Long COVID
Following acute COVID-19, some patients develop a group of debilitating symptoms that include fatigue, orthostatic intolerance, difficulty with attention and concentration (often called "brain fog"), myalgias and disrupted sleep.
- Trial name
- NCT05840237
- Testing
- Anhydrous Enol-Oxaloacetate, a "Medical Food", White Rice Flour
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Terra Biological LLC
Covid19
Study of CRP, Ferritine and D-Dimer in Covid-19 Patients Admitted To Respiratory ICU in Assuit University Hospitals
To Study serum CRP, D-dimer and serum ferritin in adult patients with COVID-19 for the presence or absence of clinically validated definitions of mortality, severe COVID-19, ARDS, and intensive care unit (ICU) care.
- Trial name
- NCT05102695
- Testing
- Serum CRP , ferritine and d-dimer
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Assiut University
Post COVID Syndrome Long Covid, Post COVID Syndrome
Whole-Body Electrostimulation for Functional Recovery in Post-COVID Syndrome
Post-COVID syndrome is a condition that affects some people after recovering from the acute phase of COVID-19. Common symptoms include persistent fatigue, reduced physical capacity, and difficulties performing everyday…
- Conditions
- Post COVID Syndrome Long Covid, Post COVID Syndrome, Long COVID Fatigue, Long Covid
- Trial name
- WB-EMS PostCOV (NCT07312357)
- Testing
- Whole-Body Electromyostimulation Suit
- Volunteers
- 30 people
- Sponsor
- Universidad Rey Juan Carlos
COVID-19
Prospective Evaluation of SARS-CoV-2 Antibodies Levels in a Vaccinated Population of Valle de Aburra
Recent research evidence shows that levels of antibodies acquierd post vacunation against SARS-Cov-2 decrease over time as well as the efficacy to control the infection, additionally in a multicenter study carried out in 2020…
- Trial name
- NCT05172167
- Testing
- Levels of IgG and IgM SARS-CoV-2 antibodies blood test., RT-PCR SARS-CoV-2 nasopharyngeal swab
- Where
- Colombia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universidad de Antioquia
COVID-19, SARS-CoV-2 Infection
COVID-19: SARS-CoV-2 Specific Memory B and T-CD4+ Cells
The current pandemic caused by the newly identified coronavirus responsible for COVID-19 is a major threat to our populations and societies.
- Trial name
- MEMO-COV2 (NCT04402892)
- Testing
- 35 ml blood, 5 tubes LITHIUM HEPARINATE at each time (hospitalized Patients ), 35 ml blood, 5 tubes LITHIUM HEPARINATE at each time (cured Patients)
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Covid-19, ARDS
Timing of Tracheotomy in Covid-19 Patients
Critically ill covid-19 patients may require respiratory support including mechanical ventilation. After an initial period with an endotracheal tube, a tracheotomy is performed in order to reduce potential airway complications…
- Conditions
- Covid-19, ARDS, Tracheostomy Complication, Respiratory Insufficiency
- Trial name
- TTCOV19 (NCT04412356)
- Testing
- Tracheotomy
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Sahlgrenska University Hospital