Clinical trials: Viral Respiratory Tract Infections
COVID-19, Chronic Heart Failure
Intermittent Hypoxic-hyperoxic Training in Patients With Cardiovascular Pathology After COVID-19 Infection.
Aim of this prospective, interventional, single-center, randomized study is to evaluate the efficacy and safety of intermittent hypoxic-hyperoxic training (IHHT) as a rehabilitation method in patients with cardiovascular…
- Conditions
- COVID-19, Chronic Heart Failure, Hypertension, Arrhythmia
- Trial name
- NCT05379608
- Testing
- Intermittent hypoxic-hyperoxic training, Intermittent hypoxic-hyperoxic training/control
- Where
- Russia
- Volunteers
- 43 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
COVID-19
A Study of Silmitasertib (CX-4945) in Healthy Subject
This is a Phase I single center, open-label, parallel design in 30 subjects to evaluate safety and tolerability of CX-4945 200mg QD, 200 mg BID and 400mg BID doses (10 subjects in each regimen) for continuously 5 days in healthy…
- Trial name
- NCT05817708
- Testing
- CX-4945
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Senhwa Biosciences, Inc.
Covid-19
Prevention and Treatment for COVID -19 (Severe Acute Respiratory Syndrome Coronavirus 2 SARS-CoV-2) Associated Severe Pneumonia in the Gambia
The trial aims to assess the impact of cheap, licenced and widely available investigational products on the natural history of SARS-CoV-2 infection in 2 groups of patients - those with mild or moderate pneumonia (Cohort 1) and…
- Trial name
- PaTS-COVID (NCT04703608)
- Testing
- Ivermectin, ASP
- Where
- The Gambia
- Volunteers
- 1,200 people
- Sponsor
- London School of Hygiene and Tropical Medicine
COVID-19
Dapsone Coronavirus SARS-CoV-2 Trial (DAP-CORONA) COVID-19
This is a multi-center, randomized, triple-blind, placebo-controlled (RCT) study to evaluate the efficacy and safety of Dapsone in older adults, and/or in adult patients (≥40yrs of age) with at least one high-risk comorbidity…
- Trial name
- DAP-CORONA (NCT04935476)
- Testing
- Dapsone 85 mg PO BID
- Where
- 7 sites in United States, Canada
- Volunteers
- 3,000 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Cancer, COVID
Early Treatment With Ivermectin and LosarTAN for Cancer Patients With COVID-19 Infection
Ivermectin plus losartan as prophilaxy to severe events in patients with cancer with recent diagnosis of COVID-19
- Conditions
- Cancer, COVID, Coronavirus Infection
- Trial name
- TITAN (NCT04447235)
- Testing
- Ivermectin, Losartan
- Where
- Brazil
- Volunteers
- 77 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
COVID-19
Anti-inflammatory Drug Algorithm for COVID-19 Home Treatment
The newly recognised disease COVID-19 is caused by the Severe-AcuteRespiratory-Syndrome Coronavirus 2 (SARS-CoV-2), which rapidly spread globally in late 2019, reaching pandemic proportions.
- Trial name
- COVER3 (NCT05249790)
- Testing
- Recommended treatment schedule, Usual care
- Sponsor
- Mario Negri Institute for Pharmacological Research
Corona Virus Disease 2019,COVID-19
Tetrandrine Tablets Used in the Treatment of COVID-19
The study is expected to treat patients with mild and severe neo-coronary pneumonia through standard treatment regimens in combination with tetrandrine tablets, thereby reducing the clinical progress of some patients, improving…
- Trial name
- TT-NPC (NCT04308317)
- Testing
- Tetrandrine
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Henan Provincial People's Hospital
COVID-19
Assessment of Clinical Effects of Coenzyme Q10 Levels in COVID-19 Patients in Intensive Care Unit
The study will be done in Hacettepe University Anesthesiology and Reanimation Intensive Care Unit. The investigators will accept COVID-19 diagnosed or suspected patients to the ICU.
- Trial name
- NCT05058716
- Testing
- blood sample
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Hacettepe University
Tachycardia, Dyspnea
Post-Acute Sequelae of Coronavirus-19 (COVID-19) With Dyspnea on Exertion And Associated TaChycardia TrEatment Study
Most patients with acute COVID-19 (Coronavirus 19) recover within weeks, however a significant number of individuals will develop the post-acute COVID 19 syndrome (PASC).
- Conditions
- Tachycardia, Dyspnea, COVID-19
- Trial name
- PEACE (NCT05096884)
- Testing
- Metoprolol Succinate
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Hackensack Meridian Health
Covid-19 (SARS-CoV-2)
Incidence of Infection Reported by COVID-19 in Attendees of a Commercial Music Concert
From the beginning of the pandemic caused by SARS-CoV-2, most events with massive participants have been canceled due to being considered high-risk events for the SARS-CoV-2 transmission.
- Trial name
- NCT04824625
- Where
- Spain
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
Cancer, Covid19
COVID-19 Prevention and Treatment in Cancer; a Sequential Multiple Assignment Randomised Trial;
A multi-centre Australian trial with four arms aims to evaluate several different immune modulating drugs for prevention and treatment of COVID-19 specifically in the cancer population.
- Conditions
- Cancer, Covid19, Respiratory Viral Infection
- Trial name
- C-SMART (NCT04534725)
- Testing
- Interferon alfa, Selinexor, Lenzilumab
- Where
- 5 sites in Australia
- Volunteers
- 441 people
- Sponsor
- Peter MacCallum Cancer Centre, Australia
Covid19, Surgery
The Effect of the Covid-19 Pandemic Among Operated Patients
This project covers several research aims and uses different research methods, such as cohort analyses.
- Trial name
- NCT04525716
- Testing
- COVID-19 infection status, Socioeconomic status
- Where
- Sweden
- Volunteers
- 300,000 people
- Sponsor
- Karolinska Institutet
Mycobacterium Avium-intracellulare Infection, HIV Infections
A Study to Evaluate the Effects of Azithromycin on MAC Disease Prevention in HIV-Positive Patients
This study is designed to find out whether HIV-positive patients whose immune systems have improved after receiving anti-HIV treatment should take azithromycin to prevent Mycobacterium avium complex (MAC) disease.
- Trial name
- NCT00000947
- Testing
- Azithromycin
- Where
- 19 sites in United States
- Volunteers
- 850 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
COVID-19, Influenza A
Clinical Evaluation of the Panbio™ COVID-19/Flu A&B Panel to Support Home Use
This study is designed to demonstrate the performance and usability of the the Panbio™ COVID-19/Flu A\&B Panel Self Test in the hands of patients/lay-users.
- Conditions
- COVID-19, Influenza A, Influenza Type B
- Trial name
- NCT06124638
- Testing
- Panbio™ COVID-19/Flu A&B Panel
- Where
- 2 sites in United States
- Volunteers
- 624 people
- Sponsor
- Abbott Rapid Dx
Covid19
Novaferon for COVID-19 Treatment Trial (NCTT-005)
A multicenter, randomized, double-blind, placebo-controlled trial for hospitalized moderate COVID-19 patients
- Trial name
- NCT04708158
- Testing
- Novaferon
- Where
- 22 sites in Japan
- Volunteers
- 385 people
- Sponsor
- Genova Inc.
Covid19
Sustained Immunity to COVID-19 as Measured by SARS-CoV-2 Serology Assays
The primary objective is to assess the ability of COVID-19 IgG and IgM assays to detect an immune response in COVID-19 patients in the Henry Ford Health System (HFHS), both during hospitalization and over the following 12 months.
- Trial name
- NCT04562285
- Testing
- Serologic immunoassays to SARS-CoV-2 antibodies
- Where
- United States
- Volunteers
- 829 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Healthy Volunteers
Spirulina Oral Supplement for Enhancing Host Resilience to Virus Infection
This randomized, double blind, placebo controlled study aims to establish the impact of the oral supplement, Immulina TM, on enhancing host resilience to the effects of viral influenza infection in humans.
- Trial name
- NCT05447078
- Testing
- Immulina TM
- Where
- United States
- Volunteers
- 492 people, healthy volunteers welcome
- Sponsor
- University of Mississippi Medical Center
COVID-19
Efficacy of a Multiplex BangasureTM RT-PCR Kit for the Detection of COVID-19
The outbreak of the severe acute respiratory syndrome (SARS) corona virus (CoV)-2 continues to increase globally. To control the coronavirus disease 2019 (COVID-19) transmission, diagnose is very important step which would help…
- Trial name
- COVID-19 (NCT05190016)
- Where
- Bangladesh
- Volunteers
- 150 people
- Sponsor
- DR. MALA KHAN
Sars-CoV2
Rhu-pGSN for Severe Covid-19 Pneumonia
Study Objectives: Primary To assess the efficacy (survival without organ failure on Day 14) of three doses of rhu-pGSN administered intravenously (IV) plus standard of care (SOC) to hospitalized subjects with a primary diagnosis…
- Trial name
- NCT04358406
- Testing
- Recombinant human plasma gelsolin (Rhu-pGSN)
- Where
- 3 sites in Romania, Spain
- Volunteers
- 64 people
- Sponsor
- BioAegis Therapeutics Inc.
Pneumonitis, SARS-CoV Infection
GLS-1027 for the Prevention of Severe Pneumonitis Caused by SARS-CoV-2 Infection (COVID-19)
This clinical trial will evaluate the safety, tolerability and efficacy of GLS-1027 in the prevention of severe pneumonitis caused by SARS-CoV-2 infection
- Trial name
- NCT04590547
- Testing
- GLS-1027
- Where
- 17 sites in United States, Bulgaria and 3 more
- Volunteers
- 132 people
- Sponsor
- GeneOne Life Science, Inc.
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