Clinical trials: Viral Respiratory Tract Infections
COVID-19
Glassy Trial for Effects of Wearing Glasses
Randomized trial testing 6 forms of a communication summarizing the results of a recent study (about the effects of wearing glasses on reducing covid infection risk).
- Trial name
- NCT05642754
- Testing
- Overall uncertainty language
- Where
- Norway
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- Trustees of Dartmouth College
COVID-19
Study on Determine the Utilisation and Clinical Outcomes of Evusheld in COVID-19 PrEP in China
Evusheld(AZD7442) is a combination of 2 human long-acting antibodies, which was selected for maximal potency and demonstrated synergistic neutralization of SARS-CoV-2 in vitro.
- Trial name
- CLEAR (NCT05917951)
- Where
- China
- Volunteers
- 248 people
- Sponsor
- AstraZeneca
Covid19
Clinical Efficiency of Surgical Masks and Filtering Face-piece 2 Masks
Recent results demonstrated an increased risk of COVID-19 infection among healthcare workers (HCW), particularly when access to personal protective equipment (PPE) was inadequate. (ref).
- Trial name
- NCT04823351
- Testing
- Surgical Mask
- Where
- Switzerland
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Nurse, Student
Psychological Impact of the Covid-19 Pandemic on Student Nurses
The World Health Organization (WHO) declared in early 2020 the emergence of a new highly contagious SARS-CoV-2 coronavirus responsible for a global public health emergency.
- Conditions
- Nurse, Student, Post Traumatic Stress Disorder, COVID-19
- Trial name
- StudentCov (NCT04402229)
- Where
- 2 sites in France
- Volunteers
- 2,000 people
- Sponsor
- Versailles Hospital
COVID-19
High Dose Inhaled Nitric Oxide for COVID-19 (ICU Patients)
Novel therapies are desperately needed for treatment of COVID-19 patients. At present, there are no proven interventions to prevent progression of the disease or to rapidly treat patients with COVID-19 related respiratory…
- Trial name
- NCT04383002
- Testing
- Nitric Oxide
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- University Health Network, Toronto
Influenza
A Study of Tamiflu (Oseltamivir) for Treatment of Influenza With a Focus on (H1N1) 2009 Flu Strain
This randomized, double-blind, multi-center study of Tamiflu (Oseltamivir) will evaluate the efficacy against viral activity, the effectiveness in resolving the disease symptoms, and the safety and tolerability in patients with…
- Trial name
- NCT01032837
- Testing
- Oseltamivir
- Where
- 100 sites in United States
- Volunteers
- 102 people
- Sponsor
- Hoffmann-La Roche
COVID-19 Infection, Sars-cov-2
Use of Dexmedetomidine in Light to Moderate Sedation in the Patient in the Palliative Situation of a Sars-cov-2 / COVID-19 Infection
The current sars-cov-2 epidemic is responsible for severe respiratory infections leading to end-of-life situations. Dexmedetomidine may be indicated in mild to moderate sedation in palliative patients, due to its pharmacological…
- Conditions
- COVID-19 Infection, Sars-cov-2, Respiratory Failure, Palliative Situation
- Trial name
- PRODEX (NCT04350086)
- Testing
- Treatment with Dexmedetomidine
- Where
- France
- Sponsor
- University Hospital, Limoges
Acute Respiratory Failure
A Check-list Including Lung Ultrasound for ED Patients With ARF
The aim of the study is to evaluate if a check-list including lung ultrasonography can help to identify the etiology of the acute respiratory failure of patients managed at the emergency room.
- Trial name
- CHECKIRA-COVID (NCT04791241)
- Testing
- check-list including lung ultrasound
- Where
- 3 sites in France
- Volunteers
- 105 people
- Sponsor
- Centre Hospitalier Metropole Savoie
COVID-19, Post-COVID-19 Syndrome
Cohort Follow-up of Epidemic and Neuroimaging for Patients During the 1st Wave of the COVID-19 in China
Our main objective is to analyze the development of physical impact, mental health and blood profile over follow-up time during the 1st wave of the COVID-19.
- Conditions
- COVID-19, Post-COVID-19 Syndrome, Acute COVID-19, Post-Acute COVID-19
- Trial name
- NCT05745805
- Testing
- Simultaneous cortico-spinal magnetic resonance imaging, Serum
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
SARS-CoV-2, Covid19
Clinical Evaluation of a Point-of-Care (POC), COVID-19 Rapid Antigen Test (CoviDx™)
Prospective study that will evaluate the clinical agreement of the CoviDx™ Rapid Antigen test compared to SARS-CoV-2 RT-PCR.
- Trial name
- CoviDx (NCT04750629)
- Testing
- POC CoviDx™ Rapid Antigen Test
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- Lumos Diagnostics
Coronavirus Infections
In-depth Immunological Investigation of COVID-19.
The COntAGIouS trial (COvid-19 Advanced Genetic and Immunologic Sampling; an in-depth characterization of the dynamic host immune response to coronavirus SARS-CoV-2) proposes a transdisciplinary approach to identify host factors…
- Trial name
- COntAGIouS (NCT04327570)
- Testing
- Patient sampling
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Covid19, Kidney Transplant Infection
Optimized Management of Covid-19 Positive Kidney Transplant Recipients: Single Center Experience From the Middle East
Methods: Out of 2000 kidney transplant recipients in our center in Kuwait, collecting data was started for all COVID-19-positive kidney transplant recipients till August 2020.
- Conditions
- Covid19, Kidney Transplant Infection, Risk Factor, Cardiovascular, Immunosuppression
- Trial name
- OMC-KTR (NCT04542954)
- Testing
- Optimized Management of Covid-19 Positive Kidney Transplant Recipients: Single Center Experience from the Middle East
- Where
- Kuwait
- Volunteers
- 104 people
- Sponsor
- Hamid Al-Essa Organ Transplant Center
Supplemental Nutrition Assistance Program Education, Post COVID Syndrome
Effect of a Non-pharmacological Intervention on Endothelial Function, Body Composition, and Physical Functionality in Recovered COVID-19 Patients.
This study aims to evaluate the impact of a non-pharmacological treatment (nutritional therapy and pulmonary rehabilitation) on endothelial function, body composition, and physical functionality in recovered COVID-19 patients.
- Conditions
- Supplemental Nutrition Assistance Program Education, Post COVID Syndrome, Endothelial Function
- Trial name
- NCT07544186
- Testing
- L-citrulline supplementation
- Where
- Mexico
- Volunteers
- 43 people
- Sponsor
- Instituto Nacional de Enfermedades Respiratorias
COVID-19, Inflammation
SARS CoV-2 Infection and Inflammatory Biomarkers
Early research suggests that inflammation plays a key role in the development of SARS CoV-2 infection. The immune response to respiratory infection is characterized by an influx of neutrophils to the lungs.
- Trial name
- NCT05145751
- Testing
- Simple inflammatory biomarkers measurement
- Where
- Greece
- Volunteers
- 115 people
- Sponsor
- University of Thessaly
Chronic Rhinosinusitis (Diagnosis), COVID-19
The Nasal Microbiome and Its Importance in Disease
Methods: all studies are case control studies on six different groups: normal individuals, non-COVID-19 patients with olfactory dysfunction, COVID-19 positive patients, previous COVID-19 positive patients with prolonged olfactory…
- Conditions
- Chronic Rhinosinusitis (Diagnosis), COVID-19, Anosmia
- Trial name
- NCT05061329
- Where
- Denmark
- Volunteers
- 619 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
SARS-CoV2 Infection, Multisystem Inflammatory Syndrome in Children
MISC COVID-19 Study in Pediatric Population
Rationale: Severe Acute Respiratory Syndrome - Coronavirus - 2 (SARS-CoV2) and its related Coronavirus Disease - 19 (COVID-19) has become a health emergency worldwide.
- Trial name
- COVID-19 (NCT04844242)
- Where
- India
- Volunteers
- 180 people
- Sponsor
- Tuberculosis Research Centre, India
Covid-19, Sars-CoV2
Low-Dose Radiotherapy For Patients With SARS-COV-2 (COVID-19) Pneumonia
Low doses of radiation in the form of chest x-rays has been in the past to treat people with pneumonia. This treatment was thought to reduce inflammation and was found to be effective without side effects.
- Conditions
- Covid-19, Sars-CoV2, Pneumonia
- Trial name
- PREVENT (NCT04466683)
- Testing
- Low dose radiation 35 cGy, High dose radiation 100 cGy
- Where
- 7 sites in United States, Colombia
- Volunteers
- 37 people
- Sponsor
- Ohio State University
COVID-19
Study on Sequential Immunization of Omicron Inactivated COVID-19 Vaccine and Prototype Inactivated COVID-19 Vaccine in Population Aged 18 Years Old and Above
This is a randomized, double blind, positive controlled study to evaluate the safety and immunogenicity of Omicron COVID-19 Vaccine (Vero Cell), Inactivated in population aged 18 years old and above who have been vaccinated with…
- Trial name
- COVID-19 (NCT05374954)
- Testing
- Omicron COVID-19 Vaccine (Vero Cell), Inactivated, COVID-19 Vaccine (Vero Cell), Inactivated
- Where
- 10 sites in China
- Volunteers
- 4,200 people, healthy volunteers welcome
- Sponsor
- China National Biotec Group Company Limited
SARS-CoV-2
Safety and Immune Response of Adjuvanted SARS-CoV-2 (COVID-19) Beta Variant RBD Recombinant Protein (DoCo-Pro-RBD-1 + MF59®) and mRNA (MIPSCo-mRNA-RBD-1) Vaccines in Healthy Adults
This is a study of two experimental SARS-CoV-2 vaccines against the virus called SARS-CoV-2 virus. The first of the experimental vaccines is called DoCo-Pro-RBD-1 + M59® and contains a laboratory made protein which looks the same…
- Trial name
- NCT05272605
- Testing
- Adjuvanted SARS-CoV-2 beta variant RBD recombinant protein vaccine (DoCo-Pro-RBD-1 + MF59), SARS-CoV-2 beta variant RBD mRNA vaccine, Normal Saline
- Where
- 2 sites in Australia
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Melbourne
COVID-19 Pulmonary Complications, COVID-19
Covid-19 Infection and Pulmonary Distress Treatment With Zanubrutinib in Hospitalized Participants
The primary objective of this study was to evaluate if the addition of zanubrutinib to supportive care increases the respiratory failure-free survival rate at Day 28 in participants hospitalized for Corona Virus Disease 2019…
- Trial name
- NCT04382586
- Testing
- Zanubrutinib, Supportive Care
- Where
- 10 sites in United States
- Volunteers
- 63 people
- Sponsor
- BeiGene
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