Clinical trials: Virus Disease
Head and Neck Cancer, Covid19
Impact of Covid-19 Pandemic on Management of Head and Neck Cancers
Since its emergence in late December 2019, the SARS-CoV-2 coronavirus has spread rapidly, causing a global health crisis. The disease caused by this highly contagious respiratory virus is called COVID-19.
- Conditions
- Head and Neck Cancer, Covid19, Patient Care
- Trial name
- VADS-Covid (NCT04704466)
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Childhood Burkitt Lymphoma, Childhood Lymphoblastic Lymphoma
Studying Genes Associated With Non-Hodgkin Lymphoma in Young Patients
This research studies genes associated with non-Hodgkin lymphoma in young patients. Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and…
- Trial name
- NCT01623856
- Testing
- laboratory biomarker analysis
- Where
- United States
- Volunteers
- 483 people, healthy volunteers welcome
- Sponsor
- Children's Oncology Group
Long Covid
Validation of Biomarkers for Long COVID in the LIINC Viral Immunopathogenesis and Persistence Repeat Donor Cohort (VIPER)
The purpose of this study is to better understand the biological changes associated with Long COVID and to identify laboratory tests (biomarkers) that may help diagnose the condition and measure how it changes over time.
- Trial name
- VIPER (NCT07770022)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Poliomyelitis
An Immunity Persistence Study of Sabin Inactivated Poliovirus Vaccine(Vero Cell) After Four Doses
This is an open and observational follow-up clinical trial based on the previous Phase III clinical trial of Sabin Inactivated Poliovirus Vaccine manufactured by Sinovac Biotech Co.
- Trial name
- NCT04989231
- Testing
- Investigational sIPV, Control IPV
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Sinovac Biotech Co., Ltd
COVID-19 Pandemic
Fourth COVID-19 Vaccine Dose- mRNA1273
The Omicron variant of concern (VOC) is currently rapidly spreading worldwide, with extremely high transmission rates, with an estimated R of >3.
- Trial name
- NCT05230953
- Testing
- mRNA1273 vaccine
- Where
- Israel
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
HPV Infection, HPV-Related Carcinoma
To Evaluate the Safety and Immunogenicity of 15-valent HPV Recombinant Vaccine in Chinese People Aged 9-45 Years
To evaluate the safety and Immunogenicity of 15-valent HPV vaccine in 9-45year-old participants.
- Conditions
- HPV Infection, HPV-Related Carcinoma, HPV-Related Intraepithelial Neoplasia, Genital Wart
- Trial name
- NCT06756269
- Testing
- Medium dose for 15-HPV vaccine, High dose for 15-HPV vaccine, 9-HPV vaccine
- Where
- China
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Shanghai Bovax Biotechnology Co., Ltd.
Human Immunodeficiency Virus
Jamii Bora: A Home-Based Couples Intervention
The purpose of the study is to develop and pilot-test a home-based intervention to facilitate sate HIV testing and disclosure within pregnant couples in order to increase use of prevention-of-mother-to-child-transmission (PMTCT)…
- Trial name
- NCT02403583
- Testing
- Intervention- Home Visits
- Where
- 5 sites in Kenya
- Volunteers
- 233 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
HIV Infections
ADAPT-POL: Planned Parenthood Center of El Paso Adopting and Demonstrating the Adaptation of Prevention Techniques
This study will look at the following questions: Was there a significant difference in HIV prevention knowledge, risk reduction attitudes, norms, intentions, self efficacy, number of sexual partners, and incidence of unprotected…
- Trial name
- NCT00252083
- Testing
- Popular Opinion Leader
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Covid19
Hidroxicloroquina With Azitromicina Versus Hidroxicloroquina and Placebo Int Patients With Mild COVID-19
Chloroquine and hydroxychloroquine are two antimalarial drugs that are also used in autoimmune diseases. Chloroquine analogs have been shown to inhibit endosome acidification and exhibit nonspecific antiviral activity at high…
- Trial name
- Omehecatl (NCT04964583)
- Testing
- Hydroxychloroquine with Azithromycin
- Where
- 3 sites in Mexico
- Volunteers
- 105 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Coronavirus, Covid19
Inflammatory Signal Inhibitors for COVID-19 (MATIS)
The Multi-arm trial of Inflammatory Signal Inhibitors for COVID-19 (MATIS) study is a two-stage, open-label, randomised controlled trial assessing the efficacy of ruxolitinib (RUX) and fostamatinib (FOS) individually, compared to…
- Conditions
- Coronavirus, Covid19, Pneumonia
- Trial name
- MATIS (NCT04581954)
- Testing
- Ruxolitinib, Fostamatinib, Standard of care
- Where
- 5 sites in United Kingdom
- Volunteers
- 185 people
- Sponsor
- Imperial College London
HIV/AIDS
Study in Healthy Males to Measure Maraviroc in Blood, Saliva, Seminal Fluid, and Rectal Tissue
This study is being conducted to look at how the body handles the drug maraviroc. It will measure the amount of maraviroc in blood, semen, saliva and in the rectum of men.
- Trial name
- NCT00775294
- Testing
- Maraviroc
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
HIV Infections
Prospective Open-Label Study of the Emergence of Drug Resistance in Patients Infected With HIV-1 Who Are Taking Oral U-87201E
To determine the time course of development of resistance to atevirdine mesylate ( U-87201E ) in patients with HIV isolates showing in vitro resistance to zidovudine ( AZT ).
- Trial name
- NCT00002094
- Testing
- Atevirdine mesylate
- Where
- United States
- Sponsor
- Pharmacia and Upjohn
Prevention of COVID-19
Assessing Immune Response of Different COVID-19 Vaccines in Older Adults
This is a randomised controlled, adaptive, multicentre Phase II protocol evaluating different booster strategies in individuals aged 75 years and older already vaccinated against SARS-CoV-2.
- Trial name
- EU-COVAT-1 (NCT05160766)
- Testing
- Comirnaty (BTN162b2), Spikevax (mRNA-1273)
- Where
- 9 sites in Germany, Lithuania and 2 more
- Volunteers
- 323 people, healthy volunteers welcome
- Sponsor
- Oliver Cornely, MD
COVID-19, Respiratory Disease
Health Communication to Influence COVID-19 Vaccination Intent and Message Propagation
This is a randomised controlled experiment in the form of a web based survey study which randomly exposes participants to different forms of public health messages, after which participants will be assessed on their intent to…
- Conditions
- COVID-19, Respiratory Disease, Vaccine Refusal, Infectious Disease
- Trial name
- CONVINCE (NCT05244356)
- Testing
- Health message exposure
- Where
- Malaysia
- Volunteers
- 5,784 people, healthy volunteers welcome
- Sponsor
- Clinical Research Centre, Malaysia
Chronic Hepatitis C
Observational Study Evaluating the Quality of Pegylated Interferon Alfa-2a and Ribavirin Treatment for Chronic Hepatitis C in Cooperation With the BNG (Association of German Resident Gastroenterologists)
This observational study will examine the efficacy and safety of pegylated interferon (peginterferon) alfa-2a, mostly in combination with ribavirin treatment in chronic hepatitis C (CHC). Quality of care will also be assessed.
- Trial name
- NCT02106156
- Testing
- Pegylated interferon alfa-2a, Ribavirin
- Where
- Germany
- Volunteers
- 10,228 people
- Sponsor
- Hoffmann-La Roche
COVID-19
Noncoding RNAs in COVID-19 and COVID-19 Related Kidney Dysfunction
In this study, critically ill patients with highly suspected or confirmed COVID-19 will be included. Main goal is the identification of noncoding RNAs in COVID-19 associated organ dysfunction with an emphasis on acute kidney…
- Trial name
- MiRCOVID (NCT04381351)
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Infection, Bacterial, Infection Viral
Access MeMed BV Assay Clinical Study Collection Protocol - Infectious Adult and Pediatric Cohorts
The purpose of the pivotal study is to collect blood specimens and clinical data from pediatric (>90 days old) and adult (≥18 years old) patients presenting with signs and symptoms suggestive of acute bacterial or viral…
- Trial name
- NCT06379061
- Testing
- Adult and Pediatrics
- Where
- 4 sites in United States
- Volunteers
- 650 people
- Sponsor
- Beckman Coulter, Inc.
AIDS/HIV PROBLEM
Rapid Oral Test for Therapeutic Response in HIV/AIDS Patients
This study has been designed to evaluate a new oral test for therapeutic monitoring of HIV/AIDS patients that are receiving the combination Anti-Retroviral Therapy (cART).
- Trial name
- NCT01507142
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Gaia Medical Institute
COVID-19
A Trial to Investigate Recovery From COVID-19 With C21 in Adult Subjects
This trial is a randomized, double-blind, placebo-controlled, parallel-group, 2-arm, multicenter trial to evaluate the efficacy and safety of C21 versus placebo as add-on to standard of care (SoC) in adult subjects with COVID-19.
- Trial name
- ATTRACT-3 (NCT04880642)
- Testing
- C21
- Where
- 60 sites in United States, Argentina and 8 more
- Volunteers
- 272 people
- Sponsor
- Vicore Pharma AB
Leukemia, Lymphoma
Total-Body Irradiation, Cyclophosphamide, and Stem Cell Transplantation in Treating Patients With Hematologic Cancer
RATIONALE: Adjusting the dose of drugs used in chemotherapy such as cyclophosphamide may decrease side effects while stopping cancer cells from dividing so they stop growing or die.
- Conditions
- Leukemia, Lymphoma, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Diseases
- Trial name
- NCT00062140
- Testing
- cyclophosphamide, allogeneic bone marrow transplantation, peripheral blood stem cell transplantation
- Where
- United States
- Sponsor
- Fred Hutchinson Cancer Center