Clinical trials: Visceral Hypersensitivity
Endometriosis, Irritable Bowel Syndrome
Dietary Treatment of Endometriosis-related Irritable Bowel Syndrome
Many patients with endometriosis experience extra genital and abdominal symptoms as a major part of their problem. This includes gastrointestinal dysfunction with pain, urinary symptoms compatible with interstitial cystitis and…
- Conditions
- Endometriosis, Irritable Bowel Syndrome, Visceral Syndrome, Visceral Hypersensitivity
- Trial name
- NCT02924493
- Testing
- Diet low in fermentable carbohydrates (low FODMAP diet)
- Where
- Denmark
- Volunteers
- 22 people
- Sponsor
- University of Aarhus
Irritable Bowel Syndrome
Association Between High Faecal Calprotectin, Increased Intestinal Permeability and Visceral Hypersensitivity in IBS-D Patients
Visceral hypersensitivity, low grade inflammation and increased intestinal permeability are three main pathophysiological mechanisms involved in irritable bowel syndrome. The connexion between these abnormalities is not known.
- Trial name
- SIIMPA (NCT02550704)
- Testing
- Colonoscopy with eleven biopsies in the left colon to assess intestinal permeability
- Where
- France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Rouen
Obesity
Egg Diet to Improve Metabolic Health and Function
The purpose of this study is to determine the effects of change in diet quality (carbohydrate restriction versus fat restriction) on body composition, fat distribution, cardiometabolic risk factors, physical function, and quality…
- Trial name
- NCT02760641
- Testing
- Egg-based diet (EBD), Carbohydrate-based diet (CBD)
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Lactose Intolerance, Irritable Bowel Syndrome
The Effects of Lactose Intolerance on Gastrointestinal Function and Symptoms in a Chinese Population
Lactose is a carbohydrate found in milk,and Lactase Deficiency (LD) is a condition in which the small intestine cannot digest this carbohydrate due to absent or insufficient amounts of lactase.Individuals with LD may be…
- Trial name
- NCT01286597
- Testing
- dietary restriction
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Sir Run Run Shaw Hospital
Healthy, Glucose Metabolism Disorders
Energy Metabolism and Acute Effects of Protein Diets in Metabolically Obese Normal Weight Individuals
Asians tend to develop type 2 diabetes (T2D) at lower body mass index (BMI) levels and younger ages compared to other populations.
- Conditions
- Healthy, Glucose Metabolism Disorders, Obesity, Visceral, Obesity; Endocrine
- Trial name
- MONW (NCT06802341)
- Testing
- Normal protein diet, Animal protein diet, Plant based diet
- Where
- Singapore
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Irritable Bowel Syndrome, Visceral Hypersensitivity
Gut Permeability, Sensitivity and Symptomatology
To better understand the relationship between gut barrier function and the symptomatology and pathophysiology of irritable bowel syndrome (IBS).
- Trial name
- GPSS (NCT02358564)
- Testing
- Gastrointestinal Permeability Test, Upper Endoscopy, Rectal Barostat and Infusion of Fats
- Where
- 2 sites in United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Rumination
Role of Vagal Tone in Rumination Syndrome
Rumination syndrome is a condition in which people repeatedly and unintentionally regurgitate undigested or partially digested food from the stomach, rechew it, and then either re-swallow it or spit it out.
- Trial name
- NCT03912636
- Testing
- Diaphragmatic breathing, Deep Slow Breathing, Normal breathing
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Irritable Bowel Syndrome
Characterization of Pain Processing Mechanisms in Irritable Bowel Syndrome
This study is being done to collect new information on irritable bowel syndrome, a disease that causes abdominal pain that does get better with treatment or keeps coming back ("chronic").
- Trial name
- NCT00108446
- Testing
- dextromethorphan, naloxone, fentanyl
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Gut-Brain Disorders, GERD Without Erosive Esophagitis
Cognitive-behavioral Therapy for the Diseases Associated With Esophageal-brain-gut Axis Communication Abnormalities.
Gastroesophageal reflux disease (GERD) is a challenging gastrointestinal disorder, and proton pump inhibitors (PPIs) are typically the first line of treatment.
- Trial name
- NCT06939465
- Testing
- Cognitive Behavioral Therapy (CBT)
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Hualien Tzu Chi General Hospital
Menopause
Healthy Transitions: Menopause Effect on Obesity, Energy Balance, and Insulin
The purpose of this study is to determine the effect of menopause on obesity, energy balance, and insulin in postmenopausal, obese women.
- Trial name
- NCT00412269
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Irritable Bowel Syndrome, Visceral Hypersensitivity
Evaluation of Bowel Sensitivity Threshold in IBS Patients Versus in Healthy Controls Using the Novel Rapid Barostat Bag
BACKGROUND \& AIMS: Bowel hypersensitivity (lower threshold for discomfort in response to distention of a balloon in the rectum compared to healthy controls) is a key documented feature in Irritable Bowel Syndrome (IBS)…
- Trial name
- NCT03224494
- Testing
- Rapid Barostat Bag, IBS severity scoring system questionnaire (IBS-SSS), HAD scale questionnaire
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Queen's University
Major Depression, Pain
Effect of Escitalopram vs. Reboxetine on Gastro-intestinal Sensitivity of Patients With Major Depressive Disorder
Patients with major depressive disorder (MDD) commonly have many gastrointestinal complaints. Gastrointestinal pain is classified into 2 categories: visceral and somatic pain.
- Conditions
- Major Depression, Pain, Abdominal Pain
- Trial name
- NCT00209807
- Testing
- escitalopram, Reboxetine, No intervention
- Where
- Spain
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Obesity, Insulin Resistance
Smectite Gel and Probiotic for Obesity and Insulin Resistance
Probiotics are defined as live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. Smectite is a natural silicate clay belonging to the dioctahedral smectite class formed from…
- Conditions
- Obesity, Insulin Resistance, Insulin Sensitivity, Type2 Diabetes Mellitus
- Trial name
- NCT04293731
- Testing
- Symbiter-Smectite
- Where
- Ukraine
- Volunteers
- 55 people
- Sponsor
- Bogomolets National Medical University
Visceral Hypersensitivity, Irritable Bowel Syndrome
Rifaximin on Visceral Hypersensitivity
Irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders, with a global prevalence of 11% according to a recent meta-analysis.
- Trial name
- NCT03462966
- Testing
- Rifaximin
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Cedars-Sinai Medical Center
Irritable Bowel Syndrome, Sexual Dysfunction
Visceral Sensitivity in Women With BS and Sexual Dysfunction
This study aims to compare visceral rectal sensitivity and quality of life of 40 Irritable Bowel Syndrome women, with (20) and without sexual dysfunction (20).
- Trial name
- IBS (NCT04716738)
- Testing
- Blood analyses and coprological
- Volunteers
- 20 people
- Sponsor
- Hospital General de Mexico
Insulin Resistance, Insulin Sensitivity
Adaptive Immune Response in Visceral and Subcutaneous Fat: Role in Human Insulin Resistance
The proposed study is designed to test the hypothesis that in human obesity, the balance of pro- and anti-inflammatory T cells in fat tissue is in fact related to macrophage phenotype and insulin resistance, and how it is…
- Conditions
- Insulin Resistance, Insulin Sensitivity, Obesity, Inflammation
- Trial name
- NCT04708535
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Stanford University
Type 2 Diabetes Mellitus (T2DM), Type 2 Diabetes
Osaka Cardiometabolic Epidemiological Study: Ohtori Study Part 2
The aim of this study is to investigate the relationship between body fat distribution measured by CT scan and related risk factors with the risk of incident metabolic and cardiovascular disease in a prospective cohort study of…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Type 2 Diabetes, Diabetes Mellitus, Hypertension
- Trial name
- OCES-2 (NCT06694012)
- Where
- Japan
- Volunteers
- 2,000 people
- Sponsor
- Osaka Metropolitan University
Irritable Bowel Syndrome (IBS), Pediatrics
Pentabiocel in Pediatric IBS
Irritable Bowel Syndrome (IBS) is a common gastrointestinal disorder characterized by chronic abdominal pain and altered bowel habits, including diarrhea, constipation, or a combination of both.
- Trial name
- NCT06720805
- Testing
- Pentabiocel
- Where
- 4 sites in Italy
- Volunteers
- 56 people
- Sponsor
- University of Roma La Sapienza
Glucose Metabolism Disorders, Obesity, Visceral
The "Metabolically-obese Normal-weight" Phenotype and Its Reversal by Calorie Restriction
The prevalence of overweight and obesity in Singapore is approximately half of that in the United States, yet the incidence of type 2 diabetes is similar, and is expected to double in the near future.
- Conditions
- Glucose Metabolism Disorders, Obesity, Visceral, Obesity; Endocrine, Insulin Sensitivity/Resistance
- Trial name
- NCT03239782
- Testing
- Calorie restriction
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Irritable Bowel Syndrome
Are Sleeping Disorders Associated With Visceral Hypersensitivity in Irritable Bowel Syndrome Patients ?
Visceral hypersensitivity is frequent in IBS population up to 60% and is correlated with severity and altered quality of life. Sleeping troubles are most frequent in IBS population.
- Trial name
- S3i (NCT04168047)
- Testing
- Barostat procedure, Anxiety and Depression Evaluation, Assessment of sleep quality
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen