Clinical trials: Visual Loss, open to volunteers
MELAS Syndrome, Lebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus)
A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)
This is a parallel arm non-randomized dose-escalation, open-label basket exploratory phase 1 clinical trial where Mitochondrial encephalopathy, lactic acidosis, stroke-like episodes (MELAS) and Leber's hereditary optic…
- Trial name
- NCT06792500
- Testing
- Glycerol Tributyrate
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- George Washington University
Vision Disorders, Diabetes
Implementing Artificial Intelligence to Prevent Vision Loss From Diabetes
This pragmatic clinical trial is being conducted to test the effectiveness of AI in improving screening and follow-up eye care compared to usual-care among patients with diabetes across 4 primary care clinics.
- Trial name
- NCT07559292
- Testing
- AI, Usual Practice
- Where
- United States
- Volunteers
- 1,700 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Alveolar Bone Loss, Dental Implant
Magnetic Mallet Vs Conventional Drilling in D4 Posterior Maxilla
The goal of this clinical trial is to evaluate whether the magnetic mallet technique improves primary implant stability and clinical outcomes compared with conventional drilling during dental implant placement in the posterior…
- Conditions
- Alveolar Bone Loss, Dental Implant, Osseodensification Drilling Technique
- Trial name
- NCT07424820
- Testing
- Conventional drilling osteotomy, Magnetic mallet osteotomy
- Where
- Iraq
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Mosul
Hemianopia, Brain Injuries
Biofeedback Training for Hemianopia
This is a prospective study that compares biofeedback training on the microperimetry (BT) to a control group in patient s with hemianopia.
- Trial name
- NCT06995313
- Testing
- Biofeedback training
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University Health Network, Toronto
Hearing Loss, Audiometric Tests
From Early Music Audiometry to Tone Audiograms
Hearing tests are crucial for a child's development, but the standard test, Visual Reinforcement Audiometry (VRA), often doesn't work for those with social communication disorders (SCD) and autism spectrum disorder (ASD).
- Trial name
- FERMATA (NCT07722936)
- Testing
- Soundfield Behavioral Audiometry
- Where
- 2 sites in United Kingdom
- Volunteers
- 100 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Low Vision, One Eye, Unspecified Eye, Low Vision Blindness
Health Education vs Meditation in Irreversible Age-Related Vision Loss Patients and Their Caregivers
Investigators aim to assess the feasibility of delivering two augmentation interventions, Meditation and a Health Enhancement Program, for potentially enhancing the quality of life and mental health of Irreversible Age-Related…
- Trial name
- NCT03166072
- Testing
- Meditation, Health Enhancement Program
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Vision Loss Night, Vision Disorders
OPI-NXYDLD-303 Safety and Efficacy of Phentolamine Ophthalmic Solution in Keratorefractive Surgery Participants With Decreased Mesopic Visual Acuity
The goal of this clinical trial is to learn if Phentolamine Ophthalmic Solution works to treat adults that have had keratorefractive surgery and have decreased visual acuity under mesopic conditions.
- Trial name
- LYNX-3 (NCT07140783)
- Testing
- 0.75% Phentolamine Ophthalmic Solution
- Where
- 20 sites in United States
- Volunteers
- 580 people
- Sponsor
- Opus Genetics, Inc
Radiation Retinopathy, Visual Impairment
Intravitreal Faricimab Injections or Fluocinolone Acetonide (0.19 mg) Intravitreal Implants vs Observation for Prevention of VA Loss Due to Radiation Retinopathy
This randomized controlled trial will evaluate the effect of intravitreal faricimab or fluocinolone acetonide (FAc) intravitreal implant compared with observation on long-term visual acuity following treatment of choroidal…
- Trial name
- AL (NCT05844982)
- Testing
- Faricimab, fluocinolone acetonide
- Where
- 29 sites in United States
- Volunteers
- 600 people
- Sponsor
- Jaeb Center for Health Research
Optic Neuritis
VIsual Pathways Model in Neuro-inflammatory Disorders
In neuroinflammatory diseases of the central nervous system (CNS) such as multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD) and anti-MOG antibody-associated disorders (MOGAD), neuronal degeneration is the…
- Trial name
- VIP-MODEL (NCT05487989)
- Testing
- Clinical examen
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Lille
Retinitis Pigmentosa (RP), Usher Syndrome
Observational Study to Investigate the Short-term Effects of Transcorneal Electrical Stimulation on Visual Performance
Retinitis pigmentosa and similar degenerative diseases of the retina lead to progressive loss of vision. TES therapy with the CE-marked OkuStim® System is a treatment approved in the EU for slowing the progression of the disease.
- Conditions
- Retinitis Pigmentosa (RP), Usher Syndrome, Cone Rod Dystrophy
- Trial name
- TES-STEP (NCT07548944)
- Testing
- Transcorneal Electrical Stimulation using the OkuStim System
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Okuvision GmbH
Stroke, Visual Field Loss
Vision on the Road: Vision Rehabilitation for Driving After Stroke
The goal of this clinical trial is to learn if vision training works to improve functional vision in people with visual field loss after stroke.
- Conditions
- Stroke, Visual Field Loss, Hemianopia
- Trial name
- DRIVE (NCT07147660)
- Testing
- Compensatory scanning training, Delayed Compensatory scanning training
- Where
- 2 sites in Norway
- Volunteers
- 52 people
- Sponsor
- University of South-Eastern Norway
Cortical Blindness
Multisensory Rehabilitation of Vision Loss After Cortical Damage
Damage to visual cortex on one side of the brain frequently produces a profound and permanent blindness in contralesional space (hemianopia), a debilitating condition that causes enormous suffering for patients and their families.
- Trial name
- NCT07659691
- Testing
- Multisensory Rehabilitation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Wake Forest University Health Sciences
Retinitis Pigmentosa
Role of UC-MSC and CM to Inhibit Vision Loss in Retinitis Pigmentosa Phase I/II
The study will perform UC-MSCs and CM transplantation. There are two groups with different dosages. The first group will be transplanted with 1.5 million cells, meanwhile, the second group is 5 million cells.
- Trial name
- NCT05909488
- Testing
- 1.5 x 10^6 UC-MSC + CM, 5 x 10^6 UC-MSC + CM
- Where
- Indonesia
- Volunteers
- 30 people
- Sponsor
- PT. Prodia Stem Cell Indonesia
Age-related Macular Degeneration
Visual Remapping to Aid Reading With Field Loss
Reading performance in patients with Central Vision Loss and age matched controls with artificial scotomas will be measured with and without different kinds of remapping of missing text to different parts of the visual field.
- Trial name
- NCT03848663
- Testing
- Traditional Remapping, Personalized Remapping
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Retinal Disease, Age-Related Macular Degeneration
Stem Cell Ophthalmology Treatment Study II
This study will evaluate the use of autologous bone marrow derived stem cells (BMSC) for the treatment of retinal and optic nerve damage or disease.
- Conditions
- Retinal Disease, Age-Related Macular Degeneration, Retinitis Pigmentosa, Stargardt Disease
- Trial name
- SCOTS2 (NCT03011541)
- Testing
- Arm 1
- Where
- 4 sites in United States, Austria and 1 more
- Volunteers
- 500 people
- Sponsor
- MD Stem Cells
Homonymous Hemianopsia, Homonymous Quadrantanopia
PAVE (Parallactic Visual-Field Enhancement) System for Treatment of Chronic Visual Field Loss Due to Stroke, Traumatic Brain Injury, or Brain Surgery
This is a research study to evaluate the effectiveness of the PAVE (Parallactic Visual-Field Enhancement) System for the treatment of chronic visual field loss due to stroke, traumatic brain injury, or brain surgery.
- Trial name
- NCT07185971
- Testing
- PAVE (Parallactic Visual-Field Enhancement) treatment using a virtual reality head mounted display
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- NeuroAEye LLC
Glaucoma, Open-Angle
Nicotinamide in Glaucoma (NAMinG): A Randomised, Placebo-controlled, Multi-centre, Phase III Trial
Glaucoma is the leading cause of sight impairment and blindness worldwide. It is a long-term eye disease which can cause permanent loss of sight and sometimes blindness and affects 1 in 50 people over 50 years of age.
- Trial name
- NAMinG (NCT05405868)
- Testing
- Nicotinomide
- Where
- 10 sites in United Kingdom
- Volunteers
- 496 people
- Sponsor
- University College, London
Neurofibromatosis Type 1 (NF1), NF2-related Schwannomatosis
How Can the Experience of Hospital Outpatient Departments be Improved?
This project aims to improve outpatient departments by working with patients and staff to make these spaces more inclusive for people with sensory challenges (it focuses on people with nerve tumour conditions as they are more…
- Trial name
- NCT07818213
- Testing
- Qualitative data collection activities
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- King's College London
Optic Neuritis
Assessment of Clemastine Fumarate as a Remyelinating Agent in Acute Optic Neuritis (ReCOVER)
The main purpose of this study is to assess clemastine as a remyelinating agent in patients with acute optic neuritis.The study will also evaluate the tolerability of clemastine, originally approved as first-generation…
- Trial name
- ReCOVER (NCT02521311)
- Testing
- Clemastine
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of California, San Francisco
Depression, Anxiety, Visual Impairment
Developing Evidence-Based Cognitive Approaches to Improve Adjustment to Vision Loss
The goal of this study is to develop and pilot test a therapeutic strategy combining cognitive behavioral therapy (CBT) with mindfulness practices tailored for individuals adjusting to vision loss.
- Conditions
- Depression, Anxiety, Visual Impairment, Adjustment, Adjustment Disorder With Anxious Mood
- Trial name
- NCT07073521
- Testing
- Integrated Cognitive Behavioral Therapy (CBT) & Mindfulness Group Intervention for Adjustment to Vision Loss
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- The Chicago Lighthouse