Clinical trials: Visual Perception
Methylmalonic Aciduria and Homocystinuria,Cblc Type, Genetic Disease
EPI-743 in Cobalamin C Defect: Effects on Visual and Neurological Impairment
The aim of the research is to investigate the safety and efficacy of EPI-743 treatment in patients with Cbl-C defect and related visual and neurological impairment.
- Conditions
- Methylmalonic Aciduria and Homocystinuria,Cblc Type, Genetic Disease, Retinopathy
- Trial name
- NCT01793090
- Testing
- Epi-743
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Choroidal Melanoma
Safety and Efficacy of Silicone Oil Tamponade for Surgical Attenuation of Radiation Damage in Choroidal Melanoma
A prospective, experimental, case series of 20 patients, with choroidal melanoma, in which pars plana vitrectomy and Silicone oil as vitreous substitute will be used as intraocular shielding for attenuating the deleterious…
- Trial name
- NCT01460810
- Testing
- 1000CsK Silicon Oil Tamponade
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Colorado, Denver
Angle Closure Glaucoma
Comparing Nd:YAG Laser and Sequential Double Frequency YAG-Nd:YAG Laser Iridotomy
No single type of laser or set of laser parameters is appropriate for all type of irides. Pure Nd:YAG laser iridotomy is very effective in the light color irides. It was considered as the gold standard for iridotomy.
- Trial name
- NCT02474238
- Testing
- The sequential technique, The pure Nd:YAG laser technique
- Where
- Thailand
- Volunteers
- 82 people
- Sponsor
- Prince of Songkla University
Amblyopia
Efficacy of Over-glasses Patch Treatment for Amblyopia in Children : OPTA Study
This is a study to investigate efficacy of over-glasses patch treatment for amblyopic children using visual function improvement and Amblyopia Treatment Index (ATI) changes.
- Trial name
- OPTA (NCT03080285)
- Testing
- over-glasses patch, Conventional patch
- Volunteers
- 107 people
- Sponsor
- Pusan National University Hospital
Cataract, Glaucoma
Comparison of Phaco-Trabeculectomy and MSICS-Trab in Cataract and Glaucoma Patients
The goal of this interventional study is to compare the outcomes of two surgical techniques, Phaco-Trabeculectomy and Manual Small Incision Cataract Surgery (MSICS) with Trabeculectomy, in patients with coexisting cataract and…
- Trial name
- NCT06739343
- Testing
- PHACO-Trabeculectomy, MSICS-Trabeculectomy
- Where
- Nigeria
- Volunteers
- 122 people
- Sponsor
- Emeka John Dingwoke
Cardiac Surgical Patients
FORE-SIGHT Tissue Oximeter During Cardiac Surgery
The purpose of this study is to measure cerebral and lower extremity oximetry on patients during cardiac surgery.
- Trial name
- FORE-SIGHT (NCT02426268)
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of California, Los Angeles
Ocular Physiology, Regional Blood Flow
Effects of Topical Clonidine vs. Brimonidine on Choroidal Blood Flow and Intraocular Pressure During Isometric Exercise
Brimonidine tartrate is an alpha-2 agonist ocular hypotensive drug that exerts its effect by causing both a decrease in aqueous production and an increase in uveoscleral outflow.
- Trial name
- NCT00312416
- Testing
- Clonidin, Brimonidine
- Where
- Austria
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Glaucoma
Eye Pressure Lowering Surgery
The purpose of this study is to determine if lowering the pressure inside the eye improves blood flow to the eye.
- Trial name
- IOP (NCT01931904)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Oregon Health and Science University
Glaucoma
The Minimally Invasive Micro Sclerostomy (MIMS®) System is Intended for the Reduction of Elevated Intraocular Pressure (IOP): The Minimally Invasive Micro Sclerostomy (MIMS®) System is Intended for the Reduction of Elevated Intraocular Pressure (IOP)
No new investigational device is used in this study. This study is an extension follow up study conducted in continuation of the prior MIMS® study (see: STUDY ID: MMS EEU-1), in which the long-term (i.e., 28, 36, 42 months)…
- Trial name
- NCT07051174
- Testing
- MIMS
- Where
- Armenia
- Volunteers
- 88 people
- Sponsor
- Sanoculis Ltd
Glaucoma
Efficacy and Safety of XEN63 Gel Implant
The study is prospective, observational, multicenter and has the aim of evaluating the efficacy and safety of the XEN63 implant in patients with primary or secondary glaucoma who require surgery in association or not with…
- Trial name
- XEN63 (NCT06844240)
- Where
- 19 sites in Italy
- Volunteers
- 96 people
- Sponsor
- Mario Stirpe
Strabismus; Intermittent
Eye Alignment and Eye Control Changes Through Follow up Period After Application of Eye Exercises Post Strabismus Surgery
The aim of this study is to determine the patient status through its follow up period and weather the eye alignment and eye control are as the same as the last physiotherapy treatment session or there is any deterioration of them.
- Trial name
- NCT06543212
- Testing
- physiotherapy exercises
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Amany Refaat Mohamed Abdel Wahid
Glaucoma Associated With Other Ocular Disorders
oCular Examination at Cell RESolution With Optical TransmissionTomography
Understanding the pathogenesis of eye diseases has benefited greatly from recent advances in ophthalmic imaging. However, current clinical imaging systems, such as optical coherence tomography (OCT), are limited in terms of…
- Trial name
- CERES-OTT (NCT06976034)
- Testing
- Optical Transmission Tomography (OTT), Optical Coherence Tomography (OCT), Specular Microscopy (SM)
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Sarcoidosis, Tuberculosis
The Serum Angiotensin Converting Enzyme and Lysozyme Levels in Patients Non-infectious and Infectious Uveitis
This study evaluates the significance of differences in serum angiotensin converting enzyme and lysozyme levels of patients with ocular involvement of other autoimmune inflammatory and infectious diseases.
- Trial name
- uveitis (NCT02627209)
- Testing
- spectrophotometric assay, radial immunodiffusion
- Where
- Turkey (Türkiye)
- Volunteers
- 280 people
- Sponsor
- Ozlem Sahin
Cataracts
Visual Function Evaluation of Bilateral AcrySof ReSTOR Aspheric IOL
The objective of this study is to evaluate postoperative visual function in patients implanted bilaterally with the ReSTOR Aspheric Intraocular Lens (IOL).
- Trial name
- NCT00818116
- Testing
- AcrySof ReSTOR Aspheric IOL
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Alcon Research
Glaucoma
Rocklatan® Evaluation
The objective of this study is to evaluate the IOP-lowering effect when subjects are switched from various latanoprost-based regimens to Rocklatan.
- Trial name
- NCT05283395
- Testing
- Netarsudil 0.02%/latanoprost 0.005% fixed dose combination ophthalmic solution
- Where
- 21 sites in United States
- Volunteers
- 136 people
- Sponsor
- Aerie Pharmaceuticals
Keratitis, Herpetic, Ocular Herpes Simplex
Herpetic Eye Disease Study (HEDS) II
To determine whether early treatment (with oral acyclovir) of herpes simplex virus (HSV) ulcerations of the corneal epithelium prevents progression to the blinding complications of stromal keratitis and iridocyclitis.
- Conditions
- Keratitis, Herpetic, Ocular Herpes Simplex, Herpes Simplex
- Trial name
- NCT00000139
- Testing
- Stress, Acyclovir
- Where
- 8 sites in United States
- Sponsor
- National Eye Institute (NEI)
Pre-Eclampsia
Prevention of Preeclampsia With Aspirin in Recipients of Donated Oocytes.
The main objective of this trial is to study the occurrence of preeclampsia in recipients of donated oocytes receiving aspirin at an early stage during pregnancy and to compare the results with those obtained in patients…
- Trial name
- PROVAS (NCT02174328)
- Testing
- Acetylsalicylic acid
- Where
- Spain
- Volunteers
- 81 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Ocular Hypertension, Open Angle Glaucoma
Dose Finding Clinical Trial With SYL040012 to Evaluate the Tolerability and Effect on Intraocular Pressure in Subjects With Ocular Hypertension or Open Angle Glaucoma
The aim of this dose-finding clinical trial is to evaluate the systemic tolerability, local tolerability and intraocular pressure lowering effect of three different doses of SYL040012 in subjects with ocular hypertension or…
- Trial name
- NCT01739244
- Testing
- SYL040012
- Where
- 11 sites in Estonia, Germany and 1 more
- Volunteers
- 80 people
- Sponsor
- Sylentis, S.A.
Bipolar Disorder, Light Sensitivity
Light at Night Study
The purpose of this mechanistic study is to examine light sensitivity (melatonin suppression) in people with bipolar depression I, and compare it to healthy controls. This is not a treatment study.
- Trial name
- LAN (NCT04251234)
- Testing
- Light intensity, ~30 lux, Baseline light intensity, <1 lux
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Age - Related Macular Degeneration (AMD)
Enhanced Vision and Imaging Tests for Enabling Treatment Trials in Early and Intermediate AMD
This monocentric prospective longitudinal observational study will validate fundus-tracked dark adaptometry as an endpoint for future treatment trials in early and intermediate age-related macular degeneration (AMD).
- Trial name
- EVITE-AMD (NCT07515521)
- Where
- Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Maximilian Pfau