Clinical trials: Vitamin B 12 Deficiency
Vitamin B12 Deficiency
Holotranscobalamin Remains Unchanged During Pregnancy
Background and objective: Plasma cobalamins decrease during pregnancy but it is not fully elucidated how this is reflected in the total and cobalamin saturated transport proteins, transcobalamin (total TC, holoTC) and haptocorrin…
- Trial name
- NCT00467623
- Where
- Denmark
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Vitamin B12 Deficiency
Vitamin Deficiencies and Suppletion in Morbid Obesity
The purpose of this study is to evaluate the most effective treatment for patients who underwent a Roux-en-Y gastric bypass and developed postoperatively a vitamin B12 deficiency.
- Trial name
- NCT02270749
- Testing
- Hydroxocobalamin, FitForMe vitamin B12
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Rijnstate Hospital
Vitamin B 12 Deficiency
Cobalamin Supply and Metabolism in Healthy Children From Birth to the Age of 12 Months and in Their Mothers (Cbl_Neo)
Introduction: Infants with severe vitamin B12 (cobalamin, Cbl) deficiency can develop severe, sometimes irreparable neurological damage in the first months of life.
- Trial name
- Cbl_Neo (NCT05315843)
- Where
- 2 sites in Austria, Germany
- Volunteers
- 160 people
- Sponsor
- University Children's Hospital, Zurich
Development, Vitamin Deficiency
Vitamin B12, Neurodevelopment and Growth in Nepal
Rationale: Globally, vitamin B12 deficiency is one of the most common micronutrient deficiencies. The only relevant source of Vitamin B12 is animal-source foods.
- Conditions
- Development, Vitamin Deficiency, Malnutrition
- Trial name
- BeLive (NCT02272842)
- Testing
- Vitamin B12
- Where
- Nepal
- Volunteers
- 600 people
- Sponsor
- Centre For International Health
Vitamin B 12 Deficiency
Cobalamin Supplementation During Infancy; Effect on B-vitamin Status, Growth and Psychomotor Development
Adequate levels of vitamin B12 (cobalamin) is necessary for normal growth and development in infants. We have earlier investigated cobalamin status in healthy children and we observed metabolic evidence of impaired cobalamin…
- Trial name
- NCT00479479
- Testing
- Hydroxycobalamin (Vitamin B12 Depot, Nycomed Pharma)
- Where
- Norway
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Vitamin B12 Deficiency
Long-term Use of Proton Pump Inhibitors May Cause Vitamin B12 Deficiency in the Institutionalized Elderly
This study was designed to determine whether elderly residents of long term care facilitated who had been taking proton pump inhibitors (PPI) for more than 12 months were more likely to have vitamin B12 deficiency than residents…
- Trial name
- NCT00843453
- Testing
- blood collection, treatment (cyanocobalamin nasal spray)
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Megaloblastic Anemia Nos, Pernicious Anemia
Megadose of Hydroxocobalamin for the Treatment of Pernicious Anemia
Demonstrate the effectiveness of a single dose of a multivitamin complex for the treatment of megaloblastic anemia
- Trial name
- NCT03372447
- Testing
- Hydroxocobalamin 10,000mcg, Thiamin 100mg, Pyridoxine 50mg
- Where
- Mexico
- Volunteers
- 13 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Folate Deficiency, Iodine Deficiency
Acceptability and Nutritional Impact of Double-fortified Salt Containing Iodine and Folic Acid
The overarching objective of this two-phase project is to assess the effects of fortifying iodized salt with folic acid on improving women's folate status.
- Conditions
- Folate Deficiency, Iodine Deficiency, Anemia Macrocytic, Anemia Deficiency
- Trial name
- DFS-IoFA-2 (NCT06223854)
- Testing
- Iodized salt, Experimental: Iodized salt with lower-dose folic acid fortification, Experimental: Iodized salt with higher-dose folic acid fortification
- Where
- Ethiopia
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Type 2 Diabetes, Vitamin B12 Deficiency
Effect of Vitamin B12 Supplementation on Glycaemic Control in Uncontrolled Hyperhomocysteinemic Type 2 Diabetic Patients
Increased plasma homocysteine level is associated with macroangiopathy and nephropathy in type 2 diabetes. Also increased levels of serum homocysteine are associated with microalbuminuria which is associated with increased…
- Conditions
- Type 2 Diabetes, Vitamin B12 Deficiency, Hyperhomocysteinemia
- Trial name
- NCT02540642
- Testing
- METHYLCOBALAMIN 500 micrograms
- Where
- India
- Volunteers
- 38 people
- Sponsor
- Smt. Kashibai Navale Medical College and General Hospital
Anemia, Folate Deficiency
Periconceptional Surveillance in India
Women of reproductive age are a high-risk population for anaemia and micronutrient deficiencies. Evidence supports the role of periconceptional nutrition in the development of adverse pregnancy complications.
- Conditions
- Anemia, Folate Deficiency, Vitamin B12 Deficiency
- Trial name
- NCT04048330
- Where
- India
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Cornell University
Diabetes Mellitus, Type 2, Vitamin B 12 Deficiency
The Vitamin B Status in Type 2 Diabetes (VITA) Study
The objective of this study was to evaluate vitamin B deficiency (particularly vitamin B6 deficiency) in diabetic patients in Germany in relation to the presence or absence of proteinuria, and global vascular risk.
- Conditions
- Diabetes Mellitus, Type 2, Vitamin B 12 Deficiency, Vitamin B 6 Deficiency
- Trial name
- VITA (NCT03447275)
- Testing
- Type 2 diabetes
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Rima Obeid
Obesity, Morbid, Homocystine; Metabolic Disorder
Homocysteine After Laparoscopic Roux-enY Gastric Bypass
Changes in homocysteine values after bariatric surgery remain controversially discussed. This is the first comprehensive summary to depict timeline changes in homocysteine levels following laparoscopic roux-en-Y gastric bypass.
- Conditions
- Obesity, Morbid, Homocystine; Metabolic Disorder, Bariatric Surgery Candidate, Folate Deficiency
- Trial name
- NCT03489538
- Testing
- laparoscopic long limb roux-en-Y gastric bypass
- Where
- Austria
- Volunteers
- 708 people
- Sponsor
- Medical University of Vienna
Mild Cognitive Impairment
A Retrospective Analysis of Cerefolin NAC® in Cognitively Impaired Patients
This retrospective analysis of de-identified data from 700 charts of consecutive patients from this patient population is to investigate the prevalence of hyperhomocysteinemia and associated metabolic abnormalities in this…
- Trial name
- NCT01594541
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- Pamlab, Inc.
Vitamin B 12 Deficiency
Vitamin B12 Dose Escalation Trial in Pregnancy
Vitamin B12 is a cofactor for 2 enzymes that have essential functions in pregnancy, both for maternal health and for fetal development.
- Trial name
- MM4MN-B12 (NCT05426395)
- Testing
- Vitamin B12 2.6 µg, Vitamin B12 10 µg, Vitamin B12 50 µg
- Where
- Tanzania
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- George Washington University
Mild Cognitive Impairment, Dementia
COMPARATIVE EFFECTIVENESS OF MCI and DEMENTIA TREATMENTS IN A COMMUNITY-BASED DEMENTIA PRACTICE
This retrospective study is a more extensive, confirmatory analysis of the cognitive and functional outcomes initially seen in 2 groups of MCI/dementia patients in Springfield, MA and compares specialized dementia care and a…
- Conditions
- Mild Cognitive Impairment, Dementia, Hypoxia, Hyperhomocysteinemia
- Trial name
- NCT02860338
- Volunteers
- 900 people
- Sponsor
- Clionsky Neuro Systems Inc.
Vitamin B 12 Deficiency
Vitamin B12 Acceptance and Biomarker Response Study
In this study, biomarker response after supplementation with oral and intramuscular vitamin B12 will be compared in a randomized clinical trial.
- Trial name
- NCT01832129
- Testing
- Oral administration of vitamin B12, i.m. injection of vitamin B12
- Where
- Switzerland
- Volunteers
- 37 people
- Sponsor
- University Hospital, Basel, Switzerland
Iron Deficiency, Vitamin A Deficiency
Nutritional Status and Bouillon Use in Northern Ghana
This pilot aims to generate data that are critical for informing the design of a planned, more detailed study to evaluate the effect of multiple micronutrient (MN)-fortified bouillon cube on biomarkers of nutrient status of women…
- Conditions
- Iron Deficiency, Vitamin A Deficiency, Vitamin B 12 Deficiency, Folate Deficiency
- Trial name
- NCT04632771
- Testing
- N/A (observational study)
- Where
- Ghana
- Volunteers
- 995 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Vitamin B12 Deficiency
Supplementary Vitamin B12 Effects on Elevated Homocysteine Levels of Vegetarians - Clinical Trial
Vegetarians are known to be deficient in vitamin B12, due to a lack or absence of dietary animal produce, which can elevate homocysteine.
- Trial name
- NCT01661309
- Testing
- Inactive lozenge, Methylcobalamin
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of West London
Vitamin B-12 Deficiency, Achlorhydria
Cobalamin Absorption From Fortified Food
To determine B12 bioavailability from 14C-B12 fortified bread in healthy subjects and in subjects with proton pump inhibitor induced achlorhydria.
- Trial name
- FL-72 (NCT01399164)
- Testing
- 14C-B12 fortified bread
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International