Clinical trials: Vitamin D, open to volunteers
Hypovitaminosis D
The Effectiveness of a Weight-dependent Algorithm for Dosing Vitamin D.
Vitamin D is essential for calcium absorption and bone growth, brain development, and immune system function. Vitamin D is produced by the body in response to natural sunlight.
- Trial name
- NCT07876843
- Testing
- Vitamin D3, Calcium, and Vitamin C
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Atlantic Health System
Vision Loss Night, Vision Disorders
OPI-NXYDLD-303 Safety and Efficacy of Phentolamine Ophthalmic Solution in Keratorefractive Surgery Participants With Decreased Mesopic Visual Acuity
The goal of this clinical trial is to learn if Phentolamine Ophthalmic Solution works to treat adults that have had keratorefractive surgery and have decreased visual acuity under mesopic conditions.
- Trial name
- LYNX-3 (NCT07140783)
- Testing
- 0.75% Phentolamine Ophthalmic Solution
- Where
- 20 sites in United States
- Volunteers
- 580 people
- Sponsor
- Opus Genetics, Inc
Vitamin D 25-Hydroxylase Deficiency, Undernutrition
Impact of Trout Fish, Cow Milk With Egg, Vitamin D Supplementation, and Dietary Education on Vitamin D Status, Undernutrition, and Neurocognitive Outcomes Among School Children in Pakistan: An Open-label Individually Randomized Controlled Trial
Vitamin D deficiency and undernutrition are major public health concerns globally, particularly among children in low-resource and high-altitude settings.
- Conditions
- Vitamin D 25-Hydroxylase Deficiency, Undernutrition, Neurocognitive Development
- Trial name
- NCT07864662
- Testing
- Vitamin D supplement 4000 IU weekly, 200 grams of cooked trout fish, 250 milliliters of whole cow milk + whole egg
- Where
- Pakistan
- Volunteers
- 304 people
- Sponsor
- Aga Khan University
Vitamin D Deficiency
Vitamin D Status and Its Influencing Factors in Zhejiang Province: A Multicenter Cross-Sectional Study
Vitamin D deficiency is a global public health problem, with an estimated 1 billion people affected worldwide, and large-scale systematic data for Zhejiang Province remain scarce.
- Trial name
- NCT07866391
- Where
- 2 sites in China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Vitamin D Deficiency
Bone Myoregulation Reflex and Postural Control in Vitamin D Deficiency
This observational study aims to investigate the relationship between vitamin D deficiency, postural stability, and neuromuscular control mechanisms in adults.
- Trial name
- BMR-VITD (NCT07435935)
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Healthy, Suboptimal Vitamin C Levels
The Impact of Qualia Vitamin C+ on Individuals With Suboptimal and Adequate Vitamin C Levels
This is a double-blind, placebo-controlled, parallel-group, study evaluating the effect of a Qualia Vitamin C+ formulation on Whole Blood Vitamin C levels in the blood of healthy adults aged 25 years or older that have suboptimal…
- Conditions
- Healthy, Suboptimal Vitamin C Levels, Adequate Vitamin C Levels
- Trial name
- NCT07652346
- Testing
- Qualia Vitamin C+
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Qualia Life Sciences
Healthy Adult Participants, Vitamin D Insufficiency
Supplementation of Cholecalciferol and Related Active Metabolites Through Bioenhancing Layer's Eggs
The purpose of this research is to evaluate if 1) consumption of vitamin D3- or 25(OH)D3-biofortified eggs will increase vitamin D and 25(OH)D status in young adults who consume these bioenhanced eggs, 2) to determine if the gut…
- Trial name
- SCRAMBLE (NCT07859280)
- Testing
- Vitamin D3 bioenhanced eggs, 25(OH)D3 bioenhanced eggs
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cornell University
Deficiency, Vitamin C, Chronic Disease
A Long-term Observational Study to Describe the Use of Vitamin-C Injektopas® 7.5 g in Patients With Vitamin C Deficiency
The goal of this observational study is to learn more about the disease and the symptoms where the product will use and in which patient groups. Further on, it is interesting to know clinical pictures, the symptoms improve.
- Conditions
- Deficiency, Vitamin C, Chronic Disease, Acute Disease
- Trial name
- NCT06983847
- Where
- Austria
- Volunteers
- 1,000 people
- Sponsor
- Pascoe Pharmazeutische Praeparate GmbH
Infant Vitamin K Status, Vitamin K Deficiency Bleeding
The OK Daily Study
The OK Daily Study is a multi-centred, part-randomised, part blinded, four cohort study. We are exploring daily dietary supplementation with vitamin K2, specifically menaquinone-7 (MK-7), given to breastfed infants or…
- Trial name
- NCT07620236
- Testing
- Combined MK-7 + vitamin D3 drops, Vitamin D3 Drops, MK-7 capsules
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Norfolk and Norwich University Hospitals NHS Foundation Trust
Sarcoidosis, Vitamin D Insufficiency
Vitamin D Homeostasis in Sarcoidosis
This study evaluates the relationship between vitamin-D status and severity of sarcoidosis, and the effects of vitamin-D repletion in vitamin-D insufficient patients with sarcoidosis.
- Trial name
- NCT03621553
- Testing
- Ergocalciferol, Calcium Citrate with Vitamin D2
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Texas Southwestern Medical Center
Adequate Vitamin C Status, Inadequate Vitamin C Status
Anti-inflammatory Activities of Vitamin C Supplementation on the Gut Barrier Function in Adults With Obesity
This study is testing whether taking vitamin C every day can help improve gut health and reduce inflammation in adults with obesity.
- Trial name
- NCT07151105
- Testing
- Vitamin C Supplement + Low Vitamin C Diet
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Ohio State University
Triple Negative Breast Cancer, Vitamin D Deficiency
Impact of Vitamin D Supplementation on the Rate of Pathologic Complete Response in Vitamin D Deficient Patients
A two arm pilot study investigating the rate of pathologic complete response in patients with vitamin D deficiency and triple negative breast cancer undergoing standard neoadjuvant chemotherapy + vitamin D supplementation…
- Conditions
- Triple Negative Breast Cancer, Vitamin D Deficiency, Invasive Breast Cancer
- Trial name
- NCT04677816
- Testing
- Standard of Care Neoadjuvant Chemotherapy (NAC), Vitamin D3, Drug Diary
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Wake Forest University Health Sciences
Major Depressive Disorder (MDD), Thiamine
Oral Thiamine (Vitamin B1) for Depression in Children and Adolescents
The goal of this study is to examine the effectiveness of thiamine in reducing depressive symptoms in children and adolescents. The investigators hypothesize that thiamine administration will alleviate depressive symptoms in…
- Conditions
- Major Depressive Disorder (MDD), Thiamine, Vitamin B1, Thiamine Diphosphate (TDP)
- Trial name
- B1Ped (NCT07793071)
- Testing
- thiamine hydrochloride 100 mg
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Graft Vs Host Disease, Vitamin A Deficiency
Vitamin A Supplementation in Allogeneic Stem Cell Transplantation.
The investigators hypothesize that single oral high dose supplementation with vitamin A will reduce the incidence of moderate-severe chronic graft-versus-host disease (GVHD) compared with placebo.
- Conditions
- Graft Vs Host Disease, Vitamin A Deficiency, Vitamin D Deficiency
- Trial name
- NCT06450925
- Testing
- Vitamin A
- Where
- 3 sites in United States
- Volunteers
- 190 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Vitamin D
Comparing Vitamin D Results and Acceptability of Sampling Obtained From Dried Blood Spot, Tasso+ Capillary Sampling, and Venous Blood.
This study will evaluate the performance and acceptability of different sampling methods for measuring vitamin D, specifically 25-hydroxyvitamin D₂ and 25-hydroxyvitamin D₃.
- Trial name
- VitD TASSO (NCT07782528)
- Testing
- Vit D Tasso+
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
Polycystic Ovarian Syndrome in Adolescent Females, Vitamin D Deficiency
Evaluation of the Clinical and Psychological Impact of Vitamin D Replacement in Adolescent Females at Risk for Polycystic Ovarian Syndrome (PCOS)
This study is a double blind, placebo controlled, randomized trial of study subjects with PCOS and low vitamin D to 2 groups- placebo and vitamin D replacement.
- Trial name
- NCT04355572
- Testing
- Vitamin D 4000IU daily
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Yale University
Locally Advanced Cervical Cancer, Vitamin D Concentration
Vitamin D Status and Clinical Outcomes in Locally Advanced Cervical Cancer
Background. Definitive chemoradiotherapy represents the standard therapeutic approach for the management of locally advanced cervical cancer.
- Trial name
- CERVITAL (NCT07743918)
- Testing
- Pretreatment Vitamin D Assessment in Serum and Cervical Lavage Fluid
- Where
- Serbia
- Volunteers
- 100 people
- Sponsor
- University of Kragujevac
Cholestatic Liver Disease, Chronic Liver Disease (CLD)
Vitamin D2 vs Vitamin D2 Plus Calcitriol in Cholestatic Children With Vitamin D Deficiency
The goal of this clinical trial is to learn whether adding calcitriol to vitamin D2 can improve vitamin D deficiency in children with cholestasis and chronic liver disease.
- Conditions
- Cholestatic Liver Disease, Chronic Liver Disease (CLD), Vitamin D Deficiency, Children
- Trial name
- VITD-CHOL (NCT07670611)
- Testing
- Vitamin D2, Calcitriol
- Where
- Thailand
- Volunteers
- 54 people
- Sponsor
- Chulalongkorn University
Vitamin D Insufficiency
25(OH)-Vitamin D and Its Association With Structural and Functional Parameters in Hospitalized Patients With Neurological Diseases
The NeuroVitD study aims to assess vitamin D levels in hospitalized cohorts with neurological disorders resulting in motor disabilities, providing epidemiological data necessary for guidelines.
- Trial name
- NeuroVitD (NCT06791044)
- Testing
- DELTIUS
- Where
- 2 sites in Greece
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Dionyssiotis, Yannis, M.D.
Premature, Preterm Infant Health
Vitamin A Supplementation and Breast Milk Vitamin A Levels in Mothers of Preterm Infants
Preterm infants are at increased risk of vitamin A deficiency because they are born with low vitamin A stores and depend largely on breast milk to meet their nutritional needs.
- Conditions
- Premature, Preterm Infant Health, Vitamin A Deficiency, Human Milk
- Trial name
- VITAL (NCT07736768)
- Testing
- Oral multivitamin containing vitamin A
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Mississippi Medical Center