Clinical trials: Vitamin Deficiencies
Oral Lichen Planus, Vitamin D Deficiency
Vitamin D Deficiency As a Risk Factor for the Development and Malignant Transformation of Oral Lichen Planus
To examine how a lack of vitamin D may increase the risk of developing oral lichen planus and its malignant progression while accounting for sex, food habits, sunlight, socioeconomic level, and psychological variables.
- Trial name
- NCT06033105
- Testing
- ELISA
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Hypovitaminosis D, Insulin Resistance
Hypovitaminosis D : A Link Between Bone/Mineral and Fat/Fuel Metabolism
The optimal dose of vitamin D needed to optimize beneficial effects on musculoskeletal outcomes remains to be defined. Equally unclear is the impact of vitamin D on fuel metabolism and insulin sensitivity in human subjects.
- Conditions
- Hypovitaminosis D, Insulin Resistance, Obesity, Osteoporosis
- Trial name
- GEHF-VitD (NCT01315366)
- Testing
- Euro D and Ci-CalD, Euro D, Ci-CalD
- Where
- Lebanon
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Hypothyroidism, Primary Hypothyroidism
Effect of Vitamin C Supplementation in Patients With Primary Hypothyroidism
Thyroid disease affects almost a quarter of a billion individuals worldwide and more than 50% of them being not aware of this condition.
- Conditions
- Hypothyroidism, Primary Hypothyroidism, Vitamin C Deficiency
- Trial name
- NCT05733078
- Testing
- Vitamin C, Oral Rehydration Salt Formulations
- Where
- United Arab Emirates
- Volunteers
- 40 people
- Sponsor
- Dr Adnan Agha
Vitamin D Deficiency, Spinal Cord Injury
Vitamin D Supplementation in Wheelchair Indoor Athletes
There is a high prevalence of vitamin D deficiency in Switzerland. In indoor-athletes as well as wheelchair users, vitamin D deficiency occurs even more often.
- Conditions
- Vitamin D Deficiency, Spinal Cord Injury, Drug Effects, Dietary Supplements
- Trial name
- VitD_SCI (NCT02621320)
- Testing
- Vitamin D
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Swiss Paraplegic Research, Nottwil
Vitamin D Deficiency
Evaluation of Vitamin D Requirements During Pregnancy
The purpose of this study is to determine the effectiveness of vitamin D supplementation during pregnancy starting at the beginning of the second trimester.
- Trial name
- NCT00292591
- Testing
- cholecalciferol (vitamin D3), cholecalciferol
- Where
- United States
- Volunteers
- 501 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Schizophrenia, Metabolic Syndrome
The Influence of Vitamin D on Atypical Antipsychotic-induced Weight Gain
Schizophrenia and bipolar disorders are major public health problems. The second generation anti-psychotic drugs have efficacy for both positive and negative symptoms and a favorable risk profile as far as movement disorders.
- Conditions
- Schizophrenia, Metabolic Syndrome, Vitamin D Deficiency
- Trial name
- NCT02281162
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Creighton University
Rickets, Osteomalacia
Maternal and Infant Vitamin Status During the First Nine Months of Infant Life
In this study the investigators wanted to assess vitamin D status and possible consequences of low plasma 25-hydroxyvitamin D levels in a population of healthy mothers and their infants, in the community of Aarhus, Denmark.
- Conditions
- Rickets, Osteomalacia, Osteoporosis
- Trial name
- NCT02548520
- Testing
- Blood and breastmilk samples
- Where
- Denmark
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Premature, Preterm Infant Health
Vitamin A Supplementation and Breast Milk Vitamin A Levels in Mothers of Preterm Infants
Preterm infants are at increased risk of vitamin A deficiency because they are born with low vitamin A stores and depend largely on breast milk to meet their nutritional needs.
- Conditions
- Premature, Preterm Infant Health, Vitamin A Deficiency, Human Milk
- Trial name
- VITAL (NCT07736768)
- Testing
- Oral multivitamin containing vitamin A
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Mississippi Medical Center
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Vitamin A Deficiency
Using Stable Isotope Techniques to Monitor and Assess the Vitamin A Status of Children Susceptible to Infection
The combination of infectious diseases and malnutrition is the most prevalent, preventable public health problem in the world, responsible for millions of deaths annually, particularly in infants and children.
- Trial name
- NCT02363985
- Testing
- Mega-dose of vitamin A supplement
- Where
- Ethiopia
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Ethiopian Public Health Institute
Vitamin D Deficiency, Aging Well
Innovative Food Structures to Enhance Nutrient Bioavailability
This randomized controlled trial (RCT) will compare the change in vitamin D status (25-hydroxyvitamin D nmol/L) after a 4 week intervention with 4 groups: 1. Vitamin D enriched (20ug) olive oil emulsion drink 2.
- Trial name
- NutriPlus (NCT04156074)
- Testing
- Vitamin D enriched (20 mcg/day) olive oil emulsion drink, Vitamin D enriched (20 mcg/day) coconut oil emulsion drink, Vitamin D supplement (20 mcg/day)
- Where
- Ireland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Septic Shock, Shock, Septic
Thiamine Supplementation in Patients With Septic Shock
To determine if intravenous thiamine would decrease the time to reversal of shock in patients with septic shock.
- Conditions
- Septic Shock, Shock, Septic, Lactic Acidosis, Thiamine Deficiency
- Trial name
- NCT03122678
- Testing
- Thiamine
- Where
- United States
- Sponsor
- The Cleveland Clinic
End Stage Renal Disease (ESRD), CKD 5D, Hemodialysis
Activated Charcoal Use in Chronic Kidney Disease Patients
Hyperphosphatemia management is initially based on restricting dietary phosphorus intake. Hyperphosphatemia is almost always seen in patients on dialysis and may contribute to progressive vascular calcification.
- Conditions
- End Stage Renal Disease (ESRD), CKD 5D, Hemodialysis, CKD-MBD - Chronic Kidney Disease Mineral and Bone Disorder
- Trial name
- NCT06906874
- Testing
- Activated Charcoal, Phosphate Binders
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Mansoura University
Vitamin A Deficiency
Efficacy of Biofortified Maize to Improve Maternal and Infant Vitamin A Status
The purpose of this randomized control trial is to test the impact of provitamin A carotenoid biofortified maize meal consumption on maternal and infant vitamin A status.
- Trial name
- NCT02804490
- Testing
- Conventional white maize, Provitamin A carotenoid biofortified maize, Preformed vitamin A fortified maize
- Where
- Zambia
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Hypophosphatasia (HPP)
Safety and Efficacy Study of Asfotase Alfa in Severely Affected Infants With Hypophosphatasia (HPP)
This clinical trial studies the safety and efficacy of asfotase alfa in infants and young children with infantile onset HPP.
- Trial name
- NCT00744042
- Testing
- asfotase alfa
- Where
- 10 sites in United States, Canada and 2 more
- Volunteers
- 11 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Extreme Prematurity, Anemia of Prematurity
Folic Acid Supplementation to Reduce Anemia in Extremely Preterm Infants
Anemia of Prematurity (AOP) is very common in extremely preterm infants and often leads to blood transfusions. Folic acid, essential for growth and DNA synthesis, is deficient in premature infants.
- Trial name
- FASCINATE (NCT06220461)
- Testing
- Folic acid
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- University of Calgary
Type 2 Diabetes Mellitus, Obesity
Effect of Vitamin D Supplementation on the Metabolic Control and Body Composition of Type 2 Diabetes Subjects in Ajman (UAE)
The incidence of type 2 diabetes mellitus and obesity is increasing at an alarming rate both nationally and worldwide. Accumulating evidence suggests that serum cholecalciferol levels may be inversely related to the prevalence of…
- Conditions
- Type 2 Diabetes Mellitus, Obesity, Hypovitaminosis D
- Trial name
- VDIS (NCT02101151)
- Testing
- Vitamin D3(cholecalciferol)
- Where
- United Arab Emirates
- Volunteers
- 87 people
- Sponsor
- Rashid Centre for Diabetes and Research
Vitamin D Deficiency
FREQUENCY OF VITAMIN D DEFICIENCY IN PREMATURE NEWBORN BORN BEFORE 32 WEEKS AND/OR WITH A BIRTH WEIGHT UNDER 1500g
Vitamin D plays an important role in phosphocalcic metabolism and bone homeostasis in newborns. Premature newborns are at risk of vitamin D deficiency and may require supplementation.
- Trial name
- PremaVitaD (NCT06315452)
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Vitamin D Deficiency, Diabetes
Vitamin D and Inflammatory Markers of Cardiovascular Disease in African Americans With Type 2 Diabetes
Recent clinical trials in non diabetics showed that vitamin D supplementation markedly reduced serum levels of C-reactive protein (CRP), interleukin-6, and tissue matrix metallo-proteinases.
- Trial name
- NCT01153243
- Testing
- Ergocalciferol
- Volunteers
- 117 people
- Sponsor
- Cook County Health
Vitamin D Deficiency
Effect of Vitamin D on Everolimus Trough Concentrations Among Heart Transplanted Patients
Vitamin D is part of the regular treatment regimen among patients after heart transplantation. Due to potential drug-drug interaction between vitamin D and everolmus, these patients are in increased risk for increased everolimus…
- Trial name
- NCT03403647
- Testing
- Vitamin D
- Where
- Israel
- Volunteers
- 11 people
- Sponsor
- Sheba Medical Center
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