Clinical trials: Vitamin E
Allergic Asthma
Study on the Role of Treatment With Vitamin E on Asthmatic Responses in Allergic Asthmatics
Asthma is a common respiratory disease of unknown etiology which currently affects approximately 7.5 % of the adult population ( ). Asthma is an inflammatory disorder of the airways.
- Trial name
- NCT00581048
- Testing
- Natural source d-α-tocopheryl acetate
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Vanderbilt University
Cataract, Macular Degeneration
S0000B: Vitamin E and/or Selenium in Preventing Cataract and Age-Related Macular Degeneration in Men on SELECT SWOG-S0000
RATIONALE: Aging may affect a person's vision. Vitamin E and/or selenium may help prevent cataracts or age-related macular degeneration in men receiving these drugs as part of a clinical trial for the prevention of prostate…
- Trial name
- SEE (NCT00784225)
- Testing
- selenium, vitamin E
- Where
- United States
- Volunteers
- 13,475 people, healthy volunteers welcome
- Sponsor
- SWOG Cancer Research Network
Endothelial Dysfunction
Impact of Smoking Cessation and γ-Tocopherol to Restore Vascular Endothelial Function
Cigarette smoking is a significant risk factor for cardiovascular disease (CVD) and is the leading cause of premature mortality in the US.
- Trial name
- NCT01314443
- Testing
- Nicotine Replacement Therapy (NRT), Gamma-Tocopherol, Smoking cessation
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
NAFLD, NASH - Nonalcoholic Steatohepatitis
Vitamin E for NASH Treatment in HIV Infected Individuals
The purpose of this study is to see how taking Vitamin E daily affects fatty liver in persons living with HIV. Subjects will have both HIV and a fatty liver and the purpose of the study is to learn if underlying liver condition…
- Conditions
- NAFLD, NASH - Nonalcoholic Steatohepatitis, HIV Infections
- Trial name
- NCT03669133
- Testing
- Vitamin E
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- Indiana University
Noise-Induced Hearing Loss
Micronutrients to Prevent Noise-induced Hearing Loss
Noise-induced hearing loss (NIHL) is a significant clinical, social, and economic issue. Studies in animals have allowed us to identify mechanisms contributing to NIHL, including direct mechanical trauma, free radicals formed in…
- Trial name
- NCT00808470
- Testing
- beta-carotene, vitamins C and E, magnesium
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Cardiovascular Diseases, Cerebrovascular Disorders
Women's Health Study (WHS): A Randomized Trial of Low-dose Aspirin and Vitamin E in the Primary Prevention of Cardiovascular Disease and Cancer
The purpose of this study is to evaluate the effects of low-dose aspirin and vitamin E in primary prevention of cardiovascular disease and cancer in apparently healthy women.
- Conditions
- Cardiovascular Diseases, Cerebrovascular Disorders, Coronary Disease, Heart Diseases
- Trial name
- WHS (NCT00000479)
- Testing
- Aspirin, Vitamin E
- Volunteers
- 39,876 people
- Sponsor
- Brigham and Women's Hospital
Brain Metastasis
Evaluation of the Use of Trental and Vitamin E For Prophylaxis of Radiation Necrosis
The purpose of this study is to determine whether the use of Trental and Vitamin E can help reduce the incidence of radiation necrosis (a lesion that usually occurs at the original tumor site) after radiosurgery.
- Trial name
- NCT01508221
- Testing
- Trental, Vitamin E
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Cincinnati
Hypercholesterolemia
Effects of a Supplement Derived From Palm Oil on Cholesterol Levels in the Blood
Elevated blood cholesterol, and particularly LDL cholesterol, is a risk factor for heart disease. Tocotrienols are naturally-occurring compounds in foods that may have beneficial effects on blood cholesterol.
- Trial name
- TRF (NCT02634606)
- Testing
- Gamma Delta Tocotrienols - Low Dose, Gamma Delta Tocotrienols - High Dose, Sugar Pill
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Prostate Cancer
Biomarker Study of Neoadjuvant Vitamin E in Patients With Locally Treatable Prostate Cancer
The purpose of this study is to find out if vitamin E can help treat prostate cancer. Vitamin E acts primarily as an anti-oxidant. By decreasing the oxidation in the cancer cell, the tumor cells may die.
- Trial name
- NCT00809458
- Testing
- Vitamin E
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- New Mexico Cancer Research Alliance
Mild, Allergic Asthma
Effect of Gamma Tocopherol Enriched Supplementation on Response to Inhaled LPS
To test the hypothesis that gamma tocopherol (vitamin E) supplement inhibits endotoxin induced airways inflammation in allergic asthmatics
- Trial name
- Vitalps (NCT02104505)
- Testing
- Gamma Tocopherol 700 mg capsules,
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of North Carolina, Chapel Hill
Colorectal Cancer, Precancerous Condition
S0000D: Effect of Vitamin E and/or Selenium on Colorectal Polyps in Men Enrolled on SELECT Trial SWOG-S0000
RATIONALE: Studying tissue samples in the laboratory from participants receiving treatment on the Selenium and Vitamin E Cancer Prevention Trial (SELECT) SWOG-S0000 may help doctors predict a participant's response to treatment…
- Trial name
- ACP (NCT00706121)
- Testing
- Vitamin E, Selenium
- Where
- United States
- Volunteers
- 8,094 people, healthy volunteers welcome
- Sponsor
- SWOG Cancer Research Network
Fibrosis
Trental & Vitamin E for Radiation-Induced Fibrosis
This study seeks to determine if a combination of Trental and Vitamin E prevents the development of radiation fibrosis in women treated with radiation for the definitive management of their breast cancer.
- Trial name
- NCT00583700
- Testing
- Pentoxifylline, Vitamin E
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Iowa
Airway Inflammation, Asthma
A Study of Gamma Tocopherol-enriched Supplement on Lower Airway Responses to Inhaled Wood Smoke in Healthy Adults
Purpose: To determine the efficacy of 1400 mg gamma tocopherol-enriched supplement for mitigating inhaled wood smoke particle-induced airway inflammation in healthy adults with no more than mild asthma.
- Trial name
- SmokeyT (NCT03444298)
- Testing
- Gamma Tocopherol
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Osteoradionecrosis
Management of Mandibular ORN: PENTO as Medical Treatment
Mandibular osteoradionecrosis, despite its low incidence, remains being the most problematic and irreversible complication after head and neck radiotherapy with no medical treatment to limit or reduce symptoms.
- Trial name
- PENTO (NCT02368457)
- Testing
- Pentoxifylline and Tocopherol
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- Hospital Vall d'Hebron
Keloid, Hypertrophic Scar
A Randomized Comparative Study Evaluating the Tolerability and Efficacy of Two Topical Therapies for the Treatment of Keloids and Hypertrophic Scars
Keloids are thought to result from derailments in the typical wound healing process following cutaneous injury. Current treatment options for keloids include intralesional corticosteroids, silicone gel sheeting, compression…
- Conditions
- Keloid, Hypertrophic Scar, Cicatrix, Hypertrophic
- Trial name
- NCT00754247
- Testing
- 0.5% hydrocortisone, silicone, vitamin E lotion, Onion extract gel, Cetearyl alcohol lotion
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Miami
Non-Alcoholic Fatty Liver Disease, Non-Alcoholic Fatty Liver
Vitamin E and DHA-EE on NAFLD - Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Clinical Trial (PUVENAFLD)
Multicenter, randomized, double-blinded, placebo-controlled clinical trial is focused on novel treatments for non-alcoholic fatty liver disease (NAFLD), the most common cause of chronic liver disease.
- Conditions
- Non-Alcoholic Fatty Liver Disease, Non-Alcoholic Fatty Liver, Non-Alcoholic Steatohepatitis
- Trial name
- PUVENAFLD (NCT04198805)
- Testing
- Vitamin E [(all-rac)-α-tocopheryl acetate], Omega-3 fatty acid (DHA EE), Omega-3 fatty acid (DHA EE) & Vitamin E [(all-rac)-α-tocopheryl acetate]
- Where
- 15 sites in United States
- Volunteers
- 205 people
- Sponsor
- Naga P. Chalasani
Nonalcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis
Vitamin E Dosing Study
This is a multicenter, randomized, double masked, placebo-controlled, parallel treatment groups dosing trial of Vitamin E in adult nonalcoholic fatty liver disease (NAFLD).
- Trial name
- VEDS (NCT04801849)
- Testing
- Vitamin E
- Where
- 9 sites in United States
- Volunteers
- 200 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
End Stage Cardiac Failure, Pulmonary Failure
Human Tissue Distribution of Orally Supplemented Natural Vitamin E Tocotrienol
Levels of tocotrienol in human tissues following supplementation is not currently known. The objective of this present study is to determine the levels of this form of vitamin E in the human tissues such as skin, heart, lung…
- Conditions
- End Stage Cardiac Failure, Pulmonary Failure, End Stage Liver Disease, Morbid Obesity
- Trial name
- NCT00678834
- Testing
- To surgery patients, Tocopherol capsules., Tocotrienol to healthy subjects., To surgery patients, Tocotrienol capsules.
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chandan K Sen
Burn
Vitamin E Supplementation in Burned Patients
A dietary antioxidant, alpha-tocopherol, will be used to potentially attenuate Vitamin E short- and long-term losses in plasma and adipose, reverse the oxidative stress of burn injury and, in the process, decrease the secondary…
- Trial name
- NCT01749371
- Testing
- Vitamin E
- Where
- 3 sites in United States
- Volunteers
- 27 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Alzheimer's Disease
A Randomized, Clinical Trial of Vitamin E and Memantine in Alzheimer's Disease
The purpose of this study is to determine whether alpha-tocopherol, memantine (Namenda), or the combination will significantly delay clinical progression in mild to moderately demented patients with Alzheimer's disease compared…
- Trial name
- TEAM-AD (NCT00235716)
- Testing
- dl-alpha-tocopherol, Memantine
- Where
- 14 sites in United States, Puerto Rico
- Volunteers
- 613 people
- Sponsor
- US Department of Veterans Affairs