Clinical trials: Vitamin K 2
CKD 5D, Hemodialysis
Vitamin K2 Supplementation to Activate Matrix Gla Protein (MGP) as Endogenous Inhibitor of Vascular Calcification in Hemodialysis Patients
Vascular calcification (VC) is a predictor of cardiovascular morbidity and mortality. Hemodialysis (HD) patients suffer from severe vascular calcifications.
- Trial name
- NCT01407601
- Testing
- daily supplementation of MK-7 over 6 weeks
- Where
- 3 sites in Germany
- Volunteers
- 53 people
- Sponsor
- RWTH Aachen University
Coagulation, Bleeding
Does Low Dose Oral Vitamin K Improve International Normalized Ratio (INR) Stability?
Warfarin is highly effective for the prevention of both first and recurrent thrombotic events, however even minor excursions outside the reference INR range of 2.0 to 3.0 are associated with bleeding or thrombotic complications.
- Conditions
- Coagulation, Bleeding, Thrombosis
- Trial name
- OVWAC VII (NCT00990158)
- Testing
- Phytonadione (Vitamin K1)
- Where
- 4 sites in Canada
- Volunteers
- 235 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Healthy Women, Osteocalcin
Jarlsberg Cheese Compared to Camembert Cheese
The study objective consists of the following three aims: 1. To compare the effect of daily intake of Jarlsberg cheese and Camembert cheese in change of the Osteocalcin level in healthy women after 6 weeks. 2.
- Trial name
- NCT04189796
- Testing
- Cheese
- Where
- Norway
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Prof Stig Larsen
Inflammation, Oxidative Stress
viTAmin K2 and rEcOVery From ExeRcise
The aim of the current study, therefore, is to investigate the effects of vitamin K2 supplementation on the physiological responses to an acute bout of resistance exercise.
- Conditions
- Inflammation, Oxidative Stress, Vitamin K, Exercise
- Trial name
- TAKEOVER (NCT04676958)
- Testing
- Vitamin K2, Micro-crystalline cellulose
- Where
- 2 sites in United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Bioavailability
Arabic Gum-Absorption Study
Previous studies have indicated that menaquinone-7 (MK-7) is the most effective form of vitamin K. The Japanese soya product natto is one of the richest food sources of MK-7, but its taste is not appreciated by the Western…
- Trial name
- NCT00858767
- Testing
- menaquinone-7 from casein capsules, menaquinone-7 from arabic gum capsules, menaquinone-7 from linseed oil capsules
- Where
- Netherlands
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Arterial Calcification, Diabetes Mellitus Type 2
A Randomized, Placebo-controlled, Double Blind Trial to Investigate Whether Vitamin K2 Can Influence Arterial Calcification in Patients With Type 2 Diabetes
Arterial calcification is an independent predictor of coronary events associated with a 3-4 fold increased risk of cardiovascular events. Currently, no effective intervention exists to reduce arterial calcification.
- Trial name
- Vitacal (NCT02839044)
- Testing
- Menaquinone-7
- Where
- Netherlands
- Volunteers
- 68 people
- Sponsor
- UMC Utrecht
Thromboembolism
Applying Pharmacogenetic Algorithms to Individualize Dosing of Warfarin
The purpose of this study is to determine whether DNA analysis improves the efficiency of dosing and safety in patients who are being started on warfarin therapy.Warfarin, a blood thinner (anticoagulant) prescribed to 1-2 million…
- Trial name
- Coumagen-II (NCT00927862)
- Testing
- IWPC adapted genotype-guided dosing algorithm for warfarin, Modified IWPC genetic-guided warfarin dosing algorithm, Standard of care treatment
- Where
- United States
- Volunteers
- 2,415 people
- Sponsor
- Intermountain Health Care, Inc.
Obesity, Insulin Resistance
Vitamin K and Glucose Metabolism in Adults at Risk for Diabetes (Vita-K 'n' Adults Study)
Given that glutamate carboxylation or decarboxylation is key to the metabolic role of osteocalcin (at least in mouse models) and that carboxylation is vitamin K dependent, it is critical to isolate the effect of vitamin K…
- Conditions
- Obesity, Insulin Resistance, Insulin Sensitivity, Beta-Cell Dysfunction
- Trial name
- NCT02366481
- Testing
- Low-Dose Vitamin K2 Supplement (menaquinone-7; 90-mcg/d), High-Dose Vitamin K2 Supplement (menaquinone-7; 180-mcg/d)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Augusta University
Overweight and Obesity, Cardiometabolic Risk Factors
Effect of Vitamin K2 Over Osteocalcin, Leptin, Cytokines, and Cardiovascular Risk in Young Adults With Overweight and Obesity
The goal of this clinical trial is to compare de effect of vitamin K2 in young adults with overweight or obesity. The main questions to answer are: What is the effect of Vitamin K2 supplementation on methylation, serum…
- Trial name
- NCT05995522
- Testing
- Vitamin K2, Cornstarch
- Where
- Mexico
- Volunteers
- 51 people
- Sponsor
- University of Guadalajara
Vitamin K Deficiency, End Stage Renal Disease
The Effect of Vitamin K2 Supplementation on Arterial Stifness and Cardiovascular Events in PEritonial DIAlysis
VIKIPEDIA is a multi-centre, placebo-controlled, randomized, open-label intervention clinical trial on Peritoneal Dialysis (PD) patients.
- Conditions
- Vitamin K Deficiency, End Stage Renal Disease, Peritoneal Dialysis, Arterial Stiffness
- Trial name
- VIKIPEDIA (NCT04900610)
- Testing
- MenaQ7 ®, Nattopharma, ASA, Hovik, Norway
- Volunteers
- 120 people
- Sponsor
- Aristotle University Of Thessaloniki
Aortic Valve Stenosis, Aortic Valve Calcification
SLOW-Slower Progress of caLcificatiOn With Vitamin K2
A randomized 12-month trial will include two groups of 100 individuals aged over 50 years, with asymptomatic mild to moderate Aortic valve stenosis (AVA > 1 cm2, Vmax < 4 m/s).
- Conditions
- Aortic Valve Stenosis, Aortic Valve Calcification, Mitral Annular Calcification, Mitral Valve Calcification
- Trial name
- NCT04429035
- Testing
- Vitamin K2
- Where
- 2 sites in Greece
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Bioequivalence, Bioavailability
Bio-equivalence Study
The primary objective of this study is to compare absorption of vitamin K2 (menaquinone-7) after intake of three different vitamin K2 supplements.
- Trial name
- NCT01638143
- Testing
- MenaQ7 M-1500 capsules, Gnosis P-1000 capsules, Gnosis M-1500 capsules
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Atrial Fibrillation (AF)
Study to Gather Information About the Proper Dosing of the Oral FXIa Inhibitor BAY 2433334 and to Compare the Safety of the Study Drug to Apixaban, a Non-vitamin K Oral Anticoagulant (NOAC) in Patients With Irregular Heartbeat (Atrial Fibrillation) That Can Lead to Heart-related Complications.
The purpose of this study is to try to find the best dose of the new drug BAY 2433334 to give to participants and to look at how well BAY 2433334 works in patients with irregular heartbeat (atrial fibrillation) that can lead to…
- Trial name
- PACIFIC-AF (NCT04218266)
- Testing
- BAY2433334, Apixaban
- Where
- 93 sites in Austria, Belgium and 12 more
- Volunteers
- 755 people
- Sponsor
- Bayer
Osteoporosis, Osteopenia
A Pilot Study of Vitamin K2 (Menaquinone-7, Soloways ™) in Patients With Osteopenia/Osteoporosis Carrying a VDR Gene Variant
This pilot, genotype-stratified clinical trial aims to evaluate the safety and preliminary efficacy of vitamin K2 (menaquinone-7, MK-7) supplementation in patients with low bone mineral density (osteopenia or osteoporosis) who…
- Trial name
- NCT06867952
- Testing
- Vitamin K2 plus vitamin D3
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- S.LAB (SOLOWAYS)
Muscle Atrophy, Cachexia
Vitamin K2 Supplements for Muscle Recovery
Ankle injury is one of the most common injuries which can have long term consequences. Ankle immobilization is often applied for up to six weeks to ensure healing of the soft tissue and fractured bones after such an injury.
- Trial name
- Recovery (NCT05161975)
- Testing
- Vitamin K2
- Where
- 2 sites in Lithuania
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lithuanian Sports University
Diabete Type 2
Vitamin K2 and Muscle Weakness in Type 2 Diabetes
The aim of the current study is to determine the effects of vitamin K2 supplementation on muscle size and function in adults with muscle weakness and type 2 diabetes.
- Trial name
- SARK2 (NCT05375630)
- Testing
- Vitamin K2
- Where
- Kuwait
- Volunteers
- 150 people
- Sponsor
- Dasman Diabetes Institute
Atrial Fibrillation
Oral Anticoagulation in Hemodialysis
The investigators refer to the trial with clinicaltrials.gov indentifier NCT02610933 entitled Effect on Vascular Calcification of Replacing Warfarin by Rivaroxaban With or Without VitK2 in Hemodialysis Patients.
- Trial name
- NCT03799822
- Testing
- Rivaroxaban 10 MG Oral Tablet, MK-7 2000µg thrice weekly, Vitamin K Antagonist - Drug
- Where
- Belgium
- Volunteers
- 132 people
- Sponsor
- Onze Lieve Vrouw Hospital
Vascular Calcifications
Risk Factors for Vascular Calcifications in Hemodialysis Patients: to What Extent is Vitamin K2 Deficiency Involved?
Vitamin K2 deficiency has been shown to be profound in hemodialysis patients. It is reflected by high plasma levels of dephosphorylated-undercarboxylated Matrix Gla protein (dp-ucMGP) and seems to be correlated with vascular…
- Trial name
- NCT02876354
- Testing
- Menaquinone
- Where
- Lebanon
- Volunteers
- 50 people
- Sponsor
- Saint-Joseph University
Valvular Heart Disease
RIvaroxaban for Valvular Heart diseasE and atRial Fibrillation Trial -RIVER Trial
RIvaroxaban for Valvular heart diseasE and atRial fibrillation trial (RIVER trial).
- Trial name
- NCT02303795
- Testing
- Rivaroxaban, Warfarin
- Where
- Brazil
- Volunteers
- 1,005 people
- Sponsor
- Hospital do Coracao
Infant Vitamin K Status, Vitamin K Deficiency Bleeding
The OK Daily Study
The OK Daily Study is a multi-centred, part-randomised, part blinded, four cohort study. We are exploring daily dietary supplementation with vitamin K2, specifically menaquinone-7 (MK-7), given to breastfed infants or…
- Trial name
- NCT07620236
- Testing
- Combined MK-7 + vitamin D3 drops, Vitamin D3 Drops, MK-7 capsules
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Norfolk and Norwich University Hospitals NHS Foundation Trust