Clinical trials: Vitamin K 2
Vascular Calcification, Systemic and Arterial Stiffness
Treatment to Reduce Vascular Calcification in Hemodialysis Patients Using Vitamin K
The proposed study will seek to evaluate the prevalence and the progression of vascular calcification in a cohort of maintenance hemodialysis patients in Asian population.
- Conditions
- Vascular Calcification, Systemic and Arterial Stiffness, Complication of Hemodialysis, Deficiency of Vitamin K2
- Trial name
- TReVasc-HDK (NCT02870829)
- Testing
- menaquinone-7
- Where
- Singapore
- Volunteers
- 178 people
- Sponsor
- National University Health System, Singapore
Aortic Valve Stenosis, Multidetector Computed Tomography
The Aortic Valve DECalcification (AVADEC) Trial
Aortic stenosis is a common heart valve disease and due to the growing elderly population the prevalence is increasing. The disease is progressive with increasing calcification of the valve cusps.
- Conditions
- Aortic Valve Stenosis, Multidetector Computed Tomography, Vitamin K 2, Randomised Clinical Trial
- Trial name
- AVADEC (NCT03243890)
- Testing
- Menaquinone-7 720 µg/day including the recommended daily dose of vitamin D (25 µg/day).
- Where
- Denmark
- Volunteers
- 389 people
- Sponsor
- Axel Diederichsen
Diabetes Mellitus
Vitamin D, K2 Plus Empagliflozin Combination in Type Two Diabetes Mellitus
The main purpose of the VETA trial is to verify the potential beneficial effects of the combination of micronutrients namely Vitamin D3 and K2 in combination with oral antihyperglycemic Empagliflozin in Diabetes Mellitus
- Trial name
- VETA (NCT05417880)
- Testing
- Oral Hypoglycemic Agents,Oral, Voreta, Voreta plus SunnyD PRO
- Where
- Pakistan
- Volunteers
- 340 people
- Sponsor
- Scotmann Pharmaceuticals
Chronic Kidney Diseases
Role of Vitamin K2 in Chronic Kidney Disease
This randomized placebo controlled double blind parallel clinical study will be conducted on 44 non-dialysis chronic kidney disease (CKD) patients (Stages 2-3b).Clinical Study Evaluating the Role of Vitamin K2 as Adjuvant Therapy…
- Trial name
- NCT05942053
- Testing
- Vitamin K 2
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Tanta University
Bone Loss, Arteriosclerosis
Beneficial Effects of Long Term Menaquinone-7
From all K-vitamins, menaquinone-7 (MK-7) has been identified now as the most effective cofactor for the carboxylation reaction of Gla-proteins such as osteocalcin (in bone) and matrix-Gla protein (in the arterial vessel wall).
- Trial name
- NCT00642551
- Testing
- menaquinone-7
- Where
- Netherlands
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Vascular Calcifications
Risk Factors for Vascular Calcifications in Hemodialysis Patients: to What Extent is Vitamin K2 Deficiency Involved?
Vitamin K2 deficiency has been shown to be profound in hemodialysis patients. It is reflected by high plasma levels of dephosphorylated-undercarboxylated Matrix Gla protein (dp-ucMGP) and seems to be correlated with vascular…
- Trial name
- NCT02876354
- Testing
- Menaquinone
- Where
- Lebanon
- Volunteers
- 50 people
- Sponsor
- Saint-Joseph University
Skin Aging of Face and Neck
The Skin Anti-Aging Effects of Vitamin K2 (MK-7): a Clinical Split-Face/Neck Trial
The goal of this clinical trial is to evaluate the efficacy of a facial and neck cream containing Vitamin K2 in improving skin hydration, elasticity, firmness, and reducing wrinkles in 36 female participants aged 35-60 years with…
- Trial name
- NCT07403942
- Testing
- Face-and-Neck Cream (with 0.05% Vitamin K2)
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Nanjing Ascend Biotech Technology Co., Ltd.
Vascular Stiffness
Vitamin K2 Effect on Vascular Stiffening in Subjects With a Poor Vitamin K-status
Vitamin K is required for the activation of the inhibitor of vascular calcification: Matrix Gla Protein (MGP). In an earlier study the beneficial effect of menaquinone-7 (MK-7), a vitamin K2 form, was observed on the stiffness of…
- Trial name
- NCT02404519
- Testing
- Menaquinone-7
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Carboxylation Level, Vitamin K-dependent Proteins
Comparison of Efficacy of Different Dosages Vitamin K2
Vitamin K is a group name for a number of compounds: K1 is present in chloroplasts in green vegetables, K2 is of microbial origin.
- Trial name
- NCT01194778
- Testing
- vitamin K1, vitamin K2
- Where
- Netherlands
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Healthy
Safety Study of Vitamin K2 During Anticoagulation in Human Volunteers
Oral anticoagulants that are widely used for the treatment of thrombo-embolic disease exert their effect by blocking the recycling of vitamin K.
- Trial name
- NCT00512928
- Testing
- acenocoumarol, menaquinone-7
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Inflammation, Oxidative Stress
viTAmin K2 and rEcOVery From ExeRcise
The aim of the current study, therefore, is to investigate the effects of vitamin K2 supplementation on the physiological responses to an acute bout of resistance exercise.
- Conditions
- Inflammation, Oxidative Stress, Vitamin K, Exercise
- Trial name
- TAKEOVER (NCT04676958)
- Testing
- Vitamin K2, Micro-crystalline cellulose
- Where
- 2 sites in United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Overweight and Obesity, Cardiometabolic Risk Factors
Effect of Vitamin K2 Over Osteocalcin, Leptin, Cytokines, and Cardiovascular Risk in Young Adults With Overweight and Obesity
The goal of this clinical trial is to compare de effect of vitamin K2 in young adults with overweight or obesity. The main questions to answer are: What is the effect of Vitamin K2 supplementation on methylation, serum…
- Trial name
- NCT05995522
- Testing
- Vitamin K2, Cornstarch
- Where
- Mexico
- Volunteers
- 51 people
- Sponsor
- University of Guadalajara
Kidney Diseases, Coronary Artery Calcification
Vitamin K2 and Vessel Calcification in Chronic Kidney Disease Patients
Vessel calcification is a recognised cardiovascular morbidity risk factor in patients with chronic kidney disease (CKD). Recent reports indicate a significant role of Matrix Gla-protein (MGP) in decreasing calcification…
- Trial name
- CACSK2 (NCT01101698)
- Testing
- Vitamin K2+10μg cholecalciferol, Vitamin D
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Medical University of Lodz
CKD 5D, Hemodialysis
Vitamin K2 Supplementation to Activate Matrix Gla Protein (MGP) as Endogenous Inhibitor of Vascular Calcification in Hemodialysis Patients
Vascular calcification (VC) is a predictor of cardiovascular morbidity and mortality. Hemodialysis (HD) patients suffer from severe vascular calcifications.
- Trial name
- NCT01407601
- Testing
- daily supplementation of MK-7 over 6 weeks
- Where
- 3 sites in Germany
- Volunteers
- 53 people
- Sponsor
- RWTH Aachen University
Vitamin K Supplementation, Endstage Renal Disease
Effect of Vitamin K2 (MK7) on Cardiovascular and Bone Disease in Dialysis Patients
Cardiovascular disease (CVD) is the most frequent cause of death in patients (ptt.) with chronic kidney disease (CKD). Compared to the general population death due to CVD is 10-20 times higher in CKD ptt.
- Conditions
- Vitamin K Supplementation, Endstage Renal Disease, Cardiovascular Disease, Bone Disease
- Trial name
- RenaKvit (NCT02976246)
- Testing
- Vitamin K2 (MK7)
- Where
- Denmark
- Volunteers
- 123 people
- Sponsor
- Zealand University Hospital
Nocturnal Leg Cramps
Effect of Vitamin K2 in the Treatment of Nocturnal Leg Cramps in Older Population
Nocturnal leg cramps (NLCs) are sudden contractions of the leg muscles, usually in the posterior calf muscles at night, affecting sleep quality.
- Trial name
- NCT05547750
- Testing
- Vitamin K2
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The Third People's Hospital of Chengdu
Vitamin K Deficiency, End Stage Renal Disease
The Effect of Vitamin K2 Supplementation on Arterial Stifness and Cardiovascular Events in PEritonial DIAlysis
VIKIPEDIA is a multi-centre, placebo-controlled, randomized, open-label intervention clinical trial on Peritoneal Dialysis (PD) patients.
- Conditions
- Vitamin K Deficiency, End Stage Renal Disease, Peritoneal Dialysis, Arterial Stiffness
- Trial name
- VIKIPEDIA (NCT04900610)
- Testing
- MenaQ7 ®, Nattopharma, ASA, Hovik, Norway
- Volunteers
- 120 people
- Sponsor
- Aristotle University Of Thessaloniki
End Stage Renal Disease on Dialysis
Comparative Study Evaluating the Effect of Vitamin K1 Versus Vitamin K2 on Vascular Calcification in Dialysis Patients
To evaluate the effect of supplementation of vitamin K2 (menaquinone, MK-7)vs vitamin k1 on circulating levels of calcification regulators and to assess their safety in patients on regular dialysis patients.
- Trial name
- NCT04477811
- Testing
- Vitamin K1, Vitamin k2
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Vitamin K-status, Vascular Health
Effects of Dairy on Vitamin K-status
In this study, the beneficial effect of a nutrient enriched dairy product will be investigated on vitamin K-status. To achive this benefit, the study product contains extra vitamin K2.
- Trial name
- NCT01672099
- Testing
- nutrient enriched product, basic dairy product
- Where
- Netherlands
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Bioequivalence, Bioavailability
Bio-equivalence Study
The primary objective of this study is to compare absorption of vitamin K2 (menaquinone-7) after intake of three different vitamin K2 supplements.
- Trial name
- NCT01638143
- Testing
- MenaQ7 M-1500 capsules, Gnosis P-1000 capsules, Gnosis M-1500 capsules
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center