Clinical trials: Vitiligo Vulgaris
Generalized Vitiligo
Comparing the Efficacy of Visible Light-Ultraviolet A1 Light Versus Narrowband-Ultraviolet B on Generalized Vitiligo
As part of this study, you may have a procedure called phototherapy which involves either VL-UVA or NB-UVB irradiation. NB-UVB phototherapy is not experimental in vitiligo, but use of VL-UVA1 phototherapy in vitiligo is.
- Trial name
- NCT05238077
- Testing
- Visible Light-Ultraviolet A Light or Narrowband-Ultraviolet B phototherapy
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Henry Ford Health System
Vitiligo
Vitiligo Treated With TL01 Combined With Tacrolimus Ointment Versus Placebo
BACKGROUND Vitiligo is a common, often distressing condition. Many of the patients do not achieve sufficient effect from what is regarded as the treatment of choice at present, narrow band(NB)UVB(Tl01).
- Trial name
- NCT00807690
- Testing
- Tacrolimus ointment
- Sponsor
- Oslo University Hospital
Vitiligo
Contribution of Skin Color in Stabilization of Active Cases of Vitiligo by Narrow Band UVB
Vitiligo is a disease in which autoimmunity plays a major role. Multiple treatment options are available, of which narrow-band UVB is a cornerstone, acting through immunosuppression and repigmentation by stimulating reservoir…
- Trial name
- NCT04030988
- Testing
- Oral dexamethasone minipulse
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Vitiligo, Pigmentation
Randomized, Split-body, Single-blinded Clinical Trial of NB-UVB Treatment for Vitiligo
The objective of this study is to assess the effectiveness and safety of narrowband-ultraviolet B (NB-UVB) treatment in adult subjects with vitiligo.
- Conditions
- Vitiligo, Pigmentation, Dyschromia
- Trial name
- NCT02506101
- Testing
- narrow-band ultraviolet B phototherapy
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Johns Hopkins University
Vitiligo
Feasibility Study to Evaluate RECELL and Melanocyte Keratinocyte Transplantation Procedure for Repigmentation of Stable Vitiligo Lesions
Prospective randomized within-subject controlled feasibility study to evaluate the clinical performance of RECELL for repigmentation of stable, depigmented lesions.
- Trial name
- NCT04271501
- Testing
- Melanocyte-Keratinocyte Transplantation and Ultraviolet Lamp (UVB), RECELL 1:5 and Ultraviolet Lamp (UVB), RECELL 1:10 and Ultraviolet Lamp (UVB)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Avita Medical
Leukoderma
Evaluation of Treatment for Leukoderma by Cellular Level Resolution Full-field Optical Coherence Tomography
OCT is an optical technology that emerged as a non-invasive skin imaging for the skin. In this protocol, the investigators plan to study the optical imaging features of leukoderma.
- Trial name
- NCT04935424
- Testing
- ApolloVue® S100 Image System (Apollo Medical Optics)
- Where
- Taiwan
- Volunteers
- 65 people
- Sponsor
- Chang Gung Memorial Hospital
Vitiligo - Evaluation of Methotrexate Iontophoresis and Topical Methotrexate Gel as Localized Treatment Approache
Methotrexate Iontophoresis Versus Methotrexate 1% Gel on Depigmentation in Vitiligo Patients
Vitiligo is a common autoimmune depigmenting disorder characterized by selective destruction of melanocytes. Methotrexate (MTX) has shown potential in stabilizing disease activity and promoting repigmentation; however, systemic…
- Trial name
- NCT07208890
- Testing
- Methotrexate Iontophoresis/a low-intensity electric current
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pharos University in Alexandria
Non-segmental Vitiligo
The Evaluation of Vitiligous Lesions Repigmentation After Topical Administration of Methotrexate in Patients With Active Vitiligo
The aim of this study is to evaluate the influence of two concentrations of methotrexate on vitiligous lesions in patients with non-segmental vitiligo
- Trial name
- EVRAM (NCT04942860)
- Testing
- 1% Methotrexate gel, 0.5% Methotrexate gel
- Where
- Poland
- Volunteers
- 25 people
- Sponsor
- Nicolaus Copernicus University
Vitiligo
Narrowband UVB Treatment in Patients With Vitiligo
The study offers narrowband UVB light therapy to patients who have 5% of their body involved with vitiligo. The hypothesis is that Narrowband UVB promotes melanocyte proliferation in vitiligo lesions.
- Trial name
- NCT00398723
- Testing
- Narrowband UVB
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mary Sullivan-Whalen
Pigmentation, Gingiva
Post Gingival Depigmentation Assessment: Comparison of Surgical Stripping vs (Er,Cr:YSGG) Laser
The appearance and health of the gingiva significantly contribute to an aesthetically pleasing smile. Pink gingiva indicates healthy gums and is generally preferred over dark or mixed colors.
- Trial name
- NCT06075641
- Testing
- Gingival depigmentation
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Vitiligo
Vitiligo Severity, Quality of Life, Work Productivity and Activity Impairment
translate and validate the vitiligo specific quality of life (VITIQOL) questionnaire to Arabic language. evaluate the effect of vitiligo on patient quality of life using vitiligo specific quality of life questionnaire (VitiQoL).
- Trial name
- NCT06877000
- Testing
- VITIQOL questionnaire
- Volunteers
- 400 people
- Sponsor
- Assiut University
Alopecia Areata, Vitiligo
A Pilot Cohort Study of Risk Factors and Novel Methods of Skin Lesion Assessments in Adults With Atopic Dermatitis, Alopecia Areata, Psoriasis or Vitiligo
The objective of the study is to explore various clinical and biochemical parameters and their potential associations with disease severity, activity, and prognosis in atopic dermatitis, psoriasis, alopecia areata, and vitiligo.
- Conditions
- Alopecia Areata, Vitiligo, Atopic Dermatitis, Psoriasis
- Trial name
- Derma-001 (NCT06319781)
- Testing
- Observational
- Where
- 3 sites in Denmark
- Volunteers
- 370 people
- Sponsor
- Blueskin AS
Alopecia Areata, Vitiligo
A Study of DR-01 in Subjects With Alopecia Areata and Vitiligo
This is a multi-center, parallel-group, open-label, randomized, Phase 1b study to explore the safety, clinical activity, pharmacokinetics and pharmacodynamics of DR-01 in adults with Alopecia Areata or Vitiligo.
- Trial name
- NCT06602232
- Testing
- DR-01
- Where
- 20 sites in United States, Australia and 1 more
- Volunteers
- 81 people
- Sponsor
- Dren Bio
Type 1 Diabetes, Autoimmune Diseases
Additional Autoimmune Diseases With Type 1 Diabetes in Pediatrics at Diabetes Diagnosis and During Follow-up
This study aims to describe the prevalence of additional autoimmune diseases and their specific antibodies at type 1 diabetes (T1D) diagnosis, and their incidence rate during follow-up, for children and adolescents.
- Conditions
- Type 1 Diabetes, Autoimmune Diseases, Hashimoto Disease, Graves Disease
- Trial name
- AADT1D (NCT04789993)
- Testing
- No intervention.
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Central Hospital, Nancy, France
Inherited Ophthalmic Diseases, Hypopigmentation Disorder
National Ophthalmic Genotyping and Phenotyping Network (eyeGENE (Registered Trademark)), Stage 3 - Expansion of DNA and Data Repositories for Rare Inherited Ophthalmic Diseases
Background: The eyeGENE (Registered Trademark) program is a research resource for inherited eye conditions which includes genotypic and phenotypic data, imaging, and a corresponding biobank of DNA samples from people with a…
- Conditions
- Inherited Ophthalmic Diseases, Hypopigmentation Disorder, Corneal Dystrophy, Blue-cone Monochromacy
- Trial name
- NCT06491615
- Where
- 2 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- National Eye Institute (NEI)
Vitiligo
A Clinical Trial of Multiple Doses of GR2301 Injection Combined With Phototherapy in Trial Participants With Vitiligo
This is a randomized, double-blind, placebo-controlled Phase Ib/II clinical trial of multiple subcutaneous injections of GR2301 in combination with phototherapy to evaluate the tolerability, safety, pharmacokinetics, and…
- Trial name
- GREVIT (NCT07647237)
- Testing
- GR2301 injection
- Volunteers
- 116 people
- Sponsor
- Genrix (Shanghai) Biopharmaceutical Co., Ltd.
Melanocyte, Vitiligo
The Mechanism of Melanocyte Self-Assembly on Biomaterials and the Functional Analysis
The aim of this study is to survey melanocytes in the ability of self-assembly on biomaterials and functional analysis in vitro.
- Trial name
- NCT00509314
- Testing
- melanocyte self-assembly and functional analysis
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- National Taiwan University Hospital
Vitiligo
Tissue-resident Memory T Cells Expression Among the Repigmentation Patterns Induced by NB-UVB Phototherapy in Vitiligo
Vitiligo is the most commonly acquired depigmentation disorder characterized by selective destruction of melanocytes resulting in well-circumscribed achromic macules.
- Trial name
- NCT05506995
- Where
- Mexico
- Volunteers
- 11 people
- Sponsor
- Universidad Autonoma de San Luis Potosí
Vitiligo
Evaluation of AMG 714 for Vitiligo
This study is designed to evaluate the efficacy of AMG 714 for the treatment of adult participants with vitiligo.
- Trial name
- REVEAL (NCT04338581)
- Testing
- AMG 714, nbUVB phototherapy
- Where
- 7 sites in United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Non-segmental Vitiligo
Phase 2 Study to Evaluate EI-001 in Non-segmental Vitiligo Patients
The primary purpose of this study is to evaluate whether the drug EI-001 can help improve vitiligo symptoms. EI-001 is a novel antibody drug that affects the immune system to decrease uncontrolled inflammation.
- Trial name
- NCT07223229
- Testing
- EI-001
- Where
- 8 sites in United States, Taiwan
- Volunteers
- 45 people
- Sponsor
- Elixiron Immunotherapeutics (Hong Kong) Ltd.