Clinical trials: Vitrectomy, active
Cataract, Vitreous Hemorrhage
Surgical Procedure Efficiency Evaluation stuDy
The purpose of this real-world evidence study is to compare surgical procedure times for UNITY® VCS and CONSTELLATION® Vision System.
- Conditions
- Cataract, Vitreous Hemorrhage, Retinal Detachment, Macular Pucker
- Trial name
- NCT07228091
- Testing
- UNITY VCS, CONSTELLATION
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- Alcon Research
Macular Hole
Outcomes of Macular Hole Surgery With Inverted Flap With vs Without Post op Posturing With SF6 in Macular Hole More Than 400 Micrometres
This study evaluated the outcomes of surgery for large full-thickness macular holes measuring more than 400 micrometres using the inverted internal limiting membrane flap technique with sulphur hexafluoride (SF6) gas tamponade.
- Trial name
- NCT07787390
- Testing
- Macular Hole Surgery With Inverted Internal Limiting Membrane Flap and SF6 Gas Tamponade, Face-Down Postoperative Positioning, No Face-Down Postoperative Positioning
- Where
- Pakistan
- Volunteers
- 52 people
- Sponsor
- Lahore General Hospital
Myopic Traction Maculopathy
Predictors of Vitrectomy Outcomes in Myopic Foveoschisis
This prospective pilot study evaluates factors that predict outcomes after vitrectomy for myopic foveoschisis (MFS), a sight-threatening complication of high myopia that can lead to progressive visual loss, foveal detachment…
- Trial name
- NCT07774637
- Testing
- pars plana vitrectomy
- Where
- Singapore
- Volunteers
- 30 people
- Sponsor
- Singapore National Eye Centre
Proliferative Diabetic Retinopathy (PDR)
Early Vitrectomy vs PRP in Early Proliferative Diabetic Retinopathy
The goal of this clinical trial is to learn whether early microincision vitrectomy surgery (MIVS) can improve retinal neovascularization outcomes compared to standard pan-retinal photocoagulation (PRP) in patients with early…
- Trial name
- NCT07586787
- Testing
- Microincision Vitrectomy Surgery, Panretinal Photocoagulation
- Where
- 6 sites in China
- Volunteers
- 100 people
- Sponsor
- Xiamen Ophthalmology Center Affiliated to Xiamen University
Proliferative Diabetic Retinopathy, Diabetic Retinopathy
Continuous Delivery of Ranibizumab Via the Port Delivery System for Proliferative Diabetic Retinopathy-related Vitreous Hemorrhage With Pars Plana Vitrectomy and Limited PRP.
In prolifertive diabetic retinopathy (PDR) eyes with bleeding known as vitreous hemorrhage (VH) requiring a surgical procedure to remove the vitreous, called a vitrectomy, we will determine if the benefit and safety of adding a…
- Conditions
- Proliferative Diabetic Retinopathy, Diabetic Retinopathy, Diabetes
- Trial name
- 4 PORT (NCT07864480)
- Testing
- PDS Implant filled with 100 mg/mL Ranibizumab, Ranibizumab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Southeast Retina Center, Georgia
Rhegmatogenous Retinal Detachment, Proliferative Vitreoretinopathy
Topical Netarsudil for the Prevention of Proliferative Vitreoretinopathy in Patients With Retinal Detachment
This study has two main objectives. The first objective is to study the pharmacokinetics of topical netarsudil administration in the posterior segment of the eye, where netarsudil must exert its effect in order to prevent…
- Trial name
- NCT06033703
- Testing
- Netarsudil Ophthalmic
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Diabetes Mellitus
Fovea Sparing ILM Peeling in Diabetic Patients
The goal of this clinical trial is to compare between foveal sparing ILM peeling and total ILM peeling in diabetic patients (both type 1 and II) with proliferative diabetic retinopathy (PDR) indicated for pars plana vitrectomy…
- Trial name
- NCT07271719
- Testing
- Pars plana vitrectomy (PPV) with fovea sparing ILM peeling., PPV with total ILM peeling
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- David Nashaat Shafik Fahmy
Epiretinal Membrane, Macular Edema (ME)
Minimal Vitrectomy Surgery for Epiretinal Membrane
This multicenter randomized controlled trial evaluates Minimal Vitrectomy Surgery (MVS) versus conventional vitrectomy for idiopathic epiretinal membrane (ERM).
- Conditions
- Epiretinal Membrane, Macular Edema (ME), Nuclear Cataract
- Trial name
- MVS-ERM (NCT07019896)
- Testing
- Minimal Vitrectomy Surgery, Conventional Vitrectomy
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Peking Union Medical College Hospital
Retinal Detachment Rhegmatogenous
Air Tamponade Versus Fluorinated Gas Tamponade for Rhegmatogenous Retinal Detachment
TITLE: RCT of air tamponade versus fluorinated gas tamponade for rhegmatogenous retinal detachment DESIGN: Non-inferiority RCT of 150 patients from 10 UK centres AIMS: To assess whether air tamponade is non inferior to gas…
- Trial name
- GREEN (NCT07034469)
- Testing
- air, Gas SF6 (Sulfur Hexafluoride) and others
- Volunteers
- 150 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Retinal Detachment
Impact of ILM Peeling in RRD/ I-Peel
Retinal detachment is associated with a substantial risk of re-detachment in 10-20% and to the formation of secondary epiretinal membranes in up to 15%.
- Trial name
- I-Peel (NCT04767555)
- Testing
- ILM (inner limiting membrane) peeling
- Where
- Switzerland
- Volunteers
- 250 people
- Sponsor
- Berner Augenklinik
Retinal Detachment
Spring Loaded Syringe for Active Silicon Oil Extraction
The aim of our study is to compare between two techniques used for active SOR. The outcomes include efficiency and safety. Patients with silicon filled eyes and prepared for SOR 540 eyes of 505 patients (one eye in 470 patients…
- Trial name
- NCT07363889
- Testing
- Vitrectomy machine, Spring loaded syringe
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Sohag University
Vitrectomy
Analgesic Effect and Safety of Oliceridine and Oxycodone in Vitrectomy
Traditional opioid analgesia is a method to treat moderate to severe pain. However, the use of opioids is not without risks. When treating acute pain, patients may have hypotension, respiratory depression, hypoxia, nausea and…
- Trial name
- NCT07097038
- Testing
- Oliceridine, Oxycodone
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Henan Provincial People's Hospital
Endophthalmitis, Infectious Endophthalmitis
Vitrectomy Combined With Povidone-Iodine Vitreous Irrigation for Infectious Endophthalmitis
Infectious endophthalmitis is a severe infection inside the eye that can rapidly cause permanent vision loss or loss of the eye.
- Trial name
- NCT07888205
- Testing
- Povidone-iodine intravitreal irrigation with povidone-iodine containing 0.0025% available iodine, BSS intravitreal irrigation solution
- Volunteers
- 38 people
- Sponsor
- Beijing Tongren Hospital
Retinal Detachment, Macular Hole
Head Position Monitoring After Pars Planar Vitrectomy
In ophthalmic surgical practice, particularly for treating retinal detachment and macular hole disorders, vitrectomy procedures are routinely performed to remove the vitreous body followed by the injection of tamponade agents…
- Trial name
- HPMPPV (NCT06985030)
- Testing
- gyroscope embedded eye-sheild
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Hospital
Epiretinal Membrane, Macular Oedema
Evaluation of Retinal Parameters in Patients With Epiretinal Membrane After Vitrectomy
The goal of this interventional study is to assess the dynamics of structural and functional retinal changes in eyes with epiretinal membrane (ERM) after pars plana vitrectomy (PPV).
- Conditions
- Epiretinal Membrane, Macular Oedema, Macular Diseases, Retinal Diseases
- Trial name
- NCT07165626
- Testing
- Subtreshold micropulse laser therapy, Pars plana vitrectomy
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Pomeranian Medical University Szczecin
Retina; Detachment, Rhegmatogenous
Head Positioning After Retina Detachment Repair
This study aims to determine if one day post-operative prone head positioning can be as good as seven days post-operative prone head positioning in patients with retinal detachments with inferior retinal breaks after pars that…
- Trial name
- NCT03714503
- Testing
- Retina re-attachment repair using C3F8 gas tamponade
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Kansas Medical Center
PDR - Proliferative Diabetic Retinopathy
The Preliminary Safety and Efficacy of RRG001 After Vitrectomy in Subjects With Proliferative Diabetic Retinopathy (PDR)
This study aims to slow down disease progression, reduce postoperative complications and decrease retreatment frequency in subjects with proliferative diabetic retinopathy (PDR) by administering a single subretinal injection of…
- Trial name
- NCT06412224
- Testing
- RRG001
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Li Xiaorong
Epiretinal Membranes, Retinal Detachment
Subjective Pain Scoring for Subtenonal Anesthesia During Vitrectomy
Subtenonal anesthesia is a well-known technique of local anesthesia for patients undergoing pars plana vitrectomies. It was described to be efficient with respect to anesthesia of the eye and it showed less risks compared to…
- Conditions
- Epiretinal Membranes, Retinal Detachment, Full Thickness Macular Hole
- Trial name
- NCT06830070
- Testing
- subjective pain score assessment
- Where
- Austria
- Volunteers
- 70 people
- Sponsor
- Prim. Prof. Dr. Oliver Findl, MBA
Macular Holes
Comparative Study of Decellularized Human Amniotic Membrane Hydrogel and Inverted Internal Limiting Membrane Flap in Idiopathic Large Macular Holes
The human amniotic membrane (hAM) patch, introduced by Rizzo et al. in 2018, showed a 100% anatomical success rate for large or failed macular holes over a 6-month follow-up.
- Trial name
- MACROHOLE (NCT06433284)
- Testing
- 25-gauge pars plana vitrectomy with inverted flap technique and SF6 tamponade, 25-gauge pars plana vitrectomy with complete internal limiting membrane peeling with amniotic membrane hydrogel filling and SF6 tamponade
- Where
- Thailand
- Volunteers
- 26 people
- Sponsor
- Walailak University
Eye Diseases, Macular Degeneration, Wet
Vitrectomy, Subretinal Tissue Plasminogen Activator (TPA) and Intravitreal Gas for Submacular Haemorrhage Secondary to Exudative (Wet) Age-related Macular Degeneration (TIGER).
The centre of the retina (macula) at the back of the eye contains cells that give us our central vision that we use for reading and recognising faces.
- Conditions
- Eye Diseases, Macular Degeneration, Wet, Sub-Macular Hemorrhage
- Trial name
- TIGER (NCT04663750)
- Testing
- Pars plana vitrectomy, Intravitreal 2 mg aflibercept will be injected at baseline then monthly for two further doses, then 2-monthly until month 12, subretinal injection of recombinant TPA (Alteplase) up to a maximum of 25 micrograms in 0.2 mls
- Where
- 42 sites in Germany, Ireland and 5 more
- Volunteers
- 210 people
- Sponsor
- King's College Hospital NHS Trust