Clinical trials: Vitreous Disorder
Choroidal Neovascularization
Evaluation of the Effect of Vitreous Composition Determined by Ultrasound and Optical Coherence Tomography (OCT) on Ranibizumab Therapy
The primary objective: *To measure the difference in the number of Ranibizumab therapies needed in 12 months in the Posterior Vitreous Detachment (PVD) positive and Posterior Vitreous Detachment (PVD) negative group.
- Trial name
- PVD (NCT01256632)
- Testing
- Ranibizumab
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Vision Research Foundation
Vitreous Detachment, Diabetic Retinopathy
Assessment of Intravitreous Injections of Vitrase for Inducing Posterior Vitreous Detachment
The purpose of this study is to assess the efficacy of intravitreous injections of Vitrase to induce posterior vitreous detachment(PVD) in subjects with moderate to severe non-proliferative diabetic retinopathy.
- Trial name
- NCT00198471
- Testing
- Vitrase
- Where
- 4 sites in United States
- Volunteers
- 10 people
- Sponsor
- Bausch & Lomb Incorporated
Diabetic Retinopathy, Glaucoma, Neovascular
Intravitreal Ranibizumab Injection as Adjuvant in the Treatment of Postvitrectomy Diabetic Vitreous Hemorrhage Accompanied by Neovascular Glaucoma
To determine the efficacy of intravitreal ranibizumab injection as adjuvant therapy in the treatment of postvitrectomy diabetic vitreous hemorrhage (PDVH) accompanied by neovascular glaucoma (NVG) as a means of preventing…
- Trial name
- NCT02647515
- Testing
- ranibizumab
- Volunteers
- 18 people
- Sponsor
- Ruijin Hospital
Senile Cataract, Epiretinal Membrane
Clareon Intraocular Lens Stability in Vitrectomy Patients: CLOVE Study
This prospective randomized controlled trial will be conducted to investigate Clareon intraocular lens (IOL) stability in vitrectomy patients. The investigator plans to target the patients undergoing cataract surgery.
- Conditions
- Senile Cataract, Epiretinal Membrane, Vitreous Hemorrhage
- Trial name
- NCT06383754
- Testing
- Clareon, Tecnis 1
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- The University of Hong Kong
Macular Edema Due to Diabetes Mellitus, Vitreous Hemorrhage
Comparison of Restoration in Vitreous Hemorrhage Patients With DME After or Not Removing Inner Limiting Membrane
This study is conducted to compare the anti-VEGF effect and visual function in vitreous hemorrhage patients with diabetic macular edema after pars plana vitrectomy with inner limiting membrane peeling or not
- Trial name
- NCT05529589
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Endophthalmitis, Cataract
Early Vitrectomy for Endophthalmitis After Cataract Surgery
Post-operative infectious endophthalmitis is devastating condition that causes a diffuse intraocular inflammation and may lead to blindness.
- Conditions
- Endophthalmitis, Cataract, Vitreous Detachment, Retinal Detachment
- Trial name
- NCT05249413
- Testing
- Early 23-gauge pars-plana vitrectomy
- Where
- Egypt
- Volunteers
- 11 people
- Sponsor
- Benha University
Proliferative Diabetic Retinopathy
Bevacizumab and Long Acting Gas in Diabetic Vitrectomy
Persistent or recurrent vitreous hemorrhage after vitrectomy for diabetic retinopathy complications is a common occurrence with an incidence of 12% to 63%.
- Trial name
- NCT00656435
- Testing
- Bevacizumab
- Where
- Taiwan
- Volunteers
- 16 people
- Sponsor
- National Taiwan University Hospital
Persistent Fetal Vasculature, Congenital Cataract
Congenital Cataract With Persistent Fetal Vasculature
To observe the clinical characteristics and surgical treatment of 24 cases of congenital cataract complicated with Persistent Fetal Vasculature (PFV) in 28 cases of congenital cataract in our hospital.
- Trial name
- NCT03341624
- Testing
- cataract surgery cataract extraction and intraocular implantation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Yune Zhao
Uveitis, Intermediate Uveitis
Safety Study of Suprachoroidal Triamcinolone Acetonide Via Microneedle to Treat Uveitis
This study is designed to determine the safety and tolerability of a single microinjection of triamcinolone acetonide (TRIESENCE®) into the suprachoroidal space (SCS) of patients who have non-infectious uveitis.
- Conditions
- Uveitis, Intermediate Uveitis, Posterior Uveitis, Panuveitis
- Trial name
- NCT01789320
- Testing
- triamcinolone acetonide (Triesence®)
- Where
- 3 sites in United States
- Volunteers
- 11 people
- Sponsor
- Clearside Biomedical, Inc.
Recurrent, Hemorrhage
Adjuvant Intravitreal Bevacizumab in Pars Plana Vitrectomy for Diabetic Vitreous Hemorrhage
Postoperative vitreous hemorrhage is a common complication after vitrectomy for proliferative diabetic retinopathy. There have been efforts to lower the incidence of postoperative vitreous hemorrhage such as preoperative…
- Trial name
- ABeVi (NCT01151722)
- Testing
- bevacizumab injection
- Where
- Brazil
- Volunteers
- 2 people
- Sponsor
- University of Sao Paulo
Diabetic Macular Edema
Evaluation of the Role of Intravitreal Tissue Plasminogen Activator in Treatment of Refractory Diabetic Macular Edema
Purpose: to evaluate the effect of intravitreal injection of tissue plasminogen activator(tPA) in treatment of refractory diabetic macular edema(DME).
- Trial name
- NCT01141881
- Testing
- Tissue Plasminogen Activator,bevacizumab ,follow up
- Where
- Iran
- Sponsor
- Mashhad University of Medical Sciences
Epiretinal Membrane, Macular Hole
UNITY VCS Vitreoretinal Surgery
This purpose of this study is to compare the safety and effectiveness of two eye surgery systems-UNITY VCS and CONSTELLATION-in treating adults with vitreoretinal diseases or disorders.
- Conditions
- Epiretinal Membrane, Macular Hole, Visually Significant Vitreous Floater, Vitreomacular Traction
- Trial name
- NCT07054281
- Testing
- UNITY Vitreoretinal Cataract System (VCS), CONSTELLATION Vision System, Vitreoretinal ophthalmic surgery
- Where
- 8 sites in United States
- Sponsor
- Alcon Research
Vitreomacular Adhesion
Prevalence of Vitreomacular Adhesion in Patients 40 Years and Older
The purpose of this study is to evaluate the prevalence of vitreomacular adhesion (VMA) in patients 40 years and older using Spectral Domain Optical Coherence Tomography.
- Trial name
- VAST (NCT02160340)
- Where
- 18 sites in United States
- Volunteers
- 1,584 people, healthy volunteers welcome
- Sponsor
- Nova Southeastern University
Proliferative Diabetic Retinopathy, Macular Degeneration
Analysis of Aqueous and Vitreous Humor
Clinical Retina research studies often collect aqueous samples in hopes of estimating levels of drug or cytokines in the vitreous. Little is known about how well vitreous and aqueous correlate.
- Conditions
- Proliferative Diabetic Retinopathy, Macular Degeneration, Macular Hole, Neovascular Glaucoma
- Trial name
- ARK (NCT02067013)
- Testing
- Ranibizumab, No Ranibizumab
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- California Retina Consultants
Optic Disc Pit Maculopathy
Vitrectomy for Optic Disc Pit Maculopathy
The purpose of this study is to evaluate the efficacy of vitrectomy, without gas tamponade or laser photocoagulation to the margin of the optic nerve, for the treatment of macular detachment associated with optic disc pits and to…
- Trial name
- NCT01340703
- Testing
- vitrectomy without laser or gas tamponade
- Where
- Japan
- Volunteers
- 8 people
- Sponsor
- Kyorin University
Visual Snow Syndrome, Migraine
Investigating Brain Function in People With and Without Visual Snow Syndrome Using Adaptation to Visual Stimuli
The goal of this study is to learn more about the brain pathways and activity involved in creating Visual Snow Syndrome (VSS). The main questions it aims to answer are: Does VSS arise from spontaneous activity in brain pathways?…
- Conditions
- Visual Snow Syndrome, Migraine, Healthy
- Trial name
- VPVSS (NCT06961864)
- Testing
- Visual Adaptation, Assessments and Questionnaires, Functional Magnetic Resonance Imaging (fMRI)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Abnormal Vitreous Humor Morphology, Abnormal Choroid Morphology
Accuracy of the Red Reflex Test in the Pediatric Population
This study is designed to investigate the sensitivity and specificity of the Red Reflex Test (RRT), with and without dilation, for early detection of ocular abnormalities in children and newborns.
- Conditions
- Abnormal Vitreous Humor Morphology, Abnormal Choroid Morphology, Optic Nerve Diseases, Retinal Disease
- Trial name
- NCT04125043
- Testing
- Direct ophthalmoscope
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Vitreous Hemorrhage, Proliferative Diabetic Retinopathy
Intravitreal Bevacizumab for Proliferative Diabetic Retinopathy
To evaluate the efficacy of intravitreal bevacizumab injections for treatment of proliferative diabetic retinopathy (PDR) with new dense vitreous hemorrhage (VH) after previous full panretinal photocoagulation (PRP).
- Trial name
- NCT01724385
- Testing
- intravitreal injection of bevacizumab
- Where
- Thailand
- Volunteers
- 18 people
- Sponsor
- Khon Kaen University