Clinical trials: Vocal Cord Disease
Vocal Cord Paralysis
Bilateral Laryngeal Paralysis Reinnervation
Bilateral laryngeal reinnervation induces a rise in laryngeal resistance and speech alteration. The aim of this study is to propose laryngeal reinnervation by a phrenic nerve root to patients with bilateral laryngeal paralysis.
- Trial name
- NCT00213616
- Testing
- surgical reinnervation
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Rouen
Dysphonia, Unilateral Vocal Cord Paralysis
The Effects of Adding Expiratory Muscle Strength Training in Voice Therapy
Evaluate if adding expiratory muscle strength training to traditional voice therapy for individuals with dysphonia due to glottal insufficiency improves maximal expiratory pressure, acoustic and aerodynamic measures (i.e.
- Trial name
- NCT03692494
- Testing
- Standard of care voice therapy, Expiratory muscle strength training (EMST)
- Where
- United States
- Sponsor
- University of Miami
Unilateral Vocal Cord Paralysis
The Function of Cricothyroid Muscle and Its Impaction on Mandarin Lexical Tones in Unilateral Vocal Fold Paralysis
Mandarin Chinese phonemically distinguishes four tones, with Tone 1 having high-level pitch, Tone 2 high-rising pitch, Tone 3 low-dipping pitch, and Tone 4 high-falling pitch The same segmental context carries different meanings…
- Trial name
- NCT02184377
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Chang Gung Memorial Hospital
Unilateral Vocal Cord Paralysis
Establish Quantitative Measurements of Laryngeal Sensorimotor Functions and Evaluating the Grade of Phonation and Swallowing Impairment
Laryngeal motor and sensory nerve dysfunction may cause phonation and swallowing disturbance, which often happens after the treatment for laryngopharyngeal and esophageal cancer and may induce fatal complications such as…
- Trial name
- NCT02243722
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- Chang Gung Memorial Hospital
Unilateral Vocal Cord Paralysis, Unilateral Vocal Cord Paresis
Recurrent Laryngeal Nerve Monitoring During Pediatric Aerodigestive Tract and Cardiac Surgery
This research studies whether a device used during surgery can help doctors better protect the nerve that moves a child's vocal cords. Damage to this nerve can affect speaking, swallowing, and sometimes breathing.
- Trial name
- NCT07604623
- Testing
- Intraoperative laryngeal nerve monitor
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Laryngismus
Laryngeal Mask Airway (LMA) Insertion With Sevoflurane and Remifentanil
The purpose of this study was to determine the most suitable effect-site concentration of remifentanil for the LMA insertion during inhaled induction with 8% sevoflurane in adults.
- Trial name
- NCT01456299
- Testing
- Remifentanil 1, Control, Remifentanil 2
- Where
- South Korea
- Volunteers
- 102 people
- Sponsor
- Gachon University Gil Medical Center
Vocal Cord Disease, Vocal Cord Cyst
Comparison of Flow Controlled Ventilation and Volume Controlled Ventilation
Flow-Controlled Ventilation is designed to ventilate the patient with constant flows during both inspiration and expiration. During inspiration, the pressure rises linearly from a set positive end-expiratory pressure (PEEP) to a…
- Trial name
- NCT06493162
- Testing
- Intubation, Flow Controlled Ventilation, Volume Controlled Ventilation
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Kocaeli University
Glottis Tumor, Larynx Cancer
VoiceS: Voice Quality After Transoral CO2-Laser Surgery Versus Single Vocal Cord Irradiation for Larynx Cancer
Laser surgery and radiotherapy are well-established standards of care for unilateral stage 0 \& I carcinoma in situ (Cais) and squamous cell carcinoma of glottic larynx (SCCGL).
- Trial name
- VoiceS (NCT04057209)
- Testing
- Single Vocal Cord Irradiation (SVCI), Arm A: Transoral CO2-Laser Microsurgical Cordectomy (TLM)
- Where
- 4 sites in France, India and 1 more
- Volunteers
- 34 people
- Sponsor
- Olgun Elicin
Vocal Cord Paralysis
Voice Rest and Injection Laryngoplasty
The purpose of this study is to evaluate the subjective, objective, and aerodynamic impact of voice rest following injection augmentation and compare the outcomes to patients with no post-procedure voice restrictions.
- Trial name
- NCT05542550
- Testing
- Voice Rest, No Voice Rest
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Vocal Cord; Injury, Superficial
Laryngeal Injuries After Removal of the Tracheal Tube: A Comparison Between Sevoflurane and Propofol
Vocal cord injuries occur not only during tracheal intubation, but also during surgery and during removal of tracheal tube. Volatile anesthetics increase neuromuscular block of muscle relaxants.
- Trial name
- NCT01616966
- Testing
- Sevoflurane, propofol
- Where
- Germany
- Volunteers
- 65 people
- Sponsor
- University of Rostock
Vocal Cord Dysfunction, Speech Disorders
Clinical Feasibility & Validation of the Virtual Reality GlenxRose Speech-Language Therapies
Factors related to successful rehabilitation are often directly related to adherence; for instance, dosage, frequency, and intensity can burden the patient regarding time and motivational factors.
- Trial name
- NCT05695131
- Testing
- GlenXRose Virtual Reality Speech Therapies
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Alberta
Cardiac Disease
Dysphagia and VFMI in Cardiac Patients
The proposed study seeks to determine the incidence of dysphagia and vocal fold mobility impairment (VFMI) in individuals undergoing cardiothoracic surgical procedures.
- Trial name
- NCT03768739
- Testing
- Fiberoptic Endoscopic Evaluation of Swallowing
- Where
- 3 sites in United States
- Volunteers
- 207 people
- Sponsor
- University of Florida
One Lung Ventillation (OLV)
Postoperative Vocal Cord Palsy Between Double-lumen Endobronchial Tube and Bronchial Blocker for Robot-assisted Esophagectomy
The goal of this clinical trial is to investigate whether the use of bronchial blocker could reduce the incidence of postoperative vocal cord palsy than the use of double-lumen endobronchial tube in robot-assisted esophagectomy.
- Trial name
- NCT06897501
- Testing
- bronchial blocker, double-lumen endobronchial tube
- Where
- South Korea
- Volunteers
- 202 people
- Sponsor
- Samsung Medical Center
Esophageal Squamous Cell Cancer (SCC), Recurrent Laryngeal Nerve Palsy
CT and Endoscopic Biopsy Image-Based Deep Learning for Predicting Left Recurrent Laryngeal Nerve Lymph Node Metastasis in Esophageal Cancer
The goal of this observational study is to develop a predictive model for left recurrent laryngeal nerve (RLN) lymph node metastasis using deep learning algorithms.
- Conditions
- Esophageal Squamous Cell Cancer (SCC), Recurrent Laryngeal Nerve Palsy, Deep Learning, Postoperative Complication
- Trial name
- NCT07074535
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Malignant Neoplasm of Thyroid Gland
Trial on Intraoperative Neuromonitoring (IONM) in Thyroid Cancer Surgery.
Scientific objectives: Primary objective: To assess if the use of IONM can decrease the rates of temporary RLN palsy after thyroid cancer surgery Secondary objectives: To assess if the use of IONM can decrease permanent RLN palsy…
- Trial name
- ACTION (NCT04842994)
- Testing
- IONM tube
- Where
- India
- Volunteers
- 448 people
- Sponsor
- Tata Memorial Hospital
Hemorrhage, Hypocalcemia
The No-Tie Technique Using the Harmonic Scalpel in Total Thyroidectomy With Central Neck Dissection: A Prospective Randomized Study
To investigate the safety and efficacy of the no-tie technique using the harmonic scalpel (HS) in terms of the operating time and complications in total thyroidectomy with central neck dissection (CND).
- Conditions
- Hemorrhage, Hypocalcemia, Vocal Cord Palsy
- Trial name
- NCT00506103
- Where
- South Korea
- Sponsor
- Soonchunhyang University Hospital
Intrathoracic Malignancies, Unilateral Vocal Cord Paralysis
Improving Functional Outcomes in Patients With Unilateral Vocal Cord Paralysis: Assessment of Adaptation Using Functional Magnetic Resonance Imaging
The purpose of this study is to see how the brain re-learns to control the larynx in speaking and swallowing when undergoing surgical rehabilitation in the form of either thyroplasty or vocal fold augmentation for unilateral…
- Trial name
- NCT00597844
- Testing
- voice evaluation and fMRI, undergo voice evaluation and fMRI prior
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Upper Aerodigestive Tract Neoplasms, Upper AerodigestiveTract Cancer
AI-Assisted Endoscopy for Upper Aerodigestive Tract Lesions
This is a prospective observational clinical study designed to evaluate the performance of artificial intelligence (AI) algorithms applied to upper aerodigestive tract (UADT) video-endoscopy.
- Conditions
- Upper Aerodigestive Tract Neoplasms, Upper AerodigestiveTract Cancer, Upper Aero-digestive Tract (UADT) Neoplasm, Squamous Cell Carcinoma
- Trial name
- H&NANCE (NCT07596355)
- Where
- 3 sites in Belgium, Italy and 1 more
- Volunteers
- 283 people
- Sponsor
- Istituto Italiano di Tecnologia
Evaluation of the Role of IONM in Minimally Invasive Parathyroidectomy Performed for Solitary Parathyroid Adenoma
Evaluation of the Role of Intraoperative Neuromonitoring(IONM) in Patients Undergoing Parathyroid Surgery for Solitary Parathyroid Adenoma
Aim: Intraoperative neuromonitoring (IONM) is frequently used in cases of primary hyperparathyroidism (pHPT); however, its role in cases of solitary parathyroid adenoma has not been clearly defined, and differing opinions exist…
- Trial name
- NCT07836335
- Testing
- INTRAOPERATIVE NEUROMONITORING
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Izmir Katip Celebi University
Aspiration Pneumonia
Dynamic Laryngotracheal Separation for Aspiration
People who aspirate after neurologic insults such as stroke often develop fatal pneumonia. This study examines the effects of dynamic vocal cord closure on swallowing.
- Trial name
- NCT00580346
- Testing
- Placement of laryngeal implant
- Where
- United States
- Sponsor
- University Hospitals Cleveland Medical Center