Clinical trials: Vocal Cord Paralysis
Bilateral Vocal Fold Paralysis (BVFP)
Laryngeal Pacing Study
Standard treatment options for patients who are diagnosed with BVFP include tracheostomy, cordotomy, arytenoidectomy, and suture tie-back.
- Trial name
- BVFP IDE (NCT03085316)
- Testing
- Investigational device
- Volunteers
- 2 people
- Sponsor
- Vanderbilt University Medical Center
Adults Patients Undergoing Major Lung Resection in the Context of Lung Cancer
Predictive Value of a Preliminary Swallowing Test Compared to Postoperative Nasofibroscopy to Identify Vocal Cord Paralysis After Pulmonary Resection
The literature describes recurrent nerve damage during thoracic surgery as a fairly complication (5 to 31% of patients). This nerve damage leads to paresis or paralysis of the ipsilateral vocal cord.
- Trial name
- SwaLO (NCT05193240)
- Testing
- preliminary swallowing test
- Where
- France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Rouen
Unilateral Vocal Cord Paralysis
The Function of Cricothyroid Muscle and Its Impaction on Mandarin Lexical Tones in Unilateral Vocal Fold Paralysis
Mandarin Chinese phonemically distinguishes four tones, with Tone 1 having high-level pitch, Tone 2 high-rising pitch, Tone 3 low-dipping pitch, and Tone 4 high-falling pitch The same segmental context carries different meanings…
- Trial name
- NCT02184377
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Chang Gung Memorial Hospital
Recurrent Paralysis of Vocal Cords
Efficacy of Oral Corticosteroid Therapy in Recurrent Paralyzes After Thyroidectomy
Thyroidectomy is a common surgical procedure in France. Recurrent paralysis is one of the main complications. Oral corticosteroid therapy are frequently used at a dosage of 1mg/kg for seven days, in case of recurrent paralysis to…
- Trial name
- NCT03553342
- Testing
- Corticoids
- Where
- France
- Volunteers
- 156 people
- Sponsor
- Poitiers University Hospital
Vocal Cord Paralysis
Implantation of Porous Titanium Prosthesis in Laryngeal Surgery
This study evaluates a medialization implant to treat vocal cord paralysis, to permit it to adjust the quality of the voice under local or general anesthesia.
- Trial name
- NCT00213863
- Testing
- Vocal fold medialization (thyroplasty) prosthesis by insertion of a new implant allowing very easy and quick setting
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Strasbourg, France
Bilateral Vocal Cord Paralysis
Performance of the SPIRION Laryngeal Pacemaker in BVFP Patients Without Glottal Enlargement
The goal of this clinical investigation is to learn about the use of a novel medical device, the SPIRION Laryngeal Pacemaker, in patients suffering from bilateral vocal fold paralysis (BVFP).
- Trial name
- NCT06007170
- Testing
- SPIRION Laryngeal Pacemaker System Implantation and follow-up
- Where
- 6 sites in Austria, Germany
- Volunteers
- 20 people
- Sponsor
- MED-EL Elektromedizinische Geräte GmbH
Voice Change, Hypocalcemia
The Use of Dexamethasone in Total Thyroidectomy to Improve Voice Outcome and Hypocalcaemia
Thyroidectomy is a standard procedure for benign and malignant pathologies of the thyroid gland. Each year, some 100 total thyroidectomies are performed in Kowloon East Cluster, Hospital Authority, Hong Kong.
- Trial name
- NCT05732883
- Testing
- Dexamethasone, Normal saline
- Where
- Hong Kong
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tseung Kwan O Hospital, Hong Kong
Unilateral Vocal Cord Paralysis
Non-phonatory Exercises in Patients with Unilateral Vocal Fold Paralysis Post-thyroidectomy
Thyroidectomy is the most common iatrogenic cause of vocal fold paralysis. Patients complain of hoarseness caused by incomplete glottic closure and have effort to raise vocal intensity with consequent elevation of the larynx…
- Trial name
- ENFP (NCT05963165)
- Testing
- Non-phonatory exercises
- Where
- Italy
- Volunteers
- 56 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Unilateral Vocal Cord Paralysis, Vocal Cord Atrophy
Outcomes Tracking in Unilateral Vocal Fold Paralysis (UVFP) and Atrophy After Medialization Laryngeal Surgery
The goal of this observational study is to learn about the long-term outcomes of Laryngeal Framework Surgery (LFS) in patients with Unilateral Vocal Fold Paralysis (UVFP) or Vocal Fold Atrophy (VFA).
- Trial name
- NCT07579364
- Testing
- Laryngeal Framework Surgery
- Where
- 10 sites in United States
- Volunteers
- 500 people
- Sponsor
- University of California, San Francisco
Bilateral Vocal Fold Paralysis (BVFP)
Functional Electrical Stimulation of the Bilaterally Paralyzed Human Larynx
The primary purpose of this project is to evaluate the safety of new treatment termed bilateral laryngeal pacing to improve treatment outcomes in patients with bilateral vocal fold paralysis (BVFP) (Aim 1).
- Trial name
- NCT04028674
- Testing
- Laryngeal Pacing Device
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Vanderbilt University Medical Center
Recurrent Laryngeal Nerve Palsy, Postoperative Dysphonia
Post Thyroidectomy Echographic Method for Study of Vocal Fold Motion
One of the major risks of endocrine surgery is recurrent nerve palsy (RNP), leading to vocal folds (VF) immobility. It happens in 5% of cases, leading to high morbidity: dysphonia, aspirations, impossibility to work.
- Trial name
- VOCALE (NCT03976011)
- Testing
- Transcutaneous Laryngeal Ultrasonography
- Where
- 5 sites in France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Thyroidectomy, Paralysis of Vocal Cords
Performance of Ultrasound in the Early Diagnosis of Vocal Cords Paralysis
Thyroid and parathyroid surgery concerns around 50 000 patients a year in France. One of its main complications is paralysis of vocal cords, and the consequences can be serious.
- Trial name
- PECV (NCT03727217)
- Testing
- Pre and postoperative ultrasound
- Where
- France
- Volunteers
- 113 people
- Sponsor
- Lille Catholic University
Vocal Cord Paralysis
Whole Genome Scan of Extended Families With Familial Vocal Cord Paralysis
Vocal cord paralysis is a common cause of congenital stridor and airway obstruction. In this study we plan to identify the genetic locus of the genes in two extended families who suffer of the disease.
- Trial name
- NCT00382369
- Where
- Israel
- Volunteers
- 11 people
- Sponsor
- Hadassah Medical Organization
Evaluation of the Role of IONM in Minimally Invasive Parathyroidectomy Performed for Solitary Parathyroid Adenoma
Evaluation of the Role of Intraoperative Neuromonitoring(IONM) in Patients Undergoing Parathyroid Surgery for Solitary Parathyroid Adenoma
Aim: Intraoperative neuromonitoring (IONM) is frequently used in cases of primary hyperparathyroidism (pHPT); however, its role in cases of solitary parathyroid adenoma has not been clearly defined, and differing opinions exist…
- Trial name
- NCT07836335
- Testing
- INTRAOPERATIVE NEUROMONITORING
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Izmir Katip Celebi University
Unilateral Vocal Cord Paralysis, Central Auditory Processing Disorder
Early UVFP Management Based on Neurological Evidences (ION-UVFP) - Preliminary Study
The purpose of this preliminary study is to help clarify our hypotheses for the longitudinal study by investigating the relationship between vocal cord paralysis and central auditory processes and thus the interpretation of…
- Trial name
- NCT03966183
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
One Lung Ventillation (OLV)
Postoperative Vocal Cord Palsy Between Double-lumen Endobronchial Tube and Bronchial Blocker for Robot-assisted Esophagectomy
The goal of this clinical trial is to investigate whether the use of bronchial blocker could reduce the incidence of postoperative vocal cord palsy than the use of double-lumen endobronchial tube in robot-assisted esophagectomy.
- Trial name
- NCT06897501
- Testing
- bronchial blocker, double-lumen endobronchial tube
- Where
- South Korea
- Volunteers
- 202 people
- Sponsor
- Samsung Medical Center
Vocal Cord Paralysis
Voice Rest and Injection Laryngoplasty
The purpose of this study is to evaluate the subjective, objective, and aerodynamic impact of voice rest following injection augmentation and compare the outcomes to patients with no post-procedure voice restrictions.
- Trial name
- NCT05542550
- Testing
- Voice Rest, No Voice Rest
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Herpes Esophagitis, Vocal Fold Palsy
Unusual Clinical Findings of Herpes Esophagitis
Herpes esophagitis presents a clinical diagnostic challenge. The investigators report the first case of herpes esophagitis presenting as vocal fold palsy in an immunocompetent host.
- Trial name
- NCT01501526
- Where
- Taiwan
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Hemorrhage, Hypocalcemia
The No-Tie Technique Using the Harmonic Scalpel in Total Thyroidectomy With Central Neck Dissection: A Prospective Randomized Study
To investigate the safety and efficacy of the no-tie technique using the harmonic scalpel (HS) in terms of the operating time and complications in total thyroidectomy with central neck dissection (CND).
- Conditions
- Hemorrhage, Hypocalcemia, Vocal Cord Palsy
- Trial name
- NCT00506103
- Where
- South Korea
- Sponsor
- Soonchunhyang University Hospital
Dysphonia, Unilateral Vocal Cord Paralysis
The Effects of Adding Expiratory Muscle Strength Training in Voice Therapy
Evaluate if adding expiratory muscle strength training to traditional voice therapy for individuals with dysphonia due to glottal insufficiency improves maximal expiratory pressure, acoustic and aerodynamic measures (i.e.
- Trial name
- NCT03692494
- Testing
- Standard of care voice therapy, Expiratory muscle strength training (EMST)
- Where
- United States
- Sponsor
- University of Miami