Clinical trials: Voice Disorders, open to volunteers
Pain, Anxiety
Active vs. Passive VR During Office-based ENT Procedures
The purpose of this research is to evaluate whether active virtual reality reduces pain and anxiety more effectively than passive virtual reality during office-based ENT procedures.
- Conditions
- Pain, Anxiety, Chronic Rhinosinusitis (CRS), Nasal Obstruction
- Trial name
- NCT07599826
- Testing
- Passive virtual reality headset or goggles, Active virtual reality headset or goggles
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Cedars-Sinai Medical Center
Long COVID
Development of Voice Biomarkers of Frequent COVID-19 and Long Covid-related Symptoms Based on Data From Users of the Long COVID Companion App
The LIH DDP research team focuses its research topics on vocal biomarkers and Long COVID, among others. Voice is indeed a promising tool to monitor health, as it contains many information on our health and is easy to collect.
- Trial name
- EVO-LC (NCT07156994)
- Testing
- No Intervention: Observational Cohort
- Where
- Luxembourg
- Volunteers
- 300 people
- Sponsor
- Luxembourg Institute of Health
Postoperative Sore Throat, Hoarseness
A Randomized, Comparative, Controlled Study of Differences in the Incidence of Postoperative Sore Throat (POST) by Inner Diameter Size of the TaperGuardTM Endotracheal Tube (ETT)
Postoperative sore throat (POST) is a common complication following general anesthesia involving endotracheal intubation, often leading to decreased patient satisfaction.
- Trial name
- NCT07511998
- Testing
- TaperGuard™ Endotracheal Tube
- Where
- South Korea
- Volunteers
- 246 people
- Sponsor
- Kyungpook National University Chilgok Hospital
Prevention of Voice Disorders in Professional Voice Users, Treatment of Functional Voice Disorders in Professional Voice Users
Efficacy of Flow Ball Phonation in Professional Voice Users
The aim of this study is to investigate the effects of flow ball phonation on the voice of professional voice users and elite vocal performers, both with and without functional voice disorders.
- Trial name
- NCT06960772
- Testing
- Flow Ball Intervention, Straw Phonation Intervention
- Where
- Belgium
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University Ghent
Kidney Failure, Chronic Therapy; Hemodialysis
Web-based Advance Care Planning Intervention for Patients With Kidney Failure on Dialysis: Pilot Testing of 'My Voice'
'My Voice' is a website intervention developed to enable advance care planning (ACP) conversations for patients with kidney disease on dialysis, educate patients on their illness, help identify their goals and preferences for EOL…
- Trial name
- NCT07309367
- Testing
- My Voice website intervention with patient and caregiver modules
- Where
- Singapore
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Duke-NUS Graduate Medical School
Laryngeal Dystonia, Focal Dystonia
Effects of Neuromodulation in Laryngeal Dystonia
Laryngeal dystonia (LD) causes excessive vocal fold abduction (opening) or adduction (closing) leading to decreased voice quality, job prospects, self-worth and quality of life.
- Trial name
- NCT05095740
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- MGH Institute of Health Professions
Auditory Hallucination, Psychotic Disorders
Avatar-mediated Therapy Versus Cognitive Behavioural Therapy for Persisting Experiences of Hearing Voices
The aim of this study is to compare the effects of a new psychological therapy, Avatar Therapy, to the current standard therapy, Cognitive Behavioural Therapy (CBT), in improving outcomes in people living with psychotic disorders…
- Conditions
- Auditory Hallucination, Psychotic Disorders, Schizophrenia and Related Disorders
- Trial name
- AMETHYST (NCT05982158)
- Testing
- Avatar therapy, Cognitive behavioural therapy (CBT)
- Where
- Australia
- Volunteers
- 212 people
- Sponsor
- Swinburne University of Technology
Laryngeal Dystonia, Adductor Spastic Dysphonia of Dystonia
Deep Brain Stimulation for Laryngeal Dystonia: From Mechanism to Optimal Application
Deep Brain Stimulation (DBS) is a neurosurgical procedure used to treat tremors, and dystonia. This study will enroll people who have a form of focal dystonia that affects their vocal cords called Adductor Laryngeal dystonia…
- Trial name
- NCT05506085
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Indiana University
Head and Neck Squamous Cell Carcinoma, HPV-Negative Squamous Cell Carcinoma
Ficerafusp Alfa, Pembrolizumab, and Stereotactic Body Radiotherapy (SBRT) for Head and Neck Squamous Cell Carcinoma (HNSCC)
The study is an open-label phase I/II clinical trial. The study will enroll patients to receive neoadjuvant SBRT plus 1 or 2 doses of neoadjuvant pembrolizumab with concurrent ficerafusp alfa (4 doses) prior to definitive…
- Trial name
- NCT07552558
- Testing
- Hypofractionated Stereotactic Body Radiotherapy (SBRT), Pembrolizumab, Ficerafusp alfa
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Washington University School of Medicine
Cardiovascular Diseases
A Study of Mayo Clinic CV Research Heart & Voice Study
The purpose of the study is to determine whether voice recordings acquired from patient-owned Android and Apple (iOS) smartphones can be used to monitor cardiovascular health.
- Trial name
- NCT07224685
- Testing
- Voice Recording
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Traumatic Brain Injury, Stroke
Long-term Brain Stimulation of the Motor Ventral Thalamus (VOP/VIM) to Improve Motor Function
This study aims to recruit patients already implanted with Deep Brain Stimulation (DBS) for movement disorders to complete tasks assessing parameters of motor output, speech, and swallowing functions, both with and without…
- Conditions
- Traumatic Brain Injury, Stroke, Brain Disease, Movement Disorders (Incl Parkinsonism)
- Trial name
- NCT07056348
- Testing
- Deep Brain Stimulation (DBS) of the Motor Thalamus
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jorge Gonzalez-Martinez
Laryngeal Cancer, Hypopharyngeal Cancer
The Voice as a Tool to Detect Recurrence of Laryngeal and Hypopharyngeal Cancer
The investigators will obtain three-monthly voice recordings and fiberendoscopic examinations of the larynx/hypopharynx for a minimal period of 6 months from all laryngeal/hypopharyngeal squamous cell carcinoma (LSCC/HPSCC)…
- Trial name
- VoiceDetect (NCT05894070)
- Testing
- Voice recording, ENT (Ear, Nose and Throat) examination including transnasal fiberendoscopy, and VHI-30-questionnaire
- Where
- 2 sites in Switzerland
- Volunteers
- 100 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Glottis Tumor, Larynx Cancer
VoiceS: Voice Quality After Transoral CO2-Laser Surgery Versus Single Vocal Cord Irradiation for Larynx Cancer
Laser surgery and radiotherapy are well-established standards of care for unilateral stage 0 \& I carcinoma in situ (Cais) and squamous cell carcinoma of glottic larynx (SCCGL).
- Trial name
- VoiceS (NCT04057209)
- Testing
- Single Vocal Cord Irradiation (SVCI), Arm A: Transoral CO2-Laser Microsurgical Cordectomy (TLM)
- Where
- 4 sites in France, India and 1 more
- Volunteers
- 34 people
- Sponsor
- Olgun Elicin
Voice Disorders, Voice Fatigue
Brain and Voice Signatures in Teachers
Primary muscle tension dysphonia voice disorder with symptoms of vocal strain and vocal fatigue is common and can have a significant negative impact on quality of Life.
- Trial name
- BRAVO1 (NCT06126627)
- Testing
- Stress induction
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Infant, Premature, Kangaroo Mother Care
Effect of Developmental Care on Comfort, Growth, and Oral Feeding Transition in Preterm Infants
This randomized controlled study aims to evaluate the effects of kangaroo care combined with maternal voice and fetal positioning on the comfort, growth, and transition to full oral feeding in preterm infants aged 30 to 34 weeks…
- Conditions
- Infant, Premature, Kangaroo Mother Care, Comfort, Feeding
- Trial name
- KCareInfant (NCT07045402)
- Testing
- Kangaroo Care + Maternal Voice + Fetal Position Group, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Fenerbahce University
Spasmodic Dysphonia, Singer's Dystonia
Brain Networks in Dystonia
To date, there is only limited knowledge about the distinct neural abnormalities that lead to the development of different forms of focal dystonia.
- Conditions
- Spasmodic Dysphonia, Singer's Dystonia, Writer's Cramp, Musician's Focal Hand Dystonia
- Trial name
- NCT03042962
- Testing
- MRI, Blood draw
- Where
- United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Perioperative Care, Pediatric Anesthesia
Giving Children a Voice in Paediatric Anaesthesia
This project will identify the research priorities for paediatric anaesthesia and perioperative medicine in participating countries and highlight areas where further research and information can be provided to optimise the…
- Conditions
- Perioperative Care, Pediatric Anesthesia, Pain Management, Anxiety
- Trial name
- TR-VP26 (NCT07524049)
- Where
- 7 sites in Switzerland
- Volunteers
- 1,040 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hallucinations, Auditory
Impact of EDEN College Courses on the Quality of Life of Voice-Hearers
The goal of this Mixed study, combining a randomized controlled trial and an Interpretative Phenomenological Analysis (IPA-qualitative study) is to evaluate the effects of the EDEN College courses on quality of life, compared…
- Trial name
- EDEN-RCT (NCT07694193)
- Testing
- EDEN College, TAU
- Where
- 8 sites in France
- Volunteers
- 240 people
- Sponsor
- Hôpital le Vinatier
Voice Fatigue, Voice Disorder
"Effects of EMST and Triflo on Voice Parameters and Vocal Fatigue"
A healthy voice is essential for meeting professional and communicative demands, particularly for professional voice users such as academics, who are at increased risk of voice disorders due to prolonged and intensive voice use…
- Conditions
- Voice Fatigue, Voice Disorder, Academic Voice Use and Voice Fatigue, Academician's Risk of Developing Voice Disorder
- Trial name
- NCT07371351
- Testing
- Triflo, EMST
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medipol University
Gastric Cancer, Hepatic Carcinoma
Laryngopharyngeal Injury After Endotracheal Intubation Under General Anesthesia
This study retrospectively analyzed patients who underwent tracheal intubation under general anesthesia at the First Affiliated Hospital of Zhejiang University School of Medicine between October 1, 2015, and September 30, 2025…
- Conditions
- Gastric Cancer, Hepatic Carcinoma, Pulmonary Carcinoma, Pancreatic Carcinoma
- Trial name
- NCT07359586
- Where
- 2 sites in China
- Volunteers
- 1,200 people
- Sponsor
- Zhejiang University