Clinical trials: Voice Hoarseness
Spasmodic Dysphonia, Voice Tremor
Voice Tremor in Spasmodic Dysphonia: Central Mechanisms and Treatment Response
The proposed research aims to determine brain abnormalities in patients with spasmodic dysphonia (SD) and voice tremor (VT) as the basis for characterization of central mechanisms underlying symptom improvement following the use…
- Trial name
- NCT01961297
- Testing
- Sodium oxybate
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Kristina Simonyan
Voice Disorders in Children, Vocal Nodules in Children
Effect of Semi-occluded Vocal Tract Therapy on the Phonation of Children With Vocal Fold Nodules
The goal of this clinical trial is to determine and compare the effects of different voice therapy programs in children with vocal fold nodules.
- Conditions
- Voice Disorders in Children, Vocal Nodules in Children, Hoarseness, Dysphonia
- Trial name
- NCT05878197
- Testing
- Straw phonation, Resonant voice therapy, Vocal Hygiene
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- University Hospital, Ghent
Spasmodic Dysphonia, Voice Tremor
Sodium Oxybate in Spasmodic Dysphonia and Voice Tremor
Using a comprehensive approach of clinico-behavioral testing, neuroimaging and pharmacogenetics, the researchers will examine the clinical effects of sodium oxybate and the matched placebo on voice symptoms in spasmodic dysphonia…
- Trial name
- NCT03292458
- Testing
- Sodium Oxybate
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Kristina Simonyan
Spasmodic Dysphonia
Zinc Supplementation Prior to Botox Injections for Spasmodic Dysphonia
One initial study has shown that Botulinum Toxin (BT) in combination with zinc supplementation may increase the duration of effects BT treatment. This initial study was in the context of facial aesthetics.
- Trial name
- NCT05892770
- Testing
- Zinc gluconate supplement, Botulinum toxin type A
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Florida
Adductor Spasmodic Dysphonia, Voice Disorders
DaxibotulinumtoxinA Injection for Treatment of Adductor Spasmodic Dysphonia
Spasmodic Dysphonia (SD) is a neurologic condition causing inappropriate contraction of the laryngeal musculature, leading to abnormal voicing.
- Conditions
- Adductor Spasmodic Dysphonia, Voice Disorders, Spasmodic Dysphonia
- Trial name
- NCT05158166
- Testing
- DaxibotulinumtoxinA
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of California, San Francisco
Spasmodic Dysphonia
Laryngeal Vibration for Spasmodic Dysphonia
The general aim of the research is to provide scientific evidence that vibro-tactile stimulation (VTS) represents a non-invasive form of neuromodulation that can induce measurable improvements in the speech of people with…
- Trial name
- SD-VTS (NCT03746509)
- Testing
- Laryngeal Vibration (Treatment), Laryngeal Vibration (Comparator)
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Spasmodic Dysphonia, Laryngeal Dystonia
Thalamic Deep Brain Stimulation for Spasmodic Dysphonia- DEBUSSY Trial
Laryngeal Dystonia (LD), also commonly referred to as spasmodic dysphonia, is a neurological voice disorder characterized by involuntary dystonic contractions of the laryngeal muscles.
- Conditions
- Spasmodic Dysphonia, Laryngeal Dystonia, Deep Brain Stimulation
- Trial name
- NCT02558634
- Testing
- VIM Thalamic Deep Brain Stimulation ON, VIM Thalamic Deep Brain Stimulation OFF
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- University of British Columbia
Sore-throat, Dysphonia
No Post Intubation Laryngeal Symptoms
The purpose of the study is to test a novel endotracheal tube support device that reduces pressure of the tube on the voice box for prevention of post intubation laryngeal symptoms including sore throat, change in voice and…
- Conditions
- Sore-throat, Dysphonia, Dysphagia, Intubation Complication
- Trial name
- No-PILS (NCT05383417)
- Testing
- EndoClip
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Dysphonia
Dietary Control Alone Versus Dietary Control Plus Use of Proton Pump Inhibitors to Treat Pediatric Hoarseness
This study will examine whether lansoprazole (Prevacid) and dietary control versus dietary control alone will improve pediatric hoarseness symptoms.
- Trial name
- NCT00637416
- Testing
- Lansoprazole
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Kansas Medical Center
Spasmodic Dysphonia, Adductor Spasmodic Dysphonia
Assessment of Laryngopharyngeal Sensation in Adductor Spasmodic Dysphonia
Study investigators have completed a study testing laryngopharyngeal sensation at specific laryngopharyngeal subsites using a novel buckling force aesthesiometer in a series of 22 healthy adults at this institution.
- Conditions
- Spasmodic Dysphonia, Adductor Spasmodic Dysphonia, Voice Disorders
- Trial name
- SDTT (NCT05158179)
- Testing
- Sensation testing
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of California, San Francisco
Anesthesia Intubation Complication, Tracheal Disease
The Effect of Prophylactic Ketorolac on Sore Throat After Thyroid Surgery
Sore throat is one of most frequent complaints related to general anesthesia with tracheal intubation. Although sore throat is regarded as a minor and short-lasting discomfort after surgery, its incidence and intensity in high…
- Trial name
- NCT02039427
- Testing
- Ketorolac, Dexamethasone
- Where
- South Korea
- Volunteers
- 192 people
- Sponsor
- Yeungnam University College of Medicine
Dysphonia
Investigation of the Role of Steroids in Enhancing Voice Therapy Outcomes
Despite the considerable use of oral steroids in the regular management of benign vocal fold lesions there is little evidence base in the literature.
- Trial name
- AAO (NCT02286960)
- Testing
- Steroid, Lactose Pills
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Laryngopharyngeal Reflux
Safety and Efficacy of Lansoprazole 30mg Twice Daily in Treatment of Laryngitis Associated With Gastroesophageal Reflux
The purpose of this study is to determine whether Lansoprazole 30mg taken twice daily is effective in the treatment of laryngitis due to gastroesophageal reflux.
- Trial name
- NCT00369265
- Testing
- Lansoprazole, Sugar pill
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- American Institute for Voice and Ear Research
Gastroesophageal Reflux Disease (GERD)
Retrospective TIF Study for Treatment of Gastroesophageal Reflux Disease (GERD). The RetroTIF Study
The purpose of this retrospective, open-label, post-market study is to evaluate the safety and efficacy of Transoral Incisionless Fundoplication (TIF) performed with EsophyX (brand name) in a broad range of GastroEsophageal…
- Trial name
- RetroTIF (NCT01327963)
- Testing
- Transoral Incisionless Fundoplication
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- EndoGastric Solutions
Post Operative Sore Throat, Dysphagia
Post-operative Sore Throat as Determined by Endotracheal Tube Inflation Technique
The purpose of this study is to test whether the incidence of sore throat and other tracheal co-morbidities such as dysphagia and hoarseness can be lessened by use of a cuff manometer at the beginning of surgery to inflate to the…
- Conditions
- Post Operative Sore Throat, Dysphagia, Hoarseness
- Trial name
- NCT01305265
- Testing
- cuff manometer
- Where
- United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Spasmodic Dysphonia, Laryngeal Dystonia
Usability of Vibro-tactile Stimulation to Treat Spasmodic Dysphonia
The general aim of the study was to provide evidence for the usability and feasibility of applying vibro-tactile stimulation (VTS) at home as a non-invasive form of neuromodulation to improve speech in people with spasmodic…
- Trial name
- NCT06111027
- Testing
- Vibro-tactile stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Minnesota
Spasmodic Dysphonia
Spasmodic Dysphonia Pain
This study aims to identify adjuvant methods to improve patient comfort during in-office laryngology procedures.
- Trial name
- NCT04648891
- Testing
- Lidocaine, Vibrating wand
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Mayo Clinic
Vocal Fold Nodules, Muscle Tension Dysphonia
Preliminary Study 2 to Test the Effects of Ambulatory Voice Biofeedback
Patients with vocal hyperfunction will undergo standard of care voice therapy with ambulatory voice monitoring before therapy and after the first 3 voice therapy sessions.
- Trial name
- NCT03416868
- Testing
- Ambulatory voice biofeedback
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Massachusetts General Hospital
Dysphagia, Dysphonia
The Effect of IV NSAID's and Corticosteroids on Dysphasia and Dysphonia Following ASDF
This study is to assess the efficacy of intra-operative intravenous non-steroidal anti-inflammatory drug (Ketorolac) versus intravenous (dexamethasone) administration on dysphagia and dysphonia after anterior cervical discectomy…
- Trial name
- NCT04650893
- Testing
- Intravenous Ketorolac, Intravenous Dexamethasone
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Voice and Resonance Disorders, Vocal Fold Polyp
Efficacy of a Semi-occluded Mask in the Treatment of Patients With Voice Disorders
Current semi-occluded vocal tract therapies limit the type of vocalizations that can be produced to single vowels, which does not promote learning of the healthy voice behavior in connected speech or generalization to…
- Conditions
- Voice and Resonance Disorders, Vocal Fold Polyp, Vocal Cord Cyst, Vocal Cord Polyp
- Trial name
- NCT03410797
- Testing
- Inclusion of semi-occluded mask in voice therapy
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Jacqueline Gartner-Schmidt