Clinical trials: Volatile Organic Compound
Asthma
The Asthma Bronchial Challenge Study
This is a randomised, controlled, cross-over study to determine the effect of indirect bronchial challenge testing upon volatile organic compounds (VOCs) in the exhaled breath of adults with well-controlled, mild-to-moderate…
- Trial name
- ABC (NCT03575663)
- Testing
- Indirect bronchial challenge
- Where
- United Kingdom
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Lung Cancer
NanoSpectrometer Biomarker Discovery and Confirmation Study
This study will evaluate exhaled volatile organic compounds (VOC's) in the breath of participants with stage 1 lung cancer, their house-mates, and matched controls.
- Trial name
- NCT03275688
- Testing
- Breath Analysis
- Where
- United States
- Volunteers
- 332 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Appendicitis Acute
Investigation of Oxidative Stress in Appendectomy - Open Versus Laparoscopic in Childhood and Adolescence
In the planned prospective randomized study, oxidative stress will be investigated by analyzing volatile organic compounds in the exhaled air in children.
- Trial name
- OSAE (NCT03723642)
- Testing
- Initial serum malondialdehyde level, Final serum malondialdehyde level, Initial differential white blood cell count
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Graz
Oral Cavity Squamous Cell Carcinoma, Oropharyngeal Squamous Cell Carcinoma
Identification of Breath Biomarkers in Head and Neck Squamous Cell Carcinoma
In this study the Investigators aim to determine specific volatile compounds present in breath samples of patients with oral cavity or oropharyngeal squamous cell carcinoma before and after tumour resection or before and after…
- Trial name
- NCT02156180
- Where
- Australia
- Volunteers
- 13 people
- Sponsor
- Queensland Centre of Excellence for Head and Neck Cancer
SARS-CoV Infection, Covid19
Can the Electronic Nose Smell COVID-19?
Infection with SARS-CoV-2 causes Corona Virus Disease (COVID-19). The most standard diagnostic method is reverse transcription-polymerase chain reaction (RT-PCR) on a nasopharyngeal and/or an oropharyngeal swab.
- Trial name
- NCT04475562
- Testing
- Aeonose
- Where
- Netherlands
- Volunteers
- 219 people
- Sponsor
- Maastricht University Medical Center
Upper GI Bleeding
Analysis the Vocs in Upper GI Bleeding Patients
This project aims to collect the exhaled breath of patients with acute upper gastrointestinal bleeding clinically, divide them into large, small and no bleeding groups according to the results of gastroscopy, analyze the…
- Trial name
- NCT05457062
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Respiratory Disease
Analysis of Volatile Organic Compounds in Expired Air in Healthy Volunteers: Comparison of Three Mass Spectrometry Techniques for the Characterization of Volatolome in Clinical Studies
A major obstacle in precision medicine is the unavailability of biomarkers that are easy to access, non-invasive, measurable with high-performance techniques, fast, easy to use, reproducible, inexpensive and easily deployable on…
- Trial name
- VOC-COMPARE (NCT06020521)
- Testing
- Three spectrometry differents technics
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hopital Foch
Congenital Diaphragmatic Hernia
Microbiome and Volatile Organic Compounds in Patients With CDH
Despite improved prenatal diagnostics and therapeutic possibilities, congenital diaphragmatic hernia (CDH) represents a cross-disciplinary challenge.
- Trial name
- CDHVOCS (NCT03787160)
- Testing
- initial VOC, initial fecal microbiome, initial pulmonary microbiome
- Where
- Austria
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Malaria
Diagnostic Utility of Volatile Organic Compounds in Human Breath for Acute Clinical Malaria in Ethiopia
This is a diagnostic efficacy study to evaluate a set of biomarkers in human breath indicative of an acute malaria infection. The investigators plan to enroll 75 malaria patients and 175 febrile non-malaria patients in Ethiopia.
- Trial name
- NCT02793414
- Sponsor
- Menzies School of Health Research
Lung Cancer, Breast Cancer
Non Invasive Detection of Lung and Breast Cancer by Odor Signature
The investigators have developed an early detection solution for lung and breast cancer. A system which can distinguish between different medical odors based on biosensors.
- Trial name
- NCT02195076
- Testing
- non-invasive detection of cancer odor
- Where
- Israel
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- BioSense Medical LTD
Lung Cancer
Diagnosis of Lung Cancer From Exhaled Breath With Silicon Biophotonic Device
The overall objective of this proposal is to develop a non-invasive, inexpensive and accurate device that detects VOCs in exhaled breath for lung cancer screening.
- Trial name
- NCT01660087
- Testing
- Biophotonic platform for VOC detection
- Where
- 2 sites in Singapore
- Volunteers
- healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
COVID-19 Infections, Respiratory Infections, Acute
Volatile Organic Compounds Analysis by PTR-TOF-MS for Screening Respiratory Infections Using Exhaled Breath.
Emerging respiratory diseases are a global health threat. Viruses such as influenza and coronaviruses have been the main cause of pandemics over the last century.
- Trial name
- VORTEX 1 (NCT07348380)
- Testing
- Volatile Organic compounds (VOC) analysis in Exhaled breath using PTR-TOF-MS
- Where
- 3 sites in France
- Volunteers
- 1,665 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Cystic Fibrosis
Volatilomic Approaches for the Study of CFTR Modulators (VOLATIL-CF)
This study relies on the hypotheses that (1) exhaled breath is intimately correlated to the patient's lung condition and that (2)the composition of exhaled breath , i.e.
- Trial name
- VOLATIL-CF (NCT05726994)
- Testing
- exhaled breath collection, Data collection
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Colorectal Cancer, Colon Polyp
Volatile Organic Compounds (VOCs) Profile in Colorectal Cancer Patients and Healthy Controls.
Volatile organic compounds (VOCs) are low molecular weight (<1 kDa) compounds which represent the final products of cell metabolism.
- Trial name
- NCT04217083
- Testing
- Breath sampling
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Societa Italiana di Chirurgia ColoRettale
Malignant Pleural Mesothelioma
Using E-Nose Technology to Measure Response to Treatment in People With Malignant Pleural Mesothelioma
The researchers are doing this study to test the ability of a new technology called breathprinting, or electronic nose (E-Nose), to measure how people respond to standard treatment for malignant pleural mesothelioma (MPM).
- Trial name
- NCT06037941
- Testing
- E-Nose testing, Research blood
- Where
- 7 sites in United States
- Volunteers
- 20 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cirrhosis, Cirrhosis, Liver
Volatile Organic Compounds for the Assessment of Liver Disease
This study aims to determine whether a breath test could be used for early detection of hepatic fibrosis, cirrhosis or hepatocellular carcinoma.
- Conditions
- Cirrhosis, Cirrhosis, Liver, Fibrosis, Liver, Hepatocellular Carcinoma
- Trial name
- VOCAL (NCT04620538)
- Testing
- Breath Analysis
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Pneumonia, Ventilator-associated
Early Detection of Ventilator-associated Pneumonia (VAP)
The study goal consists in the sequential collection of exhaled breath condensates (EBC) from patients receiving invasive ventilation.
- Trial name
- cheqVAP (NCT02753608)
- Testing
- Collection of exhaled breath condensate
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Jena University Hospital
Axial Spondyloarthritis
The Impact of Simulated Forest Immersion Therapy on Pain and Anxiety in Patients Axial Spondyloarthritis (axSpA)
The purpose of the study is to learn about the ease of using a humidified fragrant citrus forest oil, along with a virtual simulation of a forest environment (i.e., with sights and sounds of nature using a personal tablet Surface…
- Trial name
- NCT06072859
- Testing
- Humidified Forest Oils, Forest oils and audio-visual forest exposure
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Oregon Health and Science University
Colorectal Cancer, Colorectal Polyps
The Colorectal Breath Analysis (COBRA) Study
This study aims to determine whether a breath test could be used for early detection of colorectal cancer and colorectal polyps.
- Conditions
- Colorectal Cancer, Colorectal Polyps, Colorectal Adenocarcinoma
- Trial name
- COBRA (NCT03699163)
- Testing
- Breath sample
- Where
- 8 sites in United Kingdom
- Volunteers
- 1,855 people
- Sponsor
- Imperial College London
Lung Cancer
Breathomics: May it Become an Affordable, New Tool for Early Diagnosis and Screening of Lung Cancer?
Breath analysis examining specific patterns of volatile organic compounds (VOCs) has been demonstrated to be able to discriminate lung cancer (LC) patients from healthy controls (HC).
- Trial name
- NCT06034730
- Testing
- Portable GC device for brath analysis
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari