Clinical trials: Volume
Adverse Reaction to Peripheral Nerve- and Plexus-blocking Anesthetics
Reducing Respiratory Side Effects of Interscalene Brachial Plexus Block
Shoulder surgery is known to be extremely painful requiring high doses of opiate analgesics (morphine) to control pain. Morphine has numerous unwanted side effects including sedation, hallucinations and vomiting.
- Trial name
- NCT01374464
- Testing
- Interscalene brachial plexus block
- Where
- United Kingdom
- Volunteers
- 92 people
- Sponsor
- Royal Surrey County Hospital NHS Foundation Trust
Non-small Cell Lung Cancer Stage III
Durvalumab and Chemotherapy Induction Followed by Durvalumab and Radiotherapy in Large Volume Stage III NSCLC
Standard treatment for stage III Non-Small Cells Lung Cancer (NSCLC) not eligibile for surgery is concomitant chemoradiotherapy.
- Trial name
- BRIDGE (NCT04765709)
- Testing
- durvalumab plus platinum-based chemotherapy (cisplatin or carboplatin plus vinorelbine or pemetrexed), Durvalumab plus radiotherapy, durvalumab
- Where
- 3 sites in France, Italy and 1 more
- Volunteers
- 10 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Lumbar Disc Herniation Surgery, Mechanical Ventilation
Flow-Controlled Versus Volume-Controlled Ventilation in Lumbar Disc Herniation Surgery
This prospective randomized trial aims to compare the effects of flow-controlled ventilation (FCV) and volume-controlled ventilation (VCV) on intraoperative airway pressures and oxygenation in patients undergoing lumbar disc…
- Trial name
- NCT07614555
- Testing
- FCV Group, VCV Group
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ankara Etlik City Hospital
Kidney Transplant; Complications
Kidney Transplant Volumetry
This study assesses the reproducibility of 3 different formulas in calculating the volume of a transplanted kidney by ultrasound in-vivo measurements.
- Trial name
- NCT03855085
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Tours
Prostatic Neoplasm, Urinary Bladder Neoplasm
Positive End-expiratory Pressure-induced Increase in Central Venous Pressure as a Predictor of Fluid Responsiveness in Robot-assisted Laparoscopic Surgery
In urologic robotic surgery with steep Trendelenburg position, maintenance of cardiac preload and cardiac output is important for clinical prognosis.
- Trial name
- NCT02977143
- Testing
- Fluid loading of volulyte 300 ml
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Cardiac Output and Preload Assessment, Lung Water Assessment
Clinical Evaluation of a New Transpulmonary Thermodilution Method to Assess Thermodilution Cardiac Output, Global End Diastolic Volume and Extravascular Lung Water
The primary objective of this study is to obtain the TPTD, GEDV and EVLW measurements from existing indwelling femoral arterial Volume View™ catheter and central venous catheters.
- Trial name
- NCT01405040
- Where
- 4 sites in Germany, Switzerland
- Volunteers
- 97 people
- Sponsor
- Edwards Lifesciences
Respiration Disorders
Non-invasive Methods of Measuring Lung Volume
Each breath humans take can be split into different measurements that clinicians can use to see how well a patient's lungs are working.
- Trial name
- NIM-LV (NCT06681467)
- Testing
- Respiratory monitoring band
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Respiratory Distress Syndrome, Newborn, Respiratory Failure
Cerebral and Circulatory Effects of Neonatal Volume Targeted Ventilation
The aim of the study was to assess the effect of volume targeted vs. pressure-controlled mechanical ventilation (MV) on circulatory parameters and cerebral oxygenation in the extremely preterm infants.
- Conditions
- Respiratory Distress Syndrome, Newborn, Respiratory Failure, Premature Birth
- Trial name
- NCT04391634
- Testing
- volume guarantee, pressure-controlled
- Where
- Poland
- Volunteers
- 25 people
- Sponsor
- Poznan University of Medical Sciences
Mitral Regurgitation
Molecular Mechanisms of Volume Overload-Aim 1(SCCOR in Cardiac Dysfunction and Disease)
The investigators hypothesize that beta-1 receptor blockade (ß1-RB) attenuates extracellular matrix (ECM) degradation and progressive adverse Left Ventricular (LV) remodeling and failure in the volume overload of mitral…
- Trial name
- P1A1 (NCT01052428)
- Testing
- metoprolol succinate (Toprol XL)
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Cervical Spinal Cord Injury
A Comparative Study of High and Low Tidal Volume in Preventing Hypoxemia in Patients With Mechanical Ventilation After Cervical Spinal Cord Injury
This study in order to best tidal volume mechanical ventilation in patients with cervical spinal cord injury (sci) as the research point, through higher low volume Settings to find the difference of two groups of patients to…
- Trial name
- NCT04949971
- Testing
- High volume group
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking University Third Hospital
Atrial Fibrillation
Implementation of the HELIOSTARTM in Real-world Clinical Practice at a High-volume Center
The HELIOSTARTM catheter (Biosense Webster) is a new technology for pulmonary vein isolation (PVI) in atrial fibrillation (AF), combining radiofrequency (RF)-ablation and 3D-mapping visualization with the concept of…
- Trial name
- NCT05603611
- Testing
- Pulmonary vein isolation
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University Hospital Heidelberg
End-stage Renal Disease, Renal Replacement Therapy
Can High Convection Volumes be Achieved in Each Patient During Online Post-dilution Hemodiafiltration?
Two recent randomized controlled trials (RCT) on online hemodiafiltration (HDF) did not show a treatment effect on patient survival when compared with low- or high-flux hemodialysis.
- Conditions
- End-stage Renal Disease, Renal Replacement Therapy, Hemodiafiltration, Convection Volume
- Trial name
- NCT01877499
- Testing
- Optimization of HDF key parameters
- Where
- 7 sites in Netherlands
- Volunteers
- 86 people
- Sponsor
- Amsterdam UMC, location VUmc
Postoperative Delirium (POD), Cardiopulmonary Bypass
Effect of Low Tidal Volume Ventilation on Postoperative Delirium
This study aims to evaluate the effect of low tidal volume (LTV) ventilation during cardiopulmonary bypass (CPB) on postoperative delirium.
- Conditions
- Postoperative Delirium (POD), Cardiopulmonary Bypass, Low Tidal Volume Ventilation, Cognitive Dysfunction, Postoperative
- Trial name
- CLEVER (NCT06752421)
- Testing
- Group B: Low tidal volume
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people
- Sponsor
- Nevsehir Public Hospital
Intussusception
Pneumatic Reduction For Intussusception In Children: A Retrospective Cohort Study
In pediatric patients, intussusception predominantly occurs in the ileocecal region, with over 90% of cases lacking identifiable causative factors, initiating through peristalsis-driven invagination of bowel segments leading to…
- Trial name
- NCT06365333
- Testing
- Fluoroscopic-guided air-enema reduction (FGAR)
- Where
- 2 sites in Vietnam
- Volunteers
- 3,562 people
- Sponsor
- National Children's Hospital, Vietnam
Emphysema or COPD
Evaluation of the Free Flow Medical Lung Tensioning Device System for the Treatment of Severe Emphysema
Patients with severe emphysema have limited options for treatment. Current treatments include lung transplant, lung volume reduction surgery or endobronchial lung volume reduction using valves or coils.
- Trial name
- EFFORT (NCT04520152)
- Testing
- FreeFlowMedical Lung Tensioning Device
- Where
- 2 sites in Germany, Netherlands
- Volunteers
- 14 people
- Sponsor
- University Medical Center Groningen
End-stage Renal Disease
Effects of Strict Volume Control in Hypertensive Hemodialysis Patients on Cardiac Structure and Chronic Inflammation
This study aims mainly to investigate the effects of two approaches to control blood pressure in hypertensive hemodialysis patients; using antihypertensive drugs versus strict volume control (by strict dietary salt restriction…
- Trial name
- NCT00307463
- Testing
- strict volume control policy, antihypertensive drugs administration
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 258 people
- Sponsor
- Ege University
Sleep Apnea, Obstructive, Sleep Apnea, Central
Early Sleep Apnea Treatment in Stroke
Investigating the interrelation of stroke and sleep-disordered breathing (SDB) is of major importance. First because of the high occurrence rate of stroke and the fact that it is a frequent cause of long-term disability in…
- Conditions
- Sleep Apnea, Obstructive, Sleep Apnea, Central, Stroke
- Trial name
- eSATIS (NCT02554487)
- Testing
- AirCurveTM10 CS PACEWAVE Adaptive-Servo-Ventilator (ResMed Ldt., Australia)
- Where
- 6 sites in France, Germany and 2 more
- Volunteers
- 201 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Chronic Obstructive Pulmonary Disease, COPD
Effect of QVA149 (Indacaterol Maleate/Glycopyrronium Bromide) on Cardiac Function in COPD Patients
This mechanistic study is a single-center, randomized, double-blind, placebo-controlled, cross-over study to evaluate the effect of dual bronchodilation with QVA149 on cardiac and lung function parameters in hyperinflated COPD…
- Trial name
- CLAIM (NCT02442206)
- Testing
- QVA149
- Where
- Germany
- Volunteers
- 62 people
- Sponsor
- Novartis Pharmaceuticals
Intradialytic Hypotension
Central Blood Volume in Hypotensive Dialysis Patients
The purpose of the study is to test whether hypotensive episodes during dialysis - caused by withdrawal of fluid drom the circulation - can be predicted by means of two harmless monitoring techniques.
- Trial name
- NCT00257504
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Danish State Hospital
Diastolic Function, Cardiac Output
Impact of Pacing Mode and Diastolic Function on Cardiac Output
Background It is known from previous research that in patients with complete AV (atrioventricular) block and pacemaker stimulation stroke volume and cardiac output are higher with AV-synchronous than with AV-dyssynchronous…
- Conditions
- Diastolic Function, Cardiac Output, Pacemaker Stimulation Mode, Stroke Volume
- Trial name
- PADIAC (NCT04068233)
- Testing
- Pacemaker stimulation mode
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kepler University Hospital
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