Clinical trials: Vulnerable Coronary Plaques
Atherosclerosis
Imaging of Vulnerable Plaques in Coronary Artery Disease by Multidetector Computed Tomography
Atherosclerosis is a chronic and multifocal immunoinflammatory, fibroproliferative disease of medium-sized and large arteries driven by lipid.
- Trial name
- NCT00482651
- Testing
- Multidetector computed tomography scanning, Coronary angiography (CAG), Intravascular ultrasound
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- University of Aarhus
Atherosclerotic Plaque
Diagnosis of Macrophage Coronary Plaque by Optical Tomographic Imaging
This study evaluated optimal macrophage diagnosis algorithm through comparative analysis between coronary artery, OCT image, and IVUS, and improve a diagnosis rate of vulnerable coronary plaque accompanied with macrophage…
- Trial name
- OCT pathology (NCT02649881)
- Testing
- The heart subject will undergo OCT
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Young-Hak Kim, MD, PhD
Acute Coronary Syndrome, Plaque, Atherosclerotic
Prediction of Vulnerable Plaque Using Coronary CT Angiography and Computational Fluid Dynamic in Acute Coronary Syndrome
The aim of the PVCFD trial is to predict vulnerable plaque confirmed by OCT using coronary CT angiography and computational fluid dynamics in patients with acute coronary syndrome.
- Trial name
- PVCFD (NCT04524117)
- Volunteers
- 200 people
- Sponsor
- Shanghai 10th People's Hospital
Acute Coronary Syndrome
Pilot Study on the Effect of Intracoronary Cryotherapy on Stabilization of Vulnerable Plaque at Risk of Rupture
Atherosclerosis is a progressive inflammatory disease of the large and medium sized arteries, which is characterized by the formation of plaques in the vessel wall.
- Trial name
- ICEBERG (NCT04857580)
- Testing
- CTS Device
- Where
- 3 sites in Denmark, Sweden
- Sponsor
- Cryotherapeutics SA
Chronic Coronary Syndrome, Coronary Artery Disease
Feasibility of a Deep Learning-based Algorithm for Non-invasive Assessment of Vulnerable Coronary Plaque
The primary objective of this study is to assess the accuracy in terms of sensitivity, specificity, negative and positive predicted values of the DL-based algorithm with respect to correct identification of the plaque and…
- Conditions
- Chronic Coronary Syndrome, Coronary Artery Disease, Stable Angina, Acute Coronary Syndrome
- Trial name
- FOCUS DL (NCT06186336)
- Testing
- Deep Learning-based Vulnerable Plaque Detection and Assessment Tool
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- GE Healthcare
Chronic Coronary Syndrome, Atherosclerosis
Comprehensive Assessment of Morphometric, Functional, Biomechanical and Biological Interactions Between Atherosclerotic Plaque and Platelets Within the Stenosed Coronary Artery
The main objective of the present study is to verify, in vivo, whether shear forces computed solely based on coronary angiography and computational fluid dynamics (CFD) techniques are associated with the biomarkers indicating the…
- Trial name
- INTERFORCE (NCT06275399)
- Testing
- OCT examination, Blood sampling, Assessment of vFFR and shear stress parameters
- Where
- Poland
- Volunteers
- 105 people
- Sponsor
- Medical University of Warsaw
Myocardial Infarction, Myocardial Ischemia
Vulnerable Plaque Imaging in NSTEMI
Myocardial infarction (MI) frequently recurs after non-ST elevation MI (NSTEMI) that may be related to insufficient vulnerable plaque identification using invasive coronary angiography.
- Trial name
- CULPRIT (NCT02563964)
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Maastricht University Medical Center
Coronary Artery Disease, Coronary Atheroscleroses
Risk Evaluation by COronary Imaging and Artificial intelliGence Based fuNctIonal analyZing tEchniques - IV
This study is a single-center, prospective cohort study. The study is designed to identify novel circulating biomarkers for early prediction of high-risk coronary plaques.
- Conditions
- Coronary Artery Disease, Coronary Atheroscleroses, Acute Coronary Syndromes (ACS), Chronic Coronary Syndrome
- Trial name
- RECOGNIZE-IV (NCT06793787)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Ruijin Hospital
Atherosclerosis, Coronary Artery Disease
Imaging and Biomarkers of Atherosclerosis in Patients With Stable or Unstable Coronary Artery Disease
In this study, multimodal imaging of atherosclerosis and dosage of new circulating biomarkers will be used to compare patients with stable or unstable coronary artery disease
- Conditions
- Atherosclerosis, Coronary Artery Disease, Acute Coronary Syndrome
- Trial name
- BIOCORE-2 (NCT01186666)
- Testing
- Coronary intervention using IVUS-VH & FDG PET-MDCT
- Where
- France
- Volunteers
- 85 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Atherosclerosis
Evaluation of Atorvastatin on Atherosclerosis Composition
The purpose of this study is to evaluate the effects of Atorvastatin on the coronary atherosclerosis plaque morphology.
- Trial name
- NCT00576576
- Testing
- Atorvastatin
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Emory University
Coronary Artery Disease, Stable Angina
Detection of Coronary Vulnerable Plaque With Contrast-enhanced Magnetic Resonance Imaging
MRI has the ability to visualize the arterial vessel wall. Wall thickening and atherosclerotic plaque components can be visualized in the carotid arteries and the aorta.
- Conditions
- Coronary Artery Disease, Stable Angina, Unstable Angina
- Trial name
- T9M (NCT00984776)
- Testing
- Contrast enhanced MRI with Gadofosveset
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Maastricht University Medical Center
Coronary Artery Disease
Single Dose PCSK9 Inhibitor to Improve Cardiovascular Outcomes After PCI: A Pilot Study
This pilot study aims to evaluate whether a single dose of PCSK9 inhibitor administered after percutaneous coronary intervention (PCI) can improve long-term cardiovascular outcomes in patients with high post-PCI lipid core…
- Trial name
- HANYANG-PICK (NCT07084259)
- Testing
- PCSK9 inhibitor, Standard Lipid-Lowering Therapy
- Volunteers
- 352 people
- Sponsor
- Hanyang University Seoul Hospital
Acute Myocardial Infarction, Myocardial Viability
The Assessment Of Myocardial Viability Based On CTA/MRI Hybrid Models
The aim of HYBRIDHEART study is to develop new imagistic prototype for a complex evaluation of the myocardial viability by superposing computed tomographic angiographic polar maps of the myocardium with magnetic resonance imaging…
- Conditions
- Acute Myocardial Infarction, Myocardial Viability, Vulnerable Coronary Plaques, Coronary Stenosis
- Trial name
- HYBRIDHEART (NCT04397198)
- Testing
- Speckle Tracking echocardiography
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- Cardio Med Medical Center
Multivessel Coronary Artery Disease, Ischemia
COMBINE-INTERVENE: COMBINEd Ischemia and Vulnerable Plaque Percutaneous INTERVENtion to Reduce Cardiovascular Events
The COMBINE-INTERVENE Trial will investigate whether a PCI revascularization strategy based on combined FFR and OCT assessment is superior to a PCI revascularization strategy based on FFR-alone in patients with MVD with any…
- Conditions
- Multivessel Coronary Artery Disease, Ischemia, Vulnerable Plaque, Coronary Artery Disease
- Trial name
- NCT05333068
- Testing
- PCI revascularization strategy based on combined FFR and OCT assessment, PCI revascularization strategy based FFR assessment
- Where
- 49 sites in Australia, Canada and 16 more
- Volunteers
- 1,223 people
- Sponsor
- Diagram B.V.
Acute Coronary Syndrome
18F-NaF-PET for Identification of TCFA
Recently, positron emission tomography(PET) using 18F-Sodium fluoride (NaF) showed promising results for detecting vulnerable plaques in some pilot studies.
- Trial name
- NaF-PET (NCT02388412)
- Where
- South Korea
- Volunteers
- 96 people
- Sponsor
- Seoul National University Hospital
Coronary Artery Disease
Novel Imaging Approaches To Identify Unstable Coronary Plaques
Cardiovascular disease is the leading cause of death in Scotland and the Western World. Approaches to improve the identification of vulnerable or ruptured coronary atherosclerotic plaques are urgently needed to help risk…
- Trial name
- NCT01749254
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Edinburgh
Coronary Stenosis, Acute Coronary Syndrome
Multiomics and Imaging-based Assessment of Vulnerable Coronary Plaques in Acute Coronary Syndromes
The aim of Multiplaque clinical study is to assess the vulnerability degree of the atheromatous plaques, before and after a myocardial infarction (MI), based on multiomics analysis, associated with invasive and non-invasive data.
- Conditions
- Coronary Stenosis, Acute Coronary Syndrome, Acute Myocardial Infarction, Atheromatous Plaques
- Trial name
- MultiPlaque (NCT03391908)
- Testing
- cardiac imaging tests
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- Cardio Med Medical Center
Coronary Heart Disease (CHD), Diabetes (DM)
A Prospective Multicenter Clinical Study： IntracOronary neaR-Infrared Spectroscopy and OptIcal Coherence Tomography for Evaluating Coronary vulNerable Plaque in Patients With diabeTes
To evaluate the correlation between maxLCBI4mm/FCTmin(a new index of lipid plaque based on NIRS-OCT technology) and fiber cap thickness , and the prognosis of patients, providing a new quantitative index for early, accurate and…
- Trial name
- NCT06649305
- Where
- China
- Volunteers
- 1,516 people
- Sponsor
- Shanghai Zhongshan Hospital
Coronary Artery Disease
Intracoronary Imaging With NIRS-IVUS to Characterize Arterial Plaques
To characterize atherosclerotic coronary artery plaques using advanced intra-coronary imaging with a combined near-infrared spectroscopy and intravascular ultrasound catheter before and after percutaneous intervention
- Trial name
- NIRS-IVUS (NCT01694368)
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Corewell Health West
Coronary Arterial Disease (CAD), Vulnerable Coronary Plaques
Ticin Pilot Study: Sirolimus-Eluting Balloon for Stabilization and Regression of Non-Obstructive Coronary Plaques.
The goal of this pilot clinical trial is to evaluate the use of the Selution SLR sirolimus-eluting balloon, in addition to guideline-directed medical therapy (GDMT), for the preventive treatment of non-flow-limiting vulnerable…
- Conditions
- Coronary Arterial Disease (CAD), Vulnerable Coronary Plaques, Multivessel Coronary Artery Disease, Coronary Vessel
- Trial name
- NCT06928883
- Testing
- Sirolimus drug eluting ballooon therapy, Optimal guidelines-directed medical therapies (GDMT)
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- Cardiocentro Ticino