Clinical trials: Vulnerable Population
RZV Vaccine (Shingrix ®)
Comprehensive Characterization of Immune Response Induced by Adjuvanted Glycoprotein E (gE)-Based Recombinant VAccine Zoster in Vulnerable Population Receiving ImmunOmodulaNt Therapies
Varicella-zoster virus (VZV) is one of the eight herpesviruses that infect humans by manifesting as varicella. After primary infection VZV remains latent for life.
- Trial name
- NCT07534007
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
HIV Infection
Integrated Care Centers to Improve HIV Outcomes in Vulnerable Indian Populations
This is a cluster randomized trial to evaluate the effectiveness of integrated care centers (ICC) to improve access to HIV testing, prevention services, and treatment among high-risk populations of injection drug users (IDU) and…
- Trial name
- NCT01686750
- Testing
- Integrated care centers
- Where
- India
- Volunteers
- 21,726 people
- Sponsor
- Johns Hopkins University
Aging, Veterans
Geri Pride: Feasibility Pilot of a Group Intervention for Older Veterans
There are over one million Veterans who identify as lesbian, gay, bisexual, (LGB) or a related identity. Older LGB Veterans face unique hurdles as they age, including stress, anxiety, heart disease, cancer, decreased ability to…
- Conditions
- Aging, Veterans, Social Determinants of Health, Health Disparate Minority and Vulnerable Populations
- Trial name
- NCT07831759
- Testing
- Geri Pride Health Promotion Group
- Where
- 4 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Linkage to Care, Homelessness
Improving Linkage to Health and Other Services for Veterans Leaving Incarceration
Veterans leaving incarceration and re-entering their communities (often described as "reentry" Veterans) face a number of challenges, including uncertainty about housing, vulnerability to substance use and relapse, on-going…
- Conditions
- Linkage to Care, Homelessness, Substance Use Disorder, Mental Health
- Trial name
- PIE (NCT02964897)
- Testing
- Peer-support plus usual care from the Health Care for Reentry Veterans program, Usual care from the Health Care for Reentry Veterans program
- Where
- 2 sites in United States
- Volunteers
- 79 people
- Sponsor
- VA Office of Research and Development
Diabetes
Addressing Social Determinants of Health & Diabetes Self-Management in Vulnerable Populations
In this pilot and feasibility study, the investigator will randomize 100 African-American, Hispanic, and/or Medicaid (all race/ethnicities) patients from KPNW with A1C ≥ 8 to one of two 6-month interventions: 1) patient…
- Trial name
- NCT03802825
- Testing
- Diabetes Self-Management Training, Standard Patient Navigation
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Cardiovascular Disease, Hypertension
The GoodNEWS Lifestyle Enhancement Program
This study will train Lay Health Promoters (LHPs) from African-American churches to administer healthy living lessons and activities to their congregations in order to improve overall health and address cardiovascular disease.
- Conditions
- Cardiovascular Disease, Hypertension, Diabetes, Obesity
- Trial name
- GoodNEWS (NCT00669630)
- Testing
- Lay Health Promoter (LHP) with maintenance
- Where
- United States
- Volunteers
- 392 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Tobacco Use Disorder
Project 2, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Opioid Abusers
This study will examine extended exposure to cigarettes varying in nicotine content among adults with opioid use disorder. Those with opioid use disorder are at increased risk for smoking, nicotine dependence, and using high…
- Trial name
- P2S2 (NCT02250664)
- Testing
- Very low nicotine content cigarettes
- Where
- 2 sites in United States
- Volunteers
- 775 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Hypertension
Effect of Peer Mentoring and Blood Pressure Self-monitoring on Hypertension Control.
Cardiovascular diseases are increasing throughout the developing world and are the cause of almost 16.7 million deaths each year, of which 80% occur in low and middle-income countries.
- Trial name
- NCT03297229
- Testing
- Peer mentoring, Self-monitoring
- Where
- 10 sites in Argentina
- Volunteers
- 442 people
- Sponsor
- Institute for Clinical Effectiveness and Health Policy
Frequent Users of the Emergency Department, Vulnerable Populations
Case Management for Frequent Users of the Emergency Department
The purpose of this study is to evaluate a specific case management intervention for frequent users (FU) of Emergency Department (ED).
- Trial name
- NCT01934322
- Testing
- Case Management
- Where
- Switzerland
- Volunteers
- 250 people
- Sponsor
- University of Lausanne
Acute Kidney Injury (AKI), Postnatal AKI
NIRS Monitoring in the NICU and AKI
The primary objective of this study is to describe the pattern of renal tissue oxygen saturation (SrSO2) using near-infrared spectroscopy (NIRS) in premature infants <30 weeks gestational age.
- Trial name
- NCT07222722
- Testing
- NIRS Monitoring
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Obstructive Sleep Apnea, Sleep
Impact of Exogenous Ketones on Sleep Disruption in Vulnerable Populations
Obstructive Sleep Apnea (OSA) is a common medical disorder that is associated with reduced quality of life and higher risk of cardiovascular disease. Treatments for OSA and limited and not well tolerated.
- Trial name
- KETO-SLEEP 1 (NCT06655649)
- Testing
- Ketone-IQ (1,3 Butanediol)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Obesity & Overweight, Vulnerable Families
Evaluation of a Multicomponent Early Intervention for Childhood Obesity Prevention in Vulnerable Families
Childhood obesity is a public health concern. Evidence-based, multicomponent, parenting interventions targeting early childhood and adapted to families' socioeconomic context are needed to prevent childhood obesity.
- Conditions
- Obesity & Overweight, Vulnerable Families, Children, Families With Infants
- Trial name
- Bambú (NCT07529704)
- Testing
- Bambú program
- Where
- 4 sites in Spain
- Volunteers
- 526 people, healthy volunteers welcome
- Sponsor
- Helena Vall Roqué
Child Development, Developmental Disabilities
Testing the Effectiveness of Telephone-based Early Childhood Developmental Screening
The purpose of this research study is to test the effectiveness of telephone-based early childhood developmental screening and care coordination, compared to usual care in a primary care pediatrics clinic.
- Conditions
- Child Development, Developmental Disabilities, Ambulatory Care, Screening
- Trial name
- NCT02495025
- Testing
- Telephone-based developmental screening and care coordination
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Chronic Disease
Improving Advance Care Planning by Preparing Diverse Seniors for Decision Making
The objective of this proposal is to test whether a multi-media website (www.prepareforyourcare.org) that is focused on preparing older adults for communication and medical decision making can help people engage in advance care…
- Trial name
- PREPARE (NCT01990235)
- Testing
- PREPARE Intervention
- Where
- United States
- Volunteers
- 541 people
- Sponsor
- University of California, San Francisco
Type 2 Diabetes Mellitus
Impact of Medicaid Health Home on Patients With Diabetes in New York City
Type 2 diabetes is common in the United States; about 1 in 10 people have the disease. Diabetes can cause devastating health events, such as hospitalizations, kidney failure, blindness, amputation, heart attack, stroke, painful…
- Trial name
- NCT02713321
- Where
- United States
- Volunteers
- 96,759 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Prenatal Community Program, Vulnerable Population
Parkdale Infant Nutrition Security Targeted Evaluation Project: Chart Review
In Toronto Ontario, the Parkdale Community Health Centre operates a community outreach program entitled Parkdale Parents' Primary Prevention Project (5P's).
- Conditions
- Prenatal Community Program, Vulnerable Population, Postnatal Community Program
- Trial name
- PINSTEP-1 (NCT03372408)
- Testing
- Chart review
- Where
- Canada
- Volunteers
- 338 people
- Sponsor
- University of Toronto
Overweight or Obesity, Obesity, Abdominal
Hypocaloric Mediterranean Diet or Physical Activity to Lower Cardiometabolic Risk
The purpose of this randomized controlled trial is to test the effects of a hypocaloric Mediterranean diet or of physical activity in participants who take at least 2 antihypertensive drugs but do not reach blood pressure…
- Conditions
- Overweight or Obesity, Obesity, Abdominal, Hypertension
- Trial name
- MeDiPA (NCT04155112)
- Testing
- Physical activity, Hypocaloric Mediterranean diet
- Where
- Norway
- Volunteers
- 90 people
- Sponsor
- Oslo University Hospital
Clinical Trial, Acute Coronary Syndrome
Impact of Evolocumab as an Additional Lipid-lowering Therapy to Changes in Lipid Core Burden Index of Non-culprit Vulnerable Plaque in Patients Who Underwent Percutaneous Coronary Intervention for the Acute Coronary Syndrome
This study aimed to investigate the impact of intensive cholesterol-lowering therapy (including evolocumab), drug treatment for high-risk plaques (Vulnerable plaques) with a high probability of developing acute coronary syndrome.
- Trial name
- NCT04719221
- Testing
- Evolocumab, NIRS IVUS
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Korea University Anam Hospital
Tobacco Use Disorder
Low Nicotine Content Cigarettes in Vulnerable Populations: Women of Reproductive Age
Despite marked reductions in cigarette smoking in the general population, smoking among economically disadvantaged women has increased.
- Trial name
- NCT04092387
- Testing
- Varying the nicotine content of cigarettes, E-Cigarettes
- Where
- 2 sites in United States
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Pediatric HIV Infection
Evaluating an HIV Risk Screening Tool for Orphans and Vulnerable Children in Tanzania
The goal of the research was to evaluate the performance of items within the Kizazi Kipya (K2) Orphan and Vulnerable Children (OVC) HIV risk screening tool in identifying HIV-positive children, to optimize an HIV screening tool…
- Trial name
- NCT04517760
- Where
- Tanzania
- Volunteers
- 21,080 people
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation