Clinical trials: Vulvar Neoplasm
Squamous Intraepithelial Lesions, Laser Burn
Research of Laser Ablation for the Treatment of Lower Anogenital Tracts' Precancerous Lesions
Using multiple targeting CO2 laser ablation to treat the precancerous lesion of the female lower anogenital tracts and analyzing the data collected in the study, we aim to form the standard strategy of laser ablation method to…
- Trial name
- NCT05170620
- Testing
- laser ablation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Tongji Hospital
Cervical Cancer, Vulvar Cancer
Immunogenicity and Tolerability of Broad Spectrum Human Papillomavirus (HPV) Vaccine in Adult and Young Adult Women (V503-004)
This study will assess the safety and immunogenicity of GARDASIL®9 (V503) in 16- to 45-year-old women. The primary hypothesis of the study states that anti-HPV 16, 18, 31, 33, 45, 52, and 58 geometric mean titers (GMTs) at 4…
- Conditions
- Cervical Cancer, Vulvar Cancer, Vaginal Cancer, Genital Warts
- Trial name
- NCT03158220
- Testing
- V503
- Where
- 24 sites in Austria, Belgium and 4 more
- Volunteers
- 1,212 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Vulvar Neoplasm
Effectiveness of an App Intervention to Reduce Postsurgical Symptom Distress in Patients With Vulvar Neoplasia
Despite great advances in surgical therapy in the last decades, symptom relief for women with vulvar neoplasia (vulvar cancer and pre-stage of vulvar cancer) is still not optimal.
- Trial name
- NCT04541784
- Testing
- WOMAN-PRO III, Three counselling sessions with gynaecology-oncology nurses
- Where
- 4 sites in Switzerland
- Volunteers
- 18 people
- Sponsor
- St.Gallen University of Applied Sciences
Usual Type Vulval Intraepithelial Neoplasia (uVIN)
Pharmacodynamics, Safety/Tolerability and Efficacy of Topical Omiganan in Patients With uVIN
To assess the pharmacodynamics, safety/tolerability and efficacy of topical Omiganan (CLS001) in patients with usual type vulvar intraepithelial neoplasia (uVIN).
- Trial name
- NCT02596074
- Testing
- Omiganan (CLS001) topical gel, Vehicle topical gel
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- Maruho Co., Ltd.
Cervical Cancer, Uterine Cancer
Image-Guided Gynecologic Brachytherapy
Standard therapy for gynecologic cancers involves the use of brachytherapy, also called internal radiation therapy or implant radiation.
- Conditions
- Cervical Cancer, Uterine Cancer, Vaginal Cancer, Carcinoma of the Vulva
- Trial name
- AMIGO (NCT01399658)
- Testing
- Image-guided brachytherapy, 3'-Deoxy-3'-18f-Fluorothymidine
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Dana-Farber Cancer Institute
Glioblastoma, Esophageal Cancer
Serial MRI Scans During Radiation Therapy
This is a phase 1 study to determine the feasibility and utility of using serial magnetic resonance imaging (MRI) to assess treatment response during and after radiation therapy (standard of care cancer treatment) for…
- Conditions
- Glioblastoma, Esophageal Cancer, Radiotherapy, Magnetic Resonance Imaging
- Trial name
- RELAY (NCT04188535)
- Testing
- MRI IMAGING
- Where
- 2 sites in United States
- Volunteers
- 149 people
- Sponsor
- Dana-Farber Cancer Institute
Gynecologic Cancer, Endometrial Cancer
3D Printed Custom Applicators for HDR BT (DISCO)
Intracavitary brachytherapy for gynaecological cancer currently use cylinder-type applicators or custom wax moulds to place a radioactive source in close proximity to the treatment area and provide highly conformal dose…
- Conditions
- Gynecologic Cancer, Endometrial Cancer, Vaginal Cancer, Vulva Cancer
- Trial name
- NCT06432478
- Testing
- 3D-printed custom applicator
- Where
- Australia
- Volunteers
- 10 people
- Sponsor
- Royal North Shore Hospital
Cervical Intraepithelial Neoplasia, Cervical Cancer
The Durability of Protection and Immuno-persistence Study of a Recombinant HPV 16/18 Bivalent Vaccine in Female
The primary objective of this study is to evaluate the durability of protection and immuno-persistence of Recombinant Human Papillomavirus Bivalent (Types 16,18) Vaccine administered in females aged 18-45 years.
- Conditions
- Cervical Intraepithelial Neoplasia, Cervical Cancer, Vaginal Intraepithelial Neoplasia, Vulvar Intraepithelial Neoplasia
- Trial name
- NCT05045755
- Testing
- Recombinant Human Papillomavirus Bivalent (Types 16, 18) Vaccine (Escherichia coli)
- Where
- China
- Volunteers
- 1,339 people
- Sponsor
- Jun Zhang
Stage II Vulvar Cancer AJCC v8, Stage III Vulvar Cancer AJCC v8
Nelfinavir, Cisplatin, and External Beam Radiation Therapy for the Treatment of Locally Advanced Vulvar Cancer That Cannot Be Removed by Surgery
This phase I trial studies the side effects and best dose of nelfinavir when given together with cisplatin and external beam radiation therapy in treating patients with vulvar cancer that has spread to nearby tissue or lymph…
- Conditions
- Stage II Vulvar Cancer AJCC v8, Stage III Vulvar Cancer AJCC v8, Stage IIIA Vulvar Cancer AJCC v8, Stage IIIB Vulvar Cancer AJCC v8
- Trial name
- NCT04169763
- Testing
- Cisplatin, External Beam Radiation Therapy, Nelfinavir
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- M.D. Anderson Cancer Center
Cervical Cancer, Endometrial Cancer
Topotecan in Treating Patients With Gynecologic Cancer That Cannot Be Removed by Surgery
RATIONALE: Drugs used in chemotherapy, such as topotecan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Cervical Cancer, Endometrial Cancer, Fallopian Tube Cancer, Ovarian Cancer
- Trial name
- NCT00842452
- Testing
- topotecan hydrochloride, pharmacological study
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Steven Waggoner, MD
Advanced Cervical Adenocarcinoma, Advanced Vaginal Carcinoma
Stereotactic Body Radiation Therapy, Tremelimumab and Durvalumab in Treating Participants With Recurrent or Metastatic Cervical, Vaginal, or Vulvar Cancers
This phase I trial studies how well stereotactic body radiation therapy works in combination with tremelimumab and durvalumab in treating participants with cervical, vaginal, or vulvar cancers that have come back (recurrent) or…
- Conditions
- Advanced Cervical Adenocarcinoma, Advanced Vaginal Carcinoma, Advanced Vulvar Carcinoma, Human Papillomavirus-Related Cervical Squamous Cell Carcinoma
- Trial name
- NCT03452332
- Testing
- Durvalumab, Laboratory Biomarker Analysis, Stereotactic Radiosurgery
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- M.D. Anderson Cancer Center
Vulvar Mucosa Lesions, Vulvar Intraepithelial Neoplasia
Interest of the Confocal Microscope in the Diagnosis of Epidermoid Carcinoma of the Vulva and Their Precursors
The confocal microscope is a noninvasive imaging technique that provides high-resolution images to a depth of 250 microns, such as "optical" cuts in three dimensions in the thickness of the skin.
- Trial name
- NCT02735109
- Testing
- photographies, biopsy normal area
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Vulvar Intraepithelial Neoplasia, Condylomata Acuminata
Cavitronic Ultrasonic Surgical Aspiration (CUSA) Women's Health Study
The study is a single arm, retrospective, single-center, post market registry. The purpose of this Registry is to collect data to demonstrate the safety and performance of CUSA® for the treatment of Vulvar Intraepithelial…
- Trial name
- NCT06297187
- Testing
- CUSA (Cavitronic Ultrasonic Surgical Aspirator)
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Integra LifeSciences Corporation
Cervical Cancer, Endometrial Cancer
Specimen and Data Study for Ovarian Cancer Early Detection and Prevention
RATIONALE: To improve strategies for detection and prevention of early-stage disease. PURPOSE: This research study is collecting specimens and data to develop better methods for early detection and prevention of ovarian cancer…
- Conditions
- Cervical Cancer, Endometrial Cancer, Fallopian Tube Cancer, Hereditary Breast/Ovarian Cancer (brca1, brca2)
- Trial name
- NCT00005095
- Testing
- Ca-125, screening questionnaire administration, Surgery
- Where
- United States
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Stage III Vulvar Cancer, Stage IVB Vulvar Cancer
Chemotherapy, Radiation Therapy, and Surgery in Treating Patients With Locally Advanced Cancer of the Vulva
This phase II trial is studying how well giving radiation therapy together with cisplatin followed by surgery works in treating patients with locally advanced cancer of the vulva.
- Conditions
- Stage III Vulvar Cancer, Stage IVB Vulvar Cancer, Vulvar Squamous Cell Carcinoma
- Trial name
- NCT00068406
- Testing
- 3-Dimensional Conformal Radiation Therapy, Cisplatin, Conventional Surgery
- Where
- 103 sites in United States
- Volunteers
- 61 people
- Sponsor
- Gynecologic Oncology Group
Cancer
Intrapleural BG00001 in Treating Patients With Malignant Pleural Mesothelioma or Malignant Pleural Effusions
RATIONALE: Using BG00001 to insert the gene for interferon-beta into a person's pleural cavity may improve the body's ability to fight cancer.
- Trial name
- NCT00066404
- Testing
- recombinant adenovirus-hIFN-beta
- Where
- United States
- Sponsor
- Abramson Cancer Center at Penn Medicine
Cervical Cancer, Colorectal Cancer
Octreotide in Preventing Diarrhea in Patients Who Are Undergoing Radiation Therapy to the Pelvis
RATIONALE: Octreotide may be effective in preventing or controlling diarrhea in patients who are undergoing radiation therapy to the pelvis. It is not yet known whether octreotide is effective for diarrhea.
- Conditions
- Cervical Cancer, Colorectal Cancer, Diarrhea, Endometrial Cancer
- Trial name
- NCT00033605
- Testing
- octreotide acetate, radiation
- Volunteers
- 130 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Cervical Dysplasia, Vulvar Dysplasia
OCT-AF Imaging of Pre-cancers of Vulva and Cervix
The multimodal imaging technology, OCT-AFI, will be used to image sites on the cervix, the endocervical canal and vulva. The imaging probe is small enough, it can be inserted into the endocervical canal for imaging.
- Conditions
- Cervical Dysplasia, Vulvar Dysplasia, Precancerous Lesions, Vulvar Cancer
- Trial name
- NCT03285841
- Testing
- OCT-AFI
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- British Columbia Cancer Agency
Bladder Cancer, Squamous Cell Carcinoma of the Lung
A Study Evaluating the Safety, Efficacy, and Pharmacokinetics (PK) of EVOLVE104 in Participants With Advanced Urothelial and Squamous Cell Carcinomas
The goal of this study is to evaluate the safety and effectiveness of EVOLVE104 in participants with advanced urothelial and squamous cell carcinomas who have previously taken standard treatment options, have declined or have…
- Conditions
- Bladder Cancer, Squamous Cell Carcinoma of the Lung, Esophageal Squamous Cell Carcinoma, Tongue Squamous Cell Carcinoma
- Trial name
- NCT07217171
- Testing
- EVOLVE104
- Where
- 16 sites in United States
- Volunteers
- 160 people
- Sponsor
- EvolveImmune United, Inc
Lymphedema, Stage 0 Cervical Cancer
Flexitouch® Home Maintenance Therapy or Standard Home Maintenance Therapy in Treating Patients With Lower-Extremity Lymphedema Caused by Treatment for Cervical Cancer, Vulvar Cancer, or Endometrial Cancer
This randomized phase III trial is studying Flexitouch® home maintenance therapy to see how well it works compared with standard home maintenance therapy in treating patients with lower-extremity lymphedema caused by treatment…
- Conditions
- Lymphedema, Stage 0 Cervical Cancer, Stage 0 Uterine Corpus Cancer, Stage 0 Vulvar Cancer
- Trial name
- NCT00577317
- Testing
- Management of Therapy Complications, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Gynecologic Oncology Group