Clinical trials: Vulvodynia
Vulvodynia
Botulinum Toxin A as a Treatment for Provoked Vestibulodynia
Women with provoked vestibulodynia (PVD) suffer from severe dyspareuni and often present a hyperactivity of the pelvic floor muscles (PFM) which maintain the dyspareunia.
- Trial name
- NCT04057755
- Testing
- botulinum toxin A, NaCl
- Where
- Sweden
- Volunteers
- 90 people
- Sponsor
- Karolinska Institutet
Fibromyalgia, Chronic Migraine, Headache
Personality, Defences, Central Sensitization, and Trauma in Women With Chronic Migraine, Fibromyalgia, and Vulvodynia
Chronic pain (CP) is a substantial healthcare challenge with considerable economic costs. Recently, the term Nociplastic Pain (NP) has been introduced as a third descriptor of mechanisms related to CP.
- Conditions
- Fibromyalgia, Chronic Migraine, Headache, Vulvodynia
- Trial name
- PSYCHOFIBRO (NCT06138171)
- Testing
- Psychological self-reported measures assesment (questionnaire)
- Where
- Italy
- Volunteers
- 1,006 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Vestibulodynia, Temporomandibular Disorder
Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments
Vestibulodynia (VBD) is a complex chronic vulvar pain condition that impairs the psychological, physical, and sexual health of 1 in 6 reproductive aged women in the United States.
- Conditions
- Vestibulodynia, Temporomandibular Disorder, Fibromyalgia Syndrome, Irritable Bowel Syndrome
- Trial name
- NCT03844412
- Testing
- 5% lidocaine/5 mg/ml 0.02% estradiol compound cream, Nortriptyline
- Where
- 2 sites in United States
- Volunteers
- 209 people
- Sponsor
- Duke University
Episiotomy Wound, Laser
Therapeutic Efficacy of Erbium:YAG Laser in Postpartum Patients With Episiotomy Scars
Episiotomy is a planned surgical incision to the perineum and posterior wall of the vagina during the second stage of labor. The fibrotic and sclerotic scar tissue formed as part of the healing process of episiotomies may cause…
- Conditions
- Episiotomy Wound, Laser, Vulvodynia, Vulva Pain
- Trial name
- NCT05793476
- Testing
- Fotona Dynamis Er:YAG Laser System
- Where
- Turkey (Türkiye)
- Volunteers
- 5 people
- Sponsor
- Istanbul University - Cerrahpasa
Vulval Dermatoses, Vulval Pain Syndromes
A Patient Reported Outcome Measure for Vulval Conditions
To create a new patient reported outcome measure in the form of a questionnaire, which will accurately reflect the profound impact that vulval dermatoses and vulval pain syndromes have on patients' quality of life
- Trial name
- NCT05066243
- Testing
- questionnaire
- Volunteers
- 165 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Interstitial Cystitis, Sexual Dysfunction
The Women's Urology Center/WISH Database Project
Comprehensive database from the Women's Urology Center/WISH (Women's Initiative for Pelvic Pain and Sexual Health) program at Beaumont.
- Conditions
- Interstitial Cystitis, Sexual Dysfunction, Pelvic Pain, Incontinence
- Trial name
- NCT00379002
- Where
- United States
- Volunteers
- 2,923 people
- Sponsor
- Corewell Health East
Sexual Pain Disorders, Postmenopausal Symptoms
Sexual Penetration Pain in Postmenopausal Women: A Topical Botanical Drug Treatment
This study will evaluate the use of topical 5 or 10% sinecatechins, a botanical drug derived from green tea for the alleviation of sexual pain in the area around the vaginal opening (the vulvar vestibule), that is a main source…
- Conditions
- Sexual Pain Disorders, Postmenopausal Symptoms, Vulvovaginal Atrophy, Female Sexual Dysfunction
- Trial name
- NCT03682601
- Testing
- 5% sinecatechins ointment, 10% sinecatechins ointment
- Where
- 4 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- GTO Pharmaceutical, LLC
Vulvodynia
Lasertherapy for Vulvodynia
The study aims to assess the efficacy, acceptance and safety profile of vulvovaginal laser therapy in women with vulvodynia.
- Trial name
- Lydia (NCT04711369)
- Testing
- Erbium:Yag laser
- Where
- Austria
- Volunteers
- 92 people
- Sponsor
- Medical University of Graz
Vulvar Lichen Sclerosus
Clobetasol Propionate Versus Fractionated Carbon Dioxide Laser for the Treatment of Lichen Sclerosus
This study is being done to compare the effects, good and bad, of fractionated CO2 laser treatment and clobetasol propionate .05% ointment on vulvar lichen sclerosus.
- Trial name
- CuRLS (NCT02573883)
- Testing
- Fractionated Carbon Dioxide Laser, Clobetasol Propionate 0.05% ointment
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Medstar Health Research Institute
Vulvodynia, Vulvar Vestibulitis
Acupuncture for the Treatment of Vulvodynia
A randomized controlled pilot study was conducted to evaluate the effect of an acupuncture protocol for the treatment of vulvodynia. Hypotheses: 1. Acupuncture reduces vulvar pain and dyspareunia in women with vulvodynia. 2.
- Conditions
- Vulvodynia, Vulvar Vestibulitis, Pain, Dyspareunia
- Trial name
- NCT02197429
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Schlaeger, Judith M., CNM, LAc, PhD
Vulvodynia
A Randomized Clinical Trial for Women With Vulvodynia
This study will evaluate the relative effectiveness of cognitive-behavioral therapy and supportive psychotherapy for the treatment of women with vulvodynia.
- Trial name
- NCT00607490
- Testing
- Cognitive-Behavioral Therapy, Supportive Psychotherapy
- Volunteers
- 50 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Vulvodynia
Safety and Efficacy of Two Vaginal Products Versus Placebo in Patients With Vaginal Discomfort
This study will evaluate the efficacy and safety of two vaginal products compared with that of placebo to determine if the two products are better than placebo in the relief of vaginal discomfort.
- Trial name
- NCT00590590
- Testing
- Lidocaine/Diphenhydramine, lidocaine
- Where
- 48 sites in United States, Canada
- Volunteers
- 105 people
- Sponsor
- Lumara Health, Inc.
Provoked Vestibulodynia
Dry Needling for Provoked Vestibulodynia
This is a randomized and controlled study investigating the feasibility and acceptability of a dry needling treatment for women suffering from provoked vestibulodynia.
- Trial name
- NCT05797480
- Testing
- Real Dry needling, Non penetrating dry needling
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- Université de Sherbrooke
Vulvodynia, Provoked Vestibulodynia
Pregnancy, Childbirth Intentions and Outcomes Under Sexual Pain
The main purpose of this study is to assess conception, pregnancy, childbirth, and pain experiences among women who have been diagnosed with vulvodynia.
- Trial name
- PRECIOUS (NCT01731288)
- Where
- Canada
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Vulvodynia, Vulvar Vestibulitis
Dysbiosis in Localized Provoked Vulvodynia (LPV)
Currently, the pathogenesis of Localized Provoked Vulvodynia (LPV) has not been elucidated. Few observations may point to involvement of the microbiome: the association of LPV with preceding chronic recurrent candidiasis, and the…
- Trial name
- DMLPV (NCT02393911)
- Testing
- Low Oxalate Diet
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
Vulvodynia
Vulvodynia: Identification of Potential Relevant Biomarkers
Vulvodynia is a syndrome of unexplained vulvar pain that is frequently accompanied by physical disabilities, limitation of daily activities (such as sitting and walking), sexual dysfunction and psychologic disability.
- Trial name
- NCT02981433
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- St. Louis University
Provoked Vestibulodynia
Integrated Mindfulness for Provoked Vestibulodynia
This study aims to test the efficacy of a 4-session intervention (Group psychoeducational treatment) using a randomized study design. Participants will be randomized in to 'immediate treatment' or 'waitlist control'.
- Trial name
- IMPROVED (NCT01704443)
- Testing
- Group Psychoeducational Treatment, Waitlist control
- Where
- Canada
- Volunteers
- 97 people
- Sponsor
- University of British Columbia
Healthy, Vulvodynia
Pelvic Floor Myofascia: A New Player Involved in Vulvodynia
This study aims to develop novel ultrasound evaluation techniques to characterize the different pelvic myofascial tissues and to examine the intra- and inter-rater reliability of these techniques (objective 1).
- Trial name
- NCT05350618
- Testing
- Ultrasound evaluation
- Where
- Canada
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Vulvodynia
Light Emitting Diode in the Treatment of Vulvodynia
Vulvar pain can be related to a specific cause (inflammation, cancer, trauma, infection) or can be classified as vulvodynia, when vulvar pain is idiopathic and lasts for at least three months.
- Trial name
- NCT06337448
- Testing
- Blue LED
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Centro de Atenção ao Assoalho Pélvico
Provoked, Localized Vulvodynia, Provoked Vestibulodynia
Provoked, Localized Vulvodynia Treatment With Acupuncture and Lidocaine Pilot Study
The investigators research project is a randomized, controlled, single-blinded, feasibility pilot study. The investigators will study the feasibility of a novel treatment for women with Provoked Localized Vulvodynia (PLV) with…
- Conditions
- Provoked, Localized Vulvodynia, Provoked Vestibulodynia, Vulvar Vestibulitis, Vulvodynia
- Trial name
- NCT01996384
- Testing
- Classical Acupuncture, Non-classical acupuncture, Lidocaine
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Oregon College of Oriental Medicine