Clinical trials: WHIM
Primary Aldosteronism
CXCR4 Targeted PET Imaging in the Diagnosis and Identification of Primary Aldosteronism
This study aimed to prospectively evaluate the utility of C-X-C chemokine receptor type 4 (CXCR4) positron emission tomography (PET) imaging in patients with clinical suspected primary aldosteronism (PA), with postoperative…
- Trial name
- NCT06183554
- Testing
- CXCR4
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xiao Chen
Chronic Myeloid Leukemia
Imatinib and BL-8040 (Novel Anti CXCR4 Antagonist) for Improving Molecular Response in Chronic Myelogenous Leukemia
The aim of the study is to test the safety and efficacy of BL-8040 (a CXCR4 antagonist) in improving the response to imatinib in CML patients not achieving an optimal response with imatinib alone.
- Trial name
- NCT02115672
- Testing
- BL-8040
- Where
- Israel
- Sponsor
- Sheba Medical Center
Large Reperfused ST-Elevation Myocardial Infarction
CXCR4 Antagonism for Cell Mobilisation and Healing in Acute Myocardial Infarction (CATCH-AMI)
The purpose of this study is to investigate the effects of POL6326 (CXCR4 antagonist) as a stem cell mobilizing agent, on cardiac function and infarct size and on safety and tolerability, in patients with reperfused ST-Elevation…
- Trial name
- CATCH-AMI (NCT01905475)
- Testing
- POL6326
- Where
- 17 sites in Austria, Germany and 3 more
- Volunteers
- 120 people
- Sponsor
- Polyphor Ltd.
Acute Myelocytic Leukemia, Acute Lymphocytic Leukemia
Studies on the Significance of CXCR4-CXCL12 on Leukemic Cells Passing Through"Marrow-Blood Barrier"
Bone marrow consists of a complex hematopoietic cellular component.When the blood progenitor cells differentiate to mature cells, they will exit unassisted to peripheral blood.
- Trial name
- NCT00155844
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Cancer
Imaging CXCR4 Expression in Subjects With Cancer Using 64 Cu-Plerixafor
In mouse models and in patients, expression of the chemokine receptor CXCR4 on various cancers has been correlated with aggressive biological behavior, including increased rates and certain sites of metastasis, and decreased…
- Trial name
- NCT02069080
- Testing
- 64-Cu-plerixafor
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
CXCR4-related Disease, Tumor
Chemokine Receptor 4 PET/CT Imaging of CXCR4-Related Diseases
To evaluate the potential usefulness of 68Ga/18F-Pentixafor/Pentixather positron emission tomography/computed tomography (PET/CT) for the diagnosis of primary and metastatic lesions in various CXCR4-related disease patients.
- Conditions
- CXCR4-related Disease, Tumor, Positron Emission Tomography, Metastasis
- Trial name
- NCT06690736
- Testing
- CXCR4 PET/CT Imaging
- Where
- 3 sites in China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University
Healthy Volunteers
First in Man Study of ALX-0651, a Nanobody Inhibiting CXCR4
The purpose of this first-in-man Phase I study is to determine whether the CXCR4-inhibitor ALX-0651 is safe and effective after single or multiple intravenous administrations to healthy male volunteers.
- Trial name
- NCT01374503
- Testing
- ALX-0651
- Where
- Netherlands
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Ablynx, a Sanofi company
Shwachman-Diamond Syndrome, SDS
Shwachman-Diamond Syndrome Global Patient Survey and Partnering Platform
The Shwachman-Diamond Syndrome Global Patient Survey and Collaboration Program (SDS-GPS) is an opportunity for patients and their families - from anywhere in the world - to share their experience living with SDS via a safe…
- Conditions
- Shwachman-Diamond Syndrome, SDS, IBMF, Congenital Neutropenia
- Trial name
- SDS-GPS (NCT06999954)
- Where
- United States
- Volunteers
- 8,000 people
- Sponsor
- Shwachman-Diamond Syndrome Alliance Inc
Multiple Myeloma
A Pharmacodynamic Study of the Apheresis Product of Multiple Myeloma Patients Undergoing Quad-induction Followed by Motixafortide + G-CSF Mobilization
This study includes extended CD34+ profiling on the apheresis product of multiple myeloma patients undergoing standard-of-care quad-induction followed by motixafortide + G-CSF mobilization, and in addition, assesses the…
- Trial name
- NCT06547112
- Testing
- Motixafortide, G-CSF
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Washington University School of Medicine
WHIM Syndrome
Efficacy and Safety Study of Mavorixafor in Participants With Warts, Hypogammaglobulinemia, Infections, and Myelokathexis (WHIM) Syndrome
This study has a double-blind, Randomized Placebo-Controlled Period and an Open-Label Period. The primary objective of the Randomized Placebo-Controlled Period is to demonstrate the efficacy of mavorixafor in participants with…
- Trial name
- NCT03995108
- Testing
- Mavorixafor
- Where
- 23 sites in United States, Australia and 11 more
- Volunteers
- 31 people
- Sponsor
- X4 Pharmaceuticals
Cushing s Syndrome
Diagnostic Value of CXCR4-targeted PET/CT in ACTH-dependent and Independent Cushing's Syndrome
In previous clinical practice, 68Ga-Pentixafor PET/CT has demonstrated promising diagnostic utility in various neuroendocrine tumors by targeting CXCR4, a chemokine receptor overexpressed in several ACTH-secreting neoplasms.
- Trial name
- NCT07350707
- Testing
- 68Ga-Pentixafor
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Peking Union Medical College Hospital
Metastatic Pancreatic Ductal Adenocarcinoma
Phase I Study of Cosibelimab and Balixafortide in Metastatic Pancreatic Ductal Adenocarcinoma
This is a single-center, open-label, phase 1 dose escalation and dose expansion (safety confirmation) trial to evaluate the safety and tolerability of balixafortide and cosibelimab in patients with metastatic PDAC who progressed…
- Trial name
- NCT06981806
- Testing
- Balixafortide, Cosibelimab
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Arsen Osipov
Papillomavirus Infections
Natural History of Human Papillomavirus (HPV) Infections in Mid-Adult Women (WHIM)
The purpose of this study is to determine rates of oral and genital human papillomavirus (HPV) infections, and look at risk factors for HPV infection in healthy mid-adult women.
- Trial name
- WHIM (NCT01295242)
- Where
- United States
- Volunteers
- 409 people, healthy volunteers welcome
- Sponsor
- University of Washington
Multiple Myeloma, Lymphoma
Chemokine Receptor CXCR4-targeting Molecular Imaging for Metabolic Characterization of Multiple Myeloma and Lymphoma
Chemokine receptor CXCR4 was expressed in MM and lymphoma cells and CXCR4-targeting molecular imaging- 68Ga-Pentixafor PET/CT could be a promising technique to evaluate the extent of MM and lymphoma with higher accuracy.
- Trial name
- NCT03436342
- Testing
- 68Ga-Pentixafor
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking Union Medical College Hospital
Multiple Myeloma
68Ga-pentixather and 68Ga-pentixafor PET/CT in Multiple Myeloma
Chemokine receptor-4 (CXCR4) is overexpressed in multiple myeloma (MM) cells. 68Ga-pentixafor is a radio-labled tracer for CXCR4 . 68Ga-pentixafor PET/CT has shown good diagnostic performance in MM.
- Trial name
- NCT05364177
- Testing
- 68Ga-Pentixather, 68Ga-Pentixafor
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking Union Medical College Hospital
Multiple Myeloma
Safety Study of a Chemokine Receptor (CXCR4) Antagonist in Multiple Myeloma Patients
BKT-140 drug substance is a highly selective chemokine receptor (CXCR4) antagonist, which is developed by Biokine as a novel therapy for Multiple Myeloma (MM, a type of blood cancer).
- Trial name
- NCT01010880
- Testing
- BKT140
- Where
- 2 sites in Israel
- Volunteers
- 16 people
- Sponsor
- Biokine Therapeutics Ltd
Systemic Sclerosis (SSc)
As Part of a Pilot Study, Visualization of Inflammatory Activity in Systemic Sclerosis Using CXCR4 PET/CT
Systemic sclerosis (SSc) is a heterogeneous clinical picture consisting of inflammatory, vasculopathic, and fibrotic changes. Initially, inflammatory changes usually occur, which result in fibrosis over time.
- Trial name
- NCT07212959
- Testing
- CXCR4-PET/CT
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- Wuerzburg University Hospital
Systemic Lupus Erythematosus
Expression of CXCR4 in Patients With Systemic Lupus Erythematosus
The objective of this study is to estimate the possible role of CD184 in the pathogenesis of SLE; comparing its level among SLE cases to healthy controls.
- Trial name
- NCT04799730
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Coronary Artery Disease
Adiponectin and Circulating Progenitor Cells (CPC) Function
Adiponectin and exercise training contribute to the maintenance of a normal vascular tone by influencing vascular NO bioavailability and concentration and function of endothelial progenitor cells.
- Trial name
- NCT01272674
- Testing
- exercise training
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Leipzig
Laryngeal Cancer, Hypopharyngeal Cancer
The Role of Stromal Cell-Derived Factor-1 (SDF-1)/CXC Chemokine Receptor 4 (CXCR4) in Metastasis of Laryngeal and Hypopharyngeal Squamous Cell Carcinoma
The purpose of this study is to investigate the relationship between SDF-1/CXCR4 and metastasis of laryngeal and hypopharyngeal squamous cell carcinomas.
- Conditions
- Laryngeal Cancer, Hypopharyngeal Cancer, Metastasis
- Trial name
- NCT00174096
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital