Clinical trials: Wakefulness Disorder
Sleep Deprivation
Impact of THN102 on Attention, Wakefulness and Cognitive Performance During Total Sleep Deprivation
Study Objectives: THN102 is a new combination between modafinil and flecainide low-dose, a documented glial connexin inhibitor. Efficacy of THN102 was compared to modafinil and to placebo on parameters impaired by total sleep…
- Trial name
- NCT03182413
- Testing
- Modafinil, THN102
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Theranexus
Stroke, Post Stroke Fatigue
Treatment of Post Stroke Fatigue With a Wakefulness Promoting Agent
This study is an investigator initiated placebo controlled double blinded trial. The hypothesis is that treatment with modafinil positively will affect behavioural and cognitive rehabilitation after stroke, causing the treatment…
- Trial name
- NCT01800097
- Testing
- modafinil
- Where
- Denmark
- Volunteers
- 41 people
- Sponsor
- Herlev Hospital
Shift-Work Sleep Disorder
Light Treatment to Shift-working Nurses
This project examines 1) the effects of appropriately timed bright light on adaptation (in terms of sleep and sleepiness) to three consecutive night shifts; and 2) the effects of such bright light on re-adaptation (in terms of…
- Trial name
- NCT02978053
- Testing
- Bright light, Red light
- Where
- Norway
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness
fNIRS for Disorders of Consciousness
The goal of this observational study is to learn whether functional near-infrared spectroscopy (fNIRS) can measure brain activity in healthy adults and in people with disorders of consciousness (DoC) in the neuro-intensive care…
- Conditions
- Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness, Coma, Minimally Conscious State
- Trial name
- NCT07485361
- Testing
- Functional Near-Infrared Spectroscopy Monitoring
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Disorders of Consciousness, Qualitative Research
Families Expectations and Hope Raised by an Evaluation of Consciousness in Patients in a Vegetative State
Progress in resuscitation has increased the chances of survival after anoxic or traumatic brain injury. More and more patients with severe cerebral damages are resuscitated but upon awakening from coma, some patients remain in a…
- Conditions
- Disorders of Consciousness, Qualitative Research, Ethics, Neuroimaging
- Trial name
- REVE (NCT02879565)
- Testing
- Semi structured interviews + EEG exams
- Where
- 2 sites in France
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Disorder of Consciousness, Unresponsive Wakefulness Syndrome
Auditory Processing in DOC Patients
This prospective observational study investigates whether electroencephalography (EEG) can improve the differentiation between unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS) in patients with severe…
- Conditions
- Disorder of Consciousness, Unresponsive Wakefulness Syndrome, Minimally Conscious State
- Trial name
- AUD-DOC (NCT07455682)
- Testing
- Coma Recovery Scale-Revised (CRS-R), Electroencephalography (EEG)
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- BDH-Klinik Hessisch Oldendorf
Delayed Sleep Phase Disorder, Jet-lag
Melatonin Treatment for Induced Transient Insomnia
Melatonin supplements have been reported to be an effective treatment for circadian rhythm sleep disorders, including shift work dyssomnia, jet-lag, delayed sleep phase syndrome, and sleep disruption suffered by many blind…
- Conditions
- Delayed Sleep Phase Disorder, Jet-lag, Shift-work Disorder
- Trial name
- NCT00950885
- Testing
- Low Dose Melatonin, High Dose Melatonin
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Major Depression, Sleep Inertia
Study of Sleep Inertia in Major Depressive Disorder by the Psychomotor Vigilance Task
The study population comprises three groups of 30 analyzable participants: Patients with sleep inertia and Major Depressive Disorder, patients with Major Depressive Disorder but without sleep inertia, and controls without mood…
- Trial name
- IN-DEP (NCT06732284)
- Testing
- Psychomotor vigilance task, Video-polysomnography, Sleep and activity monitoring
- Where
- France
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Disorders of Consciousness Due to Severe Brain Injury, Minimally Conscious State
Assessment of Consciousness With CRS-R and SECONDs
Accurately determining the level of consciousness in patients with severe brain injury is essential for treatment planning, prognosis, and ethical decision-making.
- Conditions
- Disorders of Consciousness Due to Severe Brain Injury, Minimally Conscious State, Unresponsive Wakefulness Syndrome
- Trial name
- AssessConsc (NCT07456020)
- Testing
- Simplified Evaluation of CONsciousness Disorders (SECONDs), Coma Recovery Scale-Revised (CRS-R)
- Where
- Germany
- Volunteers
- 110 people
- Sponsor
- BDH-Klinik Hessisch Oldendorf
Diabetes Mellitus
Human Factors and Home Use Study of the Vigilant Diabetes Management Application
A human factors and home use study to assess whether subjects with diabetes and their caregivers can understand feedback received from the Vigilant Diabetes Management Application about their blood glucose patterns and whether…
- Trial name
- NCT02276131
- Testing
- Vigilant Diabetes Management Application
- Volunteers
- 61 people
- Sponsor
- InSpark Technologies, Inc.
Disorders of Consciousness, Minimally Conscious State
Aiming for a Better Understanding and Improvement of the Diagnosis and Prognosis of Patients With Disorders of Consciousness Through Multimodal Observations
Improved treatment of severe brain injuries has resulted in increased survival rates. While some of these patients regain consciousness after a transient state of coma, others may develop a disorder of consciousness (DoC).
- Conditions
- Disorders of Consciousness, Minimally Conscious State, Unresponsive Wakefulness Syndrome, Caregivers
- Trial name
- PerBrain (NCT04798456)
- Testing
- Coma scales, Imaging, electrophysiology, body signals, and brain stimulation, Questionnaires
- Where
- 4 sites in France, Germany and 2 more
- Volunteers
- 150 people
- Sponsor
- Paris Brain Institute (ICM)
Neurobehavioral Manifestations, Drug Related Sleep Disturbance
Acute and Residual Effects of Caffeinated Beer
The aim of this study is to develop information about the acute and residual effects of a new product being targeted to young adults.
- Conditions
- Neurobehavioral Manifestations, Drug Related Sleep Disturbance, Alcohol Intoxication
- Trial name
- NCT00515294
- Testing
- Caffeinated Alcoholic Beer, Non-Caffeinated Alcoholic Beer, Caffeinated Non-Alcoholic Beer
- Where
- United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Boston University
High Arousing Positive Emotion, Low Arousing Positive Condition
Do Different Arousal Levels Affect Pressure Pain Thresholds?
This study examines whether emotional arousal level alone, while maintaining positive emotional valence, can influence pressure pain thresholds (PPTs) in healthy adults.
- Trial name
- DDEALAPPT (NCT07802444)
- Testing
- Emotional high arousing intervention, Low arousal intervention
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Linnaeus University
Sleep Wake Disorders
Testing Methods to Increase the Frequency of Lucid Dreaming
This study investigates the impact of lucid dreaming on individuals and explores methods to increase the likelihood of inducing lucid dreams intentionally.
- Trial name
- RRF (NCT06440226)
- Testing
- Eye Movement Technique, Memory Recall of Previous Night's Thoughts, Recall of Previous Lucid Dreams
- Where
- United Kingdom
- Volunteers
- 101 people
- Sponsor
- Abdulraheem Mohamed Gouda
Wakefulness Disorder, Narcolepsy
Hypersomnia in the Paediatric Population
This is a 36-month, multicentric, cross-sectional study involving a paediatric population aged 6 to 17 years. Three groups will be included: Group A: children from the general population with no complaints of sleepiness; Group B…
- Conditions
- Wakefulness Disorder, Narcolepsy, Idiopathic Hypersomnia
- Trial name
- SOMNO-PED (NCT07766343)
- Testing
- Sleepness and wakeness scale, Polysomnography, Actimetry
- Where
- France
- Volunteers
- 760 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
ANCA Associated Vasculitis, Occupational Diseases
Occupational and Environmental Origins of ANCA Vasculitis: Contribution of Data From the National Network for Vigilance and Prevention of Occupational Pathologies (RNV3P)
The main objective is to identify specific risk factors for ANCA vasculitis of occupational and/or environmental origin (exposures identified by questioning, geographical distribution of cases) from the RNV3P data.
- Conditions
- ANCA Associated Vasculitis, Occupational Diseases, Environmental Exposure
- Trial name
- ANCAPRO (NCT05416723)
- Where
- 11 sites in France
- Volunteers
- 302 people
- Sponsor
- University Hospital, Brest
Consciousness Disorder, Minimally Conscious State
Transcutaneous Auricular Vagal Nerve Stimulation for Post-coma Patients With Disorders of Consciousness
Non-invasive brain stimulations techniques have recently shown promising results in patients with disorders of consciousness. Notably, a case reported improvement of level of consciousness using transcutaneous auricular vagal…
- Conditions
- Consciousness Disorder, Minimally Conscious State, Vegetative State
- Trial name
- NCT04065386
- Testing
- Active taVNS
- Where
- 2 sites in Belgium
- Volunteers
- 44 people
- Sponsor
- University of Liege
Disorders of Consciousness
Window On the Brain
Disorders of consciousness (DOC) diagnosis suffers from the difficulty to measure the level of consciousness due to the variability associated with behavioural assessments and the difficulty in detecting the residual level of…
- Trial name
- WOB (NCT06693492)
- Testing
- Ultrasound technique for diagnosis; Focused Ultrasound Stimulation for intervention
- Where
- 4 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Shift-Work Sleep Disorder
Effects of Daytime Eszopiclone Administration in Shift Workers
The purpose of this study is to test the effects of eszopiclone on daytime sleep and overnight wakefulness in shift workers.
- Trial name
- NCT00900159
- Testing
- eszopiclone
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Normal Physiology
Brain Amyloid- Retention During Wakefulness and Following Emergence From Sleep in Healthy People
Background: Brain activity creates waste products. The body s glymphatic system removes this waste, especially during sleep. One brain waste product is amyloid-beta (Ab). It plays a role in Alzheimer s disease.
- Trial name
- NCT02669225
- Testing
- [18F]florbetaben
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)