Clinical trials: Wakefulness Disorder
Sleep Disturbance in Infancy (Disorder), Neonatal Disease
Real-time State of Vigilance Monitor for the Neonatal Intensive Care Unit
The goal of this observational study is to collect data to develop a complete package (hardware, user interface software and algorithms) that can monitor sleep-wake stages in neonates.
- Trial name
- NCT04920175
- Testing
- Novel Real-time Neonatal Sleep Stage Detection Algorithm
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Michigan
Obstructive Sleep Apnea
Acoustic OSA Prediction During Wakefulness and Monitoring During Sleep
The purpose of this study is to investigate the feasibility of sound analysis for: a) sleep apnea detection both during wakefulness and sleep, and b) flow-sound relationship during both wakefulness and sleep in patients and…
- Trial name
- NCT04112927
- Where
- Canada
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Arthritis, Cancer
Immune CHeckpoint Inhibitors Monitoring of Adverse Drug ReAction
Immune checkpoint inhibitors (ICIs) might have high grade immune-related adverse events (irAEs) from rhumatologic, endocrinologic, cardiac or other system origin.
- Conditions
- Arthritis, Cancer, Cardiac Disease, Endocrine System Diseases
- Trial name
- CHIMeRA (NCT03492242)
- Testing
- Immune checkpoint inhibitor
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Parkinson Disease, Multiple Sclerosis
TeleNEURO-Rehabilitation Systems for Neurodegenerative Conditions: the FIT4TeleNEURO Pragmatic Trial
The goal of the FIT4TeleNEURO pragmatic trial is to verify, in real-life care contexts, the superiority in terms of the effectiveness of early rehabilitation intervention with Telerehabilitation (TR) protocols (TR single…
- Conditions
- Parkinson Disease, Multiple Sclerosis, Neurologic Diseases, General
- Trial name
- FIT4TeleNEURO (NCT06685744)
- Testing
- Telerehabilitation_TRsA, Educational treatment, Telerehabilitation_TRcA
- Where
- 6 sites in Italy
- Volunteers
- 300 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Obstructive Sleep Apnea
Dilator Muscle Activity in Health and Sleep Apnea
The role of control of peri-pharyngeal muscle tone in the pathogenesis of obstructive sleep apnea (OSA) is obvious: pharyngeal obstruction occurs only during sleep; and pharyngeal collapse occurs in almost all healthy subjects…
- Trial name
- NCT04254341
- Testing
- patients with OSA
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bnai Zion Medical Center
Sleep
Sleep-wakefulness Status in Preterm Infants
This study was conducted to compare the effectiveness of three stair positioning pillows and positioning materials on the sleep-wakefulness status of preterm infants.
- Trial name
- NCT06664749
- Testing
- Three stair position pillow group, Positioning material group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Harran University
Sleep Apnea, Obstructive
Effect of Dalfampridine (4-AP) on Genioglossus Muscle Activity in Healthy Adults
In this protocol the investigators will test the effect of dalfampridine (a potassium channel blocker) on genioglossus muscle activity (EMG GG) during wakefulness and sleep in healthy control subjects.
- Trial name
- APIGLOSS (NCT02656160)
- Testing
- Dalfampridine
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Healthy Volunteers, Caffeine
Caffeine Dose: Performance and Recovery
The goal of this clinical trial is to learn how different doses of caffeine taken in the evening affect rowing performance, sleep quality, and daytime alertness in trained male university rowers.
- Conditions
- Healthy Volunteers, Caffeine, Sleep Quality
- Trial name
- NCT07090421
- Testing
- Cellulose Powder, Caffeine 3 mg/kg Oral Powder, Caffeine 6 mg/kg Oral Powder
- Where
- Turkey (Türkiye)
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Ulaç Can YILDIRIM
Parkinson Disease
Characterization of the Involvement of the Subthalamic Nucleus During Wakefulness and Sleep in Parkinson's Disease: Contribution of Deep Brain Stimulation
Sleep-wake disturbances are common in Parkinson's disease. These disturbances are associated with a decline in patients' quality of life and a poor prognosis.
- Trial name
- SLEEP-STN (NCT07637955)
- Testing
- Deep Brain Stimulation
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Grenoble
Cardiac Failure, Heart Failure
Insomnia Self-Management in Heart Failure
Chronic insomnia may contribute to the development and exacerbation of heart failure (HF), incident mortality and contributes to common and disabling symptoms (fatigue, dyspnea, anxiety, depression, excessive daytime sleepiness…
- Conditions
- Cardiac Failure, Heart Failure, Congestive Heart Failure, Heart Failure, Congestive
- Trial name
- HSS (NCT02660385)
- Testing
- Cognitive Behavioral Therapy for Insomnia, Self-Management Education for Heart Failure
- Where
- United States
- Volunteers
- 195 people
- Sponsor
- Yale University
CNS Tumor
Vigilant ObservatIon of GlIadeL WAfer ImplaNT Registry
This is a prospective, observational registry in patients who have been prescribed Gliadel Wafer by the physician as part of usual care.
- Trial name
- VIGILANT (NCT02684838)
- Where
- 31 sites in United States
- Volunteers
- 272 people
- Sponsor
- Arbor Pharmaceuticals, Inc.
Disorders of Excessive Somnolence
Test-retest Reliability of the Maintenance of Wakefulness Test in Participants With Hypersomnolence
This study will provide the first measurement of the test-retest reliability of the Maintenance of Wakefulness Test (MWT) with a prospective multicenter design.
- Trial name
- REWIND (NCT07120061)
- Testing
- First MWT, second MWT, actimetry
- Where
- 4 sites in France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Shift-Work Sleep Disorder, Shift-Work Related Sleep Disturbance
Sleep and Circadian Treatments for Shift Workers
There are three components to this study: a Field Trial, a Shift Worker Survey, and Focus Groups. The Investigators will study the effectiveness, feasibility, and acceptability of an 8-h sleep intervention in older night workers…
- Trial name
- NCT03813654
- Testing
- 8-h Afternoon-Evening Sleep, 8-h Free Sleep
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Disorder of Consciousness, Stroke
tDCS and rTMS in Patients With Early Disorders of Consciousness
A randomized controlled study was conducted to explore the efficacy of early transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) to promote wakefulness in patients with disorder…
- Conditions
- Disorder of Consciousness, Stroke, Ischemic-hypoxic Encephalopathy
- Trial name
- NCT05820178
- Testing
- tDCS, rTMS
- Volunteers
- 120 people
- Sponsor
- Xuanwu Hospital, Beijing
Down Syndrome (Trisomy 21), Fragile X Syndrome (FXS)
The Neurocognitive Bases of Trust in Intellectual Disability
This project studies the neurocognitive basis of trust adjustment in intellectual disability (ID), a source of significant vulnerability for these patients, focusing on two target populations chosen for their specific social…
- Trial name
- BNConfDI (NCT07434037)
- Testing
- Confidence adjustment assessment, clinical assessment, Cognitive assessment
- Where
- France
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Stroke, Hemispatial Neglect
Guanfacine for the Treatment of Spatial Neglect and Impaired Vigilance
To find out if spatial neglect following stroke and brain injury can be reduced using guanfacine, a drug that was shown to improve neglect in two stroke patients in a previous pilot study (Malhotra et al, 2006).
- Trial name
- GASNIV (NCT00955253)
- Testing
- Guanfacine
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- Imperial College London
Disorder of Consciousness, Minimally Conscious State
Simultaneously PET/MRI in Prolonged DOC Patients
Recently introduced hybrid PET/MR scanners provide the opportunity to measure simultaneously, and in direct spatial correspondence, both metabolic demand and functional activity of the brain, hence capturing complementary…
- Conditions
- Disorder of Consciousness, Minimally Conscious State, FDG-PET, Rs-fMRI
- Trial name
- NCT04164680
- Testing
- Multimodal Neuroimaging
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hangzhou Normal University
Brain Injuries, Acute, Brain Injuries, Traumatic
Antiseizure Medication in Seizure Networks at Early Acute Brain Injury
The goal of this clinical trial is to explore the effect of FDA-approved antiseizure drugs in the brain connectivity patterns of severe and moderate acute brain injury patients with suppression of consciousness.
- Conditions
- Brain Injuries, Acute, Brain Injuries, Traumatic, Brain Ischemia, Brain Hypoxia
- Trial name
- NCT06081283
- Testing
- Phenobarbital Sodium Injection, Levetiracetam, Lacosamide Injectable Product
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of North Carolina, Chapel Hill
Cirrhosis
Method of Assessment of Driving Ability in Patients Suffering From Wakefulness Pathologies.
The project will improve scientific knowledge regarding a recent law applying potentially to every french driver. It will give for the first time an indication on the impact of alerting treatments on driving risks.
- Trial name
- AutoSop-Foie (NCT01231828)
- Testing
- L-carnitine, Lactulose
- Where
- France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Caen
Parkinson's Disease
The Effects of a High Intensity Exercise Training Program in Patients With Parkinson's Disease
The purpose of this randomized, controlled interventional study is to determine the effects of a high intensity exercise training program on objective sleep measures, daytime sleepiness, mobility, and brain health/functional…
- Trial name
- NCT02593955
- Testing
- PD exercise, Sleep Hygiene
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham