Clinical trials: Wasting Syndrome
Autologous Hematopoietic Stem Cell Transplant
Muscle Stimulation for Physical Function During Stem Cell Transplant
Some blood, bone marrow, and lymphatic (hematologic) cancers such as Hodgkin/Non-Hodgkin lymphomas, chronic lymphocytic leukemia, and multiple myeloma, are over-represented in Veterans due to exposures including Agent Orange and…
- Trial name
- NCT04364256
- Testing
- RS-4i Plus Sequential Stimulator (RS Medical, Vancouver, WA)
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- VA Office of Research and Development
Acute Malnutrition in Childhood, Wasting
Integrated Research on Acute Malnutrition in Mali (IRAM-MALI)
The IRAM MALI impact evaluation uses a cluster-randomized controlled study design to assess the impact of the package of integrated interventions aimed at reducing the longitudinal prevalence of wasting by reducing the incidence…
- Trial name
- NCT04872088
- Testing
- Strengthened SBCC, Preventive nutritional supplement, Family MUAC
- Where
- Mali
- Volunteers
- 9,797 people
- Sponsor
- International Food Policy Research Institute
Kidney Failure, Chronic
Metabolic and Inflammatory Responses to Hemodialysis and the Effect of a Meal
The objective of this study is to characterize the hormonal and inflammatory responses to hemodialysis, and to determine the effect of a meal versus fast on the metabolic changes in the post-dialytic phase.
- Trial name
- NCT01446302
- Testing
- Double meal
- Where
- 2 sites in Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Electrolyte Disturbances, Subarachnoid Hemorrhage
Electrolyte and Fluid Disturbances in Subarachnoid Hemorrhage and Traumatic Brain Injury
During the course of their acute illness patients with subarachnoid hemorrhage and severe traumatic brain injury often develop disturbances in their fluid balance and electrolyte homeostasis.
- Conditions
- Electrolyte Disturbances, Subarachnoid Hemorrhage, Traumatic Brain Injury, Natriuretic Peptides
- Trial name
- NCT01313975
- Where
- Switzerland
- Volunteers
- 85 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Undernutrition, Wasting
Evaluating Oral Nutritional Supplements on Children's Nutritional Status and Digestive Health in Vietnam.
Evaluating the efficiency of using Oral Nutritional Supplementation toward nutrition status (anthropometric index, the prevalence of wasting), digestive disorders, and anorexic in children aged 24 - 71 months.
- Conditions
- Undernutrition, Wasting, Malnourished
- Trial name
- NCT05551637
- Testing
- Kazu Gain Gold
- Where
- Vietnam
- Volunteers
- 600 people
- Sponsor
- Tu Nguyen Song
Critical Illness, Sarcopenia
Effects of Frailty, Sarcopenia and Muscle Wasting on Outcomes of Patients in the Surgical Intensive Care Unit
The primary aim of the study is to evaluate consequences of frailty in critically ill patients. We hypothesize that a higher frailty index (based on published questionnaires) predicts a longer surgical intensive care unit and…
- Conditions
- Critical Illness, Sarcopenia, Muscle Wasting
- Trial name
- NCT02270502
- Testing
- Ultrasound Philips CX50, Frailty Index Questionnaire, Muscle strength tests
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Massachusetts General Hospital
Malnutrition, Sarcopenia
Malnutrition and Sarcopenia in Adults With Chronic Kidney Disease in Tunisia
The TUN-CKDN study is a national, multicenter, prospective cohort study conducted in nephrology centers in Tunisia. It aims to describe how often malnutrition and sarcopenia (loss of muscle strength and muscle mass) occur in…
- Conditions
- Malnutrition, Sarcopenia, Renal Insufficiency, Chronic
- Trial name
- TUN-CKDN (NCT07906405)
- Testing
- Standardized nutritional and muscle assessment
- Where
- Tunisia
- Volunteers
- 4,000 people
- Sponsor
- Dacima Consulting
Protein-energy; Imbalance
Serum Level of Myokines and Protein Energy Wasting, Inflammation and Atherosclerosis in Hemodialysis Patients
The aim is to test if serum level of myokines are associated with protein energy wasting, inflammation and atherosclerotic vascular disease among Taiwanese dialysis patients.
- Trial name
- NCT02718586
- Volunteers
- 170 people
- Sponsor
- Tungs' Taichung Metroharbour Hospital
Cachexia
Study of GTx-024 on Muscle Wasting (Cachexia) Cancer.
The purpose of this study is to assess if Gtx-024 is effective in increasing lean body mass in subjects with muscle wasting related to cancer.
- Trial name
- NCT00467844
- Testing
- GTx-024
- Where
- 52 sites in United States, Canada
- Volunteers
- 159 people
- Sponsor
- GTx
Chronic Kidney Disease
Intradialytic Progressive Resistance Training for Maintenance Haemodialysis Patients
The purpose of this study is to investigate the effects of a 12 week progressive resistance training during haemodialysis on muscle quantity and physical functioning in chronic kidney disease patients receiving maintenance…
- Trial name
- PRT (NCT01007838)
- Testing
- Progressive resistance training programme, Progressive resistance training
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- Bangor University
Cachexia, Lymphoma
Celecoxib in Managing Pain, Weight Loss, and Weakness in Patients With Advanced Cancer
RATIONALE: Celecoxib may help relieve moderate or severe pain associated with cancer. It may also decrease weight loss and improve muscle strength in cancer patients.
- Conditions
- Cachexia, Lymphoma, Melanoma (Skin), Ovarian Cancer
- Trial name
- NCT00093678
- Testing
- celecoxib, anticachectic therapy, nutritional support
- Sponsor
- Eastern Cooperative Oncology Group
Sarcopenia
A 24-week Off-drug Extension Study in Sarcopenic Elderly Who Completed Treatment in the 6-month Core Study
This extension study was a 24-week off-drug follow-up of the core CBYM338E2202 (NCT ) study and the main objective was to determine the long-term durability of bimagrumab (BYM338) effect after a 6-month treatment period.
- Trial name
- NCT02468674
- Testing
- bimagrumab
- Where
- 30 sites in United States, Australia and 10 more
- Volunteers
- 160 people
- Sponsor
- Novartis Pharmaceuticals
Dialysis Patients, Dialysis
Protein Supplementation During Dialysis (PROSED)
When a patient has dialysis some nutrients are lost in the process. Nutritional losses include protein, trace elements (i.e. zinc, copper and selenium) and water-soluble vitamins (Vitamins C and B).
- Conditions
- Dialysis Patients, Dialysis, Protein Energy Wasting, Protein Intake
- Trial name
- PROSED (NCT07237997)
- Testing
- High Protein Diet/Modular protein supplements will be used
- Where
- United Kingdom
- Volunteers
- 114 people
- Sponsor
- University of Nottingham
Intensive Care Unit Acquired Paresis, Muscle Wasting
Investigation of the Role of FHL-1 and Myostatin in Intensive Care Unit Acquired Paresis (ICUAP)
The primary hypothesis for this study is that Myostatin and FHL-1 are important in the development of ICUAP and that changes in activity levels of muscle will modify the levels of expression and activity of these proteins.
- Trial name
- NCT01321320
- Testing
- Active muscle stimulation
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- Imperial College London
Chronic Kidney Disease (CKD), End-Stage Renal Disease (ESRD)
Malnutrition, Diet and Racial Disparities in Chronic Kidney Disease (CKD)
In the United States, African Americans are 3.6 time and Hispanics 1.5 times more likely to suffer from chronic kidney disease and need dialysis treatment for life, when compared to the non-Hispanic Whites.
- Trial name
- MADRAD (NCT01415570)
- Where
- United States
- Volunteers
- 1,050 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Heart Failure With Reduced Ejection Fraction
Effect of Melatonin on Cardiovascular and Muscle Mass and Function in Patients With Heart Failure
The main aim of this study is to investigate the effect of melatonin on clinical outcome, quality of life, and cardiovascular function of the patients with heart failure, as well as its effect on their skeletal muscle mass and…
- Trial name
- NCT03894683
- Testing
- Melatonin 10 mg
- Where
- Iran
- Volunteers
- 90 people
- Sponsor
- Isfahan University of Medical Sciences
Muscle Atrophy in Lung Cancer and Hemodialysed Patients
Muscle Wasting in Hemodialysis Patient
Muscle wasting is present in almost 50% of patients treated with chronic hemodialysis. It is associated with an increased risk of death (particularly from cardiovascular causes) and compromises quality of life (loss of autonomy…
- Trial name
- NCT03583177
- Testing
- No intervention
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Clermont-Ferrand
Liver Transplantation, Resistance Training
Study of Resistance Strengthening Versus Ambulation Post-Liver Transplant
Resistance strengthening exercise will increase strength and functional activity greater than ambulation in subjects post-liver transplantation.
- Conditions
- Liver Transplantation, Resistance Training, Activities of Daily Living
- Trial name
- NCT01216722
- Testing
- Resistance Strengthening Exercise Program
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Miami
Birth Outcomes, Stunting
Uganda Birth Cohort Study
The UBC was a USAID-funded longitudinal prospective cohort study of pregnant women (n= 5030) aged 15-49 years from rural North and South-Western regions of Uganda, conducted between 2014 and 2016.
- Conditions
- Birth Outcomes, Stunting, Wasting, Anemia
- Trial name
- UBC (NCT04233944)
- Where
- United States
- Volunteers
- 5,044 people
- Sponsor
- Tufts University
Cerebral Hyponatremia, SIADH
Fractional Urate Excretion in Nonedematous Hyponatremia
Hyponatremia, defined as a serum sodium < 135 mmol/l, in patients without edema has undergone significant changes where it is now evident that even mild hyponatremia should be treated because of its association with symptoms…
- Conditions
- Cerebral Hyponatremia, SIADH, Cerebral Salt-wasting Syndrome, Reset Hypothalamic Osmostat
- Trial name
- NCT01425125
- Testing
- Tolvaptan in euvolemic hyponatremia
- Where
- United States
- Sponsor
- NYU Langone Health