Clinical trials: Water-Electrolyte Imbalance
Hyponatremia, Pituitary Adenoma
Post-Operative Water Load Following Transsphenoidal Pituitary Surgery
Delayed post-operative hyponatremia occurs in 5-20% of patients following pituitary surgery and typically occurs on post-operative day 5-10.This decline in sodium can occur rapidly and have serious consequences such as altered…
- Trial name
- NCT02727686
- Testing
- Water Load (WL) Post-Operative Day 1
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Secondary Hyperparathyroidism, Hypocalcemia
Bioequivalency Study of Calcitriol Tablets Under Fasting Conditions
The objective of this study was to assess the bioequivalence of Roxane Laboratories' Calcitriol capsules, 0.25 mcg, to ROCALTROL® capsules, 0.25 mcg (Roche) using a single-dose, 2-treatment, 2-period, crossover design, under…
- Trial name
- NCT00601328
- Testing
- Calcitriol
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories
Hypernatremia
Investigation on Differences in Skin Sodium Content Between Normal Subjects and ICU-patients
This study investigates the differens in sodium storage in skin between normal subjects, patients after cardiac surgery and septic patients.
- Trial name
- InCa (NCT02912299)
- Testing
- Skin biopsies, Blood and urine analysis, Blood collection for RNA-investigation
- Where
- Netherlands
- Volunteers
- 45 people
- Sponsor
- Frisius Medisch Centrum
Hypoparathyroidism
Evaluating the Safety and Efficacy of AMOR-1 as a Treatment for Hypocalcemia Associated With Hypoparathyroidism in Adults
This clinical trial aims to evaluate the efficacy and safety of AMOR-1, consisting of Amorphous Calcium Carbonate (ACC) as the active drug substance, in treating hypocalcemia in adults with hypoparathyroidism.
- Trial name
- NCT06547151
- Testing
- AMOR-1, Crystalline Calcium Carbonate
- Where
- 9 sites in Israel
- Volunteers
- 62 people
- Sponsor
- Amorphical Ltd.
Dehydration (Physiology), Hyperthermia
Water Bolus Volumes During Continuous Exercise in Heat
Hydration is important to all individuals including occupational workers who complete physical activity in the heat. Current best practice guidelines suggest drinking a cup of water every 15-20 minutes during activity in a hot…
- Trial name
- NCT04613856
- Testing
- Hydration protocol - 237 mL water bolus, Hydration protocol - 500 mL water bolus
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Hypokalemia, Intensive Care Unit (ICU)
Management of Hypokalemia in Intensive Care Patients
Hypokalemia is a common electrolyte disorder in critically ill patients and may contribute to substantial morbidity and mortality if inadequately managed.
- Conditions
- Hypokalemia, Intensive Care Unit (ICU), Intensive Care Unit (ICU) Patients
- Trial name
- NCT07833722
- Testing
- Implementation of hypokalemia treatment algorithm
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Anadolu University
Dehydration, Hypovolemia
Validation of a Wearable Bioimpedance Sensor for Hydration Monitoring
The purpose of the project is to validate the performance of a wearable bioimpedance sensor (Re:Balans®) for monitoring hydration status.
- Trial name
- VAMOS (NCT07655401)
- Testing
- Bioimpedance sensor
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Mode Sensors AS
Diarrhea, Dehydration
Zinc-ORS in Severe and Complicated Acute Diarrhea
Three-hundred-and-fifty-two males aged 1-36 months with acute non-dysenteric diarrhoea and no systemic illness will be enrolled in this clinical trial.
- Trial name
- NCT00370968
- Testing
- Zinc sulphate
- Where
- 2 sites in India
- Volunteers
- 352 people
- Sponsor
- Centre For International Health
Hyponatremia
Analysis of the Epidemiology, Clinical Presentation and Therapy as Well as Therapy-associated Risk of Demyelination Syndrome in Patients With Profound Hyponatremia in the Emergency Department
Hyponatremia is a frequent cause for presentation to the emergency department (ED). While patients with chronic hyponatremia often exhibit minor symptoms, acute development of hyponatremia can lead to global cerebral edema…
- Trial name
- ProfHN_in_ZNA (NCT06781710)
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- University of Cologne
End Stage Renal Disease
Comparison of Serum Calcium Level Between Preoperative Vitamin D and Non-vitamin D Regimen of Total Parathyroidectomy in End-stage Renal Failure Patients in Rajavithi Hospital
This Research is compare about IV Calcium between end-stage renal failure patients who take vitamin D and non-vitamin D preoperative parathyroidectomy
- Trial name
- NCT04967469
- Testing
- Calcitriol, Alfacalcidol 0.5 MCG Oral Capsule
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Dehydration, Rehydration
Clinical Trial to Evaluate the Effects of Two Novel Hydration Beverage Formulas on Rehydration in Healthy Adults
Dehydration lowers both physical and mental performance if it is severe enough. Performance declines are more pronounced in hot conditions or after prolonged strenuous activity such as exercise.
- Conditions
- Dehydration, Rehydration, Exercise Performance, Exercise Recovery
- Trial name
- NCT05428761
- Testing
- TP1, TP2
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Liquid I.V.
Obstructive Sleep Apnea, Overhydration
Effect of Renal Transplantation on Obstructive Sleep Apnea in End Stage Renal Disease Patients (SASinTx)
The purpose of this study is to investigate the effect of renal transplantation on fluid overload and its consequence on the severity of obstructive sleep apnea, in patients with end stage chronic kidney disease.
- Conditions
- Obstructive Sleep Apnea, Overhydration, End Stage Renal Disease, Renal Transplantation
- Trial name
- SASinTx (NCT02020642)
- Testing
- Renal transplantation
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Hydration
Study of Hydration Levels in Sports and Non-sports Schoolchildren (EHC)
New knowledge regarding the negative impact of poor hydration on health highlights the need to provide recent epidemiological data on the water intake of the French population, especially among middle school students, a group…
- Trial name
- EHC (NCT06170554)
- Where
- France
- Volunteers
- 259 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Hyperkalemia, Chronic Kidney Disease
Prediction of Hyperkalemia in Dialysis Patients Through Waveform Analysis Using Wearable ECG
This study aims to evaluate whether hyperkalemia, a potentially life-threatening condition in dialysis patients, can be detected early using a wearable single-lead ECG device.
- Trial name
- NCT07054905
- Testing
- HiCardi wearable ECG
- Where
- South Korea
- Volunteers
- 32 people
- Sponsor
- Kyungho Park
Body Temperature Changes, Body Water Dehydration
Firefighter Thermoregulatory Responses in Active Fire with Betaine Supplementation
The goal of this clinical trial is to compare betaine supplementation to placebo in firefighters undergoing live burn training regarding thermoregulation and inflammation.
- Conditions
- Body Temperature Changes, Body Water Dehydration, Inflammation
- Trial name
- FFBET (NCT06042270)
- Testing
- Betaine
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Michael J. Ormsbee
Dehydration
Testing of an Electronic Patch During Mild Dehydration
The purpose of this study is to investigate the ability of a wearable bioimpedance sensor to detect mild dehydration in healthy volunteers following the administration of Furosemide.
- Trial name
- NCT05129358
- Testing
- Dehydration, Rehydration
- Where
- Norway
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Mode Sensors AS
Liver Cirrhosis, Hyponatremia
Efficacy and Safety of Tolvaptan in Cirrhotic Patients With Hyponatremia
This is a phase IV, open-label, prospective cohort study for 7 days.The recommended starting dose of tolvaptan is 15 mg daily orally.
- Trial name
- OASIS (NCT01850940)
- Testing
- Tolvaptan, conventional thearpy
- Where
- 19 sites in China
- Volunteers
- 98 people
- Sponsor
- Beijing Friendship Hospital
Gastroenteritis, Rota Virus Gastroenteritis
Admission Pattern Among Children With Gastro-intestinal Infections Before and During the Covid-19 Pandemic
During the Covid-19 pandemic, admission patterns for infections other than Covid-19 have changed dramatically among children worldwide.
- Conditions
- Gastroenteritis, Rota Virus Gastroenteritis, Dehydration in Children, Infectious Disease
- Trial name
- NCT06211621
- Where
- Denmark
- Volunteers
- 600 people
- Sponsor
- Region Zealand
Respiratory Distress Syndrome, Acute, Respiratory Insufficiency
Bioelectrical Impedance in Monitoring Hyperhydration and Polyneuromyopathy in Critically Ill Patients
This prospective, blinded observational clinical study was aimed to determine the effect of hyperhydration and muscle loss measured by Bioelectrical impedance vector analysis (BIVA) on mortality.
- Conditions
- Respiratory Distress Syndrome, Acute, Respiratory Insufficiency, Lung Ventilator, Hyperhydration
- Trial name
- NCT05991778
- Testing
- Bioelectrical impedance vector analysis (BIVA), Blood and urine analysis, cumulative water balance
- Where
- Czechia
- Volunteers
- 61 people
- Sponsor
- University Hospital Ostrava
Hyponatremia, Hypernatremia
Hypotonic Versus Isotonic Parenteral (HIP) Fluid Trial
Children who are undergoing surgery need intravenous fluids to prevent dehydration and maintain their electrolyte balance. The current standard of care in these children is to use a fluid which is low in sodium (hypotonic fluid).
- Trial name
- NCT00734214
- Testing
- 0.9% NaCl, 0.45%NaCl
- Where
- Canada
- Volunteers
- 258 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation