Clinical trials: Weakness
Ischemic Stroke
Percutaneous Recanalization in Ischemic Stroke Management (PRIISM): A Feasibility Clinical Study
The primary study objective is to assess the feasibility of using the MindFrame System to safely and effectively restore blood flow in a thrombotic neurovascular occlusion in patients experiencing an ischemic stroke.
- Trial name
- PRIISM (NCT00810095)
- Testing
- MindFrame System
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- MindFrame, Inc.
Muscle Weakness
Safety Evaluation of Functional Electrical Stimulation (FES) Cycling in Intensive Care Unit Patients
Intensive care unit acquired muscle weakness (ICUAW), is a common disease which influence rehabilitation, extend mechanical ventilation and length of stay in intensive care unit, and affect quality of life at hospital discharge.
- Trial name
- FES Cycling (NCT03526211)
- Testing
- FES cycling
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Bite Force, Botulinum Toxins, Type A
Muscle Weakness Duration After Single Botulinum Toxin Injection in Masseter
This study aimed to evaluate the duration of a reduced maximal voluntary bite force after a botulinum toxin intervention. Methods: In an intervention group, 25 units of Xeomin® (Merz Pharma GmbH \& Co KGaA, Frankfurt am Main…
- Trial name
- NCT05309564
- Testing
- Botulinum toxin type A
- Where
- Sweden
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Region Västerbotten
Intensive Care Unit-acquired Weakness
Skeletal Muscle Regeneration in Survivors of Critical Illness: How to Prevent Satellite Cell Failure?
Modern intensive care enables patients to survive insults that in the past would have been supralethal. Nonetheless, increased number of survivors suffer from failed functional outcomes associated with prolonged muscle weakness…
- Trial name
- SATELLITE (NCT05671614)
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- Charles University, Czech Republic
Muscular Weakness
Training Intrinsic Foot Muscles
The foot intrinsic muscles are increasingly targeted in foot and ankle rehabilitation. The exercises are often difficult to learn initially.
- Trial name
- NCT03670563
- Testing
- Short foot exercise protocol, Short foot exercise plus NMES
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Muscle Atrophy, Muscle Weakness
Neuromodulation for Prevention of Intensive Care Unit Acquired Weakness and Post Intensive Care Syndrome
Post-intensive care syndrome (PICS) encompasses persistent physical, cognitive, and psychiatric symptoms following ICU discharge, commonly triggered by serious conditions such as respiratory failure, sepsis, and mechanical…
- Conditions
- Muscle Atrophy, Muscle Weakness, Blood Flow
- Trial name
- NCT06238609
- Testing
- Intervention Group, Control Group
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Bijan Najafi, PhD
Intensive Care Unit Acquired Weakness, Critical Illness
The CONFUCIUS Oral Protein Supplementation Trial
Study the effect of 6-weeks porcine protein supplementation vs isocaloric comparator (carbohydrate) on functional outcomes in post ICU-patients. Patients will be included at ICU discharge.
- Trial name
- CONFUCIUS (NCT05405764)
- Testing
- Porcine protein supplement, Control product maltodextrin supplement
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- ARH van Zanten
Bronchiectasis
Relationship Between Nutritional State and Respiratory Muscle Weakness in Adult Patients With Bronchietasis
To establish a relationship between malnutrion and respiratory muscle dysfunction in patients with bronchectasis
- Trial name
- NCT06002334
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Mechanical Ventilation Complication, Neuromuscular Electrical Stimulation
NMES to Prevent Respiratory Muscle Atrophy in Mechanically Ventilated Patients
Patients requiring prolonged time on the ventilator are susceptible to a wide range of clinical complications and excess mortality. It is therefore imperative for them to wean at the earliest possible time.
- Conditions
- Mechanical Ventilation Complication, Neuromuscular Electrical Stimulation, Muscle Weakness
- Trial name
- NCT03453944
- Testing
- VentFree prototype (VF03-K) active stimulation
- Where
- 3 sites in Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Nijmegen
Heart Failure
Optoelectronic Pletysmography and Diaphragmatic Thickness in Heart Failure Patients
The investigators aimed to evaluate the effects of cardiomegaly associated with inspiratory muscle weakness on tricompartmental distribution of chest wall volumes, on the thickness of the right hemidiaphragm and on the…
- Trial name
- NCT02481388
- Testing
- Maximal exercise ramp test
- Where
- Brazil
- Volunteers
- 14 people
- Sponsor
- Universidade Federal de Pernambuco
Weight Loss, Fatigue
Swiss Frailty Network and Repository
Physical frailty is an age-related medical syndrome defined by a decline in multiple body systems, thus causing increased vulnerability, even in the face of minor stressors (1) It has been linked to multiple negative health…
- Conditions
- Weight Loss, Fatigue, Physical Frailty, Weakness, Muscle
- Trial name
- SFNR (NCT04516642)
- Where
- Switzerland
- Volunteers
- 1,500 people
- Sponsor
- University of Zurich
Muscle Atrophy, Muscle Weakness
Evaluating Muscle Function After Ankle Surgery
Patients who are forced to rest or reduce activity as a result of illness, injury, or surgery often experience resulting muscle weakness.
- Conditions
- Muscle Atrophy, Muscle Weakness, Fractures
- Trial name
- NCT00060970
- Testing
- Physical Therapy
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Motor Activity, Muscle Strength
Critical Care Observation of Motor Activity (COMA) and SICU Outcomes
In the surgical intensive care unit (SICU), goals of critical care are often discussed in long-term ventilated patients around the time of extubation.
- Conditions
- Motor Activity, Muscle Strength, Muscle Weakness
- Trial name
- COMA (NCT02994641)
- Testing
- COMA Score Assessment
- Where
- United States
- Volunteers
- 761 people
- Sponsor
- Massachusetts General Hospital
Cerebral Palsy, Central Nervous System Diseases
Power Training Combined With Interval Treadmill Training
Ambulatory children with cerebral palsy (CP) experience walking limitations which negatively influence their ability to physically participate in day to day life.
- Conditions
- Cerebral Palsy, Central Nervous System Diseases, Brain Damage, Chronic
- Trial name
- PT³ (NCT03625570)
- Testing
- Power training combined with interval treadmill training, Strength training combined with traditional treadmill training
- Where
- 2 sites in United States
- Volunteers
- 44 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Flatfoot, Flexible, Pes Valgus
Physiotherapy Program Effect on Musculoskeletal Dysfunctions in Young Football Players
The goal of this clinical study is to test the proposed physiotherapy exercise program in young football players. The main question it aims to answer is: Does the proposed physiotherapy program work well in improving young…
- Conditions
- Flatfoot, Flexible, Pes Valgus, Pes Varus, Balance; Distorted
- Trial name
- NCT05798988
- Testing
- Neurophysiology-based exercise program
- Where
- Czechia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Pseudoexfoliation Syndrome
Optical Low Coherence Reflectometry Enables Preoperative Detection of Zonular Weakness in Pseudoexfoliation Syndrome
The purpose of the study was to evaluate optical ocular components in patients with pseudoexfoliation syndrome using optical low coherence reflectometry.
- Trial name
- NCT01298895
- Where
- Croatia
- Volunteers
- 224 people
- Sponsor
- General Hospital Sveti Duh
Muscle Weakness, Sports Performance
Light Therapy and Electrical Stimulation on Functional Performance in Volleyball Athletes
Background: Volleyball players constantly perform vertical jumps, the higher the height of the jump is better sports performance of these players. Several methods have been tested to improve jumping performance in these players.
- Trial name
- NCT02443701
- Testing
- Exercise, LASER, NMES
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Centro de Traumatologia do Esporte
Pediatric Intensive Care Units
A Korean Point Prevalence Study of Acute Rehabilitation for Kids in the PICU (PARK-PICU)
This study investigates the prevalence of acute rehabilitation practices among children in pediatric intensive care units (PICUs).
- Trial name
- NCT07629297
- Testing
- Acute Rehabilitation (Observed Practice)
- Where
- 13 sites in South Korea
- Volunteers
- 396 people
- Sponsor
- Samsung Medical Center
Cerebral Palsy
Study Assessing High-Frequency Chest Wall Oscillation (HFCWO) in Preventing Pulmonary Exacerbations
To asssess efficacy of airway clearance provided by Vest therapy (HFCWO) in the reduction of respiratory exacerbations requiring hospitalization or antibiotic utilization in patients with muscle weakness and restrictive lung…
- Trial name
- NCT00739310
- Testing
- Vest Treatment (high frequency chest wall oscillation)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Hill-Rom
Cervical Radiculopathy
Does Low-does Cervical Epidural Lidocaine Cause Transient Weakness?
"Does low-does cervical epidural lidocaine cause transient weakness?"
- Trial name
- NCT03382925
- Testing
- cervical interlaminar with lidocaine, cervical interlaminar with normal saline, Lidocaine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Utah
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