Clinical trials: Weakness
Cervical Cancer, Postoperative Bladder Dysfunction
Transcutaneous Electrical Nerve Stimulation in Nerve-Sparing Radical Hysterectomy: Effects on Bladder Management and Quality of Life in Cervical Cancer
To evaluate the effects of transcutaneous electrical nerve stimulation (TENS) on bladder management, pelvic floor muscle strength, and quality of life (QoL) in patients undergoing nerve-sparing radical hysterectomy (NSRH) for…
- Conditions
- Cervical Cancer, Postoperative Bladder Dysfunction, Urinary Retention, Pelvic Floor Muscle Weakness
- Trial name
- NCT07070687
- Testing
- Transcutaneous Electrical Nerve Stimulation (TENS)
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Fudan University
Effect of Atorvastatin on the Pharmacokinetics of Lomitapide
Evaluate the Effect of Atorvastatin on the Pharmacokinetics of Lomitapide in Healthy Subjects.
The primary objective of this study is to assess the effect of atorvastatin, a weak cytochrome P450 (CYP) 3A4 inhibitor, on the pharmacokinetics (PK) of lomitapide and its 2 primary metabolites, M1 and M3.
- Trial name
- NCT02080455
- Testing
- lomitapide, Atorvastatin
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Aegerion Pharmaceuticals, Inc.
Cervicogenic Headache
Effectiveness of a Novel Device for Cervical Training in Cervicogenic Headache.
The purpose of this study is to evaluate the clinical results in cervical spine range of motion, endurance deep cervical muscles, headache impact and physical activity enjoyment by a training protocol with the new device for…
- Trial name
- NCT05479149
- Testing
- Training protocol with the cervical device for treatment (CDAT)., Conventional training protocol
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- Universitat Internacional de Catalunya
Muscle Tightness, Muscle Weakness
Stretching Techniques of Knee Muscles and Their Effect on Joint Range, Suppleness and Muscle Activity in Elderly
The goal of this clinical trial was to compare the effect of two different types of stretching techniques in elderly population. The main questions it aims to answer are: 1.
- Trial name
- NCT05785416
- Testing
- Proprioceptive Neuromuscular Stretching - Contract Relax stretching (PNF-CR), Static Stretching (SS)
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Deepak Malhotra
Shoulder Pain
PREVALENCE OF SCAPULAR DYSKINESIS
Objective: This study will aim to determine the prevalence of scapular dyskinesis (SD) among Egyptian physical therapy practitioners and will explore associated epidemiological factors, including age, sex, BMI, shoulder and neck…
- Trial name
- NCT07123532
- Where
- Egypt
- Volunteers
- 121 people
- Sponsor
- Cairo University
Sarcopenia, Aging
Effects of Functional Task Training on Muscle Health and Function in Older Adults With Sarcopenia
Sarcopenia is a condition associated with aging that causes a loss of muscle mass, strength, and physical function. This decline limits the ability to perform basic daily activities and increases the risk of falls and dependency.
- Conditions
- Sarcopenia, Aging, Physical Functional Performance, Muscle Weakness | Patient
- Trial name
- NCT07494916
- Testing
- Functional Task Training in Power Zones, Standard Functional Task Training, Traditional Resistance Training
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universidad de Granada
Old Age; Debility
Impact of a Physical Exercise Program in a Rural Area
With this work we want to assess whether there are differences in the amount of physical activity per week, measured by accelerometry in 3 groups of subjects, where one group (G1) has been carrying out a PA program called…
- Trial name
- NCT06842849
- Testing
- Exercise program
- Where
- Spain
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Upper Extremity Injury, Sport Injury
Throwers Ten Exercises On Upper Extremity Function and Explosive Power in Wheelchair Basketball and Basketball Players
Basketball is a challenging sport that requires participants to demonstrate physical fitness and special athletic skills at high levels.
- Conditions
- Upper Extremity Injury, Sport Injury, Shoulder Pain, Muscle Weakness
- Trial name
- NCT04019990
- Testing
- The effect of throwers ten exercise programme on wheelchair basketball and ambulant basketball players
- Where
- Cyprus
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Critically Ill, Post Intensive Care Syndrome
Testing of a New Therapeutic Vibration Device to Reduce Neuromuscular Weakness in Hospitalized Patients
Objective: Test the ability of vibration to produce physiologic, biochemical, and anatomic changes consistent with exercise that would help prevent the development of muscle weakness that occurs when patients are immobile for…
- Trial name
- NCT03479008
- Testing
- Therapeutic Vibration Device
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Heart Failure, Sarcopenia
Multivariate Biomarker Study for Sarcopenia in Heart Failure
In the United Kingdom, heart failure (HF) affects about 900,000 people with 60,000 new cases annually. Up to 60% of people living with HF also experience sarcopenia, known as loss of muscle mass and strength.
- Conditions
- Heart Failure, Sarcopenia, Muscle Weakness, Body Weight
- Trial name
- NCT06217640
- Testing
- Dual X Ray Absorptiometry
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Liverpool
Non-specific Complaints
Biomarker-enhanced ED Disposition Decisions
Patients presenting to emergency departments (ED) with non-specific complaints (NSC) such as "not feeling well", "feeling weak", "being tired", "general deterioration" are a very common and well-known, but poorly studied patient…
- Trial name
- BANC4 (NCT00920491)
- Testing
- biomarker-enhanced disposition decision with proADM
- Where
- Switzerland
- Volunteers
- 400 people
- Sponsor
- University Hospital, Basel, Switzerland
Old Age; Debility
Thermal Imaging in Old and Frail in the Community
This study aims to test whether infrared thermal imaging using a non-touch, non-ionising, thermal camera system is feasible and reliable as an independent technique for thermal comfort assessment in older people and frail older…
- Trial name
- NCT03884218
- Testing
- Infra red thermal imaging
- Where
- United Kingdom
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Critical Illness, Muscle Weakness
Diaphragm Protective Ventilation in the Intensive Care Unit
Due to an accident, pneumonia or surgery, patients can have severe shortness of breath or lung damage to such an extent that it compromises vital functions. At such times, mechanical ventilation can be lifesaving.
- Conditions
- Critical Illness, Muscle Weakness, Muscle Damage, Respiration, Artificial
- Trial name
- DiaPro (NCT03527797)
- Testing
- Titration of support level
- Where
- Netherlands
- Volunteers
- 41 people
- Sponsor
- Amsterdam UMC, location VUmc
Cerebrovascular Stroke, Muscle Weakness
Mirror Therapy and Cross-Education of Muscle Strength
This study was conducted to determine whether mirror therapy has an additive effect on cross-education of the strength of neuromuscular electrical stimulation (NMES) in patients with hemiplegia.
- Trial name
- NCT04887376
- Testing
- Mirror frame, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Anatomic Stage IV Breast Cancer AJCC v8, Chemotherapy-Induced Peripheral Neuropathy
Finding an Effective Dose of GM1 to Reduce or Prevent Neuropathy (Numbness or Weakness) Due to Treatment With Paclitaxel
This early phase/phase II trial tests the safety, side effects, and best dose of monosialotetrahexosylganglioside (GM1) and whether it works in reducing or preventing chemotherapy-induced peripheral neuropathy (CIPN) in patients…
- Conditions
- Anatomic Stage IV Breast Cancer AJCC v8, Chemotherapy-Induced Peripheral Neuropathy, Metastatic Breast Carcinoma
- Trial name
- NCT05751668
- Testing
- Paclitaxel, Monosialotetrahexosylganglioside, Questionnaire Administration
- Where
- 33 sites in United States
- Volunteers
- 7 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Mechanical Ventilation, Critical Illness
Neuromuscular Electrical Stimulation in a Patient on Invasive Mechanical Ventilation (MOVCARE)
This clinical study aims to compare the effects of conventional physical therapy alone versus conventional physical therapy combined with neuromuscular electrical stimulation (NMES) in patients admitted to the ICU and undergoing…
- Conditions
- Mechanical Ventilation, Critical Illness, Intensive Care Unit Patients, Muscle Weakness Condition
- Trial name
- MOVCARE (NCT07188350)
- Testing
- Conventional Physical Therapy, Neuromuscular Electrical Stimulation (NMES)
- Where
- Brazil
- Volunteers
- 150 people
- Sponsor
- Hospital Moinhos de Vento
Intensive Care Unit Acquired Weakness, Shock, Septic
Hemodynamic Phenotype-Based,Capillary Refill Time-Targeted Resuscitation In Early Septic Shock:ANDROMEDA-SHOCK-2
Over-resuscitation including fluid overload has been associated with increased morbidity (prolonged duration of organ failure) and mortality in septic shock.
- Trial name
- ANDROMEDA-FR (NCT06062303)
- Testing
- Usual care (UC)
- Where
- France
- Volunteers
- 180 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Post-Intensive Care Syndrome, ICU Acquired Weakness
Hand and Arm Rehabilitation Using VR
Patients admitted to the ICU due to critical illness often experience physical, mental, cognitive, or social issues. Research indicates that inadequate physical recovery is associated with lower handgrip strength, and hand…
- Trial name
- HANDQUEST (NCT06373341)
- Testing
- VR training for arm and hand rehabilitation
- Where
- Netherlands
- Volunteers
- 108 people
- Sponsor
- Frisius Medisch Centrum
Muscle Weakness
Magnetic Muscle Stimulation of Abdominal Muscle
Evaluate the safety and efficacy of magnetic muscle stimulation (MMS) of abdominal muscle.
- Trial name
- MMS (NCT04199312)
- Testing
- Magnetic Muscle Stimulation (MMS) device
- Where
- 3 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Zeltiq Aesthetics
Old Age; Debility
Older People Gait: Physiomechanics and Functionality
The aim of study is to investigate gait in active elderly people regarding the kinematic parameters of gait, indicators of physical fitness and quality of life.
- Trial name
- NCT04348539
- Testing
- Balance training
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
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