Clinical trials: Weaning, open to volunteers
Mechanically Ventilated ICU Patients, Diaphragm Excursion
the Effect of Doxapram on Diaphragmatic Excursion(DE) During Weaning From Mechanical Ventilation.
The goal of this clincal trial is to learn if doxapram is effective in weaning in adults on mechanical ventilation. The objectives of this study: Evaluate the effect of doxapram on diaphragmatic function (assessed by DE)during…
- Trial name
- NCT07637149
- Testing
- Doxapram
- Volunteers
- 60 people
- Sponsor
- Kasr El Aini Hospital
Ventilator Dependent
Short Effects of SIMT and EM in Prolonged Mechanically Ventilated Patients
Using mechanical ventilation for more than 18 hours can affect respiratory muscle and postural muscle control, making it difficult to wean off the ventilator and reducing mobility. The aim of this study is to: 1.
- Trial name
- NCT06368089
- Testing
- Inspiratory muscle training (IMT) group, Early mobilization (EM) group
- Where
- Thailand
- Volunteers
- 46 people
- Sponsor
- Prince of Songkla University
Airway Extubation, Weaning Mechanical Ventilation
One-Hour Positive Pressure Ventilation After a Pressure Support Spontaneous Breathing Trial
This is a randomized, open, multicenter, pragmatic, adaptive clinical trial with intention-to-treat analysis. The study will compare two weaning strategies from mechanical ventilation in critically ill patients admitted to…
- Conditions
- Airway Extubation, Weaning Mechanical Ventilation, Extubation Failure
- Trial name
- NCT07324460
- Testing
- One-hour positive pressure ventilation, Immediate extubation
- Volunteers
- 4,000 people
- Sponsor
- Hospital do Coracao
Ventilator Weaning, Sarcopenia
Comparison of Sarcopenia Index, Diaphragm Ultrasonography, and Traditional Weaning Parameters in Predicting Successful Weaning From Mechanical Ventilation
This study investigates whether the Sarcopenia Index (SI = serum creatinine/cystatin C × 100), a simple biomarker derived from routine blood tests, can predict weaning success in critically ill patients undergoing invasive…
- Conditions
- Ventilator Weaning, Sarcopenia, Diaphragm Ultrasonography
- Trial name
- NCT07844421
- Testing
- sarcopenia index, diaphragma ultrasound, parameters of mechanical ventilation (MV)
- Volunteers
- 80 people
- Sponsor
- Kocaeli City Hospital
Ventilator Weaning, Airway Extubation
Can a Pain Monitor Predict When Postoperative Intensive Care Unit Patients Are Ready to Breathe on Their Own? A Pilot Study
The goal of this observational study is to learn if a chest monitor that tracks heart rhythm can help predict whether adults on a breathing machine after surgery will be able to breathe on their own once the breathing tube is…
- Conditions
- Ventilator Weaning, Airway Extubation, Respiration, Artificial
- Trial name
- NCT07771101
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Feeding Difficulties, Remote Patient Monitoring
Parent Tube Weaning Interviews
Recent developments in remote monitoring software can provide a proactive means for data transfer for healthcare teams to communicate with families regarding activities like weaning from feeding tubes.
- Conditions
- Feeding Difficulties, Remote Patient Monitoring, Pediatric Feeding Disorders
- Trial name
- NCT07054983
- Testing
- Qualitative Research Interview
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Children's Mercy Hospital Kansas City
Mechanical Ventilation Complication, Pulmonary Edema
Systolic Function and Weaning-induced Pulmonary Edema (SystoWean Study)
The purpose of this study is to determine if the left and right ventricular systolic function is involved in the development of weaning failure related to weaning-induced pulmonary edema.
- Trial name
- SystoWean (NCT05226247)
- Testing
- Spontaneous breathing trial
- Where
- 3 sites in France
- Volunteers
- 250 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Chronic Obstructive Pulmonary Disease (COPD), Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Nutritional Risk and Diaphragmatic Thickness in Mechanically Ventilated COPD Patients
Malnutrition and muscle wasting are frequent complications in patients with chronic obstructive pulmonary disease (COPD) experiencing acute exacerbations.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Malnutrition, Respiratory Failure
- Trial name
- NCT07788170
- Volunteers
- 120 people
- Sponsor
- Assiut University
Tracheostomy, Cough
Objective Evaluation of Cough Effort in Tracheotomized Patients (LOST Study)
This study aims to evaluate how well tracheotomized patients can cough before and after their tracheostomy tube is removed. Cough strength is measured using two different tools-Peak Flow and Lorio.
- Conditions
- Tracheostomy, Cough, Weaning, Respiratory Function Tests
- Trial name
- NCT07061561
- Testing
- Peak Expiratory Flow Measurement Using Peak Flow Meter and Lorio Device
- Volunteers
- 34 people
- Sponsor
- Centre Hospitalier de Saint-Denis
Weaning From Mechanical Ventilation
Effect of Adding PNF to IMT on Weaning Off MV
the goal of this clinical trial is to find out the effect of adding proprioceptive neuromuscular facilitation to inspiratory muscle training on weaning off mechanical ventilation.
- Trial name
- PNF/IMT/MV (NCT07536347)
- Testing
- threshold inspiratory muscle training + conventional chest physiotherapy, proprioceptive neuromuscular facilitation + threshold inspiratory muscle training + conventional chest physiotherapy, Conventional Chest Physiotherapy
- Volunteers
- 93 people
- Sponsor
- Beni-Suef University
Prolonged Mechanical Ventilation
Effects of IMT on Weaning and Diaphragmatic Function in PMV Patients
Prolonged mechanical ventilation (PMV) and weaning failure can lead to extended hospital stays, as well as increased morbidity and mortality during hospitalization.
- Trial name
- NCT07200037
- Testing
- inspiratory muscle training
- Volunteers
- 120 people
- Sponsor
- Capital Medical University
Acute Respiratory Failure
Research on Respiratory Support Decision-Making for Mechanically Ventilated ICU Patients Based on a Physiological World Model
Mechanical ventilation is essential for ICU patients with respiratory failure, yet ventilator adjustment and weaning decisions remain experience-dependent and highly variable.
- Trial name
- NCT07834671
- Where
- China
- Volunteers
- 4,232 people
- Sponsor
- Ruijin Hospital
Sepsis, Low Blood Pressure
MID-STEP (MIDodrine for Sepsis Treatment and Early vasoPressor Weaning) Trial
This study is being done to determine if early administration of Midodrine can improve outcomes by maintaining a higher mean blood pressure off of intravenous medications.
- Trial name
- NCT06319248
- Testing
- Midodrine, Standard of Care
- Where
- 5 sites in United States
- Volunteers
- 308 people
- Sponsor
- Mayo Clinic
ARDS (Acute Respiratory Distress Syndrome)
Free for Weaning ECMO vs Respiratory Driven Study
In its most severe form, Acute Respiratory Distress Syndrome (ARDS) may require the use of veno-venous ECMO (vvECMO). While the criteria for vvECMO indication, ECMO settings, and ventilator management are relatively well-defined…
- Trial name
- FORWARD (NCT06876415)
- Testing
- P0.1 and delta Poeso integration into the decanulation decision
- Where
- 4 sites in France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Extubation Failure
Validation of an Effort-Based Cough Peak Flow Algorithm to Predict Extubation Outcomes
This study aims to prospectively validate the diagnostic accuracy of an effort-stratified Cough Peak Flow (CPF) decision algorithm for predicting extubation failure, maintaining strict blinding of the clinical team.
- Trial name
- NCT07737483
- Testing
- Observational measurement of Cough Peak Flow and Tidal Volume
- Volunteers
- 150 people
- Sponsor
- Hospital H+ Queretaro
Respiratory Failure, Osteopathy in Diseases Classified Elsewhere
The Utility of Osteopathic Manipulative Medicine in Weaning Patients from the Ventilator Pilot Trial
The objectives of this research are to determine the treatment effect size of OMM to wean patients off of the ventilator, determine the number of patients needed for a larger study (power), determine the willingness of…
- Trial name
- NCT06891248
- Testing
- Osteopathic Manipulative Treatment
- Volunteers
- 20 people
- Sponsor
- Oklahoma State University Center for Health Sciences
Weaning Mechanical Ventilation, ICU Ill Patients
Diaphragmatic Ultrasonography in Difficult Weaning
Weaning from mechanical ventilation (MV) is a gradual process that includes several steps until the complete withdrawal of ventilatory support.
- Conditions
- Weaning Mechanical Ventilation, ICU Ill Patients, Diaphragm Dysfunction
- Trial name
- DUS-WEAN (NCT07751237)
- Testing
- Diaphragmatic ultrasound
- Where
- Brazil
- Volunteers
- 220 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Ventilatory Failure, Hypoxemic Respiratory Failure
PREdicting Failure of Non-inVasIve Ventilatory Support Using Non-invaSIve mONitoring in Non-intubated Patients With Acute Hypoxemic Respiratory Failure or Post-extubation Failure. The PREVISION Study
The goal of this observational study is to assess the potential non-invasive tools (e.g. regional ventilation, respiratory muscle response, lung mechanic's parameters) to identify the risk of failure when using high flow nasal…
- Conditions
- Ventilatory Failure, Hypoxemic Respiratory Failure, Weaning Failure, Respiratory
- Trial name
- PREVISION (NCT06716463)
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Unity Health Toronto
Feeding Disorders
CHAMP For the Feeder: Tube Feeding Study
Single site evidence-based implementation of a mHealth application for remote patient monitoring for pediatric patients ready to wean from tube feedings (TFs).
- Trial name
- NCT06052891
- Testing
- CHAMP Application
- Where
- United States
- Volunteers
- 245 people
- Sponsor
- Lori Erickson
Weaning, Spontaneous Breathing Trial
Diaphragmatic Speckle Tracking During Spontaneous Breathing Trial
Currently, measurement of transdiaphragmatic pressure (Pdi) using oesophageal and gastric balloons is the gold standard for the assessment of diaphragmatic effort.
- Conditions
- Weaning, Spontaneous Breathing Trial, Mechanical Ventilation, Speckle Tracking
- Trial name
- DIAST (NCT06009731)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens