Clinical trials: Weaning Failure of Mechanical Ventilation
Ventilator Weaning, Weaning Failure
Voices of Patients' Relatives to Support Weaning From Mechanical Ventilation
Patients with severe brain injuries, such as ischemic stroke and intracranial hemorrhage, frequently require mechanical ventilation. Weaning of stroke patients is complicated by impaired consciousness and respiratory drive.
- Conditions
- Ventilator Weaning, Weaning Failure, Brain Injuries
- Trial name
- VOICE-WEANING (NCT03795623)
- Testing
- Voice-Weaning
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Acute Respiratory Failure
Pilot Study on Pairing Sedation Strategies and Weaning
A three-arm, randomized, pilot study, to assess the feasibility for the analgesia-first sedation (AFS) study arm/intervention (Fentanyl push first).
- Trial name
- NCT02219659
- Testing
- Sedation Protocol with Daily Interruption, Sedation Protocol Without Daily Interruption, Fentanyl Push First
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- MemorialCare Health System
Inadequate or Impaired Breathing Pattern or Ventilation
Weaning Using Noninvasive Positive Pressure Ventilation by Means of Helmet in Patients With Acute Respiratory Failure
The purpose of this study is to determine whether helmet is effective as device for noninvasive positive pressure ventilation in the weaning from mechanical ventilation.
- Trial name
- NCT01322659
- Testing
- Helmet, Endotracheal tube
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- University of Padova
Respiratory Insufficiency Requiring Mechanical Ventilation
Evaluation on the Effect of Acupuncture and Neuromuscular Electrical Stimulation on Mechanical Ventilation Patients
Acupuncture is a treatment intervention used globally for a wide variety of disorders. Its efficacy has been established over the course of 3000 years, originating in Asia and diversifying worldwide.The scientific basis for…
- Trial name
- NCT05221710
- Testing
- electroacupuncture
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Weaning Failure
Rest After Spontaneous Breathing Trial for Prevention of Post-extubation Failure
To evaluate if a rest period before extubation after a successful SBT trial could reduce the extubation failure rate.
- Trial name
- NCT01915563
- Testing
- REST
- Where
- Spain
- Volunteers
- 470 people
- Sponsor
- Althaia Xarxa Assistencial Universitària de Manresa
Weaning From Mechanical Ventilation, Weaning Failure
Characterization of Weaning Practices in ICUs of Global South Countries
This is a prospective observational study to be conducted in intensive care units of Global South countries. Patients on mechanical ventilation for more than 12 hours who have initiated the weaning process and for whom the…
- Conditions
- Weaning From Mechanical Ventilation, Weaning Failure, Weaning From Mechanical Ventilation, Extubation
- Trial name
- NCT07337408
- Where
- Brazil
- Volunteers
- 900 people
- Sponsor
- Hospital do Coracao
Acute Respiratory Failure, Respiration, Artificial
Ultrasound to Evaluate Failure of Liberation From Mechanical Ventilation
This study will evaluate the heart, lungs and diaphragm of patients who fail a trial of spontaneous breathing to determine the physiological mechanism of weaning failure.
- Conditions
- Acute Respiratory Failure, Respiration, Artificial, Weaning
- Trial name
- USEFUL (NCT02723565)
- Where
- 3 sites in Canada
- Volunteers
- 7 people
- Sponsor
- University Health Network, Toronto
Weaning Failure
Weaning From Mechanical Ventilation: Spontaneous Breathing Trial and the Assessment of Work of Breathing
The main objective of the study is to examine the extent of agreement between patient and health care provider assessments of work of breathing and the association of agreement with demographic- and disease-related factors.
- Trial name
- NCT01928277
- Where
- 2 sites in Norway
- Volunteers
- 100 people
- Sponsor
- University of Tromso
Extubation Failure
Validation of an Effort-Based Cough Peak Flow Algorithm to Predict Extubation Outcomes
This study aims to prospectively validate the diagnostic accuracy of an effort-stratified Cough Peak Flow (CPF) decision algorithm for predicting extubation failure, maintaining strict blinding of the clinical team.
- Trial name
- NCT07737483
- Testing
- Observational measurement of Cough Peak Flow and Tidal Volume
- Volunteers
- 150 people
- Sponsor
- Hospital H+ Queretaro
Muscle Weakness Condition, Mechanical Ventilation Complication
Hand Grip Strength and Medical Research Council Scale as Predictors of Weaning Failure
The handgrip strength (HGS) will be measured with a digital dynamometer. Three measurements will be taken, whose average of the three measurements will be collected.
- Conditions
- Muscle Weakness Condition, Mechanical Ventilation Complication, Weaning Failure
- Trial name
- NCT03991702
- Testing
- diagnostic test
- Where
- Brazil
- Volunteers
- 102 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Weaning Failure, Mechanical Ventilation Complication
Development of a Multimodal Index to Improve the Predictive Value of Success in Weaning From Mechanical Ventilation
Weaning from mechanical ventilation (MV) is a complex process in which patients are liberated from the ventilator. Prolongued weaning and weaning failure, defined as the need for reintubation, have different adverse effects…
- Trial name
- NCT04554095
- Testing
- Clinical data collection
- Where
- Spain
- Volunteers
- 126 people
- Sponsor
- Corporacion Parc Tauli
Weaning Mechanical Ventilation
Airway Occlusion Pressure Derived Parameters During Spotaneous Breathing Trial for Predicting Extubation Failure
Weaning from invasive mechanical ventilation (IMV) is a critical stage of the intensive care unit (ICU) stay. Premature IMV discontinuation may expose patients to substantial cardiopulmonary stress, whereas prolonged weaning…
- Trial name
- Weaning-POP (NCT07786519)
- Where
- 4 sites in France
- Volunteers
- 225 people
- Sponsor
- Rennes University Hospital
Respiratory Failure
Study to Improve Treatments and Follow-up of Children Who Need Respiratory Support
Mechanical ventilation is a vital therapeutic support, widely used in pediatric intensive care. Invasive ventilation (IV) is associated with risk of major complications ( nosocomial pneumonia, secondary pulmonary barotrauma…
- Trial name
- Edi-PTP (NCT02154542)
- Testing
- Neurovent Monitor XIII
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- St. Justine's Hospital
Critical Illness, Respiratory Insufficiency
Combined Predictive Value of RSBI and CALLY Index in Predicting Weaning Success in ICU Patients
The primary objective of this prospective observational study is to evaluate the effectiveness of combining the Rapid Shallow Breathing Index (RSBI) and CRP-Albumin-Lymphocyte (CALLY) index to predict weaning success in adult…
- Conditions
- Critical Illness, Respiratory Insufficiency, Ventilator Weaning, Weaning Failure of Mechanical Ventilation
- Trial name
- NCT07571317
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people
- Sponsor
- Istanbul University - Cerrahpasa
Weaning Failure of Mechanical Ventilation
Speckle Tracking Echocardiography for the Prediction of Weaning Failure
Deciding the optimal timing for extubation in patients who are mechanically ventilated can be challenging, and traditional weaning predictor tools are not accurate.
- Trial name
- NCT03657524
- Testing
- echocardiography
- Where
- France
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Acute Respiratory Failure
Continuous Positive Airway Pressure and Oxygen Concentration on Measurement of Rapid Shallow Breathing Index
To compare the rapid shallow breathing index (RSBI) values, the incidence of adverse reactions, and the predictive accuracy measured under 5 different ventilator strategies in the same patient group.
- Trial name
- NCT00632320
- Where
- Taiwan
- Volunteers
- 98 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Weaning Failure
Role of Non-invasive Mechanical Ventilation and Diuretics in Improving Weaning Outcome of Patients With High Lung Ultrasound Score
patients who succeeded in SBT with high lung scores by ultrasound, non-invasive ventilation, and diuretic may have a role.
- Trial name
- NCT05617989
- Testing
- lung ultrasound
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Respiratory Failure
Multicenter, Multinational, Follow-Up Clinical Trial of the Performance of RESPINOR DXT to Identify Patients at Increased Risk of Weaning Failure
The study will be a multicenter, multinational, prospective single arm blinded non-interventional follow-up study (from DXT-CS-005) to validate RESPINOR DXT's performance to identify patients at increased risk of weaning failure…
- Trial name
- DE-RISK WF II (NCT05580185)
- Testing
- RESPINOR DXT
- Where
- 8 sites in France, Norway
- Volunteers
- 145 people
- Sponsor
- Respinor AS
Respiratory Failure
Respiratory Care in Intensive Care Unit for Neuromuscular Patients
Retrospective multicentric observational study exploring the population of adult neuromuscular patients presenting a respiratory distress requiring their admission in an Intensive Care Unit (ICU) for ventilatory support.
- Trial name
- NCT02936908
- Testing
- Ventilatory support
- Where
- 4 sites in France
- Volunteers
- 300 people
- Sponsor
- Hospices Civils de Lyon
Diaphragm Injury, Weaning Failure
The Validity of Maximal Diaphragm Thickening Fraction to Measure Diaphragm Function in Mechanically Ventilated Patients
This study is designed to determine whether maximal diaphragm thickening fraction measured by ultrasound during volitional maximal inspiratory efforts is a valid measure of diaphragm function in mechanically ventilated patients.
- Conditions
- Diaphragm Injury, Weaning Failure, Mechanical Ventilation Complication
- Trial name
- SNIFF III (NCT03129217)
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- University Health Network, Toronto