Clinical trials: Weaning From Mechanical Ventilation
Mechanical Ventilation
The Ratio of Diaphragmatic Movement Between the Midaxillary Line and the Midclavicular Line Predicts the Success Rate of Weaning From Mechanical Ventilation
This study will provide individualized objective indicators for patients undergoing invasive mechanical ventilation. It will set specific assessment parameters for weaning and extubation for different patients, increase the…
- Trial name
- NCT07235956
- Testing
- Observe the ratio of diaphragmatic excursion between the midaxillary line and the midclavicular line in the successful group of invasive mechanical ventilation weaning.
- Volunteers
- 100 people
- Sponsor
- Zheng Qingjiang
Obesity, Obesity With Complications
Prevalence, Determinants and Consequences of Dyspnea During Weaning in Critically Ill Obese Patients
ICU patients encounter numerous discomforts, with dyspnea (the sensation of breathlessness) being among the most distressing and impactful.
- Conditions
- Obesity, Obesity With Complications, Weaning From Mechanical Ventilation in Care Unit, Dyspnea
- Trial name
- WEAN OBESE (NCT06867354)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Prone Position, Supine Position
The Effect of the Position Given to the Child After Weaning from Noninvasive Mechanical Ventilation on Physiological Symptoms
The aim of this clinical trial was to investigate the effect of the position given to children after weaning from noninvasive mechanical ventilation on the physiological symptoms (heart rate, oxygen saturation, respiratory rate…
- Conditions
- Prone Position, Supine Position, Child
- Trial name
- NCT06580522
- Testing
- Prone Position Group, Supine Position Group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Acibadem University
Mechanical Ventilation Complication, Weaning Failure
NIV Versus HFO Versus Standard Therapy Immediately After Weaning From Mechanical Ventilation in ARDS Patients
The weaning failure is a paramount challenge when aggressive discontinuation of respiratory support in ARDS. The aim of the study is to improve weaning safety and efficacy by a transient postextubation non-invasive respiratory…
- Conditions
- Mechanical Ventilation Complication, Weaning Failure, Acute Respiratory Distress Syndrome, High-flow Oxygenation
- Trial name
- NCT06332768
- Testing
- Respiratory support
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Northern State Medical University
Respiration, Artificial, Critical Care
Weaning Algorithm for Mechanical VEntilation
To compare the duration of mechanical ventilation and the weaning period between two groups of patients managed with either Standard Care or with mechanical ventilation adjusted according to the Beacon Caresystem, in patients…
- Conditions
- Respiration, Artificial, Critical Care, Respiratory Insufficiency, Intensive Care (ICU) Myopathy
- Trial name
- WAVE (NCT03697785)
- Testing
- Beacon Care System
- Where
- 2 sites in United Kingdom
- Volunteers
- 286 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Respiratory Insufficiency
Prediction of Outcome of Weaning From Mechanical Ventilation Using the Electrical Activity of the Diaphragm
Several types of spontaneous breathing trials (SBTs) have been proposed to evaluate when a patient is ready to be weaned from the ventilator based on breathing pattern measurements.
- Trial name
- OWED (NCT02539732)
- Where
- 3 sites in Canada, France and 1 more
- Volunteers
- 110 people
- Sponsor
- Unity Health Toronto
Ventilator Weaning
Interaction Diaphragm and Cardiac Function During Ventilator Weaning
Weaning failure is associated with prolonged duration of mechanical ventilation that itself can worsen patient's prognosis. Therefore, identification of the causes and mechanisms leading to weaning failure is important in daily…
- Trial name
- I-DISCO (NCT03486249)
- Testing
- Repetition of medical examinations performed as part of the care
- Where
- France
- Volunteers
- 47 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Respiration, Artificial, Energy Metabolism
Energy Expenditure in Weaning From Mechanical Ventilation
During weaning from mechanical ventilation process, the energy expenditure in T tube is greater than pressure support ventilation.
- Trial name
- NCT00853060
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Patients With Acute Hypercapnic Respiratory Failure
Weaning Form Mechanical Ventilation Using Extracorporeal CO2 Removal
Weaning from invasive mechanical ventilation is one of the major clinical problem especially ion those patients with a pre-existing chronic respiratory disease and chronic hypercpania.
- Trial name
- WeanPRO (NCT02259335)
- Testing
- Extracorporeal CO2 removal device
- Where
- 2 sites in Italy
- Volunteers
- 15 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Respiratory Insufficiency
B-type Natriuretic Peptide for the Management of Weaning
Several clinical findings and clinical trials have suggested that the prognosis of intensive care unit (ICU) patients may be improved by minimizing the positive fluid balance.
- Trial name
- BMW (NCT00473148)
- Testing
- BNP-guided weaning, Standard physician-directed weaning
- Where
- France
- Volunteers
- 265 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Weaning Failure, Pulmonary Edema - Acute
Quantification of Systemic Congestion by Ultrasound As a Predictor of Weaning Failure From Mechanical Ventilation
Mechanical ventilation is an essential, life-saving therapy in the ICU, allowing critically ill patients to rest and recover. Transitioning patients back to spontaneous breathing-known as weaning-is clinically challenging.
- Conditions
- Weaning Failure, Pulmonary Edema - Acute, Mechanical Ventilation, POCUS
- Trial name
- SCOUT (NCT07343882)
- Testing
- point of care ultrasound
- Volunteers
- 350 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Weaning from Mechanical Ventilation
Impact of Gamma-OH on Sleep in ICU Patients
The Main objective of the trial is to assess sleep quality with Gamma-OH® in patients difficult to wean from mechanical ventilation in the ICU.
- Trial name
- GO-SLEEP (NCT04224246)
- Testing
- Gamma Hydroxybutyrate
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Poitiers University Hospital
Respiratory Failure, Obesity
Transpulmonary Pressure Guided Mechanical Ventilation Weaning in Obesity
This study will look at whether accounting for the amount of pressure generated by the chest wall and abdomen in a obese patient, using a measurement called transpulmonary pressure, can help shorten the amount of time patients…
- Trial name
- NCT05530434
- Testing
- transpulmonary pressure guided positive end expiratory pressure, standard positive end expiratory pressure
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Mississippi Medical Center
Respiratory Insufficiency, Psychomotor Agitation
Loxapine and Weaning From Ventilator
Patients may be very agitated during the weaning period from mechanical ventilation. Administration of loxapine, a neuroleptic that does not notably affect ventilatory drive, may help in obtaining an adequate level of cooperation…
- Trial name
- NCT00122733
- Testing
- loxapine
- Where
- France
- Volunteers
- 9 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Weaning Failure
The Effect of High Flow Oxygen Therapy Via Tracheostomy on Diaphragm Function
While the high flow oxygen therapy (HFOT) respiratory support system, delivered through nasal cannulas, has demonstrated clinical benefits on respiratory function, limited data exist on whether such effects are also present in…
- Trial name
- NCT04758910
- Testing
- High Flow Oxygen Therapy, T-piece
- Volunteers
- 30 people
- Sponsor
- Evangelismos Hospital
Dysphagia, NeuroMuscular Electrical Stimulation
Effectiveness of Transcutaneous NMES as an Adjunct for Swallowing Disorders in Tracheotomized Patients
Dysphagia can reach a prevalence of up to 80% in intensive care patients. The implementation or prolonged presence of medical devices such as the intubation tube, tracheostomy, or nasogastric tube alters the physiology of…
- Trial name
- SWALEC (NCT07529210)
- Testing
- Neuromuscular Electrical Stimulation (NMES)
- Volunteers
- 238 people
- Sponsor
- Hopital Forcilles
Ventilator Weaning
A Protocol to Wean From Noninvasive Mechanical Ventilation
The investigators use a protocol to wean from noninvasive mechanical ventilation.
- Trial name
- NCT01535755
- Testing
- protocol, physician's orders
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Duan jun
Ventilator Lung
Assessment of Process and Outcome of Protocol-based Weaning From Mechanical Ventilation in the Medical Patients
This is a prospective, single-center, observational study to describe characteristics of weaning process and factors associated with duration of weaning and its outcomes in all consecutive adult (aged 19 years and older) patients…
- Trial name
- NCT05134467
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Samsung Medical Center
Weaning From Mechanical Ventilation, Extubation
Direct Extubation Versus Extubation After a Spontaneous Breathing Trial in Patients at Low Risk of Extubation Failure
This randomized controlled open label trial aims at comparing a weaning strategy including a spontaneous breathing trial as a prerequisite for extubation to a weaning strategy without a spontaneous breathing trial (direct…
- Trial name
- T-REX (NCT07019636)
- Testing
- Weaning strategy with direct extubation (no spontaneous breathing trial), Weaning strategy with extubation only after a successful spontaneous breathing
- Where
- France
- Volunteers
- 314 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Intensive Care (ICU)
Role of Lung Ultrasound in Weaning From Mechanical Ventilation in Postoperative Neurosurgical ICU Patients
The aim of this study is to demonstrate the role of lung ultrasound in weaning from mechanical ventilation in neurosurgical ICU patients compared to the ordinary tools as chest X-ray , ABG, rapid shallow breathing index…
- Trial name
- NCT03921112
- Testing
- lung ultrasound, routine tools
- Where
- Egypt
- Volunteers
- 130 people
- Sponsor
- Ain Shams University